Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
November-2017 Volume 16 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2017 Volume 16 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Retinoic acid ameliorates photoaged skin through RAR‑mediated pathway in mice

  • Authors:
    • Zhangjun Li
    • Xinwu Niu
    • Shengxiang Xiao
    • Huiqun Ma
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China
  • Pages: 6240-6247
    |
    Published online on: August 23, 2017
       https://doi.org/10.3892/mmr.2017.7336
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Retinoic acid (RA), the bioactive metabolite of vitamin A, has demonstrated efficacy in the treatment of photoaged skin; however, the mechanism of action of RA remains unclear. The aim of the present study was to examine whether the therapeutic effects of RA on photoaged skin are mediated by retinoic acid receptor (RAR) and/or retinoid X receptor (RXR) in mice, and to investigate the underlying mechanism. Photoaged skin in Imprinting Control Region mice was induced by repeated exposure to ultraviolet (UV) irradiation. Mice were randomly divided into nine groups: Normal; UV control; all‑trans retinoic acid (ATRA); ATRA + RAR antagonist; ATRA + RXR antagonist; RAR agonist; RAR agonist + RAR antagonist; RXR agonist; and RXR agonist + RXR antagonist. Masson's trichrome staining was used to examine skin collagen fibers. Hydroxyproline assays were used to determine collagen content. The protein expression of matrix metalloproteinase (MMP)‑3, MMP‑13, type I procollagen, c‑Jun and c‑Fos was detected using western blot analysis. The results demonstrated that ATRA and RAR agonist ameliorated the UV‑induced damage to skin collagen fibers, and increased the collagen content in photoaged skin through RAR. Furthermore, ATRA and RAR agonist stimulated type I procollagen protein expression, and inhibited MMP‑3, MMP‑13 and c‑Jun protein expression through RAR in photoaged skin. However, ATRA and RAR agonist exhibited no significant effect on the protein expression of c‑Fos in photoaged skin. These findings suggest that RA ameliorates photoaged skin through a RAR‑mediated signaling pathway in mice.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Quan T, Qin Z, Xia W, Shao Y, Voorhees JJ and Fisher GJ: Matrix-degrading metalloproteinases in photoaging. J Investig Dermatol Symp Proc. 14:20–24. 2009; View Article : Google Scholar : PubMed/NCBI

2 

Svobodová A and Vostálová J: Solar radiation induced skin damage: Review of protective and preventive options. Int J Radiat Biol. 86:999–1030. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Yaar M and Gilchrest BA: Photoageing: Mechanism, prevention and therapy. Br J Dermatol. 157:874–887. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Quan T, He T, Voorhees JJ and Fisher GJ: Ultraviolet irradiation induces Smad7 via induction of transcription factor AP-1 in human skin fibroblasts. J Biol Chem. 280:8079–8085. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Nelson AR, Fingleton B, Rothenberg ML and Matrisian LM: Matrix metalloproteinases: Biologic activity and clinical implications. J Clin Oncol. 18:1135–1149. 2000. View Article : Google Scholar : PubMed/NCBI

6 

Feng XX, Yu XT, Li WJ, Kong SZ, Liu YH, Zhang X, Xian YF, Zhang XJ, Su ZR and Lin ZX: Effects of topical application of patchouli alcohol on the UV-induced skin photoaging in mice. Eur J Pharm Sci. 63:113–123. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Schorpp M, Mattei MG, Herr I, Gack S, Schaper J and Angel P: Structural organization and chromosomal localization of the mouse collagenase type I gene. Biochem J. 308:211–217. 1995. View Article : Google Scholar : PubMed/NCBI

8 

Ascenso A, Ribeiro H, Marques HC, Oliveira H, Santos C and Simões S: Is tretinoin still a key agent for photoaging management? Mini Rev Med Chem. 14:629–641. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Torok HM and Pillai R: Safety and efficacy of micronized tretinoin gel (0.05%) in treating adolescent acne. J Drugs Dermatol. 10:647–652. 2011.PubMed/NCBI

10 

Weinstein GD, Koo JY, Krueger GG, Lebwohl MG, Lowe NJ, Menter MA, Lew-Kaya DA, Sefton J, Gibson JR and Walker PS; Tazarotene Cream Clinical Study Group, : Tazarotene cream in the treatment of psoriasis: Two multicenter, double-blind, randomized, vehicle-controlled studies of the safety and efficacy of tazarotene creams 0.05% and 0.1% applied once daily for 12 weeks. J Am Acad Dermatol. 48:760–767. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Lippman SM, Parkinson DR, Itri LM, Weber RS, Schantz SP, Ota DM, Schusterman MA, Krakoff IH, Gutterman JU and Hong WK: 13-cis-retinoic acid and interferon alpha-2a: Effective combination therapy for advanced squamous cell carcinoma of the skin. J Natl Cancer Inst. 84:235–241. 1992. View Article : Google Scholar : PubMed/NCBI

12 

Ho ET, Trookman NS, Sperber BR, Rizer RL, Spindler R, Sonti S, Gotz V and Mehta R: A randomized, double-blind, controlled comparative trial of the anti-aging properties of non-prescription tri-retinol 1.1% vs. prescription tretinoin 0.025%. J Drugs Dermatol. 11:64–69. 2012.PubMed/NCBI

13 

Bouloc A, Vergnanini AL and Issa MC: A double-blind randomized study comparing the association of Retinol and LR2412 with tretinoin 0.025% in photoaged skin. J Cosmet Dermatol. 14:40–46. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Bagatin E, Guadanhim LR, Enokihara MM, Sanudo A, Talarico S, Miot HA and Gibson L: Low-dose oral isotretinoin versus topical retinoic acid for photoaging: A randomized, comparative study. Int J Dermatol. 53:114–122. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Konta T, Xu Q, Furusu A, Nakayama K and Kitamura M: Selective roles of retinoic acid receptor and retinoid X receptor in the suppression of apoptosis by all-trans-retinoic acid. J Biol Chem. 276:12697–12701. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Mihály J, Gericke J, Lucas R, de Lera AR, Alvarez S, Törőcsik D and Rühl R: TSLP expression in the skin is mediated via RARγ-RXR pathways. Immunobiology. 221:161–165. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Gericke J, Ittensohn J, Mihály J, Alvarez S, Alvarez R, Töröcsik D, de Lera AR and Rühl R: Regulation of retinoid-mediated signaling involved in skin homeostasis by RAR and RXR agonists/antagonists in mouse skin. PLoS One. 8:e626432013. View Article : Google Scholar : PubMed/NCBI

18 

Mukherjee S, Date A, Patravale V, Korting HC, Roeder A and Weindl G: Retinoids in the treatment of skin aging: An overview of clinical efficacy and safety. Clin Interv Aging. 1:327–348. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Kang S, Bergfeld W, Gottlieb AB, Hickman J, Humeniuk J, Kempers S, Lebwohl M, Lowe N, McMichael A, Milbauer J, et al: Long-term efficacy and safety of tretinoin emollient cream 0.05% in the treatment of photodamaged facial skin: A two-year, randomized, placebo-controlled trial. Am J Clin Dermatol. 6:245–253. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Wang XF, Huang YF, Wang L, Xu LQ, Yu XT, Liu YH, Li CL, Zhan JY, Su ZR, Chen JN and Zeng HF: Photo-protective activity of pogostone against UV-induced skin premature aging in mice. Exp Gerontol. 77:76–86. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Neuman RE and Logan MA: The determination of collagen and elastin in tissues. J Biol Chem. 186:549–556. 1950.PubMed/NCBI

22 

Huang X, Zhu B, Wang X, Xiao R and Wang C: Three-dimensional co-culture of mesenchymal stromal cells and differentiated osteoblasts on human bio-derived bone scaffolds supports active multi-lineage hematopoiesis in vitro: Functional implication of the biomimetic HSC niche. Int J Mol Med. 38:1141–1151. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Kong SZ, Chen HM, Yu XT, Zhang X, Feng XX, Kang XH, Li WJ, Huang N, Luo H and Su ZR: The protective effect of 18β-Glycyrrhetinic acid against UV irradiation induced photoaging in mice. Exp Gerontol. 61:147–155. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Hwang E, Park SY, Lee HJ, Lee TY, Sun ZW and Yi TH: Gallic acid regulates skin photoaging in UVB-exposed fibroblast and hairless mice. Phytother Res. 28:1778–1788. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Hwang KA, Yi BR and Choi KC: Molecular mechanisms and in vivo mouse models of skin aging associated with dermal matrix alterations. Lab Anim Res. 27:1–8. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Fisher GJ, Talwar HS, Lin J, Lin P, McPhillips F, Wang Z, Li X, Wan Y, Kang S and Voorhees JJ: Retinoic acid inhibits induction of c-Jun protein by ultraviolet radiation that occurs subsequent to activation of mitogen-activated protein kinase pathways in human skin in vivo. J Clin Invest. 101:1432–1440. 1998. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li Z, Niu X, Xiao S and Ma H: Retinoic acid ameliorates photoaged skin through RAR‑mediated pathway in mice. Mol Med Rep 16: 6240-6247, 2017.
APA
Li, Z., Niu, X., Xiao, S., & Ma, H. (2017). Retinoic acid ameliorates photoaged skin through RAR‑mediated pathway in mice. Molecular Medicine Reports, 16, 6240-6247. https://doi.org/10.3892/mmr.2017.7336
MLA
Li, Z., Niu, X., Xiao, S., Ma, H."Retinoic acid ameliorates photoaged skin through RAR‑mediated pathway in mice". Molecular Medicine Reports 16.5 (2017): 6240-6247.
Chicago
Li, Z., Niu, X., Xiao, S., Ma, H."Retinoic acid ameliorates photoaged skin through RAR‑mediated pathway in mice". Molecular Medicine Reports 16, no. 5 (2017): 6240-6247. https://doi.org/10.3892/mmr.2017.7336
Copy and paste a formatted citation
x
Spandidos Publications style
Li Z, Niu X, Xiao S and Ma H: Retinoic acid ameliorates photoaged skin through RAR‑mediated pathway in mice. Mol Med Rep 16: 6240-6247, 2017.
APA
Li, Z., Niu, X., Xiao, S., & Ma, H. (2017). Retinoic acid ameliorates photoaged skin through RAR‑mediated pathway in mice. Molecular Medicine Reports, 16, 6240-6247. https://doi.org/10.3892/mmr.2017.7336
MLA
Li, Z., Niu, X., Xiao, S., Ma, H."Retinoic acid ameliorates photoaged skin through RAR‑mediated pathway in mice". Molecular Medicine Reports 16.5 (2017): 6240-6247.
Chicago
Li, Z., Niu, X., Xiao, S., Ma, H."Retinoic acid ameliorates photoaged skin through RAR‑mediated pathway in mice". Molecular Medicine Reports 16, no. 5 (2017): 6240-6247. https://doi.org/10.3892/mmr.2017.7336
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team