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Article

MicroRNA-219 is downregulated in non-small cell lung cancer and inhibits cell growth and metastasis by targeting HMGA2

Retraction in: /10.3892/mmr.2024.13237
  • Authors:
    • Xiaoping Sun
    • Min Xu
    • Haiyan Liu
    • Kunxiu Ming
  • View Affiliations / Copyright

    Affiliations: Department of Emergency, Yidu Central Hospital of Weifang, Weifang Medical University, Weifang, Shandong 262500, P.R. China, Department of Emergency Medicine, Weifang People's Hospital, Weifang, Shandong 261000, P.R. China
  • Pages: 3557-3564
    |
    Published online on: July 15, 2017
       https://doi.org/10.3892/mmr.2017.7000
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Abstract

Lung cancer is the most commonly diagnosed cancer and the leading cause of cancer-associated mortality worldwide. Non-small cell lung cancer (NSCLC) is the predominant type of lung cancer, and accounts for ~85% of all lung cancer cases. An increasing number of studies suggest that microRNAs (miRs) may be involved in the regulation of NSCLC carcinogenesis and progression. However, the expression and function of miRNA-219 in NSCLC, and its underlying mechanisms of action, remain unknown. In the present study, miR-219 expression in NSCLC tissues and cell lines was determined using reverse transcription-quantitative polymerase chain reaction. Following transfection with miR-219 mimics, the effects of miR-219 overexpression on NSCLC cell proliferation, migration and invasion were examined. Furthermore, the miR-219 target in NSCLC was investigated. miR-219 was observed to be downregulated in NSCLC tissues and NSCLC cell lines. In addition, miR-219 was demonstrated to function as a tumor suppressor in NSCLC, through inhibiting cell proliferation, migration and invasion in vitro. Furthermore, high mobility group AT-hook 2 (HMGA2) was identified to be a direct target of miR-219 in NSCLC, and downregulation of HMGA2 suppressed NSCLC cell proliferation, migration and invasion in vitro. HMGA2 expression was upregulated in NSCLC tissues, and was inversely correlated with miR-219 expression. In conclusion, miR-219 functions as a tumor suppressor and may be important in inhibiting the growth and metastasis of NSCLC cells via directly targeting HMGA2. Therefore, miR-219 may present a potential novel therapeutic target for NSCLC.
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Copy and paste a formatted citation
Spandidos Publications style
Sun X, Xu M, Liu H and Ming K: MicroRNA-219 is downregulated in non-small cell lung cancer and inhibits cell growth and metastasis by targeting HMGA2 Retraction in /10.3892/mmr.2024.13237. Mol Med Rep 16: 3557-3564, 2017.
APA
Sun, X., Xu, M., Liu, H., & Ming, K. (2017). MicroRNA-219 is downregulated in non-small cell lung cancer and inhibits cell growth and metastasis by targeting HMGA2 Retraction in /10.3892/mmr.2024.13237. Molecular Medicine Reports, 16, 3557-3564. https://doi.org/10.3892/mmr.2017.7000
MLA
Sun, X., Xu, M., Liu, H., Ming, K."MicroRNA-219 is downregulated in non-small cell lung cancer and inhibits cell growth and metastasis by targeting HMGA2 Retraction in /10.3892/mmr.2024.13237". Molecular Medicine Reports 16.3 (2017): 3557-3564.
Chicago
Sun, X., Xu, M., Liu, H., Ming, K."MicroRNA-219 is downregulated in non-small cell lung cancer and inhibits cell growth and metastasis by targeting HMGA2 Retraction in /10.3892/mmr.2024.13237". Molecular Medicine Reports 16, no. 3 (2017): 3557-3564. https://doi.org/10.3892/mmr.2017.7000
Copy and paste a formatted citation
x
Spandidos Publications style
Sun X, Xu M, Liu H and Ming K: MicroRNA-219 is downregulated in non-small cell lung cancer and inhibits cell growth and metastasis by targeting HMGA2 Retraction in /10.3892/mmr.2024.13237. Mol Med Rep 16: 3557-3564, 2017.
APA
Sun, X., Xu, M., Liu, H., & Ming, K. (2017). MicroRNA-219 is downregulated in non-small cell lung cancer and inhibits cell growth and metastasis by targeting HMGA2 Retraction in /10.3892/mmr.2024.13237. Molecular Medicine Reports, 16, 3557-3564. https://doi.org/10.3892/mmr.2017.7000
MLA
Sun, X., Xu, M., Liu, H., Ming, K."MicroRNA-219 is downregulated in non-small cell lung cancer and inhibits cell growth and metastasis by targeting HMGA2 Retraction in /10.3892/mmr.2024.13237". Molecular Medicine Reports 16.3 (2017): 3557-3564.
Chicago
Sun, X., Xu, M., Liu, H., Ming, K."MicroRNA-219 is downregulated in non-small cell lung cancer and inhibits cell growth and metastasis by targeting HMGA2 Retraction in /10.3892/mmr.2024.13237". Molecular Medicine Reports 16, no. 3 (2017): 3557-3564. https://doi.org/10.3892/mmr.2017.7000
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