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Article

LncRNA H19 regulates ID2 expression through competitive binding to hsa-miR-19a/b in acute myelocytic leukemia

  • Authors:
    • Tong‑Feng Zhao
    • Hui‑Zhen Jia
    • Zhen‑Zhen Zhang
    • Xiao‑Su Zhao
    • Yan‑Fen Zou
    • Wei Zhang
    • Jun Wan
    • Xiao‑Fan Chen
  • View Affiliations / Copyright

    Affiliations: Shenzhen Key Laboratory for Neuronal Structural Biology, Biomedical Research Institute, Shenzhen Peking University‑The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong 518036, P.R. China, Department of Hematology, Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing 100044, P.R. China, Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China, Shenzhen Key Laboratory for Translational Medicine of Dermatology, Biomedical Research Institute, Shenzhen Peking University‑The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong 518036, P.R. China
  • Pages: 3687-3693
    |
    Published online on: July 18, 2017
       https://doi.org/10.3892/mmr.2017.7029
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Abstract

Acute myelocytic leukemia (AML) is the most common type of acute leukemia. Long non‑coding RNAs (lncRNAs) serve an important role in regulating gene expression through chromatin modification, transcription and post‑transcriptional processing. LncRNA H19 was considered as an independent prognostic marker for patients with tumors. The expression of lncRNA H19 was identified to be significantly upregulated in bone marrow samples from patients with AML‑M2. Furthermore, it was demonstrated that the knockdown of lncRNA H19 resulted in increased expression of hsa‑microRNA (miR)‑19a/b and decreased expression of inhibitor of DNA binding 2 (ID2) in AML cells. The knockdown of lncRNA H19 inhibited the proliferation of AML cells in vitro, which could be partially reversed by ID2 overexpression. Furthermore, the results of the bioinformatic analysis revealed potential hsa‑miR‑19a/b‑3p binding sites in lncRNA H19 and ID2. Altogether, the results of the present study suggest that lncRNA H19 regulates the expression of ID2 through competitive binding to hsa‑miR‑19a and hsa‑miR‑19b, which may serve a role in AML cell proliferation.
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1 

Ferrara F and Schiffer CA: Acute myeloid leukaemia in adults. Lancet. 381:484–495. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Kapranov P, Cheng J, Dike S, Nix DA, Duttagupta R, Willingham AT, Stadler PF, Hertel J, Hackermüller J, Hofacker IL, et al: RNA maps reveal new RNA classes and a possible function for pervasive transcription. Science. 316:1484–1488. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Gibb EA, Brown CJ and Lam WL: The functional role of long non-coding RNA in human carcinomas. Mol Cancer. 10:382011. View Article : Google Scholar : PubMed/NCBI

4 

Perez DS, Hoage TR, Pritchett JR, Ducharme-Smith AL, Halling ML, Ganapathiraju SC, Streng PS and Smith DI: Long, abundantly expressed non-coding transcripts are altered in cancer. Hum Mol Genet. 17:642–655. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Louro R, Smirnova AS and Verjovski-Almeida S: Long intronic noncoding RNA transcription: Expression noise or expression choice? Genomics. 93:291–298. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Khalil AM, Guttman M, Huarte M, Garber M, Raj A, Morales D Rivea, Thomas K, Presser A, Bernstein BE, van Oudenaarden A, et al: Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression. Proc Natl Acad Sci USA. 106:11667–11672. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Li L, Feng T, Lian Y, Zhang G, Garen A and Song X: Role of human noncoding RNAs in the control of tumorigenesis. Proc Natl Acad Sci USA. 106:12956–12961. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Verhaegh GW, Verkleij L, Vermeulen SH, den Heijer M, Witjes JA and Kiemeney LA: Polymorphisms in the H19 gene and the risk of bladder cancer. Eur Urol. 54:1118–1126. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Zhu Z, Song L, He J, Sun Y, Liu X and Zou X: Ectopic expressed long non-coding RNA H19 contributes to malignant cell behavior of ovarian cancer. Int J Clin Exp Pathol. 8:10082–10091. 2015.PubMed/NCBI

10 

Berteaux N, Lottin S, Monté D, Pinte S, Quatannens B, Coll J, Hondermarck H, Curgy JJ, Dugimont T and Adriaenssens E: H19 mRNA-like noncoding RNA promotes breast cancer cell proliferation through positive control by E2F1. J Biol Chem. 280:29625–29636. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Wu T, Qu L, He G, Tian L, Li L, Zhou H, Jin Q, Ren J, Wang Y, Wang J, et al: Regulation of laryngeal squamous cell cancer progression by the lncRNA H19/miR-148a-3p/DNMT1 axis. Oncotarget. 7:11553–11566. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Wang L, Cai Y, Zhao X, Zhang J, Liu J, Zhen H, Wang T, Tang X, Liu Y and Wang J: Down-regulated long non-coding RNA H19 inhibits carcinogenesis of renal cell carcinoma. Neoplasma. 62:412–418. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Zhou X, Yin C, Dang Y, Ye F and Zhang G: Identification of the long non-coding RNA H19 in plasma as a novel biomarker for diagnosis of gastric cancer. Sci Rep. 5:115162015. View Article : Google Scholar : PubMed/NCBI

14 

Zhou X, Ye F, Yin C, Zhuang Y, Yue G and Zhang G: The interaction between MiR-141 and lncRNA-H19 in regulating cell proliferation and migration in gastric cancer. Cell Physiol Biochem. 36:1440–1452. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Zhang E, Li W, Yin D, De W, Zhu L, Sun S and Han L: c-Myc-regulated long non-coding RNA H19 indicates a poor prognosis and affects cell proliferation in non-small-cell lung cancer. Tumour Biol. 37:4007–4015. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Luo M, Li Z, Wang W, Zeng Y, Liu Z and Qiu J: Long non-coding RNA H19 increases bladder cancer metastasis by associating with EZH2 and inhibiting E-cadherin expression. Cancer Lett. 333:213–221. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Dalton WT Jr, Ahearn MJ, McCredie KB, Freireich EJ, Stass SA and Trujillo JM: HL-60 cell line was derived from a patient with FAB-M2 and not FAB-M3. Blood. 71:242–247. 1988.PubMed/NCBI

18 

Luo M, Li Z, Wang W, Zeng Y, Liu Z and Qiu J: Upregulated H19 contributes to bladder cancer cell proliferation by regulating ID2 expression. FEBS J. 280:1709–1716. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Li K, Yao L, Chen L, Cao ZG, Yu SJ, Kuang XY, Hu X and Shao ZM: ID2 predicts poor prognosis in breast cancer, especially in triple-negative breast cancer, and inhibits E-cadherin expression. Onco Targets Ther. 7:1083–1094. 2014.PubMed/NCBI

20 

Wang C, Chen Q, Hamajima Y, Sun W, Zheng YQ, Hu XH, Ondrey FG and Lin JZ: Id2 regulates the proliferation of squamous cell carcinoma in vitro via the NF-κB/Cyclin D1 pathway. Chin J Cancer. 31:430–439. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Xia T, Liao Q, Jiang X, Shao Y, Xiao B, Xi Y and Guo J: Long noncoding RNA associated-competing endogenous RNAs in gastric cancer. Sci Rep. 4:60882014. View Article : Google Scholar : PubMed/NCBI

22 

May AM, Frey AV, Bogatyreva L, Benkisser-Petersen M, Hauschke D, Lübbert M, Wäsch R, Werner M, Hasskarl J and Lassmann S: ID2 and ID3 protein expression mirrors granulopoietic maturation and discriminates between acute leukemia subtypes. Histochem Cell Biol. 141:431–440. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Salmena L, Poliseno L, Tay Y, Kats L and Pandolfi PP: A ceRNA hypothesis: The Rosetta Stone of a hidden RNA language? Cell. 146:353–358. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Liang WC, Fu WM, Wong CW, Wang Y, Wang WM, Hu GX, Zhang L, Xiao LJ, Wan DC, Zhang JF and Waye MM: The lncRNA H19 promotes epithelial to mesenchymal transition by functioning as miRNA sponges in colorectal cancer. Oncotarget. 6:22513–22525. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Liang WC, Fu WM, Wang YB, Sun YX, Xu LL, Wong CW, Chan KM, Li G, Waye MM and Zhang JF: H19 activates Wnt signaling and promotes osteoblast differentiation by functioning as a competing endogenous RNA. Sci Rep. 6:201212016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhao TF, Jia HZ, Zhang ZZ, Zhao XS, Zou YF, Zhang W, Wan J and Chen XF: LncRNA H19 regulates ID2 expression through competitive binding to hsa-miR-19a/b in acute myelocytic leukemia. Mol Med Rep 16: 3687-3693, 2017.
APA
Zhao, T., Jia, H., Zhang, Z., Zhao, X., Zou, Y., Zhang, W. ... Chen, X. (2017). LncRNA H19 regulates ID2 expression through competitive binding to hsa-miR-19a/b in acute myelocytic leukemia. Molecular Medicine Reports, 16, 3687-3693. https://doi.org/10.3892/mmr.2017.7029
MLA
Zhao, T., Jia, H., Zhang, Z., Zhao, X., Zou, Y., Zhang, W., Wan, J., Chen, X."LncRNA H19 regulates ID2 expression through competitive binding to hsa-miR-19a/b in acute myelocytic leukemia". Molecular Medicine Reports 16.3 (2017): 3687-3693.
Chicago
Zhao, T., Jia, H., Zhang, Z., Zhao, X., Zou, Y., Zhang, W., Wan, J., Chen, X."LncRNA H19 regulates ID2 expression through competitive binding to hsa-miR-19a/b in acute myelocytic leukemia". Molecular Medicine Reports 16, no. 3 (2017): 3687-3693. https://doi.org/10.3892/mmr.2017.7029
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao TF, Jia HZ, Zhang ZZ, Zhao XS, Zou YF, Zhang W, Wan J and Chen XF: LncRNA H19 regulates ID2 expression through competitive binding to hsa-miR-19a/b in acute myelocytic leukemia. Mol Med Rep 16: 3687-3693, 2017.
APA
Zhao, T., Jia, H., Zhang, Z., Zhao, X., Zou, Y., Zhang, W. ... Chen, X. (2017). LncRNA H19 regulates ID2 expression through competitive binding to hsa-miR-19a/b in acute myelocytic leukemia. Molecular Medicine Reports, 16, 3687-3693. https://doi.org/10.3892/mmr.2017.7029
MLA
Zhao, T., Jia, H., Zhang, Z., Zhao, X., Zou, Y., Zhang, W., Wan, J., Chen, X."LncRNA H19 regulates ID2 expression through competitive binding to hsa-miR-19a/b in acute myelocytic leukemia". Molecular Medicine Reports 16.3 (2017): 3687-3693.
Chicago
Zhao, T., Jia, H., Zhang, Z., Zhao, X., Zou, Y., Zhang, W., Wan, J., Chen, X."LncRNA H19 regulates ID2 expression through competitive binding to hsa-miR-19a/b in acute myelocytic leukemia". Molecular Medicine Reports 16, no. 3 (2017): 3687-3693. https://doi.org/10.3892/mmr.2017.7029
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