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Investigating the mechanisms of papillary thyroid carcinoma using transcriptome analysis

  • Authors:
    • Jie Qiu
    • Wenwei Zhang
    • Qingsheng Xia
    • Fuxue Liu
    • Shuwei Zhao
    • Kailing Zhang
    • Min Chen
    • Chuanshan Zang
    • Ruifeng Ge
    • Dapeng Liang
    • Yan Sun
  • View Affiliations / Copyright

    Affiliations: Otolaryngology Head and Neck Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China, Radiology Department, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China, Otolaryngology Head and Neck Surgery, Qingdao Municipal Hospital, Qingdao, Shandong 266071, P.R. China, Otolaryngology Head and Neck Surgery, Shaoxing Municipal Hospital, Shaoxing, Zhejiang 312000, P.R. China, Otolaryngology Head and Neck Surgery, Shanghai Chang Zheng Hospital, Shanghai 200003, P.R. China
    Copyright: © Qiu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5954-5964
    |
    Published online on: August 24, 2017
       https://doi.org/10.3892/mmr.2017.7346
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Abstract

As the predominant thyroid cancer, papillary thyroid cancer (PTC) accounts for 75‑85% of thyroid cancer cases. This research aimed to investigate transcriptomic changes and key genes in PTC. Using RNA‑sequencing technology, the transcriptional profiles of 5 thyroid tumor tissues and 5 adjacent normal tissues were obtained. The single nucleotide polymorphisms (SNPs) were identified by SAMtools software and then annotated by ANNOVAR software. After differentially expressed genes (DEGs) were selected by edgR software, they were further investigated by enrichment analysis, protein domain analysis, and protein‑protein interaction (PPI) network analysis. Additionally, the potential gene fusion events were predicted using FusionMap software. A total of 70,172 SNPs and 2,686 DEGs in the tumor tissues, as well as 83,869 SNPs in the normal tissues were identified. In the PPI network, fibronectin 1 (FN1; degree=31) and transforming growth factor β receptor 1 (TGFβR1; degree=22) had higher degrees. A total of 7 PPI pairs containing the non‑synonymous risk SNP loci in the interaction domains were identified. Particularly, the interaction domains involved in the interactions of FN1 and 5 other proteins (such as FN1‑tenascin C, TNC) had non‑synonymous risk SNP loci. Furthermore, 11 and 4 gene fusion events were identified in all of the tumor tissues and normal tissues, respectively. Additionally, the NK2 homeobox 1‑surfactant associated 3 (NKX2‑1‑SFTA3) gene fusion was identified in both tumor and normal tissues. These results indicated that TGFβR1 and the NKX2‑1‑SFTA3 gene fusion may be involved in PTC. Furthermore, FN1 and TNC containing the non‑synonymous risk SNP loci might serve a role in PTC by interacting with each other.
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View References

1 

Carling T and Udelsman R: Thyroid cancer. Annu Rev Med. 65:125–137. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Vecchia CL, Malvezzi M, Bosetti C, Garavello W, Bertuccio P, Levi F and Negri E: Thyroid cancer mortality and incidence: A global overview. Int J Cancer. 136:2187–2195. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Dinets A, Hulchiy M, Sofiadis A, Ghaderi M, Höög A, Larsson C and Zedenius J: Clinical, genetic, and immunohistochemical characterization of 70 Ukrainian adult cases with post-Chornobyl papillary thyroid carcinoma. Eur J Endocrinol. 166:1049–1060. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Mitchell RS, Kumar V, Abbas AK and Fausto N: Robbins Basic Pathology. 8 edition. Philadelphia: Saunders; 8. pp. 345–355. 2007

5 

Xing M, Alzahrani AS, Carson KA, Shong YK, Kim TY, Viola D, Elisei R, Bendlová B, Yip L, Mian C, et al: Association between BRAF V600E mutation and recurrence of papillary thyroid cancer. J Clin Oncol. 33:42–50. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Xing M, Liu R, Liu X, Murugan AK, Zhu G, Zeiger MA, Pai S and Bishop J: BRAF V600E and TERT promoter mutations cooperatively identify the most aggressive papillary thyroid cancer with highest recurrence. J Clin Oncol. 32:2718–2726. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Lesueur F, Corbex M, McKay JD, Lima J, Soares P, Griseri P, Burgess J, Ceccherini I, Landolfi S, Papotti M, et al: Specific haplotypes of the RET proto-oncogene are over-represented in patients with sporadic papillary thyroid carcinoma. J Med Genet. 39:260–265. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Stephens LA, Powell NG, Grubb J, Jeremiah SJ, Bethel JA, Demidchik EP, Bogdanova TI, Tronko MD and Thomas GA: Investigation of loss of heterozygosity and SNP frequencies in the RET gene in papillary thyroid carcinoma. Thyroid. 15:100–104. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Salvatore G, Giannini R, Faviana P, Caleo A, Migliaccio I, Fagin JA, Nikiforov YE, Troncone G, Palombini L, Basolo F and Santoro M: Analysis of BRAF point mutation and RET/PTC rearrangement refines the fine-needle aspiration diagnosis of papillary thyroid carcinoma. J Clin Endocrinol Metab. 89:5175–5180. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Salajegheh A, Smith RA, Kasem K, Gopalan V, Nassiri MR, William R and Lam AK: Single nucleotide polymorphisms and mRNA expression of VEGF-A in papillary thyroid carcinoma: Potential markers for aggressive phenotypes. Eur J Surg Oncol. 37:93–99. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Ciampi R, Knauf JA, Kerler R, Gandhi M, Zhu Z, Nikiforova MN, Rabes HM, Fagin JA and Nikiforov YE: Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer. J Clin Invest. 115:94–101. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Wang X and Clark AG: Using next-generation RNA sequencing to identify imprinted genes. Heredity (Edinb). 113:156–166. 2014. View Article : Google Scholar : PubMed/NCBI

13 

de Klerk E, den Dunnen JT and 't Hoen PA: RNA sequencing: From tag-based profiling to resolving complete transcript structure. Cell Mol Life Sci. 71:3537–3551. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Costa V, Esposito R, Ziviello C, Sepe R, Bim LV, Cacciola NA, Decaussin-Petrucci M, Pallante P, Fusco A and Ciccodicola A: New somatic mutations and WNK1-B4GALNT3 gene fusion in papillary thyroid carcinoma. Oncotarget. 6:11242–11251. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Smallridge RC, Chindris AM, Asmann YW, Casler JD, Serie DJ, Reddi HV, Cradic KW, Rivera M, Grebe SK, Necela BM, et al: RNA sequencing identifies multiple fusion transcripts, differentially expressed genes, and reduced expression of immune function genes in BRAF (V600E) mutant vs BRAF wild-type papillary thyroid carcinoma. J Clin Endocrinol Metab. 99:E338–E347. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Abuín JM, Pichel JC, Pena TF and Amigo J: BigBWA: Approaching the Burrows-Wheeler aligner to Big Data technologies. Bioinformatics. 31:4003–4005. 2015.PubMed/NCBI

17 

Li H, Handsaker B, Wysoker A, Fennell T, Ruan J, Homer N, Marth G, Abecasis G and Durbin R: 1000 Genome Project Data Processing Subgroup: The Sequence alignment/map (SAM) format and SAMtools. Bioinformatics. 25:2078–2079. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Yang H and Wang K: Genomic variant annotation and prioritization with ANNOVAR and wANNOVAR. Nat Protoc. 10:1556–1566. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Robinson MD, McCarthy DJ and Smyth GK: edgeR: A Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 26:139–140. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Park BJ, Lord D and Hart J: Bias properties of Bayesian statistics in finite mixture of negative binomial regression models in crash data analysis. Accid Anal Prev. 42:741–749. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Haynes W: Benjamini-Hochberg MethodEncyclopedia of Systems Biology. Springer; pp. 78. 2013, View Article : Google Scholar

22 

Ge H, Liu K, Juan T, Fang F, Newman M and Hoeck W: FusionMap: Detecting fusion genes from next-generation sequencing data at base-pair resolution. Bioinformatics. 27:1922–1928. 2011. View Article : Google Scholar : PubMed/NCBI

23 

An J, Lai J, Sajjanhar A, Batra J, Wang C and Nelson CC: J-Circos: An interactive Circos plotter. Bioinformatics. 31:1463–1465. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Tweedie S, Ashburner M, Falls K, Leyland P, McQuilton P, Marygold S, Millburn G, Osumi-Sutherland D, Schroeder A, Seal R, et al: FlyBase: Enhancing Drosophila gene ontology annotations. Nucleic Acids Res. 37(Database issue): D555–D559. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Kotera M, Moriya Y, Tokimatsu T, Kanehisa M and Goto S: KEGG and GenomeNet, New Developments, Metagenomic AnalysisEncyclopedia of Metagenomics. Nelson KE: Springer; New York, NY: pp. 329–339. 2015

26 

Dennis G Jr, Sherman BT, Hosack DA, Yang J, Gao W, Lane HC and Lempicki RA: DAVID: Database for annotation, visualization, and integrated discovery. Genome Biol. 4:P32003. View Article : Google Scholar : PubMed/NCBI

27 

Goel R, Harsha HC, Pandey A and Prasad TSK: Human Protein Reference Database and Human Proteinpedia as resources for phosphoproteome analysis. Mol Biosyst. 8:453–463. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Kohl M, Wiese S and Warscheid B: Cytoscape: Software for visualization and analysis of biological networks. Methods Mol Biol. 696:291–303. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Finn RD, Coggill P, Eberhardt RY, Eddy SR, Mistry J, Mitchell AL, Potter SC, Punta M, Qureshi M, Sangrador-Vegas A, et al: The Pfam protein families database: Towards a more sustainable future. Nucleic Acids Res. 44:D279–D285. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Yellaboina S, Tasneem A, Zaykin DV, Raghavachari B and Jothi R: DOMINE: A comprehensive collection of known and predicted domain-domain interactions. Nucleic Acids Res. 39(Database issue): D730–D735. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Ma S, Wang Q, Ma X, Wu L, Guo F, Ji H, Liu F, Zhao Y and Qin G: FoxP3 in papillary thyroid carcinoma induces NIS repression through activation of the TGF-β1/Smad signaling pathway. Tumor Biol. 120:34–35. 2016.

32 

Zhang J, Wang Y, Li D and Jing S: Notch and TGF-β/Smad3 pathways are involved in the interaction between cancer cells and cancer-associated fibroblasts in papillary thyroid carcinoma. Tumor Biol. 35:379–385. 2014. View Article : Google Scholar

33 

Choe BK, Kim SK, Park HJ, Park HK, Kwon KH, Lim SH and Yim SV: Polymorphisms of TGFBR2 contribute to the progression of papillary thyroid carcinoma. Mol Cellular Toxicol. 8:1–8. 2012. View Article : Google Scholar

34 

Prasad ML, Pellegata NS, Huang Y, Nagaraja HN, de la Chapelle A and Kloos RT: Galectin-3, fibronectin-1, CITED-1, HBME1 and cytokeratin-19 immunohistochemistry is useful for the differential diagnosis of thyroid tumors. Mod Pathol. 18:48–57. 2005. View Article : Google Scholar : PubMed/NCBI

35 

da Silveira Mitteldorf CA, de Sousa-Canavez JM, Leite KR, Massumoto C and Camara-Lopes LH: FN1, GALE, MET and QPCT overexpression in papillary thyroid carcinoma: Molecular analysis using frozen tissue and routine fine-needle aspiration biopsy samples. Diagn Cytopathol. 39:556–561. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Tseleni-Balafouta S, Gakiopoulou H, Fanourakis G, Voutsinas G, Balafoutas D and Patsouris E: Tenascin-C protein expression and mRNA splice variants in thyroid carcinoma. Exp Mol Pathol. 80:177–182. 2006. View Article : Google Scholar : PubMed/NCBI

37 

Matsuse M, Takahashi M, Mitsutake N, Nishihara E, Hirokawa M, Kawaguchi T, Rogounovitch T, Saenko V, Bychkov A, Suzuki K, et al: The FOXE1 and NKX2-1 loci are associated with susceptibility to papillary thyroid carcinoma in the Japanese population. J Med Genet. 48:645–648. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Ngan ES, Lang BH, Liu T, Shum CK, So MT, Lau DK, Leon TY, Cherny SS, Tsai SY, Lo CY, et al: A germline mutation (A339V) in thyroid transcription factor-1 (TITF-1/NKX2. 1) in patients with multinodular goiter and papillary thyroid carcinoma. J Natl Cancer Inst. 101:162–175. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Gilbert-Sirieix M, Makoukji J, Kimura S, Talbot M, Caillou B, Massaad C and Massaad-Massade L: Wnt/β-catenin signaling pathway is a direct enhancer of thyroid transcription factor-1 in human papillary thyroid carcinoma cells. PLoS One. 6:e222802011. View Article : Google Scholar : PubMed/NCBI

40 

Ambroziak M, Pachucki J, Stachlewska-Nasfeter E, Nauman J and Nauman A: Disturbed expression of type 1 and type 2 iodothyronine deiodinase as well as titf1/nkx2-1 and pax-8 transcription factor genes in papillary thyroid cancer. Thyroid. 15:1137–1146. 2005. View Article : Google Scholar : PubMed/NCBI

41 

Kondo T, Nakazawa T, Ma D, Niu D, Mochizuki K, Kawasaki T, Nakamura N, Yamane T, Kobayashi M and Katoh R: Epigenetic silencing of TTF-1/NKX2-1 through DNA hypermethylation and histone H3 modulation in thyroid carcinomas. Lab Invest. 89:791–799. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Qiu J, Zhang W, Xia Q, Liu F, Zhao S, Zhang K, Chen M, Zang C, Ge R, Liang D, Liang D, et al: Investigating the mechanisms of papillary thyroid carcinoma using transcriptome analysis. Mol Med Rep 16: 5954-5964, 2017.
APA
Qiu, J., Zhang, W., Xia, Q., Liu, F., Zhao, S., Zhang, K. ... Sun, Y. (2017). Investigating the mechanisms of papillary thyroid carcinoma using transcriptome analysis. Molecular Medicine Reports, 16, 5954-5964. https://doi.org/10.3892/mmr.2017.7346
MLA
Qiu, J., Zhang, W., Xia, Q., Liu, F., Zhao, S., Zhang, K., Chen, M., Zang, C., Ge, R., Liang, D., Sun, Y."Investigating the mechanisms of papillary thyroid carcinoma using transcriptome analysis". Molecular Medicine Reports 16.5 (2017): 5954-5964.
Chicago
Qiu, J., Zhang, W., Xia, Q., Liu, F., Zhao, S., Zhang, K., Chen, M., Zang, C., Ge, R., Liang, D., Sun, Y."Investigating the mechanisms of papillary thyroid carcinoma using transcriptome analysis". Molecular Medicine Reports 16, no. 5 (2017): 5954-5964. https://doi.org/10.3892/mmr.2017.7346
Copy and paste a formatted citation
x
Spandidos Publications style
Qiu J, Zhang W, Xia Q, Liu F, Zhao S, Zhang K, Chen M, Zang C, Ge R, Liang D, Liang D, et al: Investigating the mechanisms of papillary thyroid carcinoma using transcriptome analysis. Mol Med Rep 16: 5954-5964, 2017.
APA
Qiu, J., Zhang, W., Xia, Q., Liu, F., Zhao, S., Zhang, K. ... Sun, Y. (2017). Investigating the mechanisms of papillary thyroid carcinoma using transcriptome analysis. Molecular Medicine Reports, 16, 5954-5964. https://doi.org/10.3892/mmr.2017.7346
MLA
Qiu, J., Zhang, W., Xia, Q., Liu, F., Zhao, S., Zhang, K., Chen, M., Zang, C., Ge, R., Liang, D., Sun, Y."Investigating the mechanisms of papillary thyroid carcinoma using transcriptome analysis". Molecular Medicine Reports 16.5 (2017): 5954-5964.
Chicago
Qiu, J., Zhang, W., Xia, Q., Liu, F., Zhao, S., Zhang, K., Chen, M., Zang, C., Ge, R., Liang, D., Sun, Y."Investigating the mechanisms of papillary thyroid carcinoma using transcriptome analysis". Molecular Medicine Reports 16, no. 5 (2017): 5954-5964. https://doi.org/10.3892/mmr.2017.7346
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