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Article

Myricitrin inhibits vascular adhesion molecule expression in TNF‑α‑stimulated vascular smooth muscle cells

  • Authors:
    • Li‑Jie Yan
    • Hai‑Tao Yang
    • Hong‑Yan Duan
    • Jin‑Tao Wu
    • Peng Qian
    • Xian‑Wei Fan
    • Shanling Wang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Henan Provincial People's Hospital, Zhengzhou, Henan 450003, P.R. China
  • Pages: 6354-6359
    |
    Published online on: August 22, 2017
       https://doi.org/10.3892/mmr.2017.7321
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Abstract

Increased expression of adhesion molecules is thought to serve an important role in the pathogenesis of atherosclerosis. Myricitrin, a bioactive compound of Myrica cerifera, has been demonstrated to exhibit anti‑atherogenic effects. However, the effect of myricitrin on the expression of adhesion molecules in vascular smooth muscle cells (VSMCs) remains unknown. Therefore, the aim of the present study was to evaluate the inhibitory effects of myricitrin on tumor necrosis factor‑α (TNF‑α)‑induced expression of adhesion molecules in VSMCs in vitro. The results revealed that myricitrin inhibited the adhesion of human THP‑1 monocyte cells to TNF‑α‑stimulated mouse MOVAS‑1 VSMC cells, and reduced the expression of adhesion molecules in TNF‑α‑stimulated MOVAS‑1 cells. In addition, myricitrin significantly inhibited the TNF‑α‑induced expression of nuclear factor (NF)‑κB p65, and prevented the TNF‑α‑induced degradation of nuclear factor of κ light chain enhancer in B‑cells inhibitor α. Furthermore, myricitrin inhibited the production of intracellular reactive oxygen species in TNF‑α‑stimulated MOVAS‑1 cells. In conclusion, the results of the present study indicated that myricitrin inhibits the expression of vascular cell adhesion protein‑1 and intercellular adhesion molecule‑1 in TNF‑α‑stimulated MOVAS‑1 cells potentially via the NF‑κB signaling pathway. Therefore, myricitrin may be an effective pharmacological agent for the prevention or treatment of atherosclerosis.
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Copy and paste a formatted citation
Spandidos Publications style
Yan LJ, Yang HT, Duan HY, Wu JT, Qian P, Fan XW and Wang S: Myricitrin inhibits vascular adhesion molecule expression in TNF‑α‑stimulated vascular smooth muscle cells. Mol Med Rep 16: 6354-6359, 2017.
APA
Yan, L., Yang, H., Duan, H., Wu, J., Qian, P., Fan, X., & Wang, S. (2017). Myricitrin inhibits vascular adhesion molecule expression in TNF‑α‑stimulated vascular smooth muscle cells. Molecular Medicine Reports, 16, 6354-6359. https://doi.org/10.3892/mmr.2017.7321
MLA
Yan, L., Yang, H., Duan, H., Wu, J., Qian, P., Fan, X., Wang, S."Myricitrin inhibits vascular adhesion molecule expression in TNF‑α‑stimulated vascular smooth muscle cells". Molecular Medicine Reports 16.5 (2017): 6354-6359.
Chicago
Yan, L., Yang, H., Duan, H., Wu, J., Qian, P., Fan, X., Wang, S."Myricitrin inhibits vascular adhesion molecule expression in TNF‑α‑stimulated vascular smooth muscle cells". Molecular Medicine Reports 16, no. 5 (2017): 6354-6359. https://doi.org/10.3892/mmr.2017.7321
Copy and paste a formatted citation
x
Spandidos Publications style
Yan LJ, Yang HT, Duan HY, Wu JT, Qian P, Fan XW and Wang S: Myricitrin inhibits vascular adhesion molecule expression in TNF‑α‑stimulated vascular smooth muscle cells. Mol Med Rep 16: 6354-6359, 2017.
APA
Yan, L., Yang, H., Duan, H., Wu, J., Qian, P., Fan, X., & Wang, S. (2017). Myricitrin inhibits vascular adhesion molecule expression in TNF‑α‑stimulated vascular smooth muscle cells. Molecular Medicine Reports, 16, 6354-6359. https://doi.org/10.3892/mmr.2017.7321
MLA
Yan, L., Yang, H., Duan, H., Wu, J., Qian, P., Fan, X., Wang, S."Myricitrin inhibits vascular adhesion molecule expression in TNF‑α‑stimulated vascular smooth muscle cells". Molecular Medicine Reports 16.5 (2017): 6354-6359.
Chicago
Yan, L., Yang, H., Duan, H., Wu, J., Qian, P., Fan, X., Wang, S."Myricitrin inhibits vascular adhesion molecule expression in TNF‑α‑stimulated vascular smooth muscle cells". Molecular Medicine Reports 16, no. 5 (2017): 6354-6359. https://doi.org/10.3892/mmr.2017.7321
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