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Article Open Access

Differential effects of p38 and Erk1/2 on the chondrogenic and osteogenic differentiation of dental pulp stem cells

  • Authors:
    • Pengfei Ba
    • Xiaoyu Duan
    • Guo Fu
    • Shuyan Lv
    • Pishan Yang
    • Qinfeng Sun
  • View Affiliations / Copyright

    Affiliations: Department of Periodontology, School of Stomatology, Shandong University, Jinan, Shandong 250012, P.R. China, National Engineering Laboratory, WeGo Group Co., Ltd., Weihai, Shandong 264210, P.R. China, Department of Periodontology, Weihai Stomatological Hospital, Weihai, Shandong 264200, P.R. China
    Copyright: © Ba et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 63-68
    |
    Published online on: May 10, 2017
       https://doi.org/10.3892/mmr.2017.6563
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Abstract

The extracellular signal-regulated protein kinase 1/2 (Erk1/2) and p38 mitogen‑activated protein‑kinase pathways serve important roles in the regulation of osteogenic and chondrogenic differentiation in mesenchymal stem cells (MSCs). However, the exact mechanism remains unclear, and the effect is controversial. In the present study, the effects of Erk1/2 and p38 on the osteogenic and chondrogenic differentiation of dental pulp stem cells (DPSCs) were compared in vitro. The results indicated that inhibition of Erk1/2 is able to enhance the osteogenic differentiation of DPSCs and inhibit chondrogenic differentiation, whereas inhibition of p38 demonstrated the opposite effect. When compared with previous studies, the present study further confirmed that Erk1/2 and p38 serve important, but complicated, roles in regulating the differentiation of MSCs. Different chemical and physical stimuli, cell types, culture methods, times of inhibitor administration and the dosage of the inhibitor may influence the effect of Erk1/2 and p38 on the differentiation of MSCs. The present study aims to better understand the mechanisms that control the differentiation of MSCs and may be helpful in creating more effective tissue regeneration.
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Copy and paste a formatted citation
Spandidos Publications style
Ba P, Duan X, Fu G, Lv S, Yang P and Sun Q: Differential effects of p38 and Erk1/2 on the chondrogenic and osteogenic differentiation of dental pulp stem cells. Mol Med Rep 16: 63-68, 2017.
APA
Ba, P., Duan, X., Fu, G., Lv, S., Yang, P., & Sun, Q. (2017). Differential effects of p38 and Erk1/2 on the chondrogenic and osteogenic differentiation of dental pulp stem cells. Molecular Medicine Reports, 16, 63-68. https://doi.org/10.3892/mmr.2017.6563
MLA
Ba, P., Duan, X., Fu, G., Lv, S., Yang, P., Sun, Q."Differential effects of p38 and Erk1/2 on the chondrogenic and osteogenic differentiation of dental pulp stem cells". Molecular Medicine Reports 16.1 (2017): 63-68.
Chicago
Ba, P., Duan, X., Fu, G., Lv, S., Yang, P., Sun, Q."Differential effects of p38 and Erk1/2 on the chondrogenic and osteogenic differentiation of dental pulp stem cells". Molecular Medicine Reports 16, no. 1 (2017): 63-68. https://doi.org/10.3892/mmr.2017.6563
Copy and paste a formatted citation
x
Spandidos Publications style
Ba P, Duan X, Fu G, Lv S, Yang P and Sun Q: Differential effects of p38 and Erk1/2 on the chondrogenic and osteogenic differentiation of dental pulp stem cells. Mol Med Rep 16: 63-68, 2017.
APA
Ba, P., Duan, X., Fu, G., Lv, S., Yang, P., & Sun, Q. (2017). Differential effects of p38 and Erk1/2 on the chondrogenic and osteogenic differentiation of dental pulp stem cells. Molecular Medicine Reports, 16, 63-68. https://doi.org/10.3892/mmr.2017.6563
MLA
Ba, P., Duan, X., Fu, G., Lv, S., Yang, P., Sun, Q."Differential effects of p38 and Erk1/2 on the chondrogenic and osteogenic differentiation of dental pulp stem cells". Molecular Medicine Reports 16.1 (2017): 63-68.
Chicago
Ba, P., Duan, X., Fu, G., Lv, S., Yang, P., Sun, Q."Differential effects of p38 and Erk1/2 on the chondrogenic and osteogenic differentiation of dental pulp stem cells". Molecular Medicine Reports 16, no. 1 (2017): 63-68. https://doi.org/10.3892/mmr.2017.6563
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