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Article Open Access

JNK signaling is required for the MIP‑1α‑associated regulation of Kupffer cells in the heat stroke response

  • Authors:
    • Xiao‑Juan Chen
    • Zhong‑Zhi Tang
    • Guo‑Guo Zhu
    • Qing Cheng
    • Wen‑Kai Zhang
    • Hui‑Min Li
    • Wei Fu
    • Qi‑Ping Lu
  • View Affiliations / Copyright

    Affiliations: Department of Emergency, Wuhan General Hospital of Guangzhou Military Command, Wuhan, Hubei 430070, P.R. China, Department of General Surgery, Wuhan General Hospital of Guangzhou Military Command, Wuhan, Hubei 430070, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2389-2396
    |
    Published online on: July 5, 2017
       https://doi.org/10.3892/mmr.2017.6922
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Abstract

Severe heat stroke (HS) consists of extreme hyperthermia with thermoregulatory failure, leading to high morbidity and mortality. Liver injury is a complication of HS that is associated with inflammatory responses and Kupffer cells (KCs), which are resident macrophages in the liver that serve as a major source of inflammatory cytokines; however, the association and the underlying mechanisms of KC functions in HS‑induced endotoxemia and inflammation require an improved understanding. The important chemokine macrophage inflammatory protein‑1α (MIP‑1α) increases inflammatory responses and the secretion of inflammatory molecules from KCs, including tumor necrosis factor‑α, interleukin (IL)‑1β and IL‑6. In addition, the activation of c‑Jun N‑terminal kinase (JNK) signaling is responsible for the development of liver inflammation. Therefore, HS animal and cell models were constructed in order to investigate the pathways involved in the HS‑induced dysfunction of KCs. The results of the present study suggest that JNK may be involved in the MIP‑1α‑associated pathogenesis of KCs in HS injury.
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Copy and paste a formatted citation
Spandidos Publications style
Chen XJ, Tang ZZ, Zhu GG, Cheng Q, Zhang WK, Li HM, Fu W and Lu QP: JNK signaling is required for the MIP‑1α‑associated regulation of Kupffer cells in the heat stroke response. Mol Med Rep 16: 2389-2396, 2017.
APA
Chen, X., Tang, Z., Zhu, G., Cheng, Q., Zhang, W., Li, H. ... Lu, Q. (2017). JNK signaling is required for the MIP‑1α‑associated regulation of Kupffer cells in the heat stroke response. Molecular Medicine Reports, 16, 2389-2396. https://doi.org/10.3892/mmr.2017.6922
MLA
Chen, X., Tang, Z., Zhu, G., Cheng, Q., Zhang, W., Li, H., Fu, W., Lu, Q."JNK signaling is required for the MIP‑1α‑associated regulation of Kupffer cells in the heat stroke response". Molecular Medicine Reports 16.3 (2017): 2389-2396.
Chicago
Chen, X., Tang, Z., Zhu, G., Cheng, Q., Zhang, W., Li, H., Fu, W., Lu, Q."JNK signaling is required for the MIP‑1α‑associated regulation of Kupffer cells in the heat stroke response". Molecular Medicine Reports 16, no. 3 (2017): 2389-2396. https://doi.org/10.3892/mmr.2017.6922
Copy and paste a formatted citation
x
Spandidos Publications style
Chen XJ, Tang ZZ, Zhu GG, Cheng Q, Zhang WK, Li HM, Fu W and Lu QP: JNK signaling is required for the MIP‑1α‑associated regulation of Kupffer cells in the heat stroke response. Mol Med Rep 16: 2389-2396, 2017.
APA
Chen, X., Tang, Z., Zhu, G., Cheng, Q., Zhang, W., Li, H. ... Lu, Q. (2017). JNK signaling is required for the MIP‑1α‑associated regulation of Kupffer cells in the heat stroke response. Molecular Medicine Reports, 16, 2389-2396. https://doi.org/10.3892/mmr.2017.6922
MLA
Chen, X., Tang, Z., Zhu, G., Cheng, Q., Zhang, W., Li, H., Fu, W., Lu, Q."JNK signaling is required for the MIP‑1α‑associated regulation of Kupffer cells in the heat stroke response". Molecular Medicine Reports 16.3 (2017): 2389-2396.
Chicago
Chen, X., Tang, Z., Zhu, G., Cheng, Q., Zhang, W., Li, H., Fu, W., Lu, Q."JNK signaling is required for the MIP‑1α‑associated regulation of Kupffer cells in the heat stroke response". Molecular Medicine Reports 16, no. 3 (2017): 2389-2396. https://doi.org/10.3892/mmr.2017.6922
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