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Effects of moderate‑intensity endurance exercise on angiotensin II and angiotensin II type I receptors in the rat heart

  • Authors:
    • Xin Li
    • Kun Wang
  • View Affiliations / Copyright

    Affiliations: Department of Physical Education, Chengdu University, Chengdu, Sichuan 610106, P.R. China, Department of Physical Education, Shanghai Jiao Tong University, Shanghai 200240, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2439-2444
    |
    Published online on: June 27, 2017
       https://doi.org/10.3892/mmr.2017.6864
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Abstract

The current study was aimed at examining the effects of moderate‑intensity endurance exercise on the expression of angiotensin II (AngII) and AngII type 1 receptor (AT1R) in the rat heart. Male Sprague‑Dawley rats were randomly divided into the control group (n=20) and moderate‑intensity endurance exercise group (n=20). Cardiac hypertrophy was induced by treadmill endurance training for 8 weeks. The mRNA expression of AngII and AT1R were assessed by reverse transcription‑quantitative polymerase chain reaction. The immune response positive area and optical density of AngII and AT1R was measured by immunohistochemistry. AngII was primarily expressed in the cytoplasm and membrane, however infrequently in coronary vascular wall smooth muscle cells. AT1R was primarily expressed in the coronary vessel wall smooth muscle, rarely in cardiac cells. The mRNA expression of cardiac AngII was significantly increased after the 8‑week exercise period, while AT1R was significantly decreased. Immunohistochemistry indicated a significant increase in the AngII immune‑positive area and optical density after the 8‑week exercise. The AT1R immune‑positive area and optical density was significantly reduced following the 8‑week exercise. In conclusion, subsequent to 8‑weeks endurance training, the AngII expression was increased and the AT1R expression was decreased. AT1R may expand the coronary artery, thereby increasing coronary blood flow and ensuring the energy supply of heart during exercise. The expression change in AngII does not reflect the character of cardiac hypertrophy. The exercise‑induced change in the expression of AngII and AT1R may be a protective mechanism to avoid cardiac pathological hypertrophy.
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1 

Haack KK, Engler CW, Papoutsi E, Pipinos II, Patel KP and Zucker IH: Parallel changes in neuronal AT1R and GRK5 expression following exercise training in heart failure. Hypertension. 60:354–361. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Rajani R, Rimington H and Chambers JB: Treadmill exercise in apparently asymptomatic patients with moderate or severe aortic stenosis: Relationship between cardiac index and revealed symptoms. Heart. 96:689–695. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Lou H, Danelisen I and Singal PK: Involvement of mitogen-activated protein kinases in adriamycin-induced cardiomyopathy. Am J Physiol Heart Circ Physiol. 288:H1925–H1930. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Haudek SB, Cheng J, Du J, Wang Y, Hermosillo-Rodriguez J, Trial J, Taffet GE and Entman ML: Monocytic fibroblast precursors mediate fibrosis in angiotensin-II-induced cardiac hypertrophy. J Mol Cell Cardiol. 49:499–507. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Fenning A, Harrison G, Dwyer D, Rose'Meyer R and Brown L: Cardiac adaptation to endurance exercise in rats. Mol Cell Biochem. 251:51–59. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Wisløff U, Helgerud J, Kemi OJ and Ellingsen O: Intensity-controlled treadmill running in rats: VO(2 max) and cardiac hypertrophy. Am J Physiol Heart Circ Physiol. 280:H1301–H1310. 2001.PubMed/NCBI

7 

Xin LI: Effect of moderate-intensity endurance exercise on the expression of cardiac signaling pathway. East China Normal Univ. 2011.

8 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

9 

Kohli S, Ahuja S and Rani V: Transcription factors in heart: Promising therapeutic targets in cardiac hypertrophy. Curr Cardiol Rev. 7:262–271. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Belardinelli R: Exercise training in chronic heart failure: How to harmonize oxidative stress, sympathetic outflow, and angiotensin II. Circulation. 115:3042–3044. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Zhang GX, Ohmori K, Nagai Y, Fujisawa Y, Nishiyama A, Abe Y and Kimura S: Role of AT1 receptor in isoproterenol-induced cardiac hypertrophy and oxidative stress in mice. J Mol Cell Cardiol. 42:804–811. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Jugdutt BI and Sawicki G: AT1 receptor blockade alters metabolic, functional and structural proteins after reperfused myocardial infarction: Detection using proteomics. Mol Cell Biochem. 263:179–188. 2004. View Article : Google Scholar

13 

Bai H, Wu LL, Xing DQ, Liu J and Zhao YL: Angiotensin II induced upregulation of G alpha q/11, phospholipase C beta 3 and extracellular signal-regulated kinase 1/2 via angiotensin II type 1 receptor. Chin Med J (Engl). 117:88–93. 2004.PubMed/NCBI

14 

Anavekar NS and Solomon SD: Angiotensin II receptor blockade and ventricular remodelling. J Renin Angiotensin Aldosterone Syst. 6:43–48. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Jiang XY, Gao GD, Du XJ, Zhou J, Wang XF and Lin YX: The signalling of AT2 and the influence on the collagen metabolism of AT2 receptor in adult rat cardiac fibroblasts. Acta Cardiol. 62:429–438. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Fatini C, Guazzelli R, Manetti P, Battaglini B, Gensini F, Vono R, Toncelli L, Zilli P, Capalbo A, Abbate R, et al: RAS genes influence exercise-induced left ventricular hypertrophy: An elite athletes study. Med Sci Sports Exerc. 32:1868–1872. 2000. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li X and Wang K: Effects of moderate‑intensity endurance exercise on angiotensin II and angiotensin II type I receptors in the rat heart. Mol Med Rep 16: 2439-2444, 2017.
APA
Li, X., & Wang, K. (2017). Effects of moderate‑intensity endurance exercise on angiotensin II and angiotensin II type I receptors in the rat heart. Molecular Medicine Reports, 16, 2439-2444. https://doi.org/10.3892/mmr.2017.6864
MLA
Li, X., Wang, K."Effects of moderate‑intensity endurance exercise on angiotensin II and angiotensin II type I receptors in the rat heart". Molecular Medicine Reports 16.3 (2017): 2439-2444.
Chicago
Li, X., Wang, K."Effects of moderate‑intensity endurance exercise on angiotensin II and angiotensin II type I receptors in the rat heart". Molecular Medicine Reports 16, no. 3 (2017): 2439-2444. https://doi.org/10.3892/mmr.2017.6864
Copy and paste a formatted citation
x
Spandidos Publications style
Li X and Wang K: Effects of moderate‑intensity endurance exercise on angiotensin II and angiotensin II type I receptors in the rat heart. Mol Med Rep 16: 2439-2444, 2017.
APA
Li, X., & Wang, K. (2017). Effects of moderate‑intensity endurance exercise on angiotensin II and angiotensin II type I receptors in the rat heart. Molecular Medicine Reports, 16, 2439-2444. https://doi.org/10.3892/mmr.2017.6864
MLA
Li, X., Wang, K."Effects of moderate‑intensity endurance exercise on angiotensin II and angiotensin II type I receptors in the rat heart". Molecular Medicine Reports 16.3 (2017): 2439-2444.
Chicago
Li, X., Wang, K."Effects of moderate‑intensity endurance exercise on angiotensin II and angiotensin II type I receptors in the rat heart". Molecular Medicine Reports 16, no. 3 (2017): 2439-2444. https://doi.org/10.3892/mmr.2017.6864
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