Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
September-2017 Volume 16 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2017 Volume 16 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

MicroRNA profiling of platelets from immune thrombocytopenia and target gene prediction

  • Authors:
    • Gang Deng
    • Shifang Yu
    • Yunlei He
    • Tao Sun
    • Wei Liang
    • Lu Yu
    • Deyi Xu
    • Qiang Li
    • Ri Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, The First Affiliated Hospital of Soochow University, Soochow, Jiangsu 215006, P.R. China, Department of Transfusion Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China, The Ningbo Central Blood Station, Ningbo, Zhejiang 31501, P.R. China, Department of Laboratory Medicine, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, P.R. China
  • Pages: 2835-2843
    |
    Published online on: June 30, 2017
       https://doi.org/10.3892/mmr.2017.6901
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Immune thrombocytopenia (ITP) is an autoimmune disease characterized by a low platelet count and insufficient platelet production. Previous studies identified that microRNAs (miRNAs/miRs) are important for platelet function. However, the regulatory role of miRNAs in the pathogenesis of thrombocytopenia in ITP remains unclear. The aim of the present study is to isolate differentially expressed miRNAs, and identify their roles in platelets from ITP. A total of 5 ml blood from 22 patients with ITP and 8 healthy controls was isolated for platelet collection. A microarray assay was performed to analyze the differentially expressed miRNAs in the patients with ITP and healthy patients. Furthermore, the expression of differentially expressed miRNAs was verified by reverse transcription‑quantitative polymerase chain reaction. In addition, the target mRNAs of the differentially expressed miRNAs were predicted via miRWalk databases, and the target genes and miRNAs were classified by Gene Ontology enrichment and Kyoto Encyclopedia of Genes and Genomes analyses. In the present study, 115 miRNAs were identified to be differentially expressed in platelets from patients with ITP compared with the healthy controls (>3‑fold alteration; P<0.05). Among them, 57 miRNAs were upregulated in ITP, while 58 miRNAs were downregulated. Bioinformatic prediction demonstrated that hsa‑miR‑548a‑5p, hsa‑miR‑1185‑2‑3p, hsa‑miR‑30a‑3p, hsa‑miR‑6867‑5p, hsa‑miR‑765 and hsa‑miR‑3125 were associated with platelet apoptosis and adhesion in ITP. The present study performed miRNA profiling of platelets from patients with ITP and the results may aid in the understanding of the regulatory mechanism of ITP.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Neunert CE: Current management of immune thrombocytopenia. Hematology Am Soc Hematol Educ Program. 2013:276–282. 2013.PubMed/NCBI

2 

Varga-Szabo D, Pleines I and Nieswandt B: Cell adhesion mechanisms in platelets. Arterioscler Thromb Vasc Biol. 28:403–412. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Denis MM, Tolley ND, Bunting M, Schwertz H, Jiang H, Lindemann S, Yost CC, Rubner FJ, Albertine KH, Swoboda KJ, et al: Escaping the nuclear confines: Signal-dependent pre-mRNA splicing in anucleate platelets. Cell. 122:379–391. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Dittrich M, Birschmann I, Pfrang J, Herterich S, Smolenski A, Walter U and Dandekar T: Analysis of SAGE data in human platelets: Features of the transcriptome in an anucleate cell. Thromb Haemost. 95:643–651. 2006.PubMed/NCBI

5 

Schwertz H, Tolley ND, Foulks JM, Denis MM, Risenmay BW, Buerke M, Tilley RE, Rondina MT, Harris EM, Kraiss LW, et al: Signal-dependent splicing of tissue factor pre-mRNA modulates the thrombogenicity of human platelets. J Exp Med. 203:2433–2440. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Rowley JW, Oler AJ, Tolley ND, Hunter BN, Low EN, Nix DA, Yost CC, Zimmerman GA and Weyrich AS: Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes. Blood. 118:e101–e111. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Landry P, Plante I, Ouellet DL, Perron MP, Rousseau G and Provost P: Existence of a microRNA pathway in anucleate platelets. Nat Struct Mol Biol. 16:961–966. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Bray PF, McKenzie SE, Edelstein LC, Nagalla S, Delgrosso K, Ertel A, Kupper J, Jing Y, Londin E, Loher P, et al: The complex transcriptional landscape of the anucleate human platelet. BMC Genomics. 14:12013. View Article : Google Scholar : PubMed/NCBI

9 

Londin ER, Hatzimichael E, Loher P, Edelstein L, Shaw C, Delgrosso K, Fortina P, Bray PF, McKenzie SE and Rigoutsos I: The human platelet: Strong transcriptome correlations among individuals associate weakly with the platelet proteome. Biol Direct. 9:32014. View Article : Google Scholar : PubMed/NCBI

10 

Freedman JE, Larson MG, Tanriverdi K, O'Donnell CJ, Morin K, Hakanson AS, Vasan RS, Johnson AD, Iafrati MD and Benjamin EJ: Relation of platelet and leukocyte inflammatory transcripts to body mass index in the Framingham heart study. Circulation. 122:119–129. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Lood C, Amisten S, Gullstrand B, Jönsen A, Allhorn M, Truedsson L, Sturfelt G, Erlinge D and Bengtsson AA: Platelet transcriptional profile and protein expression in patients with systemic lupus erythematosus: Up-regulation of the type I interferon system is strongly associated with vascular disease. Blood. 116:1951–1957. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Gatsiou A, Boeckel JN, Randriamboavonjy V and Stellos K: MicroRNAs in platelet biogenesis and function: Implications in vascular homeostasis and inflammation. Curr Vasc Pharmacol. 10:524–531. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Burenbatu, Borjigin M, Eerdunduleng, Huo W, Gong C, Hasengaowa, Zhang G, Longmei, Li M, Zhang X, et al: Profiling of miRNA expression in immune thrombocytopenia patients before and after Qishunbaolier (QSBLE) treatment. Biomed Pharmacother. 75:196–204. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Qian BH, Ye X, Zhang L, Sun Y, Zhang JR, Gu ML, Qin Q, Chen J and Deng AM: Increased miR-155 expression in peripheral blood mononuclear cells of primary immune thrombocytopenia patients was correlated with serum cytokine profiles. Acta Haematol. 133:257–263. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Rodeghiero F, Stasi R, Gernsheimer T, Michel M, Provan D, Arnold DM, Bussel JB, Cines DB, Chong BH, Cooper N, et al: Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: Report from an international working group. Blood. 113:2386–2393. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Yu S, Deng G, Qian D, Xie Z, Sun H, Huang D and Li Q: Detection of apoptosis-associated microRNA in human apheresis platelets during storage by quantitative real-time polymerase chain reaction analysis. Blood Transfus. 12:541–547. 2014.PubMed/NCBI

17 

Kozomara A and Griffiths-Jones S: miRBase: Annotating high confidence microRNAs using deep sequencing data. Nucleic Acids Res. 42:(Database issue). D68–D73. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Dweep H and Gretz N: miRWalk2.0: A comprehensive atlas of microRNA-target interactions. Nat Methods. 12:6972015. View Article : Google Scholar : PubMed/NCBI

20 

Jiao X, Sherman BT, da Huang W, Stephens R, Baseler MW, Lane HC and Lempicki RA: DAVID-WS: A stateful web service to facilitate gene/protein list analysis. Bioinformatics. 28:1805–1806. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Tabas-Madrid D, Nogales-Cadenas R and Pascual-Montano A: GeneCodis3: A non-redundant and modular enrichment analysis tool for functional genomics. Nucleic Acids Res. 40:(Web Server issue). W478–W483. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Li H, Zhao H, Xue F, Zhang X, Zhang D, Ge J, Yang Y, Xuan M, Fu R and Yang R: Reduced expression of miR409-3p in primary immune thrombocytopenia. Br J Haematol. 161:128–135. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Guo Y, Qu W, Wang YH, Liu H, Li LJ, Wang HQ, Fu R, Liu H, Wu YH, Guan J, et al: The role of miR-155 in pathogenesis of immune thrombocytopenia. Zhonghua Yi Xue Za Zhi. 96:1103–1107. 2016.(In Chinese). PubMed/NCBI

25 

Bay A, Coskun E, Oztuzcu S, Ergun S, Yilmaz F and Aktekin E: Plasma microRNA profiling of pediatric patients with immune thrombocytopenic purpura. Blood Coagul Fibrinolysis. 25:379–383. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Kottke-Marchant K: Importance of platelets and platelet response in acute coronary syndromes. Cleve Clin J Med. 76:(Suppl 1). S2–S7. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Girardot M, Pecquet C, Boukour S, Knoops L, Ferrant A, Vainchenker W, Giraudier S and Constantinescu SN: miR-28 is a thrombopoietin receptor targeting microRNA detected in a fraction of myeloproliferative neoplasm patient platelets. Blood. 116:437–445. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Nagalla S, Shaw C, Kong X, Kondkar AA, Edelstein LC, Ma L, Chen J, McKnight GS, López JA, Yang L, et al: Platelet microRNA-mRNA coexpression profiles correlate with platelet reactivity. Blood. 117:5189–5197. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Yu S, Huang H, Deng G, Xie Z, Ye Y, Guo R, Cai X, Hong J, Qian D, Zhou X, et al: miR-326 targets antiapoptotic Bcl-xL and mediates apoptosis in human platelets. PLoS One. 10:e01227842015. View Article : Google Scholar : PubMed/NCBI

30 

Weyrich AS, Schwertz H, Kraiss LW and Zimmerman GA: Protein synthesis by platelets: Historical and new perspectives. J Thromb Haemost. 7:241–246. 2009. View Article : Google Scholar : PubMed/NCBI

31 

McRedmond JP, Park SD, Reilly DF, Coppinger JA, Maguire PB, Shields DC and Fitzgerald DJ: Integration of proteomics and genomics in platelets: A profile of platelet proteins and platelet-specific genes. Mol Cell Proteomics. 3:133–144. 2004. View Article : Google Scholar : PubMed/NCBI

32 

Gnatenko DV, Perrotta PL and Bahou WF: Proteomic approaches to dissect platelet function: Half the story. Blood. 108:3983–3991. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Colombo G, Gertow K, Marenzi G, Brambilla M, De Metrio M, Tremoli E and Camera M: Gene expression profiling reveals multiple differences in platelets from patients with stable angina or non-ST elevation acute coronary syndrome. Thromb Res. 128:161–168. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Rowley JW and Weyrich AS: Coordinate expression of transcripts and proteins in platelets. Blood. 121:5255–5256. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Harrison P and Goodall AH: ‘Message in the platelet’-more than just vestigial mRNA. Platelets. 19:395–404. 2008. View Article : Google Scholar : PubMed/NCBI

36 

Zhang HW, Zhou P, Wang KZ, Liu JB, Huang YS, Tu YT, Deng ZH, Zhu XD and Hang YL: Platelet proteomics in diagnostic differentiation of primary immune thrombocytopenia using SELDI-TOF-MS. Clin Chim Acta. 455:75–79. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Qiao J, Liu Y, Li D, Wu Y, Li X, Yao Y, Niu M, Fu C, Li H, Ma P, et al: Imbalanced expression of Bcl-xL and Bax in platelets treated with plasma from immune thrombocytopenia. Immunol Res. 64:604–609. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Mitchell WB, Pinheiro MP, Boulad N, Kaplan D, Edison MN, Psaila B, Karpoff M, White MJ, Josefsson EC, Kile BT and Bussel JB: Effect of thrombopoietin receptor agonists on the apoptotic profile of platelets in patients with chronic immune thrombocytopenia. Am J Hematol. 89:E228–E234. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Winkler J, Kroiss S, Rand ML, Azzouzi I, Bang KW Annie, Speer O and Schmugge M: Platelet apoptosis in paediatric immune thrombocytopenia is ameliorated by intravenous immunoglobulin. Br J Haematol. 156:508–515. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Osman A and Fälker K: Characterization of human platelet microRNA by quantitative PCR coupled with an annotation network for predicted target genes. Platelets. 22:433–441. 2011. View Article : Google Scholar : PubMed/NCBI

41 

Zhang W, Wan M, Ma L, Liu X and He J: Protective effects of ADAM8 against cisplatin-mediated apoptosis in non-small-cell lung cancer. Cell Biol Int. 37:47–53. 2013. View Article : Google Scholar : PubMed/NCBI

42 

Kroll H, Sun QH and Santoso S: Platelet endothelial cell adhesion molecule-1 (PECAM-1) is a target glycoprotein in drug-induced thrombocytopenia. Blood. 96:1409–1414. 2000.PubMed/NCBI

43 

Ulger Z, Aksu S, Aksoy DY, Koksal D, Haznedaroglu IC and Kirazli S: The adhesion molecules of L-selectin and ICAM-1 in thrombocytosis and thrombocytopenia. Platelets. 21:49–52. 2010. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Deng G, Yu S, He Y, Sun T, Liang W, Yu L, Xu D, Li Q and Zhang R: MicroRNA profiling of platelets from immune thrombocytopenia and target gene prediction. Mol Med Rep 16: 2835-2843, 2017.
APA
Deng, G., Yu, S., He, Y., Sun, T., Liang, W., Yu, L. ... Zhang, R. (2017). MicroRNA profiling of platelets from immune thrombocytopenia and target gene prediction. Molecular Medicine Reports, 16, 2835-2843. https://doi.org/10.3892/mmr.2017.6901
MLA
Deng, G., Yu, S., He, Y., Sun, T., Liang, W., Yu, L., Xu, D., Li, Q., Zhang, R."MicroRNA profiling of platelets from immune thrombocytopenia and target gene prediction". Molecular Medicine Reports 16.3 (2017): 2835-2843.
Chicago
Deng, G., Yu, S., He, Y., Sun, T., Liang, W., Yu, L., Xu, D., Li, Q., Zhang, R."MicroRNA profiling of platelets from immune thrombocytopenia and target gene prediction". Molecular Medicine Reports 16, no. 3 (2017): 2835-2843. https://doi.org/10.3892/mmr.2017.6901
Copy and paste a formatted citation
x
Spandidos Publications style
Deng G, Yu S, He Y, Sun T, Liang W, Yu L, Xu D, Li Q and Zhang R: MicroRNA profiling of platelets from immune thrombocytopenia and target gene prediction. Mol Med Rep 16: 2835-2843, 2017.
APA
Deng, G., Yu, S., He, Y., Sun, T., Liang, W., Yu, L. ... Zhang, R. (2017). MicroRNA profiling of platelets from immune thrombocytopenia and target gene prediction. Molecular Medicine Reports, 16, 2835-2843. https://doi.org/10.3892/mmr.2017.6901
MLA
Deng, G., Yu, S., He, Y., Sun, T., Liang, W., Yu, L., Xu, D., Li, Q., Zhang, R."MicroRNA profiling of platelets from immune thrombocytopenia and target gene prediction". Molecular Medicine Reports 16.3 (2017): 2835-2843.
Chicago
Deng, G., Yu, S., He, Y., Sun, T., Liang, W., Yu, L., Xu, D., Li, Q., Zhang, R."MicroRNA profiling of platelets from immune thrombocytopenia and target gene prediction". Molecular Medicine Reports 16, no. 3 (2017): 2835-2843. https://doi.org/10.3892/mmr.2017.6901
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team