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The atrophy of white and gray matter volume in patients with comitant strabismus: Evidence from a voxel-based morphometry study

  • Authors:
    • Jun Ouyang
    • Lu Yang
    • Xin Huang
    • Yu-Lin Zhong
    • Pei-Hong Hu
    • Ying Zhang
    • Chong-Gang Pei
    • Yi Shao
  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute and Oculopathy Research Centre, Nanchang, Jiangxi 330006, P.R. China
    Copyright: © Ouyang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3276-3282
    |
    Published online on: July 15, 2017
       https://doi.org/10.3892/mmr.2017.7006
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Abstract

To compare the difference in white matter volume (WMV) and gray matter volume (GMV) between the comitant strabismus (CS) patients and health controls by voxel-based morphometry (VBM) and the relationship with behavioral performance. A total of 20 patients with comitant strabismus (10 males and 10 females), and 20 healthy subjects (10 males and 10 females) with matched age, sex status underwent magnetic resonance examination. The authors analyzed the original 3D T1 brain images using the VBM module. The comitant strabismus groups were compared with the control groups for the GMW and WMV of the entire brain. Correlation analysis was performed to investigate the relationship between the GMV and WMV altered areas and the behavioral performance in comitant strabismus. CS patients were distinguishable from the healthy controls (HCs) by receiver operating characteristic curves. Results of the VBM analysis demonstrated that the CS groups had decreased GMV in the brain regions of the left middle temporal pole, left cerebellum posterior lobe, right posterior cingulate cortex, left cuneus and right premotor cortex. Meanwhile, the WMV was significantly decreased in the brain regions of the left middle temporal gyrus, right middle temporal gyrus, left middle temporal gyrus, right precuneus and right premotor cortex in the comitant strabismus patients compared with HCs. Furthermore, the duration of CS was negatively correlated with the GMV values of the left middle temporal pole (r=-0.486, P=0.030). CS caused GMV and WMV atrophy in many brain regions, which may indicate the neural mechanisms of the ocular motility disorders in CS patients.
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Copy and paste a formatted citation
Spandidos Publications style
Ouyang J, Yang L, Huang X, Zhong Y, Hu P, Zhang Y, Pei C and Shao Y: The atrophy of white and gray matter volume in patients with comitant strabismus: Evidence from a voxel-based morphometry study. Mol Med Rep 16: 3276-3282, 2017.
APA
Ouyang, J., Yang, L., Huang, X., Zhong, Y., Hu, P., Zhang, Y. ... Shao, Y. (2017). The atrophy of white and gray matter volume in patients with comitant strabismus: Evidence from a voxel-based morphometry study. Molecular Medicine Reports, 16, 3276-3282. https://doi.org/10.3892/mmr.2017.7006
MLA
Ouyang, J., Yang, L., Huang, X., Zhong, Y., Hu, P., Zhang, Y., Pei, C., Shao, Y."The atrophy of white and gray matter volume in patients with comitant strabismus: Evidence from a voxel-based morphometry study". Molecular Medicine Reports 16.3 (2017): 3276-3282.
Chicago
Ouyang, J., Yang, L., Huang, X., Zhong, Y., Hu, P., Zhang, Y., Pei, C., Shao, Y."The atrophy of white and gray matter volume in patients with comitant strabismus: Evidence from a voxel-based morphometry study". Molecular Medicine Reports 16, no. 3 (2017): 3276-3282. https://doi.org/10.3892/mmr.2017.7006
Copy and paste a formatted citation
x
Spandidos Publications style
Ouyang J, Yang L, Huang X, Zhong Y, Hu P, Zhang Y, Pei C and Shao Y: The atrophy of white and gray matter volume in patients with comitant strabismus: Evidence from a voxel-based morphometry study. Mol Med Rep 16: 3276-3282, 2017.
APA
Ouyang, J., Yang, L., Huang, X., Zhong, Y., Hu, P., Zhang, Y. ... Shao, Y. (2017). The atrophy of white and gray matter volume in patients with comitant strabismus: Evidence from a voxel-based morphometry study. Molecular Medicine Reports, 16, 3276-3282. https://doi.org/10.3892/mmr.2017.7006
MLA
Ouyang, J., Yang, L., Huang, X., Zhong, Y., Hu, P., Zhang, Y., Pei, C., Shao, Y."The atrophy of white and gray matter volume in patients with comitant strabismus: Evidence from a voxel-based morphometry study". Molecular Medicine Reports 16.3 (2017): 3276-3282.
Chicago
Ouyang, J., Yang, L., Huang, X., Zhong, Y., Hu, P., Zhang, Y., Pei, C., Shao, Y."The atrophy of white and gray matter volume in patients with comitant strabismus: Evidence from a voxel-based morphometry study". Molecular Medicine Reports 16, no. 3 (2017): 3276-3282. https://doi.org/10.3892/mmr.2017.7006
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