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Article Open Access

A proteomic analysis identifies candidate early biomarkers to predict ovarian hyperstimulation syndrome in polycystic ovarian syndrome patients

  • Authors:
    • Lan Wu
    • Yazhou Sun
    • Jun Wan
    • Ting Luan
    • Qing Cheng
    • Yong Tan
  • View Affiliations / Copyright

    Affiliations: First Clinical Medicine College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210046, P.R. China, Department of Pediatrics, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453003, P.R. China, Department of Obstetrics, Nanjing Medical University Affiliated Nanjing Maternal and Child Health Hospital, Nanjing, Jiangsu 210004, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 272-280
    |
    Published online on: May 18, 2017
       https://doi.org/10.3892/mmr.2017.6604
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Abstract

Ovarian hyperstimulation syndrome (OHSS) is a potentially life‑threatening, iatrogenic complication that occurs during assisted reproduction. Polycystic ovarian syndrome (PCOS) significantly increases the risk of OHSS during controlled ovarian stimulation. Therefore, a more effective early prediction technique is required in PCOS patients. Quantitative proteomic analysis of serum proteins indicates the potential diagnostic value for disease. In the present study, the authors revealed the differentially expressed proteins in OHSS patients with PCOS as new diagnostic biomarkers. The promising proteins obtained from liquid chromatography‑mass spectrometry were subjected to ELISA and western blotting assay for further confirmation. A total of 57 proteins were identified with significant difference, of which 29 proteins were upregulated and 28 proteins were downregulated in OHSS patients. Haptoglobin, fibrinogen and lipoprotein lipase were selected as candidate biomarkers. Receiver operating characteristic curve analysis demonstrated all three proteins may have potential as biomarkers to discriminate OHSS in PCOS patients. Haptoglobin, fibrinogen and lipoprotein lipase have never been reported as a predictive marker of OHSS in PCOS patients, and their potential roles in OHSS occurrence deserve further studies. The proteomic results reported in the present study may gain deeper insights into the pathophysiology of OHSS.
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1 

Smith V, Osianlis T and Vollenhoven B: Prevention of ovarian hyperstimulation syndrome: A review. Obstet Gynecol Int. 2015:5141592015. View Article : Google Scholar : PubMed/NCBI

2 

Nastri CO, Teixeira DM, Moroni RM, Leitão VM and Martins WP: Ovarian hyperstimulation syndrome: Patho physiology, staging, prediction and prevention. Ultrasound Obstet Gynecol. 45:377–393. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Kumar P, Sait SF, Sharma A and Kumar M: Ovarian hyperstimulation syndrome. J Hum Reprod Sci. 4:70–75. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Sukul SP, Pekelharing JE, van Hooff MH, van der Weiden RM and van Asten JC: Thrombosis in ovarian hyperstimulation syndrome. Ned Tijdschr Geneeskd. 158:A71082014.(In Dutch). PubMed/NCBI

5 

Halupczok J, Kluba-Szyszka A, Bidzińska-Speichert B and Knychalski B: Ovarian hyperstimulation caused by gonadotroph pituitary adenoma-review. Adv Clin Exp Med. 24:695–703. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Nouri K, Tempfer CB, Lenart C, Windischbauer L, Walch K, Promberger R and Ott J: Predictive factors for recovery time in patients suffering from severe OHSS. Reprod Biol Endocrinol. 12:592014. View Article : Google Scholar : PubMed/NCBI

7 

Guo JL, Zhang DD, Zhao Y, Zhang D, Zhang XM, Zhou CQ and Yao SZ: Pharmacologic interventions in preventing ovarian hyperstimulation syndrome: A systematic review and network meta-analysis. Sci Rep. 6:190932016. View Article : Google Scholar : PubMed/NCBI

8 

Miller I, Chuderland D, Ron-El R, Shalgi R and Ben-Ami I: GnRH agonist triggering modulates PEDF to VEGF ratio inversely to hCG in granulosa cells. J Clin Endocrinol Metab. 100:E1428–E1436. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Ingman WV and Robertson SA: Transforming growth factor-beta1 null mutation causes infertility in male mice associated with testosterone deficiency and sexual dysfunction. Endocrinology. 148:4032–4043. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Herr D, Bekes I and Wulff C: Local renin-angiotensin system in the reproductive system. Front Endocrinol (Lausanne). 4:1502013.PubMed/NCBI

11 

Ashrafi M, Bahmanabadi A, Akhond MR and Arabipoor A: Predictive factors of early moderate/severe ovarian hyper stimulation syndrome in non-polycystic ovarian syndrome patients: A statistical model. Arch Gynecol Obstet. 292:1145–1152. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Ocal P, Sahmay S, Cetin M, Irez T, Guralp O and Cepni I: Serum anti-Müllerian hormone and antral follicle count as predictive markers of OHSS in ART cycles. J Assist Reprod Genet. 28:1197–1203. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Markel G, Imazio M, Koren-Morag N, Galore-Haskel G, Schachter J, Besser M, Cumetti D, Maestroni S, Altman A, Shoenfeld Y, et al: CEACAM1 and MICA as novel serum biomarkers in patients with acute and recurrent pericarditis. Oncotarget. 7:17885–17895. 2016.PubMed/NCBI

14 

Xu D, Li Y, Li X, Wei LL, Pan Z, Jiang TT, Chen ZL, Wang C, Cao WM, Zhang X, et al: Serum protein S100A9, SOD3, and MMP9 as new diagnostic biomarkers for pulmonary tuberculosis by iTRAQ-coupled two-dimensional LC-MS/MS. Proteomics. 15:58–67. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Palioura E and Diamanti-Kandarakis E: Polycystic ovary syndrome (PCOS) and endocrine disrupting chemicals (EDCs). Rev Endocr Metab Disord. 16:365–371. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Golan A and Weissman A: Symposium: Update on prediction and management of OHSS. A modern classification of OHSS. Reprod Biomed Online. 19:28–32. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Nhi DM, Huy NT, Ohyama K, Kimura D, Lan NT, Uchida L, Thuong NV, Nhon CT, le Phuc H, Mai NT, et al: A proteomic approach identifies candidate early biomarkers to predict severe dengue in children. PLoS Negl Trop Dis. 10:e00044352016. View Article : Google Scholar : PubMed/NCBI

18 

Zhang Y, Kang Y, Zhou Q, Zhou J, Wang H, Jin H, Liu X, Ma D and Li X: Quantitative proteomic analysis of serum from pregnant women carrying a fetus with conotruncal heart defect using isobaric tags for relative and absolute quantitation (iTRAQ) labeling. PLoS One. 9:e1116452014. View Article : Google Scholar : PubMed/NCBI

19 

Chen L, Gu H, Li J, Yang ZY, Sun X, Zhang L, Shan L, Wu L, Wei X, Zhao Y, et al: Comprehensive maternal serum proteomics identifies the cytoskeletal proteins as non-invasive biomarkers in prenatal diagnosis of congenital heart defects. Sci Rep. 6:192482016. View Article : Google Scholar : PubMed/NCBI

20 

Ezeh U, Yildiz BO and Azziz R: Referral bias in defining the phenotype and prevalence of obesity in polycystic ovary syndrome. J Clin Endocrinol Metab. 98:E1088–E1096. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Ezcurra D and Humaidan P: A review of luteinising hormone and human chorionic gonadotropin when used in assisted reproductive technology. Reprod Biol Endocrinol. 12:952014. View Article : Google Scholar : PubMed/NCBI

22 

Lehert P, Kolibianakis EM, Venetis CA, Schertz J, Saunders H, Arriagada P, Copt S and Tarlatzis B: Recombinant human follicle-stimulating hormone (r-hFSH) plus recombinant luteinizing hormone versus r-hFSH alone for ovarian stimulation during assisted reproductive technology: Systematic review and meta-analysis. Reprod Biol Endocrinol. 12:172014. View Article : Google Scholar : PubMed/NCBI

23 

Peluso C, Fonseca FL, Gastaldo GG, Christofolini DM, Cordts EB, Barbosa CP and Bianco B: AMH and AMHR2 polymorphisms and AMH serum level can predict assisted reproduction outcomes: A cross-sectional study. Cell Physiol Biochem. 35:1401–1412. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Salmassi A, Mettler L, Hedderich J, Jonat W, Deenadayal A, von Otte S, Eckmann-Scholz C and Schmutzler AG: Cut-off levels of anti-mullerian hormone for the prediction of ovarian response, in vitro fertilization outcome and ovarian hyperstimulation syndrome. Int J Fertil Steril. 9:157–167. 2015.PubMed/NCBI

25 

Sam S: Adiposity and metabolic dysfunction in polycystic ovary syndrome. Horm Mol Biol Clin Investig. 21:107–116. 2015.PubMed/NCBI

26 

Carreau AM and Baillargeon JP: PCOS in adolescence and type 2 diabetes. Curr Diab Rep. 15:5642015. View Article : Google Scholar : PubMed/NCBI

27 

Polyzos SA, Kountouras J, Deretzi G, Zavos C and Mantzoros CS: The emerging role of endocrine disruptors in pathogenesis of insulin resistance: A concept implicating nonalcoholic fatty liver disease. Curr Mol Med. 12:68–82. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Alonso-Magdalena P, Quesada I and Nadal A: Endocrine disruptors in the etiology of type 2 diabetes mellitus. Nat Rev Endocrinol. 7:346–353. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Levy AP, Asleh R, Blum S, Levy NS, Miller-Lotan R, Kalet-Litman S, Anbinder Y, Lache O, Nakhoul FM, Asaf R, et al: Haptoglobin: Basic and clinical aspects. Antioxid Redox Signal. 12:293–304. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Orvieto R, Dratviman-Storobinsky O, Lantsberg D, Haas J, Mashiach R and Cohen Y: Interleukin-2 and SOCS-1 proteins involvement in the pathophysiology of severe ovarian hyperstimulation syndrome-a preliminary proof of concept. J Ovarian Res. 7:1062014. View Article : Google Scholar : PubMed/NCBI

31 

Elliott BM and Aledort LM: Restoring hemostasis: Fibrinogen concentrate versus cryoprecipitate. Expert Rev Hematol. 6:277–286. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Wang S, Moustaid-Moussa N, Chen L, Mo H, Shastri A, Su R, Bapat P, Kwun I and Shen CL: Novel insights of dietary polyphenols and obesity. J Nutr Biochem. 25:1–18. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Chistyakova GN, Remizova II, Gazieva IA and Chermyaninova OV: Immunological and hemostasiological disorders in women with ovarian hyperstimulation syndrome. Gynecol Endocrinol. 30:(Suppl 1). S39–S42. 2014. View Article : Google Scholar

34 

Olivecrona G: Role of lipoprotein lipase in lipid metabolism. Curr Opin Lipidol. 27:233–241. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wu L, Sun Y, Wan J, Luan T, Cheng Q and Tan Y: A proteomic analysis identifies candidate early biomarkers to predict ovarian hyperstimulation syndrome in polycystic ovarian syndrome patients. Mol Med Rep 16: 272-280, 2017.
APA
Wu, L., Sun, Y., Wan, J., Luan, T., Cheng, Q., & Tan, Y. (2017). A proteomic analysis identifies candidate early biomarkers to predict ovarian hyperstimulation syndrome in polycystic ovarian syndrome patients. Molecular Medicine Reports, 16, 272-280. https://doi.org/10.3892/mmr.2017.6604
MLA
Wu, L., Sun, Y., Wan, J., Luan, T., Cheng, Q., Tan, Y."A proteomic analysis identifies candidate early biomarkers to predict ovarian hyperstimulation syndrome in polycystic ovarian syndrome patients". Molecular Medicine Reports 16.1 (2017): 272-280.
Chicago
Wu, L., Sun, Y., Wan, J., Luan, T., Cheng, Q., Tan, Y."A proteomic analysis identifies candidate early biomarkers to predict ovarian hyperstimulation syndrome in polycystic ovarian syndrome patients". Molecular Medicine Reports 16, no. 1 (2017): 272-280. https://doi.org/10.3892/mmr.2017.6604
Copy and paste a formatted citation
x
Spandidos Publications style
Wu L, Sun Y, Wan J, Luan T, Cheng Q and Tan Y: A proteomic analysis identifies candidate early biomarkers to predict ovarian hyperstimulation syndrome in polycystic ovarian syndrome patients. Mol Med Rep 16: 272-280, 2017.
APA
Wu, L., Sun, Y., Wan, J., Luan, T., Cheng, Q., & Tan, Y. (2017). A proteomic analysis identifies candidate early biomarkers to predict ovarian hyperstimulation syndrome in polycystic ovarian syndrome patients. Molecular Medicine Reports, 16, 272-280. https://doi.org/10.3892/mmr.2017.6604
MLA
Wu, L., Sun, Y., Wan, J., Luan, T., Cheng, Q., Tan, Y."A proteomic analysis identifies candidate early biomarkers to predict ovarian hyperstimulation syndrome in polycystic ovarian syndrome patients". Molecular Medicine Reports 16.1 (2017): 272-280.
Chicago
Wu, L., Sun, Y., Wan, J., Luan, T., Cheng, Q., Tan, Y."A proteomic analysis identifies candidate early biomarkers to predict ovarian hyperstimulation syndrome in polycystic ovarian syndrome patients". Molecular Medicine Reports 16, no. 1 (2017): 272-280. https://doi.org/10.3892/mmr.2017.6604
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