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STIM1 silencing inhibits the migration and invasion of A549 cells

  • Authors:
    • Yadong Wang
    • Haiyu Wang
    • Teng Pan
    • Li Li
    • Jiangmin Li
    • Haiyan Yang
  • View Affiliations / Copyright

    Affiliations: Department of Toxicology, Henan Center for Disease Control and Prevention, Zhengzhou, Henan 450016, P.R. China, Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3283-3289
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    Published online on: July 15, 2017
       https://doi.org/10.3892/mmr.2017.7010
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Abstract

The present study aimed to explore the effects of stromal interaction molecule 1 (STIM1) knockdown on the migration, invasion and metastasis of A549 cells in vitro and in vivo. Western blotting and immunohistochemistry were used to detect protein expression levels. Wound healing and Transwell invasion assays were used to assess the migratory and invasive abilities of A549 cells transfected with STIM1‑specific short hairpin (sh)RNA (shSTIM1). In addition, a tail vein metastatic assay was performed. The results demonstrated that the frequency of STIM1 high‑expression was significantly increased in metastatic lung cancer tissues (72.2%) compared with in non‑metastatic lung cancer tissues (33.0%). STIM1 knockdown inhibited A549 cell migration and invasion in vitro and tumor metastasis in vivo. The protein expression levels of Snail1, Vimentin, matrix metalloproteinase (MMP) 2 and MMP9 were markedly decreased in A549‑shSTIM1 compared with in A549 cells transfected with control shRNA (shcon). In addition, the protein expression levels of E‑cadherin were markedly increased in A549‑shSTIM1 cells compared with in A549‑shcon cells. These results suggested that STIM1 knockdown may inhibit the migration and invasion of A549 cells in vitro, and metastasis in vivo.
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View References

1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Cui T, Srivastava AK, Han C, Yang L, Zhao R, Zou N, Qu M, Duan W, Zhang X and Wang QE: XPC inhibits NSCLC cell proliferation and migration by enhancing E-Cadherin expression. Oncotarget. 6:10060–10072. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Osarogiagbon RU, Lin CC, Smeltzer MP and Jemal A: Prevalence, prognostic implications, and survival modulators of incompletely resected non-small cell lung cancer in the U.S. national cancer data base. J Thorac Oncol. 11:e5–e16. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Lin JJ, Cardarella S, Lydon CA, Dahlberg SE, Jackman DM, Jänne PA and Johnson BE: Five-year survival in EGFR-mutant metastatic lung adenocarcinoma treated with EGFR-TKIs. J Thorac Oncol. 11:556–565. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Parker NJ, Begley CG, Smith PJ and Fox RM: Molecular cloning of a novel human gene (D11S4896E) at chromosomal region 11p15.5. Genomics. 37:253–256. 1996. View Article : Google Scholar : PubMed/NCBI

6 

Johnstone LS, Graham SJ and Dziadek MA: STIM proteins: Integrators of signalling pathways in development, differentiation and disease. J Cell Mol Med. 14:1890–1903. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Suyama E, Wadhwa R, Kaur K, Miyagishi M, Kaul SC, Kawasaki H and Taira K: Identification of metastasis-related genes in a mouse model using a library of randomized ribozymes. J Biol Chem. 279:38083–38086. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Yang S, Zhang JJ and Huang XY: Orai1 and STIM1 are critical for breast tumor cell migration and metastasis. Cancer Cell. 15:124–134. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Chen YF, Chiu WT, Chen YT, Lin PY, Huang HJ, Chou CY, Chang HC, Tang MJ and Shen MR: Calcium store sensor stromal-interaction molecule 1-dependent signaling plays an important role in cervical cancer growth, migration, and angiogenesis. Proc Natl Acad Sci USA. 108:15225–15230. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Yang N, Tang Y, Wang F, Zhang H, Xu D, Shen Y, Sun S and Yang G: Blockade of store-operated Ca(2+) entry inhibits hepatocarcinoma cell migration and invasion by regulating focal adhesion turnover. Cancer Lett. 330:163–169. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Umemura M, Baljinnyam E, Feske S, De Lorenzo MS, Xie LH, Feng X, Oda K, Makino A, Fujita T, Yokoyama U, et al: Store-operated Ca2+ entry (SOCE) regulates melanoma proliferation and cell migration. PLoS One. 9:e892922014. View Article : Google Scholar : PubMed/NCBI

12 

Sun J, Lu F, He H, Shen J, Messina J, Mathew R, Wang D, Sarnaik AA, Chang WC, Kim M, et al: STIM1- and Orai1-mediated Ca(2+) oscillation orchestrates invadopodium formation and melanoma invasion. J Cell Biol. 207:535–548. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Zhang Z, Liu X, Feng B, Liu N, Wu Q, Han Y, Nie Y, Wu K, Shi Y and Fan D: STIM1, a direct target of microRNA-185, promotes tumor metastasis and is associated with poor prognosis in colorectal cancer. Oncogene. 34:4808–4820. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Li W, Zhang M, Xu L, Lin D, Cai S and Zou F: The apoptosis of non-small cell lung cancer induced by cisplatin through modulation of STIM1. Exp Toxicol Pathol. 65:1073–1081. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Wang Y, Pan T, Wang H, Li L, Li J, Zhang C and Yang H: Silencing of TGIF attenuates the tumorigenicity of A549 cells in vitro and in vivo. Tumour Biol. 37:12725–12730. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Travis W, Brambilla E, Muller-Hermelink H and Harris C: World Health Organization classification of tumoursPathology and Genetics Tumours of the Lung, Pleura, Thymus and Heart. Lyon: IARC Press; 2004

17 

Wang Y, Zhai W, Wang H, Xia X and Zhang C: Benzo(a)pyrene promotes A549 cell migration and invasion through up-regulating Twist. Arch Toxicol. 89:451–458. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Bayne K: Revised guide for the care and use of laboratory animals available. American physiological society. Physiologist. 39:199208. –211. 1996.PubMed/NCBI

19 

Bratcher NA and Reinhard GR: Creative implementation of 3Rs principles within industry programs: Beyond regulations and guidelines. J Am Assoc Lab Anim Sci. 54:133–138. 2015.PubMed/NCBI

20 

Hui L, Zhang S, Dong X, Tian D, Cui Z and Qiu X: Prognostic significance of twist and N-cadherin expression in NSCLC. PLoS One. 8:e621712013. View Article : Google Scholar : PubMed/NCBI

21 

Bae GY, Choi SJ, Lee JS, Jo J, Lee J, Kim J and Cha HJ: Loss of E-cadherin activates EGFR-MEK/ERK signaling, which promotes invasion via the ZEB1/MMP2 axis in non-small cell lung cancer. Oncotarget. 4:2512–2522. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Gong L, Wu D, Zou J, Chen J, Chen L, Chen Y, Ni C and Yuan H: Prognostic impact of serum and tissue MMP-9 in non-small cell lung cancer: A systematic review and meta-analysis. Oncotarget. 7:18458–18468. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Yang X, Han M, Han H, Wang B, Li S, Zhang Z and Zhao W: Silencing snail suppresses tumor cell proliferation and invasion by reversing epithelial-to-mesenchymal transition and arresting G2/M phase in non-small cell lung cancer. Int J Oncol. 50:1251–1260. 2017.PubMed/NCBI

24 

Ye Z, Zhang X, Luo Y, Li S, Huang L, Li Z, Li P and Chen G: Prognostic values of Vimentin expression and its clinicopathological significance in non-small cell lung cancer: A meta-analysis of observational studies with 4118 cases. PLoS One. 11:e01631622016. View Article : Google Scholar : PubMed/NCBI

25 

Zhong Z, Xia Y, Wang P, Liu B and Chen Y: Low expression of microRNA-30c promotes invasion by inducing epithelial mesenchymal transition in non-small cell lung cancer. Mol Med Rep. 10:2575–2579. 2014.PubMed/NCBI

26 

Nitsche U, Stangel D, Pan Z, Schlitter AM, Esposito I, Regel I, Raulefs S, Friess H, Kleeff J and Erkan M: Periostin and tumor-stroma interactions in non-small cell lung cancer. Oncol Lett. 12:3804–3810. 2016.PubMed/NCBI

27 

Moss LA Shuman and Stetler-Stevenson WG: Influence of stromal components on lung cancer carcinogenesis. J Carcinog Mutagen. 13:2013.doi: 10.4172/2157-2518.S13-008.

28 

Zhang T, Xu J, Shen H, Dong W, Ni Y and Du J: Tumor-stroma ratio is an independent predictor for survival in NSCLC. Int J Clin Exp Pathol. 8:11348–11355. 2015.PubMed/NCBI

29 

Donnem T, Al-Saad S, Al-Shibli K, Delghandi MP, Persson M, Nilsen MN, Busund LT and Bremnes RM: Inverse prognostic impact of angiogenic marker expression in tumor cells versus stromal cells in non small cell lung cancer. Clin Cancer Res. 13:6649–6657. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Liotta LA and Kohn EC: The microenvironment of the tumour-host interface. Nature. 411:375–379. 2001. View Article : Google Scholar : PubMed/NCBI

31 

Sulzer MA, Leers MP, van Noord JA, Bollen EC and Theunissen PH: Reduced E-cadherin expression is associated with increased lymph node metastasis and unfavorable prognosis in non-small cell lung cancer. Am J Respir Crit Care Med. 157:1319–1323. 1998. View Article : Google Scholar : PubMed/NCBI

32 

Shibanuma H, Hirano T, Tsuji K, Wu Q, Shrestha B, Konaka C, Ebihara Y and Kato H: Influence of E-cadherin dysfunction upon local invasion and metastasis in non-small cell lung cancer. Lung Cancer. 22:85–95. 1998. View Article : Google Scholar : PubMed/NCBI

33 

Liu D, Huang C, Kameyama K, Hayashi E, Yamauchi A, Kobayashi S and Yokomise H: E-cadherin expression associated with differentiation and prognosis in patients with non-small cell lung cancer. Ann Thorac Surg. 71:949–955. 2001. View Article : Google Scholar : PubMed/NCBI

34 

Moersig W, Horn S, Hilker M, Mayer E and Oelert H: Transfection of E-cadherin cDNA in human lung tumor cells reduces invasive potential of tumors. Thorac Cardiovasc Surg. 50:45–48. 2002. View Article : Google Scholar : PubMed/NCBI

35 

Asnaghi L, Vass WC, Quadri R, Day PM, Qian X, Braverman R, Papageorge AG and Lowy DR: E-cadherin negatively regulates neoplastic growth in non-small cell lung cancer: Role of Rho GTPases. Oncogene. 29:2760–2771. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Shi Y, Wu H, Zhang M, Ding L, Meng F and Fan X: Expression of the epithelial-mesenchymal transition-related proteins and their clinical significance in lung adenocarcinoma. Diagn Pathol. 8:892013. View Article : Google Scholar : PubMed/NCBI

37 

Dauphin M, Barbe C, Lemaire S, Nawrocki-Raby B, Lagonotte E, Delepine G, Birembaut P, Gilles C and Polette M: Vimentin expression predicts the occurrence of metastases in non small cell lung carcinomas. Lung Cancer. 81:117–122. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Tadokoro A, Kanaji N, Liu D, Yokomise H, Haba R, Ishii T, Takagi T, Watanabe N, Kita N, Kadowaki N and Bandoh S: Vimentin regulates invasiveness and is a poor prognostic marker in non-small cell lung cancer. Anticancer Res. 36:1545–1551. 2016.PubMed/NCBI

39 

Havel LS, Kline ER, Salgueiro AM and Marcus AI: Vimentin regulates lung cancer cell adhesion through a VAV2-Rac1 pathway to control focal adhesion kinase activity. Oncogene. 34:1979–1990. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Rojiani MV, Alidina J, Esposito N and Rojiani AM: Expression of MMP-2 correlates with increased angiogenesis in CNS metastasis of lung carcinoma. Int J Clin Exp Pathol. 3:775–781. 2010.PubMed/NCBI

41 

Qian Z, Zhao X, Jiang M, Jia W, Zhang C, Wang Y, Li B and Yue W: Downregulation of cyclophilin A by siRNA diminishes non-small cell lung cancer cell growth and metastasis via the regulation of matrix metallopeptidase 9. BMC Cancer:. 12:4422012. View Article : Google Scholar : PubMed/NCBI

42 

He H, Zheng L, Sun YP, Zhang GW and Yue ZG: Steroidal saponins from Paris polyphylla suppress adhesion, migration and invasion of human lung cancer A549 cells via down-regulating MMP-2 and MMP-9. Asian Pac J Cancer Prev. 15:10911–10916. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Qian Q, Wang Q, Zhan P, Peng L, Wei SZ, Shi Y and Song Y: The role of matrix metalloproteinase 2 on the survival of patients with non-small cell lung cancer: A systematic review with meta-analysis. Cancer Invest. 28:661–669. 2010. View Article : Google Scholar : PubMed/NCBI

44 

Li J, Wang H, Ke H and Ni S: MiR-129 regulates MMP9 to control metastasis of non-small cell lung cancer. Tumour Biol. 36:5785–5790. 2015. View Article : Google Scholar : PubMed/NCBI

45 

Peinado H, Olmeda D and Cano A: Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype? Nat Rev Cancer. 7:415–428. 2007. View Article : Google Scholar : PubMed/NCBI

46 

Yanagawa J, Walser TC, Zhu LX, Hong L, Fishbein MC, Mah V, Chia D, Goodglick L, Elashoff DA, Luo J, et al: Snail promotes CXCR2 ligand-dependent tumor progression in non-small cell lung carcinoma. Clin Cancer Res. 15:6820–6829. 2009. View Article : Google Scholar : PubMed/NCBI

47 

Liu J, Hu G, Chen D, Gong AY, Soori GS, Dobleman TJ and Chen XM: Suppression of SCARA5 by Snail1 is essential for EMT-associated cell migration of A549 cells. Oncogenesis. 2:e732013. View Article : Google Scholar : PubMed/NCBI

48 

Liu CW, Li CH, Peng YJ, Cheng YW, Chen HW, Liao PL, Kang JJ and Yeng MH: Snail regulates Nanog status during the epithelial-mesenchymal transition via the Smad1/Akt/GSK3β signaling pathway in non-small-cell lung cancer. Oncotarget. 5:3880–3894. 2014. View Article : Google Scholar : PubMed/NCBI

49 

Merikallio H, Turpeenniemi-Hujanen T, Pääkkö P, Mäkitaro R, Riitta K, Salo S, Salo T, Harju T and Soini Y: Snail promotes an invasive phenotype in lung carcinoma. Respir Res. 13:1042012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Wang H, Pan T, Li L, Li J and Yang H: STIM1 silencing inhibits the migration and invasion of A549 cells. Mol Med Rep 16: 3283-3289, 2017.
APA
Wang, Y., Wang, H., Pan, T., Li, L., Li, J., & Yang, H. (2017). STIM1 silencing inhibits the migration and invasion of A549 cells. Molecular Medicine Reports, 16, 3283-3289. https://doi.org/10.3892/mmr.2017.7010
MLA
Wang, Y., Wang, H., Pan, T., Li, L., Li, J., Yang, H."STIM1 silencing inhibits the migration and invasion of A549 cells". Molecular Medicine Reports 16.3 (2017): 3283-3289.
Chicago
Wang, Y., Wang, H., Pan, T., Li, L., Li, J., Yang, H."STIM1 silencing inhibits the migration and invasion of A549 cells". Molecular Medicine Reports 16, no. 3 (2017): 3283-3289. https://doi.org/10.3892/mmr.2017.7010
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Wang H, Pan T, Li L, Li J and Yang H: STIM1 silencing inhibits the migration and invasion of A549 cells. Mol Med Rep 16: 3283-3289, 2017.
APA
Wang, Y., Wang, H., Pan, T., Li, L., Li, J., & Yang, H. (2017). STIM1 silencing inhibits the migration and invasion of A549 cells. Molecular Medicine Reports, 16, 3283-3289. https://doi.org/10.3892/mmr.2017.7010
MLA
Wang, Y., Wang, H., Pan, T., Li, L., Li, J., Yang, H."STIM1 silencing inhibits the migration and invasion of A549 cells". Molecular Medicine Reports 16.3 (2017): 3283-3289.
Chicago
Wang, Y., Wang, H., Pan, T., Li, L., Li, J., Yang, H."STIM1 silencing inhibits the migration and invasion of A549 cells". Molecular Medicine Reports 16, no. 3 (2017): 3283-3289. https://doi.org/10.3892/mmr.2017.7010
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