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Role of miR‑21 on vascular endothelial cells in the protective effect of renal delayed ischemic preconditioning

  • Authors:
    • Xialian Xu
    • Xiaoyan Jiao
    • Nana Song
    • Weili Luo
    • Mingyu Liang
    • Xiaoqiang Ding
    • Jie Teng
  • View Affiliations / Copyright

    Affiliations: Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China, Department of Physiology and Center of Systems Molecular Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2627-2635
    |
    Published online on: June 28, 2017
       https://doi.org/10.3892/mmr.2017.6870
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Abstract

Vascular endothelial cells may serve crucial roles in the development of acute kidney injury (AKI). microRNA (miR)‑21, which possesses a renal protective function has been found on vascular endothelial cells. The present study aimed to test the hypothesis that miR‑21 may protect vascular endothelial cells against injury, which may contribute to the protective effects of renal delayed ischemic preconditioning (IPC). Preconditioned (15 min ischemia) or Sham mice (not clamped) were subjected to 35 min occlusion of bilateral renal pedicles 4 days following preconditioning or Sham treatment. Human umbilical vein endothelial cells (HUVECs) were treated with cobalt(II) chloride (CoCl2) to establish an in vitro hypoxia model. Locked nucleic acid‑modified anti‑miR‑21 or scrambled control oligonucleotides were transfected into cells or delivered into mice via tail vein injection <1 h prior to IPC. Following 24 h of reperfusion or hypoxia, morphological and functional parameters, apoptosis and miR‑21 and programmed cell death 4 (PDCD4) expression were assessed in vivo and in vitro. Treatment of HUVECs with CoCl2 led to an upregulation of miR‑21 expression, a downregulation of PDCD4 protein expression and attenuation of apoptosis. Inhibition of miR‑21 expression led to increased expression levels of PDCD4 protein and apoptosis in HUVECs. IPC attenuated renal IR injury in mice. The protective effect of IPC appeared to be dependent on upregulated miR‑21 expression. IPC‑induced upregulation of miR‑21 expression also occurred in HUVECs, and IPC also led to reduced PDCD4 expression and vascular permeability in mouse kidneys. The effects of IPC were attenuated by the inhibition of miR‑21; miR‑21 expression attenuated damage in vascular endothelial cells, which may contribute to the protective effects of delayed IPC on renal IR injury. The present study suggested a novel target for the prevention and repair of AKI in the future.
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1 

Bonventre JV and Yang L: Cellular pathophysiology of ischemic acute kidney injury. J Clin Invest. 121:4210–4221. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Brodsky SV, Yamamoto T, Tada T, Kim B, Chen J, Kajiya F and Goligorsky MS: Endothelial dysfunction in ischemic acute renal failure: Rescue by transplanted endothelial cells. Am J Physiol Renal Physiol. 282:F1140–F1149. 2002. View Article : Google Scholar : PubMed/NCBI

3 

Jiang SH, Liu CF, Zhang XL, Xu XH, Zou JZ, Fang Y and Ding XQ: Renal protection by delayed ischaemic preconditioning is associated with inhibition of the inflammatory response and NF-kappaB activation. Cell Biochem Funct. 25:335–343. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Joo JD, Kim M, D'Agati VD and Lee HT: Ischemic preconditioning provides both acute and delayed protection against renal ischemia and reperfusion injury in mice. J Am Soc Nephrol. 17:3115–3123. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Park KM, Chen A and Bonventre JV: Prevention of kidney ischemia/reperfusion-induced functional injury and JNK, p38, and MAPK kinase activation by remote ischemic pretreatment. J Biol Chem. 276:11870–11876. 2001. View Article : Google Scholar : PubMed/NCBI

6 

Salloum FN, Yin C and Kukreja RC: Role of microRNAs in cardiac preconditioning. J Cardiovasc Pharmacol. 56:581–588. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Lee ST, Chu K, Jung KH, Yoon HJ, Jeon D, Kang KM, Park KH, Bae EK, Kim M, Lee SK and Roh JK: MicroRNAs induced during ischemic preconditioning. Stroke. 41:1646–1651. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Xu X, Kriegel AJ, Liu Y, Usa K, Mladinov D, Liu H, Fang Y, Ding X and Liang M: Delayed ischemic preconditioning contributes to renal protection by upregulation of miR-21. Kidney Int. 82:1167–1175. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Ji R, Cheng Y, Yue J, Yang J, Liu X, Chen H, Dean DB and Zhang C: MicroRNA expression signature and antisense-mediated depletion reveal an essential role of microRNA in vascular neointimal lesion formation. Circ Res. 100:1579–1588. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Guduric-Fuchs J, O'Connor A, Cullen A, Harwood L, Medina RJ, O'Neill CL, Stitt AW, Curtis TM and Simpson DA: Deep sequencing reveals predominant expression of miR-21 amongst the small non-coding RNAs in retinal microvascular endothelial cells. J Cell Biochem. 113:2098–2111. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Yasuda H, Yuen PS, Hu X, Zhou H and Star RA: Simvastatin improves sepsis-induced mortality and acute kidney injury via renal vascular effects. Kidney Int. 69:1535–1542. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Chen Y, Jiang S, Zou J, Zhong Y and Ding X: Silencing HIF-1α aggravates growth inhibition and necrosis of proximal renal tubular epithelial cell under hypoxia. Ren Fail. 38:1726–1734. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Jiao X, Xu X, Fang Y, Zhang H, Liang M, Teng J and Ding X: miR-21 contributes to renal protection by targeting prolyl hydroxylase domain protein 2 in delayed ischaemic preconditioning. Nephrology (Carlton). 22:366–373. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Dharap A, Bowen K, Place R, Li LC and Vemuganti R: Transient focal ischemia induces extensive temporal changes in rat cerebral microRNAome. J Cereb Blood Flow Metab. 29:675–687. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Frankel LB, Christoffersen NR, Jacobsen A, Lindow M, Krogh A and Lund AH: Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells. J Biol Chem. 283:1026–1033. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Eltzschig HK and Eckle T: Ischemia and reperfusion-from mechanism to translation. Nat Med. 17:1391–1401. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Rabelink TJ, Wijewickrama DC and de Koning EJ: Peritubular endothelium: The Achilles heel of the kidney? Kidney Int. 72:926–930. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Basile DP, Donohoe D, Roethe K and Osborn JL: Renal ischemic injury results in permanent damage to peritubular capillaries and influences long-term function. Am J Physiol Renal Physiol. 281:F887–F899. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Yamamoto T, Tada T, Brodsky SV, Tanaka H, Noiri E, Kajiya F and Goligorsky MS: Intravital videomicroscopy of peritubular capillaries in renal ischemia. Am J Physiol Renal Physiol. 282:F1150–F1155. 2002. View Article : Google Scholar : PubMed/NCBI

21 

Snoeijs MG, Vink H, Voesten N, Christiaans MH, Daemen JW, Peppelenbosch AG, Tordoir JH, Peutz-Kootstra CJ, Buurman WA, Schurink GW and van Heurn LW: Acute ischemic injury to the renal microvasculature in human kidney transplantation. Am J Physiol Renal Physiol. 299:F1134–F1140. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Horbelt M, Lee SY, Mang HE, Knipe NL, Sado Y, Kribben A and Sutton TA: Acute and chronic microvascular alterations in a mouse model of ischemic acute kidney injury. Am J Physiol Renal Physiol. 293:F688–F695. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Leonard EC, Friedrich JL and Basile DP: VEGF-121 preserves renal microvessel structure and ameliorates secondary renal disease following acute kidney injury. Am J Physiol Renal Physiol. 295:F1648–F1657. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Koo DD, Welsh KI, West NE, Channon KM, Penington AJ, Roake JA, Morris PJ and Fuggle SV: Endothelial cell protection against ischemia/reperfusion injury by lecithinized superoxide dismutase. Kidney Int. 60:786–796. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Xu X, Kriegel AJ, Jiao X, Liu H, Bai X, Olson J, Liang M and Ding X: miR-21 in ischemia/reperfusion injury: A double-edged sword? Physiol Genomics. 46:789–797. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Qin Y, Yu Y, Dong H, Bian X, Guo X and Dong S: MicroRNA 21 inhibits left ventricular remodeling in the early phase of rat model with ischemia-reperfusion injury by suppressing cell apoptosis. Int J Med Sci. 9:413–423. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Buller B, Liu X, Wang X, Zhang RL, Zhang L, Hozeska-Solgot A, Chopp M and Zhang ZG: MicroRNA-21 protects neurons from ischemic death. FEBS J. 277:4299–4307. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Polytarchou C, Iliopoulos D, Hatziapostolou M, Kottakis F, Maroulakou I, Struhl K and Tsichlis PN: Akt2 regulates all Akt isoforms and promotes resistance to hypoxia through induction of miR-21 upon oxygen deprivation. Cancer Res. 71:4720–4731. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Cheng Y, Zhu P, Yang J, Liu X, Dong S, Wang X, Chun B, Zhuang J and Zhang C: Ischaemic preconditioning-regulated miR-21 protects heart against ischaemia/reperfusion injury via anti-apoptosis through its target PDCD4. Cardiovasc Res. 87:431–439. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Godwin JG, Ge X, Stephan K, Jurisch A, Tullius SG and Iacomini J: Identification of a microRNA signature of renal ischemia reperfusion injury. Proc Natl Acad Sci USA. 107:14339–14344. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Jia P, Teng J, Zou J, Fang Y, Wu X, Liang M and Ding X: Xenon protects against septic acute kidney injury via miR-21 target signaling pathway. Crit Care Med. 43:e250–e259. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Qi L, Bart J, Tan LP, Platteel I, Sluis Tv, Huitema S, Harms G, Fu L, Hollema H and Berg Av: Expression of miR-21 and its targets (PTEN, PDCD4, TM1) in flat epithelial atypia of the breast in relation to ductal carcinoma in situ and invasive carcinoma. BMC Cancer. 9:1632009. View Article : Google Scholar : PubMed/NCBI

33 

Jiang S, Chen Y, Zou J, Xu X, Zhang X, Liu C, Fang Y and Ding X: Diverse effects of ischemic pretreatments on the long-term renal damage induced by ischemia-reperfusion. Am J Nephrol. 30:440–449. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Yin C, Salloum FN and Kukreja RC: A novel role of microRNA in late preconditioning: Upregulation of endothelial nitric oxide synthase and heat shock protein 70. Circ Res. 104:572–575. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Dong S, Cheng Y, Yang J, Li J, Liu X, Wang X, Wang D, Krall TJ, Delphin ES and Zhang C: MicroRNA expression signature and the role of microRNA-21 in the early phase of acute myocardial infarction. J Biol Chem. 284:29514–29525. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Weber M, Baker MB, Moore JP and Searles CD: MiR-21 is induced in endothelial cells by shear stress and modulates apoptosis and eNOS activity. Biochem Biophys Res Commun. 393:643–648. 2010. View Article : Google Scholar : PubMed/NCBI

37 

Sabatel C, Malvaux L, Bovy N, Deroanne C, Lambert V, Gonzalez ML, Colige A, Rakic JM, Noël A, Martial JA and Struman I: MicroRNA-21 exhibits antiangiogenic function by targeting RhoB expression in endothelial cells. PLoS One. 6:e169792011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xu X, Jiao X, Song N, Luo W, Liang M, Ding X and Teng J: Role of miR‑21 on vascular endothelial cells in the protective effect of renal delayed ischemic preconditioning. Mol Med Rep 16: 2627-2635, 2017.
APA
Xu, X., Jiao, X., Song, N., Luo, W., Liang, M., Ding, X., & Teng, J. (2017). Role of miR‑21 on vascular endothelial cells in the protective effect of renal delayed ischemic preconditioning. Molecular Medicine Reports, 16, 2627-2635. https://doi.org/10.3892/mmr.2017.6870
MLA
Xu, X., Jiao, X., Song, N., Luo, W., Liang, M., Ding, X., Teng, J."Role of miR‑21 on vascular endothelial cells in the protective effect of renal delayed ischemic preconditioning". Molecular Medicine Reports 16.3 (2017): 2627-2635.
Chicago
Xu, X., Jiao, X., Song, N., Luo, W., Liang, M., Ding, X., Teng, J."Role of miR‑21 on vascular endothelial cells in the protective effect of renal delayed ischemic preconditioning". Molecular Medicine Reports 16, no. 3 (2017): 2627-2635. https://doi.org/10.3892/mmr.2017.6870
Copy and paste a formatted citation
x
Spandidos Publications style
Xu X, Jiao X, Song N, Luo W, Liang M, Ding X and Teng J: Role of miR‑21 on vascular endothelial cells in the protective effect of renal delayed ischemic preconditioning. Mol Med Rep 16: 2627-2635, 2017.
APA
Xu, X., Jiao, X., Song, N., Luo, W., Liang, M., Ding, X., & Teng, J. (2017). Role of miR‑21 on vascular endothelial cells in the protective effect of renal delayed ischemic preconditioning. Molecular Medicine Reports, 16, 2627-2635. https://doi.org/10.3892/mmr.2017.6870
MLA
Xu, X., Jiao, X., Song, N., Luo, W., Liang, M., Ding, X., Teng, J."Role of miR‑21 on vascular endothelial cells in the protective effect of renal delayed ischemic preconditioning". Molecular Medicine Reports 16.3 (2017): 2627-2635.
Chicago
Xu, X., Jiao, X., Song, N., Luo, W., Liang, M., Ding, X., Teng, J."Role of miR‑21 on vascular endothelial cells in the protective effect of renal delayed ischemic preconditioning". Molecular Medicine Reports 16, no. 3 (2017): 2627-2635. https://doi.org/10.3892/mmr.2017.6870
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