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Transient cerebral ischemia induces albumin expression in microglia only in the CA1 region of the gerbil hippocampus

  • Authors:
    • Joon Ha Park
    • Jin‑A Park
    • Ji Hyeon Ahn
    • Yang Hee Kim
    • Il Jun Kang
    • Moo‑Ho Won
    • Choong‑Hyun Lee
  • View Affiliations / Copyright

    Affiliations: Department of Biomedical Science, Research Institute of Bioscience and Biotechnology, Chuncheon, Gangwon 24252, Republic of Korea, Department of Pharmacy, College of Pharmacy, Dankook University, Cheonan, South Chungcheong 31116, Republic of Korea, Department of Surgery, School of Medicine, Kangwon National University, Chuncheon, Gangwon 24341, Republic of Korea, Department of Food Science and Nutrition, Hallym University, Chuncheon, Gangwon 24252, Republic of Korea, Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, Gangwon 24341, Republic of Korea
    Copyright: © Park et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 661-665
    |
    Published online on: May 31, 2017
       https://doi.org/10.3892/mmr.2017.6671
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Abstract

Albumin, the most abundant plasma protein, is known to exhibit a neuroprotective effect in animal models of focal and global cerebral ischemia. In the present study, the expression and immunoreactivity of albumin was examined in the hippocampus following 5 min of transient cerebral ischemia in gerbils. Albumin immunoreactivity was observed in microglia of the CA1 hippocampal region 2 days post‑ischemic insult, and it was significantly increased at 4 days following ischemia-reperfusion. In addition, at 4 days post‑ischemic insult, albumin‑immunoreactive microglia were abundant in the stratum pyramidale of the CA1 region. The present results demonstrated that albumin was newly expressed post‑injury in microglia in the CA1 region, suggesting ischemia‑induced neuronal loss. Albumin expression may therefore be associated with ischemia‑induced delayed neuronal death in the CA1 region following transient cerebral ischemia.
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1 

Kirino T: Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res. 239:57–69. 1982. View Article : Google Scholar : PubMed/NCBI

2 

Kirino T and Sano K: Selective vulnerability in the gerbil hippocampus following transient ischemia. Acta Neuropathol. 62:201–208. 1984. View Article : Google Scholar : PubMed/NCBI

3 

Chan PH: Reactive oxygen radicals in signaling and damage in the ischemic brain. J Cereb Blood Flow Metab. 21:2–14. 2001. View Article : Google Scholar : PubMed/NCBI

4 

Stoll G, Jander S and Schroeter M: Inflammation and glial responses in ischemic brain lesions. Prog Neurobiol. 56:149–171. 1998. View Article : Google Scholar : PubMed/NCBI

5 

Won MH, Kang T, Park S, Jeon G, Kim Y, Seo JH, Choi E, Chung M and Cho SS: The alterations of N-Methyl-D-aspartate receptor expressions and oxidative DNA damage in the CA1 area at the early time after ischemia-reperfusion insult. Neurosci Lett. 301:139–142. 2001. View Article : Google Scholar : PubMed/NCBI

6 

Kataoka Y, Cui Y, Yamada H, Utsunomiya K, Niiya H, Yanase H, Nakamura Y, Mitani A, Kataoka K and Watanabe Y: Neovascularization with blood-brain barrier breakdown in delayed neuronal death. Biochem Biophys Res Commun. 273:637–641. 2000. View Article : Google Scholar : PubMed/NCBI

7 

Ritter LS, Orozco JA, Coull BM, McDonagh PF and Rosenblum WI: Leukocyte accumulation and hemodynamic changes in the cerebral microcirculation during early reperfusion after stroke. Stroke. 31:1153–1161. 2000. View Article : Google Scholar : PubMed/NCBI

8 

Suchadolskiene O, Pranskunas A, Baliutyte G, Veikutis V, Dambrauskas Z, Vaitkaitis D and Borutaite V: Microcirculatory, mitochondrial, and histological changes following cerebral ischemia in swine. BMC Neurosci. 15:22014. View Article : Google Scholar : PubMed/NCBI

9 

Xu XS, Ma ZZ, Wang F, Hu BH, Wang CS, Liu YY, Zhao XR, An LH, Chang X, Liao FL, et al: The antioxidant Cerebralcare Granule attenuates cerebral microcirculatory disturbance during ischemia-reperfusion injury. Shock. 32:201–209. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Yan BY, Pan CS, Mao XW, Yang L, Liu YY, Yan L, Mu HN, Wang CS, Sun K, Liao FL, et al: Icariside II improves cerebral microcirculatory disturbance and alleviates hippocampal injury in gerbils after ischemia-reperfusion. Brain Res. 1573:63–73. 2014. View Article : Google Scholar : PubMed/NCBI

11 

He Z, He B, Behrle BL, Fejleh MP, Cui L, Paule MG and Greenfield LJ: Ischemia-induced increase in microvascular phosphodiesterase 4D expression in rat hippocampus associated with blood brain barrier permeability: Effect of age. ACS Chem Neurosci. 3:428–432. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Rosenberg GA and Yang Y: Vasogenic edema due to tight junction disruption by matrix metalloproteinases in cerebral ischemia. Neurosurg Focus. 22:E42007. View Article : Google Scholar : PubMed/NCBI

13 

Petricoin EF, Belluco C, Araujo RP and Liotta LA: The blood peptidome: A higher dimension of information content for cancer biomarker discovery. Nat Rev Cancer. 6:961–967. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Belayev L, Liu Y, Zhao W, Busto R and Ginsberg MD: Human albumin therapy of acute ischemic stroke: Marked neuroprotective efficacy at moderate doses and with a broad therapeutic window. Stroke. 32:553–560. 2001. View Article : Google Scholar : PubMed/NCBI

15 

Belayev L, Saul I, Huh PW, Finotti N, Zhao W, Busto R and Ginsberg MD: Neuroprotective effect of high-dose albumin therapy against global ischemic brain injury in rats. Brain Res. 845:107–111. 1999. View Article : Google Scholar : PubMed/NCBI

16 

Eady TN, Khoutorova L, Obenaus A, Mohd-Yusof A, Bazan NG and Belayev L: Docosahexaenoic acid complexed to albumin provides neuroprotection after experimental stroke in aged rats. Neurobiol Dis. 62:1–7. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Yao X, Miao W, Li M, Wang M, Ma J, Wang Y, Miao L and Feng H: Protective effect of albumin on VEGF and brain edema in acute ischemia in rats. Neurosci Lett. 472:179–183. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Belayev L, Pinard E, Nallet H, Seylaz J, Liu Y, Riyamongkol P, Zhao W, Busto R and Ginsberg MD: Albumin therapy of transient focal cerebral ischemia: In vivo analysis of dynamic microvascular responses. Stroke. 33:1077–1084. 2002. View Article : Google Scholar : PubMed/NCBI

19 

Belayev L, Zhao W, Pattany PM, Weaver RG, Huh PW, Lin B, Busto R and Ginsberg MD: Diffusion-weighted magnetic resonance imaging confirms marked neuroprotective efficacy of albumin therapy in focal cerebral ischemia. Stroke. 29:2587–2599. 1998. View Article : Google Scholar : PubMed/NCBI

20 

Strosznajder RP, Gadamski R, Czapski GA, Jesko H and Strosznajder JB: Poly(ADP-ribose) polymerase during reperfusion after transient forebrain ischemia: Its role in brain edema and cell death. J Mol Neurosci. 20:61–72. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Institute of Laboratory Animal Research, Committee for the Update of the Guide for the Care and Use of Laboratory Animals, National Research Council: Guide for the Care and Use of Laboratory Animals. 8th. Washington, DC: National Academies Press; pp. 2202011

22 

Lee CH, Park JH, Cho JH, Ahn JH, Yan BC, Lee JC, Shin MC, Cheon SH, Cho YS, Cho JH, et al: Changes and expressions of Redd1 in neurons and glial cells in the gerbil hippocampus proper following transient global cerebral ischemia. J Neurol Sci. 344:43–50. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Park JH, Shin BN, Chen BH, Kim IH, Ahn JH, Cho JH, Tae HJ, Lee JC, Lee CH, Kim YM, et al: Neuroprotection and reduced gliosis by atomoxetine pretreatment in a gerbil model of transient cerebral ischemia. J Neurol Sci. 359:373–380. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Maeda M, Akai F, Nishida S and Yanagihara T: Intracerebral distribution of albumin after transient cerebral ischemia: Light and electron microscopic immunocytochemical investigation. Acta Neuropathol. 84:59–66. 1992. View Article : Google Scholar : PubMed/NCBI

25 

Lee CH, Park JH, Yoo KY, Choi JH, Hwang IK, Ryu PD, Kim DH, Kwon YG, Kim YM and Won MH: Pre- and post-treatments with escitalopram protect against experimental ischemic neuronal damage via regulation of BDNF expression and oxidative stress. Exp Neurol. 229:450–459. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Hooper C, Taylor DL and Pocock JM: Pure albumin is a potent trigger of calcium signalling and proliferation in microglia but not macrophages or astrocytes. J Neurochem. 92:1363–1376. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Alonso A, Reinz E, Fatar M, Hennerici MG and Meairs S: Clearance of albumin following ultrasound-induced blood-brain barrier opening is mediated by glial but not neuronal cells. Brain Res. 1411:9–16. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Ahn SM, Byun K, Cho K, Kim JY, Yoo JS, Kim D, Paek SH, Kim SU, Simpson RJ and Lee B: Human microglial cells synthesize albumin in brain. PLoS One. 3:e28292008. View Article : Google Scholar : PubMed/NCBI

29 

Byun K, Bayarsaikhan E, Kim D, Kim CY, Mook-Jung I, Paek SH, Kim SU, Yamamoto T, Won MH, Song BJ, et al: Induction of neuronal death by microglial AGE-albumin: Implications for Alzheimer's disease. PLoS One. 7:e379172012. View Article : Google Scholar : PubMed/NCBI

30 

Lehmann J, Härtig W, Seidel A, Füldner C, Hobohm C, Grosche J, Krueger M and Michalski D: Inflammatory cell recruitment after experimental thromboembolic stroke in rats. Neuroscience. 279:139–154. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Park JH, Park JA, Ahn JH, Kim YH, Kang IJ, Won MH and Lee CH: Transient cerebral ischemia induces albumin expression in microglia only in the CA1 region of the gerbil hippocampus. Mol Med Rep 16: 661-665, 2017.
APA
Park, J.H., Park, J., Ahn, J.H., Kim, Y.H., Kang, I.J., Won, M., & Lee, C. (2017). Transient cerebral ischemia induces albumin expression in microglia only in the CA1 region of the gerbil hippocampus. Molecular Medicine Reports, 16, 661-665. https://doi.org/10.3892/mmr.2017.6671
MLA
Park, J. H., Park, J., Ahn, J. H., Kim, Y. H., Kang, I. J., Won, M., Lee, C."Transient cerebral ischemia induces albumin expression in microglia only in the CA1 region of the gerbil hippocampus". Molecular Medicine Reports 16.1 (2017): 661-665.
Chicago
Park, J. H., Park, J., Ahn, J. H., Kim, Y. H., Kang, I. J., Won, M., Lee, C."Transient cerebral ischemia induces albumin expression in microglia only in the CA1 region of the gerbil hippocampus". Molecular Medicine Reports 16, no. 1 (2017): 661-665. https://doi.org/10.3892/mmr.2017.6671
Copy and paste a formatted citation
x
Spandidos Publications style
Park JH, Park JA, Ahn JH, Kim YH, Kang IJ, Won MH and Lee CH: Transient cerebral ischemia induces albumin expression in microglia only in the CA1 region of the gerbil hippocampus. Mol Med Rep 16: 661-665, 2017.
APA
Park, J.H., Park, J., Ahn, J.H., Kim, Y.H., Kang, I.J., Won, M., & Lee, C. (2017). Transient cerebral ischemia induces albumin expression in microglia only in the CA1 region of the gerbil hippocampus. Molecular Medicine Reports, 16, 661-665. https://doi.org/10.3892/mmr.2017.6671
MLA
Park, J. H., Park, J., Ahn, J. H., Kim, Y. H., Kang, I. J., Won, M., Lee, C."Transient cerebral ischemia induces albumin expression in microglia only in the CA1 region of the gerbil hippocampus". Molecular Medicine Reports 16.1 (2017): 661-665.
Chicago
Park, J. H., Park, J., Ahn, J. H., Kim, Y. H., Kang, I. J., Won, M., Lee, C."Transient cerebral ischemia induces albumin expression in microglia only in the CA1 region of the gerbil hippocampus". Molecular Medicine Reports 16, no. 1 (2017): 661-665. https://doi.org/10.3892/mmr.2017.6671
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