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Article Open Access

Farnesoid X receptor deletion improves cardiac function, structure and remodeling following myocardial infarction in mice

Corrigendum in: /10.3892/mmr.2017.7698
  • Authors:
    • Jianshu Gao
    • Xiaoqiang Liu
    • Bingjian Wang
    • Haiyan Xu
    • Qiang Xia
    • Tianfei Lu
    • Fang Wang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Shanghai General Hospital of Nanjing Medical University, Shanghai 200080, P.R. China, Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, P.R. China, Department of Cardiology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu 223300, P.R. China, Department of Transplantation and Hepatic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, P.R. China
    Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 673-679
    |
    Published online on: May 29, 2017
       https://doi.org/10.3892/mmr.2017.6643
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Abstract

The farnesoid X receptor (FXR) is implicated in cholesterol and bile acid homeostasis; however, its role following myocardial infarction (MI) has yet to be elucidated. The aim of the present study was to investigate the effects of FXR knockout on left ventricular (LV) remodeling following MI. Coronary arteries of wild type (WT) and FXR‑/‑ mice were permanently occluded to cause MI, and serial echocardiographic and histological tests were conducted. At 4 weeks post‑MI, FXR‑/‑ mice exhibited significantly smaller infarct sizes (34.20±2.58 vs. 44.20±3.19%), improved ejection fraction (47.31±1.08 vs. 37.64±0.75%) and reduced LV chamber dilation compared with WT mice. LV remodeling was significant as early as 7 days post‑MI in FXR‑/‑ compared with WT mice. Histological features associated with enhanced long‑term remodeling and improved functionality, such as increased angiogenesis via detection of CD31 and reduced fibrosis, were observed in the FXR‑/‑ group. Myocyte apoptosis within the infarcted zones appeared significantly reduced by day 7 in FXR‑/‑ mice. In conclusion, the results of the present study suggested that FXR knockout may participate in the preservation of post‑MI cardiac functionality, via reducing fibrosis and chronic apoptosis, and ameliorating ventricular function.
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Copy and paste a formatted citation
Spandidos Publications style
Gao J, Liu X, Wang B, Xu H, Xia Q, Lu T and Wang F: Farnesoid X receptor deletion improves cardiac function, structure and remodeling following myocardial infarction in mice Corrigendum in /10.3892/mmr.2017.7698. Mol Med Rep 16: 673-679, 2017.
APA
Gao, J., Liu, X., Wang, B., Xu, H., Xia, Q., Lu, T., & Wang, F. (2017). Farnesoid X receptor deletion improves cardiac function, structure and remodeling following myocardial infarction in mice Corrigendum in /10.3892/mmr.2017.7698. Molecular Medicine Reports, 16, 673-679. https://doi.org/10.3892/mmr.2017.6643
MLA
Gao, J., Liu, X., Wang, B., Xu, H., Xia, Q., Lu, T., Wang, F."Farnesoid X receptor deletion improves cardiac function, structure and remodeling following myocardial infarction in mice Corrigendum in /10.3892/mmr.2017.7698". Molecular Medicine Reports 16.1 (2017): 673-679.
Chicago
Gao, J., Liu, X., Wang, B., Xu, H., Xia, Q., Lu, T., Wang, F."Farnesoid X receptor deletion improves cardiac function, structure and remodeling following myocardial infarction in mice Corrigendum in /10.3892/mmr.2017.7698". Molecular Medicine Reports 16, no. 1 (2017): 673-679. https://doi.org/10.3892/mmr.2017.6643
Copy and paste a formatted citation
x
Spandidos Publications style
Gao J, Liu X, Wang B, Xu H, Xia Q, Lu T and Wang F: Farnesoid X receptor deletion improves cardiac function, structure and remodeling following myocardial infarction in mice Corrigendum in /10.3892/mmr.2017.7698. Mol Med Rep 16: 673-679, 2017.
APA
Gao, J., Liu, X., Wang, B., Xu, H., Xia, Q., Lu, T., & Wang, F. (2017). Farnesoid X receptor deletion improves cardiac function, structure and remodeling following myocardial infarction in mice Corrigendum in /10.3892/mmr.2017.7698. Molecular Medicine Reports, 16, 673-679. https://doi.org/10.3892/mmr.2017.6643
MLA
Gao, J., Liu, X., Wang, B., Xu, H., Xia, Q., Lu, T., Wang, F."Farnesoid X receptor deletion improves cardiac function, structure and remodeling following myocardial infarction in mice Corrigendum in /10.3892/mmr.2017.7698". Molecular Medicine Reports 16.1 (2017): 673-679.
Chicago
Gao, J., Liu, X., Wang, B., Xu, H., Xia, Q., Lu, T., Wang, F."Farnesoid X receptor deletion improves cardiac function, structure and remodeling following myocardial infarction in mice Corrigendum in /10.3892/mmr.2017.7698". Molecular Medicine Reports 16, no. 1 (2017): 673-679. https://doi.org/10.3892/mmr.2017.6643
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