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Article

Tumor necrosis factor‑α‑induced protein‑8 like 2 regulates lipopolysaccharide‑induced rat rheumatoid arthritis immune responses and is associated with Rac activation and interferon regulatory factor 3 phosphorylation

  • Authors:
    • Chunyan Shi
    • Yue Wang
    • Guohong Zhuang
    • Zhongquan Qi
    • Yanping Li
    • Ping Yin
  • View Affiliations / Copyright

    Affiliations: Organ Transplantation Institute, Anti‑Cancer Research Center, Medical College, Xiamen University, Xiamen, Fujian 361100, P.R. China, Department of Pathology, Zhongshan Hospital Affiliated to Xiamen University, Xiamen, Fujian 361100, P.R. China
  • Pages: 6346-6353
    |
    Published online on: August 22, 2017
       https://doi.org/10.3892/mmr.2017.7311
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Abstract

The endogenously activated rheumatoid arthritis (RA) synovial fibroblasts (RSFs) are likely to be the key to curing the disease. RSFs express Toll‑like receptors (TLRs) rendering them prone to activation by exogenous and endogenous TLR ligands, resulting in the production of chemokines and cytokines Germline deletion of tumor necrosis factor‑α‑induced protein‑8 like 2 (TIPE2, also known as TNFAIP8L2) results in fatal inflammation and hypersensitivity to TLR and T cell receptor stimulation. The present study demonstrates an inverse association between TIPE2 and cytokine gene expression in RSFs following lipopolysaccharide (LPS) stimulation. Enhanced TIPE2 expression decreased Ras‑related C3 botulinum toxin substrate (Rac) activation and interferon regulatory factor 3 phosphorylation, and phosphoinositide 3‑kinase and Rac inhibition significantly diminished LPS‑induced cytokine gene expression in RSFs. In conclusion, the findings of the present study demonstrate that TIPE2 serves a negative role in activating the Rac signaling pathway and in the initiation of the immune response by decreasing the activity of proinflammatory cytokines. These results may be useful in designing novel strategies for the prevention and treatment of RA.
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Copy and paste a formatted citation
Spandidos Publications style
Shi C, Wang Y, Zhuang G, Qi Z, Li Y and Yin P: Tumor necrosis factor‑α‑induced protein‑8 like 2 regulates lipopolysaccharide‑induced rat rheumatoid arthritis immune responses and is associated with Rac activation and interferon regulatory factor 3 phosphorylation. Mol Med Rep 16: 6346-6353, 2017.
APA
Shi, C., Wang, Y., Zhuang, G., Qi, Z., Li, Y., & Yin, P. (2017). Tumor necrosis factor‑α‑induced protein‑8 like 2 regulates lipopolysaccharide‑induced rat rheumatoid arthritis immune responses and is associated with Rac activation and interferon regulatory factor 3 phosphorylation. Molecular Medicine Reports, 16, 6346-6353. https://doi.org/10.3892/mmr.2017.7311
MLA
Shi, C., Wang, Y., Zhuang, G., Qi, Z., Li, Y., Yin, P."Tumor necrosis factor‑α‑induced protein‑8 like 2 regulates lipopolysaccharide‑induced rat rheumatoid arthritis immune responses and is associated with Rac activation and interferon regulatory factor 3 phosphorylation". Molecular Medicine Reports 16.5 (2017): 6346-6353.
Chicago
Shi, C., Wang, Y., Zhuang, G., Qi, Z., Li, Y., Yin, P."Tumor necrosis factor‑α‑induced protein‑8 like 2 regulates lipopolysaccharide‑induced rat rheumatoid arthritis immune responses and is associated with Rac activation and interferon regulatory factor 3 phosphorylation". Molecular Medicine Reports 16, no. 5 (2017): 6346-6353. https://doi.org/10.3892/mmr.2017.7311
Copy and paste a formatted citation
x
Spandidos Publications style
Shi C, Wang Y, Zhuang G, Qi Z, Li Y and Yin P: Tumor necrosis factor‑α‑induced protein‑8 like 2 regulates lipopolysaccharide‑induced rat rheumatoid arthritis immune responses and is associated with Rac activation and interferon regulatory factor 3 phosphorylation. Mol Med Rep 16: 6346-6353, 2017.
APA
Shi, C., Wang, Y., Zhuang, G., Qi, Z., Li, Y., & Yin, P. (2017). Tumor necrosis factor‑α‑induced protein‑8 like 2 regulates lipopolysaccharide‑induced rat rheumatoid arthritis immune responses and is associated with Rac activation and interferon regulatory factor 3 phosphorylation. Molecular Medicine Reports, 16, 6346-6353. https://doi.org/10.3892/mmr.2017.7311
MLA
Shi, C., Wang, Y., Zhuang, G., Qi, Z., Li, Y., Yin, P."Tumor necrosis factor‑α‑induced protein‑8 like 2 regulates lipopolysaccharide‑induced rat rheumatoid arthritis immune responses and is associated with Rac activation and interferon regulatory factor 3 phosphorylation". Molecular Medicine Reports 16.5 (2017): 6346-6353.
Chicago
Shi, C., Wang, Y., Zhuang, G., Qi, Z., Li, Y., Yin, P."Tumor necrosis factor‑α‑induced protein‑8 like 2 regulates lipopolysaccharide‑induced rat rheumatoid arthritis immune responses and is associated with Rac activation and interferon regulatory factor 3 phosphorylation". Molecular Medicine Reports 16, no. 5 (2017): 6346-6353. https://doi.org/10.3892/mmr.2017.7311
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