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Article

PER2 is downregulated by the LPS-induced inflammatory response in synoviocytes in rheumatoid arthritis and is implicated in disease susceptibility

  • Authors:
    • Hwayoung Lee
    • Seong‑Su Nah
    • Sung‑Hae Chang
    • Hyung‑Ki Kim
    • Jun‑Tack Kwon
    • Sanghyun Lee
    • Ik‑Hyun Cho
    • Sang Won Lee
    • Young Ock Kim
    • Seung‑Jae Hong
    • Hak‑Jae Kim
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Pharmacology, College of Medicine, Soonchunhyang University, Cheonan, Chungcheongnam 31151, Republic of Korea, Division of Rheumatology, Department of Internal Medicine, College of Medicine, Soonchunhyang University, Cheonan, Chungcheongnam 31151, Republic of Korea, Department of Integrative Plant Science, Chung‑Ang University, Anseong, Gyeonggi 17546, Republic of Korea, Department of Convergence Medical Science, Brain Korea 21 Plus Program and Institute of Korean Medicine, College of Oriental Medicine, Kyung Hee University, Seoul 02453, Republic of Korea, Department of Development of Ginseng and Medical Plants Research Institute, Rural Administration, Eumseong, Chungcheongbuk 27709, Republic of Korea, Division of Rheumatology, Department of Internal Medicine, School of Medicine, Kyung Hee University, Seoul 02453, Republic of Korea
  • Pages: 422-428
    |
    Published online on: May 11, 2017
       https://doi.org/10.3892/mmr.2017.6578
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Abstract

The clinical symptoms of rheumatoid arthritis (RA) present with circadian variation, with joint stiffness and pain more prominent in the early morning. The mammalian clock genes, which include circadian locomotor output cycles kaput, brain and muscle Arnt-like protein 1, period and cryptochrome, regulate circadian rhythms. In order to identify the association between genetic polymorphisms in the circadian clock gene period 2 (PER2) and RA, the present study genotyped three PER2 single nucleotide polymorphisms (SNPs), rs934945, rs6754875, and rs2304674, using genetic information from 256 RA patients and 499 control subjects. Primary cultured rheumatoid synovial cells were stimulated with 10 µM lipopolysaccharide (LPS). Total protein was then extracted from the synovial cells following 12 and 24 h, and PER2 protein expression was assayed by immunoblotting. The rs2304674 SNP demonstrated a significant association with susceptibility to RA following Bonferroni correction. However, statistical analysis indicated that the SNPs were not associated with any clinical features of patients with RA. Immunoblotting analysis demonstrated that PER2 protein expression was decreased by LPS‑induced inflammation in RA synovial cells; however, this was not observed in normal synovial cells. The results suggest that the PER2 gene may be a risk factor for RA, and expression of the PER2 protein may be affected by inflammation. Therefore, PER2 may contribute to the pathogenesis of RA.
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1 

Lee DM and Weinblatt ME: Rheumatoid arthritis. Lancet. 358:903–911. 2001. View Article : Google Scholar : PubMed/NCBI

2 

Haas S and Straub RH: Disruption of rhythms of molecular clocks in primary synovial fibroblasts of patients with osteoarthritis and rheumatoid arthritis, role of IL-1β/TNF. Arthritis Res Ther. 14:R1222012. View Article : Google Scholar : PubMed/NCBI

3 

Straub RH and Cutolo M: Circadian rhythms in rheumatoid arthritis: Implications for pathophysiology and therapeutic management. Arthritis Rheum. 56:399–408. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Gibbs JE and Ray DW: The role of the circadian clock in rheumatoid arthritis. Arthritis Res Ther. 15:2052013. View Article : Google Scholar : PubMed/NCBI

5 

Keller M, Mazuch J, Abraham U, Eom GD, Herzog ED, Volk HD, Kramer A and Maier B: A circadian clock in macrophages controls inflammatory immune responses. Proc Natl Acad Sci USA. 106:21407–21412. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Castanon-Cervantes O, Wu M, Ehlen JC, Paul K, Gamble KL, Johnson RL, Besing RC, Menaker M, Gewirtz AT and Davidson AJ: Dysregulation of inflammatory responses by chronic circadian disruption. J Immunol. 185:5796–5805. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Coogan AN and Wyse CA: Neuroimmunology of the circadian clock. Brain Res. 1232:104–112. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Segall LA, Perrin JS, Walker CD, Stewart J and Amir S: Glucocorticoid rhythms control the rhythm of expression of the clock protein, Period2, in oval nucleus of the bed nucleus of the stria terminalis and central nucleus of the amygdala in rats. Neuroscience. 140:753–757. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Burioka N, Fukuoka Y, Takata M, Endo M, Miyata M, Chikumi H, Tomita K, Kodani M, Touge H, Takeda K, et al: Circadian rhythms in the CNS and peripheral clock disorders: Function of clock genes: Influence of medication for bronchial asthma on circadian gene. J Pharmacol Sci. 103:144–149. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Young ME: The circadian clock within the heart: Potential influence on myocardial gene expression, metabolism, and function. Am J Physiol Heart Circ Physiol. 290:H1–H16. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Reppert SM and Weaver DR: Coordination of circadian timing in mammals. Nature. 418:935–941. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Roenneberg T and Merrow M: The network of time: Understanding the molecular circadian system. Curr Biol. 13:R198–R207. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Dunlap JC: Molecular bases for circadian clocks. Cell. 96:271–290. 1999. View Article : Google Scholar : PubMed/NCBI

14 

Young MW and Kay SA: Time zones: A comparative genetics of circadian clocks. Nat Rev Genet. 2:702–715. 2001. View Article : Google Scholar : PubMed/NCBI

15 

Yamamoto T, Nakahata Y, Soma H, Akashi M, Mamine T and Takumi T: Transcriptional oscillation of canonical clock genes in mouse peripheral tissues. BMC Mol Biol. 5:182004. View Article : Google Scholar : PubMed/NCBI

16 

Vukolic A, Antic V, Van Vliet BN, Yang Z, Albrecht U and Montani JP: Role of mutation of the circadian clock gene PER2 in cardiovascular circadian rhythms. Am J Physiol Regul Integr Comp Physiol. 298:R627–R634. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Akashi M, Tsuchiya Y, Yoshino T and Nishida E: Control of intracellular dynamics of mammalian period proteins by casein kinase I epsilon (CKIepsilon) and CKIdelta in cultured cells. Mol Cell Biol. 22:1693–1703. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Jin X, Shearman LP, Weaver DR, Zylka MJ, de Vries GJ and Reppert SM: A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock. Cell. 96:57–68. 1999. View Article : Google Scholar : PubMed/NCBI

19 

Cavadini G, Petrzilka S, Kohler P, Jud C, Tobler I, Birchler T and Fontana A: TNF-alpha suppresses the expression of clock genes by interfering with E-box-mediated transcription. Proc Natl Acad Sci USA. 104:12843–12848. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Vanselow K, Vanselow JT, Westermark PO, Reischl S, Maier B, Korte T, Herrmann A, Herzel H, Schlosser A and Kramer A: Differential effects of PER2 phosphorylation: Molecular basis for the human familial advanced sleep phase syndrome (FASPS). Genes. 20:2660–2672. 2006. View Article : Google Scholar

21 

Dunlap JC, Loros JJ and DeCoursey PT: Biological timekeeping 1st edition. Sunderland (Massachusetts): Sinauer Associates, Chronobiology; pp. 4062004

22 

Lee C, Etchegaray JP, Cagapang FR, Loudon AS and Reppert SM: Posttranslational mechanisms regulate the mammalian circadian clock. Cell. 107:855–867. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Reppert SM and Weaver DR: Molecular analysis of mammalian circadian rhythms. Annu Rev Physiol. 63:647–676. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Toh KL, Jones CR, He Y, Eide EJ, Hinz WA, Virshup DM, Ptácek LJ and Fu YH: An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome. Science. 291:1040–1043. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Zheng B, Larkin DW, Albrecht U, Sun ZS, Sage M, Eichele G, Lee CC and Bradley A: The mPer2 gene encodes a functional component of the mammalian circadian clock. Nature. 400:169–173. 1999. View Article : Google Scholar : PubMed/NCBI

26 

Bae K, Jin X, Maywood ES, Hastings MH, Reppert SM and Weaver DR: Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock. Neuron. 30:525–536. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Mottonen T, Hannonen P, Leirisalo-Repo M, Nissilä M, Kautiainen H, Korpela M, Laasonen L, Julkunen H, Luukkainen R, Vuori K, et al: Comparison of combination therapy with single-drug therapy in early rheumatoid arthritis: A randomised trial. FIN-RACo trial group. Lancet. 353:1568–1573. 1999. View Article : Google Scholar : PubMed/NCBI

28 

Moreland LW, Baumgartner SW, Schiff MH, Tindall EA, Fleischmann RM, Weaver AL, Ettlinger RE, Cohen S, Koopman WJ, Mohler K, et al: Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein. N Engl J Med. 337:141–147. 1997. View Article : Google Scholar : PubMed/NCBI

29 

Nader N, Chrousos GP and Kino T: Interactions of the circadian CLOCK system and the HPA axis. Trends Endocrinol Metab. 21:277–286. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Kowanko IC, Knapp MS, Pownall R and Swannell AJ: Domiciliary self-measurement in the rheumatoid arthritis and the demonstration of circadian rhythmicity. Ann Rheum Dis. 41:453–455. 1982. View Article : Google Scholar : PubMed/NCBI

31 

Cutolo M and Straub RH: Circadian rhythms in arthritis: Hormonal effects on the immune/inflammatory reaction. Autoimmu Rev. 7:223–228. 2008. View Article : Google Scholar

32 

Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS, et al: The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 31:315–324. 1988. View Article : Google Scholar : PubMed/NCBI

33 

Forbes EE, Dahl RE, Almeida JR, Ferrell RE, Nimgaonkar VL, Mansour H, Sciarrillo SR, Holm SM, Rodriguez EE and Phillips ML: PER2 rs2304672 polymorphism moderates circadian-relevant reward circuitry activity in adolescents. Biol Psychiatry. 71:451–457. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Lee HJ, Kim L, Kang SG, Yoon HK, Choi JE, Park YM, Kim SJ and Kripke DF: PER2 variation is associated with diurnal preference in a Korean young population. Behav Genet. 41:273–277. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Kim HK, Lee WY, Kwon JT, Sohn DR, Hong SJ and Kim HJ: Association of ultraviolet radiation resistance-associated gene polymorphisms with rheumatoid arthritis. Biomed Rep. 2:117–121. 2013.PubMed/NCBI

36 

Kwak Y, Lundkvist GB, Brask J, Davidson A, Menaker M, Kristensson K and Block GD: Interferon-gamma alters electrical activity and clock gene expression in suprachiasmatic nucleus neurons. J Biol Rhythms. 23:150–159. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Davis MC, Zautra AJ, Younger J, Motivala SJ, Attrep J and Irwin MR: Chronic stress and regulation of cellular markers of inflammation in rheumatoid arthritis: Implications for fatigue. Brain Behav Immun. 22:24–32. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Takane H, Ohdo S, Baba R, Koyanagi S, Yukawa E and Higuchi S: Relationship between 24-hour rhythm in antiviral effect of interferon-beta and interferon-alpha/beta receptor expression in mice. Jpn J Pharmacol. 90:304–312. 2002. View Article : Google Scholar : PubMed/NCBI

39 

Hayashi M, Shimba S and Tezuka M: Characterization of the molecular clock in mouse peritoneal macrophages. Biol Pharm Bull. 30:621–626. 2007. View Article : Google Scholar : PubMed/NCBI

40 

Arjona A and Sarkar DK: The circadian gene mPer2 regulates the daily rhythm of IFN-gamma. J Interferon Cytokine Res. 26:645–649. 2006. View Article : Google Scholar : PubMed/NCBI

41 

Liu J, Malkani G, Shi X, Meyer M, Cunningham-Runddles S, Ma X and Sun ZS: The circadian clock Period 2 gene regulates gamma interferon production of NK cells in host response to lipopolysaccharide-induced endotoxic shock. Infect Immun. 74:4750–4756. 2006. View Article : Google Scholar : PubMed/NCBI

42 

Keller M, Mazuch J, Abraham U, Eom GD, Herzog ED, Volk HD, Kramer A and Maier B: A circadian clock in macrophages controls inflammatory immune responses. Proc Natl Acad Sci USA. 106:21407–21412. 2009. View Article : Google Scholar : PubMed/NCBI

43 

Hashiramoto A, Yamane T, Tsumiyama K, Yoshida K, Komai K, Yamada H, Yamazaki F, Doi M, Okamura H and Shiozawa S: Mammalian clock gene Cryptochrome regulates arthritis via proinflammatory cytokine TNF-alpha. J Immunol. 184:1560–1565. 2010. View Article : Google Scholar : PubMed/NCBI

44 

Yoshida K, Hashimoto T, Sakai Y and Hashiramoto A: Involvement of the circadian rhythm and inflammatory cytokines in the pathogenesis of rheumatoid arthritis. J Immunol Res. 2014:2824952014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lee H, Nah SS, Chang SH, Kim HK, Kwon JT, Lee S, Cho IH, Lee SW, Kim YO, Hong SJ, Hong SJ, et al: PER2 is downregulated by the LPS-induced inflammatory response in synoviocytes in rheumatoid arthritis and is implicated in disease susceptibility. Mol Med Rep 16: 422-428, 2017.
APA
Lee, H., Nah, S., Chang, S., Kim, H., Kwon, J., Lee, S. ... Kim, H. (2017). PER2 is downregulated by the LPS-induced inflammatory response in synoviocytes in rheumatoid arthritis and is implicated in disease susceptibility. Molecular Medicine Reports, 16, 422-428. https://doi.org/10.3892/mmr.2017.6578
MLA
Lee, H., Nah, S., Chang, S., Kim, H., Kwon, J., Lee, S., Cho, I., Lee, S. W., Kim, Y. O., Hong, S., Kim, H."PER2 is downregulated by the LPS-induced inflammatory response in synoviocytes in rheumatoid arthritis and is implicated in disease susceptibility". Molecular Medicine Reports 16.1 (2017): 422-428.
Chicago
Lee, H., Nah, S., Chang, S., Kim, H., Kwon, J., Lee, S., Cho, I., Lee, S. W., Kim, Y. O., Hong, S., Kim, H."PER2 is downregulated by the LPS-induced inflammatory response in synoviocytes in rheumatoid arthritis and is implicated in disease susceptibility". Molecular Medicine Reports 16, no. 1 (2017): 422-428. https://doi.org/10.3892/mmr.2017.6578
Copy and paste a formatted citation
x
Spandidos Publications style
Lee H, Nah SS, Chang SH, Kim HK, Kwon JT, Lee S, Cho IH, Lee SW, Kim YO, Hong SJ, Hong SJ, et al: PER2 is downregulated by the LPS-induced inflammatory response in synoviocytes in rheumatoid arthritis and is implicated in disease susceptibility. Mol Med Rep 16: 422-428, 2017.
APA
Lee, H., Nah, S., Chang, S., Kim, H., Kwon, J., Lee, S. ... Kim, H. (2017). PER2 is downregulated by the LPS-induced inflammatory response in synoviocytes in rheumatoid arthritis and is implicated in disease susceptibility. Molecular Medicine Reports, 16, 422-428. https://doi.org/10.3892/mmr.2017.6578
MLA
Lee, H., Nah, S., Chang, S., Kim, H., Kwon, J., Lee, S., Cho, I., Lee, S. W., Kim, Y. O., Hong, S., Kim, H."PER2 is downregulated by the LPS-induced inflammatory response in synoviocytes in rheumatoid arthritis and is implicated in disease susceptibility". Molecular Medicine Reports 16.1 (2017): 422-428.
Chicago
Lee, H., Nah, S., Chang, S., Kim, H., Kwon, J., Lee, S., Cho, I., Lee, S. W., Kim, Y. O., Hong, S., Kim, H."PER2 is downregulated by the LPS-induced inflammatory response in synoviocytes in rheumatoid arthritis and is implicated in disease susceptibility". Molecular Medicine Reports 16, no. 1 (2017): 422-428. https://doi.org/10.3892/mmr.2017.6578
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