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Article Open Access

Telomere length is positively associated with the expression of IL‑6 and MIP‑1α in bone marrow mesenchymal stem cells of multiple myeloma

  • Authors:
    • Shengli Li
    • Yang Jiang
    • Ai Li
    • Xiaoli Liu
    • Xiangling Xing
    • Yanan Guo
    • Yaqi Xu
    • Yunliang Hao
    • Chengyun Zheng
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, The Second Hospital, Institute of Biotherapy for Hematological Malignancies, Shandong University, Jinan, Shandong 250033, P.R. China, Department of Hematology, Jining No. 1 People's Hospital, Jining, Shandong 272100, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2497-2504
    |
    Published online on: June 29, 2017
       https://doi.org/10.3892/mmr.2017.6885
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Abstract

Potential roles of mesenchymal stem cells (MSCs) in the pathogenesis of multiple myeloma (MM) are largely unknown. In the current study, the authors analyzed telomere length and the expressions of interleukin (IL)‑6 and macrophage inflammatory protein (MIP)‑1α in MSCs derived from the bone marrow (BM) of MM patients and controls. The current results demonstrated that there was no significant difference in cell surface expression of CD73 and CD90, and the capacity to differentiate into bone tissue were identified between the BM MSCs derived from MM patients and controls. Interestingly, telomere length (TL) and mRNA expressions of IL‑6 and MIP‑1α were significantly longer or higher in BM MSCs of MM than those of controls. Moreover, TL is positively associated with the expressions of IL‑6 and MIP‑1α at the mRNA level in BM MSCs of MM. Additionally, IL‑6 and MIP‑1α expression were significantly upregulated when MSCs from MM patients were cultured in the myeloma associated condition medium. The present study indicated that myeloma‑associated elongation of TL of BM MSCs may be a key element contributing to the increased IL‑6 and MIP‑1α expression, by which MSCs in the tumor microenvironment may facilitate MM and/or MM bone disease development.
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View References

1 

Bianchi G and Munshi NC: Pathogenesis beyond the cancer clone(s) in multiple myeloma. Blood. 125:3049–3058. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Hideshima T, Mitsiades C, Tonon G, Richardson PG and Anderson KC: Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets. Nat Rev Cancer. 7:585–598. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Manier S, Sacco A, Leleu X, Ghobrial IM and Roccaro AM: Bone marrow microenvironment in multiple myeloma progression. J Biomed Biotechnol. 2012:1574962012. View Article : Google Scholar : PubMed/NCBI

4 

Dankbar B, Padró T, Leo R, Feldmann B, Kropff M, Mesters RM, Serve H, Berdel WE and Kienast J: Vascular endothelial growth factor and interleukin-6 in paracrine tumor-stromal cell interactions in multiple myeloma. Blood. 95:2630–2636. 2000.PubMed/NCBI

5 

Gupta D, Treon SP, Shima Y, Hideshima T, Podar K, Tai YT, Lin B, Lentzsch S, Davies FE, Chauhan D, et al: Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: Therapeutic applications. Leukemia. 15:1950–1961. 2001. View Article : Google Scholar : PubMed/NCBI

6 

Nefedova Y, Cheng P, Alsina M, Dalton WS and Gabrilovich DI: Involvement of Notch-1 signaling in bone marrow stroma-mediated de novo drug resistance of myeloma and other malignant lymphoid cell lines. Blood. 103:3503–3510. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Han JH, Choi SJ, Kurihara N, Koide M, Oba Y and Roodman GD: Macrophage inflammatory protein-1alpha is an osteoclastogenic factor in myeloma that is independent of receptor activator of nuclear factor kappaB ligand. Blood. 97:3349–3353. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Abe M, Hiura K, Wilde J, Moriyama K, Hashimoto T, Ozaki S, Wakatsuki S, Kosaka M, Kido S, Inoue D and Matsumoto T: Role for macrophage inflammatory protein (MIP)-1alpha and MIP-1beta in the development of osteolytic lesions in multiple myeloma. Blood. 100:2195–2202. 2002.PubMed/NCBI

9 

Bergfeld SA and DeClerck YA: Bone marrow-derived mesenchymal stem cells and the tumor microenvironment. Cancer Metastasis Rev. 29:249–261. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Kassen D, Moore S, Percy L, Herledan G, Bounds D, Rodriguez-Justo M, Croucher P and Yong K: The bone marrow stromal compartment in multiple myeloma patients retains capability for osteogenic differentiation in vitro: Defining the stromal defect in myeloma. Br J Haematol. 167:194–206. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Noll JE, Williams SA, Tong CM, Wang H, Quach JM, Purton LE, Pilkington K, To LB, Evdokiou A, Gronthos S and Zannettino AC: Myeloma plasma cells alter the bone marrow microenvironment by stimulating the proliferation of mesenchymal stromal cells. Haematologica. 99:163–171. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Berenstein R, Blau O, Nogai A, Waechter M, Slonova E, Schmidt-Hieber M, Kunitz A, Pezzutto A, Doerken B and Blau IW: Multiple myeloma cells alter the senescence phenotype of bone marrow mesenchymal stromal cells under participation of the DLK1-DIO3 genomic region. BMC Cancer. 15:682015. View Article : Google Scholar : PubMed/NCBI

13 

Wallace SR, Oken MM, Lunetta KL, Panoskaltsis-Mortari A and Masellis AM: Abnormalities of bone marrow mesenchymal cells in multiple myeloma patients. Cancer. 91:1219–1230. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Corre J, Labat E, Espagnolle N, Hébraud B, Avet-Loiseau H, Roussel M, Huynh A, Gadelorge M, Cordelier P, Klein B, et al: Bioactivity and prognostic significance of growth differentiation factor GDF15 secreted by bone marrow mesenchymal stem cells in multiple myeloma. Cancer Res. 72:1395–1406. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Arnulf B, Lecourt S, Soulier J, Ternaux B, Lacassagne MN, Crinquette A, Dessoly J, Sciaini AK, Benbunan M, Chomienne C, et al: Phenotypic and functional characterization of bone marrow mesenchymal stem cells derived from patients with multiple myeloma. Leukemia. 21:158–163. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Li B, Shi M, Li J, Zhang H, Chen B, Chen L, Gao W, Giuliani N and Zhao RC: Elevated tumor necrosis factor-alpha suppresses TAZ expression and impairs osteogenic potential of Flk-1+ mesenchymal stem cells in patients with multiple myeloma. Stem Cells Dev. 16:921–930. 2007. View Article : Google Scholar : PubMed/NCBI

17 

André T, Najar M, Stamatopoulos B, Pieters K, Pradier O, Bron D, Meuleman N and Lagneaux L: Immune impairments in multiple myeloma bone marrow mesenchymal stromal cells. Cancer Immunol Immunother. 64:213–224. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Roccaro AM, Sacco A, Maiso P, Azab AK, Tai YT, Reagan M, Azab F, Flores LM, Campigotto F, Weller E, et al: BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression. J Clin Invest. 123:1542–1555. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Xu S, Santini Cecilia G, De Veirman K, Vande Broek I, Leleu X, De Becker A, Van Camp B, Vanderkerken K and Van Riet I: Upregulation of miR-135b is involved in the impaired osteogenic differentiation of mesenchymal stem cells derived from multiple myeloma patients. PLoS One. 8:e797522013. View Article : Google Scholar : PubMed/NCBI

20 

Garayoa M, Garcia JL, Santamaria C, Garcia-Gomez A, Blanco JF, Pandiella A, Hernández JM, Sanchez-Guijo FM, del Cañizo MC, Gutiérrez NC and Miguel San JF: Mesenchymal stem cells from multiple myeloma patients display distinct genomic profile as compared with those from normal donors. Leukemia. 23:1515–1527. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Blackburn EH: Structure and function of telomeres. Nature. 350:569–573. 1991. View Article : Google Scholar : PubMed/NCBI

22 

Harley CB, Futcher AB and Greider CW: Telomeres shorten during ageing of human fibroblasts. Nature. 345:458–460. 1990. View Article : Google Scholar : PubMed/NCBI

23 

Allsopp RC, Vaziri H, Patterson C, Goldstein S, Younglai EV, Futcher AB, Greider CW and Harley CB: Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad Sci USA. 89:10114–10118. 1992. View Article : Google Scholar : PubMed/NCBI

24 

Zimmermann S, Voss M, Kaiser S, Kapp U, Waller CF and Martens UM: Lack of telomerase activity in human mesenchymal stem cells. Leukemia. 17:1146–1149. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Choumerianou DM, Martimianaki G, Stiakaki E, Kalmanti L, Kalmanti M and Dimitriou H: Comparative study of stemness characteristics of mesenchymal cells from bone marrow of children and adults. Cytotherapy. 12:881–887. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Banfi A, Bianchi G, Notaro R, Luzzatto L, Cancedda R and Quarto R: Replicative aging and gene expression in long-term cultures of human bone marrow stromal cells. Tissue Eng. 8:901–910. 2002. View Article : Google Scholar : PubMed/NCBI

27 

Ju Z, Jiang H, Jaworski M, Rathinam C, Gompf A, Klein C, Trumpp A and Rudolph KL: Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment. Nat Med. 13:742–747. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Cawthon RM: Telomere measurement by quantitative PCR. Nucleic Acids Res. 30:e472002. View Article : Google Scholar : PubMed/NCBI

29 

Ci X, Li B, Ma X, Kong F, Zheng C, Björkholm M, Jia J and Xu D: Bortezomib-mediated down-regulation of telomerase and disruption of telomere homeostasis contributes to apoptosis of malignant cells. Oncotarget. 6:38079–38092. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

31 

Meyerson M, Counter CM, Eaton EN, Ellisen LW, Steiner P, Caddle SD, Ziaugra L, Beijersbergen RL, Davidoff MJ, Liu Q, et al: hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell. 90:785–795. 1997. View Article : Google Scholar : PubMed/NCBI

32 

Reagan MR and Ghobrial IM: Multiple myeloma mesenchymal stem cells: Characterization, origin, and tumor-promoting effects. Clin Cancer Res. 18:342–349. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Akiyama M, Hideshima T, Hayashi T, Tai YT, Mitsiades CS, Mitsiades N, Chauhan D, Richardson P, Munshi NC and Anderson KC: Cytokines modulate telomerase activity in a human multiple myeloma cell line. Cancer Res. 62:3876–3882. 2002.PubMed/NCBI

34 

Bolzoni M, Donofrio G, Storti P, Guasco D, Toscani D, Lazzaretti M, Bonomini S, Agnelli L, Capocefalo A, Dalla Palma B, et al: Myeloma cells inhibit non-canonical wnt co-receptor ror2 expression in human bone marrow osteoprogenitor cells: Effect of wnt5a/ror2 pathway activation on the osteogenic differentiation impairment induced by myeloma cells. Leukemia. 27:451–463. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Li B, Fu J, Chen P and Zhuang W: Impairment in immunomodulatory function of mesenchymal stem cells from multiple myeloma patients. Arch Med Res. 41:623–633. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Lentzsch S, Gries M, Janz M, Bargou R, Dörken B and Mapara MY: Macrophage inflammatory protein 1-alpha (MIP-1 alpha) triggers migration and signaling cascades mediating survival and proliferation in multiple myeloma (MM) cells. Blood. 101:3568–3573. 2003. View Article : Google Scholar : PubMed/NCBI

37 

Vallet S, Pozzi S, Patel K, Vaghela N, Fulciniti MT, Veiby P, Hideshima T, Santo L, Cirstea D, Scadden DT, et al: A novel role for CCL3 (MIP-1α) in myeloma-induced bone disease via osteocalcin downregulation and inhibition of osteoblast function. Leukemia. 25:1174–1181. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Van Ziffle JA, Baerlocher GM and Lansdorp PM: Telomere length in subpopulations of human hematopoietic cells. Stem Cells. 21:654–660. 2003. View Article : Google Scholar : PubMed/NCBI

39 

Samsonraj RM, Raghunath M, Hui JH, Ling L, Nurcombe V and Cool SM: Telomere length analysis of human mesenchymal stem cells by quantitative PCR. Gene. 519:348–355. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Ge W, Jiang J, Arp J, Liu W, Garcia B and Wang H: Regulatory T-cell generation and kidney allograft tolerance induced by mesenchymal stem cells associated with indoleamine 2,3-dioxygenase expression. Transplantation. 90:1312–1320. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li S, Jiang Y, Li A, Liu X, Xing X, Guo Y, Xu Y, Hao Y and Zheng C: Telomere length is positively associated with the expression of IL‑6 and MIP‑1α in bone marrow mesenchymal stem cells of multiple myeloma. Mol Med Rep 16: 2497-2504, 2017.
APA
Li, S., Jiang, Y., Li, A., Liu, X., Xing, X., Guo, Y. ... Zheng, C. (2017). Telomere length is positively associated with the expression of IL‑6 and MIP‑1α in bone marrow mesenchymal stem cells of multiple myeloma. Molecular Medicine Reports, 16, 2497-2504. https://doi.org/10.3892/mmr.2017.6885
MLA
Li, S., Jiang, Y., Li, A., Liu, X., Xing, X., Guo, Y., Xu, Y., Hao, Y., Zheng, C."Telomere length is positively associated with the expression of IL‑6 and MIP‑1α in bone marrow mesenchymal stem cells of multiple myeloma". Molecular Medicine Reports 16.3 (2017): 2497-2504.
Chicago
Li, S., Jiang, Y., Li, A., Liu, X., Xing, X., Guo, Y., Xu, Y., Hao, Y., Zheng, C."Telomere length is positively associated with the expression of IL‑6 and MIP‑1α in bone marrow mesenchymal stem cells of multiple myeloma". Molecular Medicine Reports 16, no. 3 (2017): 2497-2504. https://doi.org/10.3892/mmr.2017.6885
Copy and paste a formatted citation
x
Spandidos Publications style
Li S, Jiang Y, Li A, Liu X, Xing X, Guo Y, Xu Y, Hao Y and Zheng C: Telomere length is positively associated with the expression of IL‑6 and MIP‑1α in bone marrow mesenchymal stem cells of multiple myeloma. Mol Med Rep 16: 2497-2504, 2017.
APA
Li, S., Jiang, Y., Li, A., Liu, X., Xing, X., Guo, Y. ... Zheng, C. (2017). Telomere length is positively associated with the expression of IL‑6 and MIP‑1α in bone marrow mesenchymal stem cells of multiple myeloma. Molecular Medicine Reports, 16, 2497-2504. https://doi.org/10.3892/mmr.2017.6885
MLA
Li, S., Jiang, Y., Li, A., Liu, X., Xing, X., Guo, Y., Xu, Y., Hao, Y., Zheng, C."Telomere length is positively associated with the expression of IL‑6 and MIP‑1α in bone marrow mesenchymal stem cells of multiple myeloma". Molecular Medicine Reports 16.3 (2017): 2497-2504.
Chicago
Li, S., Jiang, Y., Li, A., Liu, X., Xing, X., Guo, Y., Xu, Y., Hao, Y., Zheng, C."Telomere length is positively associated with the expression of IL‑6 and MIP‑1α in bone marrow mesenchymal stem cells of multiple myeloma". Molecular Medicine Reports 16, no. 3 (2017): 2497-2504. https://doi.org/10.3892/mmr.2017.6885
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