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Neutrophil gelatinase‑associated lipocalin as a potential novel biomarker for ventilator‑associated lung injury

  • Authors:
    • Rui Xiao
    • Rongchang Chen
  • View Affiliations / Copyright

    Affiliations: Department of Respiration, Guangzhou Panyu Central Hospital, Guangzhou, Guangdong 511400, P.R. China, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, Guangzhou, Guangdong 510120, P.R. China
    Copyright: © Xiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3535-3540
    |
    Published online on: April 7, 2017
       https://doi.org/10.3892/mmr.2017.6442
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Abstract

Neutrophil gelatinase‑associated lipocalin (NGAL) is a 25‑kDa protein of the lipocalin superfamily and its presence was initially observed in activated neutrophils. It has previously been demonstrated that the expression of NGAL is markedly increased in stimulated epithelia, and is important in the innate immunological response to various pathophysiological conditions, including infection, cancer, inflammation and kidney injury. The present study constructed a ventilator‑associated lung injury model in mice. NGAL mRNA and protein expression levels in lung tissue were detected using reverse transcription‑quantitative polymerase chain reaction and western blotting, respectively. In addition, NGAL protein levels in bronchoalveolar lavage fluid and serum were measured via western blotting. The results of the present study suggested that NGAL expression increased under all mechanical ventilation treatments. The increase was most prominent in the high peak inflation pressure and high‑volume mechanical ventilation groups, where there was the greatest extent of lung injury. In addition, NGAL expression increased in a time‑dependent manner under high‑volume mechanical ventilation, consistent with the degree of lung injury. These findings suggested that NGAL may serve as a potential novel biomarker in ventilator‑associated lung injury.
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Copy and paste a formatted citation
Spandidos Publications style
Xiao R and Chen R: Neutrophil gelatinase‑associated lipocalin as a potential novel biomarker for ventilator‑associated lung injury. Mol Med Rep 15: 3535-3540, 2017.
APA
Xiao, R., & Chen, R. (2017). Neutrophil gelatinase‑associated lipocalin as a potential novel biomarker for ventilator‑associated lung injury. Molecular Medicine Reports, 15, 3535-3540. https://doi.org/10.3892/mmr.2017.6442
MLA
Xiao, R., Chen, R."Neutrophil gelatinase‑associated lipocalin as a potential novel biomarker for ventilator‑associated lung injury". Molecular Medicine Reports 15.6 (2017): 3535-3540.
Chicago
Xiao, R., Chen, R."Neutrophil gelatinase‑associated lipocalin as a potential novel biomarker for ventilator‑associated lung injury". Molecular Medicine Reports 15, no. 6 (2017): 3535-3540. https://doi.org/10.3892/mmr.2017.6442
Copy and paste a formatted citation
x
Spandidos Publications style
Xiao R and Chen R: Neutrophil gelatinase‑associated lipocalin as a potential novel biomarker for ventilator‑associated lung injury. Mol Med Rep 15: 3535-3540, 2017.
APA
Xiao, R., & Chen, R. (2017). Neutrophil gelatinase‑associated lipocalin as a potential novel biomarker for ventilator‑associated lung injury. Molecular Medicine Reports, 15, 3535-3540. https://doi.org/10.3892/mmr.2017.6442
MLA
Xiao, R., Chen, R."Neutrophil gelatinase‑associated lipocalin as a potential novel biomarker for ventilator‑associated lung injury". Molecular Medicine Reports 15.6 (2017): 3535-3540.
Chicago
Xiao, R., Chen, R."Neutrophil gelatinase‑associated lipocalin as a potential novel biomarker for ventilator‑associated lung injury". Molecular Medicine Reports 15, no. 6 (2017): 3535-3540. https://doi.org/10.3892/mmr.2017.6442
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