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Article Open Access

Novel therapeutic effects of sesamin on diabetes-induced cardiac dysfunction

  • Authors:
    • Tran Duong Thuy
    • Nam Nhut Phan
    • Chih-Yang Wang
    • Han-Gang Yu
    • Shu-Yin Wang
    • Pung-Ling Huang
    • Yi-Yin Do
    • Yen-Chang Lin
  • View Affiliations / Copyright

    Affiliations: Graduate Institute of Biotechnology, Chinese Culture University, YangMingShan, Taipei 11114, Taiwan, R.O.C., Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City 70000, Vietnam, Department of Anatomy, University of California San Francisco, San Francisco, CA 94143, USA, Department of Physiology and Pharmacology, West Virginia University, Morgantown, WV 26506, USA, Department of Horticulture and Landscape Architecture, National Taiwan University, Taipei 10617, Taiwan, R.O.C.
    Copyright: © Thuy et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2949-2956
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    Published online on: March 30, 2017
       https://doi.org/10.3892/mmr.2017.6420
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Abstract

Diabetes is a risk factor that increases the occurrence and severity of cardiovascular events. Cardiovascular complications are the leading cause of mortality of 75% of patients with diabetes >40 years old. Sesamin, the bioactive compound extracted from Sesamum indicum, is a natural compound that has diverse beneficial effects on hypoglycemia and reducing cholesterol. The aim of this study is to investigate sesamin effects to diabetes-inducing cardiac hypertrophy. In the present study bioinformatics analysis demonstrated cardiac hypertrophy signaling may be the most important pathway for upregulating genes in sesamin-treated groups. To verify the bioinformatics prediction, sesamin was used as the main bioactive compound to attenuate the impact of diabetes induced by streptozotocin (STZ) on cardiac function in a rat model. The results revealed that oral administration of sesamin for 4 weeks (100 and 200 mg/kg body weight) marginally improved blood glucose levels, body weight and significantly ameliorated the effects on heart rate and blood pressure in rats with type 1 diabetes relative to control rats. The QT interval of sesamin was also reduced relative to the control group. The findings indicated that sesamin has potential cardioprotective effects in the STZ-induced diabetes model. This suggested that this can be used as a novel treatment for patients with diabetes with cardiac dysfunction complication.
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Copy and paste a formatted citation
Spandidos Publications style
Thuy TD, Phan NN, Wang C, Yu H, Wang S, Huang P, Do Y and Lin Y: Novel therapeutic effects of sesamin on diabetes-induced cardiac dysfunction. Mol Med Rep 15: 2949-2956, 2017.
APA
Thuy, T.D., Phan, N.N., Wang, C., Yu, H., Wang, S., Huang, P. ... Lin, Y. (2017). Novel therapeutic effects of sesamin on diabetes-induced cardiac dysfunction. Molecular Medicine Reports, 15, 2949-2956. https://doi.org/10.3892/mmr.2017.6420
MLA
Thuy, T. D., Phan, N. N., Wang, C., Yu, H., Wang, S., Huang, P., Do, Y., Lin, Y."Novel therapeutic effects of sesamin on diabetes-induced cardiac dysfunction". Molecular Medicine Reports 15.5 (2017): 2949-2956.
Chicago
Thuy, T. D., Phan, N. N., Wang, C., Yu, H., Wang, S., Huang, P., Do, Y., Lin, Y."Novel therapeutic effects of sesamin on diabetes-induced cardiac dysfunction". Molecular Medicine Reports 15, no. 5 (2017): 2949-2956. https://doi.org/10.3892/mmr.2017.6420
Copy and paste a formatted citation
x
Spandidos Publications style
Thuy TD, Phan NN, Wang C, Yu H, Wang S, Huang P, Do Y and Lin Y: Novel therapeutic effects of sesamin on diabetes-induced cardiac dysfunction. Mol Med Rep 15: 2949-2956, 2017.
APA
Thuy, T.D., Phan, N.N., Wang, C., Yu, H., Wang, S., Huang, P. ... Lin, Y. (2017). Novel therapeutic effects of sesamin on diabetes-induced cardiac dysfunction. Molecular Medicine Reports, 15, 2949-2956. https://doi.org/10.3892/mmr.2017.6420
MLA
Thuy, T. D., Phan, N. N., Wang, C., Yu, H., Wang, S., Huang, P., Do, Y., Lin, Y."Novel therapeutic effects of sesamin on diabetes-induced cardiac dysfunction". Molecular Medicine Reports 15.5 (2017): 2949-2956.
Chicago
Thuy, T. D., Phan, N. N., Wang, C., Yu, H., Wang, S., Huang, P., Do, Y., Lin, Y."Novel therapeutic effects of sesamin on diabetes-induced cardiac dysfunction". Molecular Medicine Reports 15, no. 5 (2017): 2949-2956. https://doi.org/10.3892/mmr.2017.6420
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