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Article

Tamoxifen promotes apoptosis and inhibits invasion in estrogen‑positive breast cancer MCF‑7 cells

  • Authors:
    • Wei Li
    • Xingpeng Shi
    • Yan Xu
    • Jianmei Wan
    • Shaohua Wei
    • Ran Zhu
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215123, P.R. China, Department of General Surgery, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215123, P.R. China, Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Medical College of Soochow University, Collaborative Innovation Center of Radiation Medicine, Jiangsu Higher Education Institutions, Suzhou, Jiangsu 215123, P.R. China
  • Pages: 478-484
    |
    Published online on: May 18, 2017
       https://doi.org/10.3892/mmr.2017.6603
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Abstract

Tamoxifen (TAM) is the earliest non-steroidal antiestrogen drug, which has been widely used in endocrine therapy targeting breast cancer. The aim of the present study was to investigate the effect of TAM on the proliferation, apoptosis, migration and invasion of the estrogen‑positive (ER+) breast cancer cell line MCF‑7 in vitro, and elucidate its mechanisms. It was demonstrated that TAM suppressed proliferation, migration and invasion, and induced apoptosis in MCF‑7 cells. Further investigation revealed that the mitochondrial membrane potential and the amount of ATP were significantly decreased following the treatment of MCF‑7 cells with TAM. Mitochondria are an important source of reactive oxygen species (ROS) and they are also the target of ROS as well. In the present study, TAM promoted the formation of ROS in MCF‑7 cells. In conclusion, these results reveal the underlying mechanism by which TAM induces ER+ breast cancer cell apoptosis and inhibits invasion, thereby supporting the use of TAM in breast cancer treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Li W, Shi X, Xu Y, Wan J, Wei S and Zhu R: Tamoxifen promotes apoptosis and inhibits invasion in estrogen‑positive breast cancer MCF‑7 cells. Mol Med Rep 16: 478-484, 2017.
APA
Li, W., Shi, X., Xu, Y., Wan, J., Wei, S., & Zhu, R. (2017). Tamoxifen promotes apoptosis and inhibits invasion in estrogen‑positive breast cancer MCF‑7 cells. Molecular Medicine Reports, 16, 478-484. https://doi.org/10.3892/mmr.2017.6603
MLA
Li, W., Shi, X., Xu, Y., Wan, J., Wei, S., Zhu, R."Tamoxifen promotes apoptosis and inhibits invasion in estrogen‑positive breast cancer MCF‑7 cells". Molecular Medicine Reports 16.1 (2017): 478-484.
Chicago
Li, W., Shi, X., Xu, Y., Wan, J., Wei, S., Zhu, R."Tamoxifen promotes apoptosis and inhibits invasion in estrogen‑positive breast cancer MCF‑7 cells". Molecular Medicine Reports 16, no. 1 (2017): 478-484. https://doi.org/10.3892/mmr.2017.6603
Copy and paste a formatted citation
x
Spandidos Publications style
Li W, Shi X, Xu Y, Wan J, Wei S and Zhu R: Tamoxifen promotes apoptosis and inhibits invasion in estrogen‑positive breast cancer MCF‑7 cells. Mol Med Rep 16: 478-484, 2017.
APA
Li, W., Shi, X., Xu, Y., Wan, J., Wei, S., & Zhu, R. (2017). Tamoxifen promotes apoptosis and inhibits invasion in estrogen‑positive breast cancer MCF‑7 cells. Molecular Medicine Reports, 16, 478-484. https://doi.org/10.3892/mmr.2017.6603
MLA
Li, W., Shi, X., Xu, Y., Wan, J., Wei, S., Zhu, R."Tamoxifen promotes apoptosis and inhibits invasion in estrogen‑positive breast cancer MCF‑7 cells". Molecular Medicine Reports 16.1 (2017): 478-484.
Chicago
Li, W., Shi, X., Xu, Y., Wan, J., Wei, S., Zhu, R."Tamoxifen promotes apoptosis and inhibits invasion in estrogen‑positive breast cancer MCF‑7 cells". Molecular Medicine Reports 16, no. 1 (2017): 478-484. https://doi.org/10.3892/mmr.2017.6603
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