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Overexpression of stromal interaction molecule 1 may promote epithelial‑mesenchymal transition and indicate poor prognosis in gastric cancer

  • Authors:
    • Guobin Wu
    • Yong Li
    • Bibo Tan
    • Liqiao Fan
    • Qun Zhao
    • Yü Liu
    • Zhidong Zhang
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The Fourth Affiliated Hospital, Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 151-158
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    Published online on: May 18, 2017
       https://doi.org/10.3892/mmr.2017.6607
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Abstract

The aim of the present study was to investigate the prognostic significance of stromal interaction molecule 1 (STIM1) expression in gastric cancer (GC) and examine the association between STIM1 and epithelial‑mesenchymal transition (EMT). Immunohistochemical staining was performed to detect STIM1, E‑cadherin, β‑catenin and matrix metalloproteinase‑9 (MMP‑9) in 170 GC and 35 adjacent healthy gastric tissue samples. Positive staining of STIM1, E‑cadherin, β‑catenin and MMP‑9 in GC tissues was significantly greater compared with adjacent healthy tissues (P<0.05). Clinicopathological analysis revealed that STIM1 expression was significantly associated with LNM (P<0.001) and tumor‑node‑metastasis stage (P=0.01). The overall survival rate was significantly reduced in STIM1‑positive compared with STIM1‑negative patients (P=0.043). Cox regression analysis indicated that STIM1 expression and LNM were independent prognostic factors for GC. Chi‑square tests suggested that STIM1 expression in GC tissues was significantly associated with E‑cadherin (P<0.001) and β‑catenin (P<0.001), whereas no association was observed between STIM1 and MMP‑9 expression (P>0.05). In conclusion, the results of the present study suggested that STIM1 may be a valuable prognostic marker in GC patients, and that STIM1 may increase GC motility and invasiveness by promoting epithelial‑mesenchymal transition.
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Copy and paste a formatted citation
Spandidos Publications style
Wu G, Li Y, Tan B, Fan L, Zhao Q, Liu Y and Zhang Z: Overexpression of stromal interaction molecule 1 may promote epithelial‑mesenchymal transition and indicate poor prognosis in gastric cancer. Mol Med Rep 16: 151-158, 2017.
APA
Wu, G., Li, Y., Tan, B., Fan, L., Zhao, Q., Liu, Y., & Zhang, Z. (2017). Overexpression of stromal interaction molecule 1 may promote epithelial‑mesenchymal transition and indicate poor prognosis in gastric cancer. Molecular Medicine Reports, 16, 151-158. https://doi.org/10.3892/mmr.2017.6607
MLA
Wu, G., Li, Y., Tan, B., Fan, L., Zhao, Q., Liu, Y., Zhang, Z."Overexpression of stromal interaction molecule 1 may promote epithelial‑mesenchymal transition and indicate poor prognosis in gastric cancer". Molecular Medicine Reports 16.1 (2017): 151-158.
Chicago
Wu, G., Li, Y., Tan, B., Fan, L., Zhao, Q., Liu, Y., Zhang, Z."Overexpression of stromal interaction molecule 1 may promote epithelial‑mesenchymal transition and indicate poor prognosis in gastric cancer". Molecular Medicine Reports 16, no. 1 (2017): 151-158. https://doi.org/10.3892/mmr.2017.6607
Copy and paste a formatted citation
x
Spandidos Publications style
Wu G, Li Y, Tan B, Fan L, Zhao Q, Liu Y and Zhang Z: Overexpression of stromal interaction molecule 1 may promote epithelial‑mesenchymal transition and indicate poor prognosis in gastric cancer. Mol Med Rep 16: 151-158, 2017.
APA
Wu, G., Li, Y., Tan, B., Fan, L., Zhao, Q., Liu, Y., & Zhang, Z. (2017). Overexpression of stromal interaction molecule 1 may promote epithelial‑mesenchymal transition and indicate poor prognosis in gastric cancer. Molecular Medicine Reports, 16, 151-158. https://doi.org/10.3892/mmr.2017.6607
MLA
Wu, G., Li, Y., Tan, B., Fan, L., Zhao, Q., Liu, Y., Zhang, Z."Overexpression of stromal interaction molecule 1 may promote epithelial‑mesenchymal transition and indicate poor prognosis in gastric cancer". Molecular Medicine Reports 16.1 (2017): 151-158.
Chicago
Wu, G., Li, Y., Tan, B., Fan, L., Zhao, Q., Liu, Y., Zhang, Z."Overexpression of stromal interaction molecule 1 may promote epithelial‑mesenchymal transition and indicate poor prognosis in gastric cancer". Molecular Medicine Reports 16, no. 1 (2017): 151-158. https://doi.org/10.3892/mmr.2017.6607
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