JNK signaling is required for the MIP‑1α‑associated regulation of Kupffer cells in the heat stroke response

Chen,Xiao‑Juan; Tang,Zhong‑Zhi; Zhu,Guo‑Guo; Cheng,Qing; Zhang,Wen‑Kai; Li,Hui‑Min; Fu,Wei; Lu,Qi‑Ping

doi:10.3892/mmr.2017.6922

JNK signaling is required for the MIP‑1α‑associated regulation of Kupffer cells in the heat stroke response

Authors:
- Xiao‑Juan Chen
- Zhong‑Zhi Tang
- Guo‑Guo Zhu
- Qing Cheng
- Wen‑Kai Zhang
- Hui‑Min Li
- Wei Fu
- Qi‑Ping Lu
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Affiliations: Department of Emergency, Wuhan General Hospital of Guangzhou Military Command, Wuhan, Hubei 430070, P.R. China, Department of General Surgery, Wuhan General Hospital of Guangzhou Military Command, Wuhan, Hubei 430070, P.R. China
Published online on: July 5, 2017 https://doi.org/10.3892/mmr.2017.6922
Pages: 2389-2396
Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Severe heat stroke (HS) consists of extreme hyperthermia with thermoregulatory failure, leading to high morbidity and mortality. Liver injury is a complication of HS that is associated with inflammatory responses and Kupffer cells (KCs), which are resident macrophages in the liver that serve as a major source of inflammatory cytokines; however, the association and the underlying mechanisms of KC functions in HS‑induced endotoxemia and inflammation require an improved understanding. The important chemokine macrophage inflammatory protein‑1α (MIP‑1α) increases inflammatory responses and the secretion of inflammatory molecules from KCs, including tumor necrosis factor‑α, interleukin (IL)‑1β and IL‑6. In addition, the activation of c‑Jun N‑terminal kinase (JNK) signaling is responsible for the development of liver inflammation. Therefore, HS animal and cell models were constructed in order to investigate the pathways involved in the HS‑induced dysfunction of KCs. The results of the present study suggest that JNK may be involved in the MIP‑1α‑associated pathogenesis of KCs in HS injury.

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