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Article

hTERT C250T promoter mutation and telomere length as a molecular markers of cancer progression in patients with head and neck cancer

  • Authors:
    • Wojciech Barczak
    • Wiktoria M. Suchorska
    • Agnieszka Sobecka
    • Karolina Bednarowicz
    • Piotr Machczynski
    • Pawel Golusinski
    • Blazej Rubis
    • Michal M. Masternak
    • Wojciech Golusinski
  • View Affiliations / Copyright

    Affiliations: Department of Head and Neck Surgery, Poznan University of Medical Sciences, The Greater Poland Cancer Centre, Garbary, Poznan, Greater Poland Voivodeship 61‑866, Poland, Radiobiology Lab, The Greater Poland Cancer Centre, Garbary, Poznan, Greater Poland Voivodeship 61‑866, Poland, Department of Clinical Chemistry and Molecular Diagnostics, Poznan University of Medical Sciences, Przybyszewskiego, Poznan, Greater Poland Voivodeship 60‑355, Poland
  • Pages: 441-446
    |
    Published online on: May 17, 2017
       https://doi.org/10.3892/mmr.2017.6590
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Abstract

Squamous cell carcinoma of the head and neck (HNSCC) is the sixth leading cause of cancer worldwide, representing over half a million incidents every year. Cancer cells, including HNSCC, are characterized by increased telomerase activity. This enzymatic complex is active in ~90% of all cancer types and is responsible for the lengthening of telomeres. Highly recurrent point mutations in the human telomerase reverse transcriptase (hTERT) promoter have recently been reported in a number of human neoplasms. The aim of the present study was to analyze the prevalence of the hTERT promoter C250T mutation and telomere length in the blood leukocytes of 61 patients with HNSCC and 49 healthy individuals. Quantitative polymerase chain reaction identified the hTERT promoter mutation in 36% of patients with HNSCC. To the best of our knowledge this is first report indicating the presence of shorter telomeres in early stage tumors. In addition, the results suggest that the C250T hTERT promoter mutation and telomere length assessment may serve as important molecular markers of HNSCC progression.
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Copy and paste a formatted citation
Spandidos Publications style
Barczak W, Suchorska WM, Sobecka A, Bednarowicz K, Machczynski P, Golusinski P, Rubis B, Masternak MM and Golusinski W: hTERT C250T promoter mutation and telomere length as a molecular markers of cancer progression in patients with head and neck cancer. Mol Med Rep 16: 441-446, 2017.
APA
Barczak, W., Suchorska, W.M., Sobecka, A., Bednarowicz, K., Machczynski, P., Golusinski, P. ... Golusinski, W. (2017). hTERT C250T promoter mutation and telomere length as a molecular markers of cancer progression in patients with head and neck cancer. Molecular Medicine Reports, 16, 441-446. https://doi.org/10.3892/mmr.2017.6590
MLA
Barczak, W., Suchorska, W. M., Sobecka, A., Bednarowicz, K., Machczynski, P., Golusinski, P., Rubis, B., Masternak, M. M., Golusinski, W."hTERT C250T promoter mutation and telomere length as a molecular markers of cancer progression in patients with head and neck cancer". Molecular Medicine Reports 16.1 (2017): 441-446.
Chicago
Barczak, W., Suchorska, W. M., Sobecka, A., Bednarowicz, K., Machczynski, P., Golusinski, P., Rubis, B., Masternak, M. M., Golusinski, W."hTERT C250T promoter mutation and telomere length as a molecular markers of cancer progression in patients with head and neck cancer". Molecular Medicine Reports 16, no. 1 (2017): 441-446. https://doi.org/10.3892/mmr.2017.6590
Copy and paste a formatted citation
x
Spandidos Publications style
Barczak W, Suchorska WM, Sobecka A, Bednarowicz K, Machczynski P, Golusinski P, Rubis B, Masternak MM and Golusinski W: hTERT C250T promoter mutation and telomere length as a molecular markers of cancer progression in patients with head and neck cancer. Mol Med Rep 16: 441-446, 2017.
APA
Barczak, W., Suchorska, W.M., Sobecka, A., Bednarowicz, K., Machczynski, P., Golusinski, P. ... Golusinski, W. (2017). hTERT C250T promoter mutation and telomere length as a molecular markers of cancer progression in patients with head and neck cancer. Molecular Medicine Reports, 16, 441-446. https://doi.org/10.3892/mmr.2017.6590
MLA
Barczak, W., Suchorska, W. M., Sobecka, A., Bednarowicz, K., Machczynski, P., Golusinski, P., Rubis, B., Masternak, M. M., Golusinski, W."hTERT C250T promoter mutation and telomere length as a molecular markers of cancer progression in patients with head and neck cancer". Molecular Medicine Reports 16.1 (2017): 441-446.
Chicago
Barczak, W., Suchorska, W. M., Sobecka, A., Bednarowicz, K., Machczynski, P., Golusinski, P., Rubis, B., Masternak, M. M., Golusinski, W."hTERT C250T promoter mutation and telomere length as a molecular markers of cancer progression in patients with head and neck cancer". Molecular Medicine Reports 16, no. 1 (2017): 441-446. https://doi.org/10.3892/mmr.2017.6590
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