Protective effects of DL‑3‑n‑butylphthalide in the lipopolysaccharide‑induced mouse model of Parkinson's disease

  • Authors:
    • Mu‑Jun Jiang
    • Yu‑Hua Chen
    • Li Li
    • Li Xu
    • Hao Liu
    • Xiao‑Long Qu
    • Juan‑Juan Xu
    • Bo‑Bo Ge
    • Hong‑Dang Qu
  • View Affiliations

  • Published online on: August 24, 2017     https://doi.org/10.3892/mmr.2017.7352
  • Pages: 6184-6189
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Abstract

DL‑3‑n‑butylphthalide (NBP) is extracted from rapeseed and exhibits multiple neuroprotective effects, exerted by inhibiting the inflammatory process, including reducing oxidative stress, improving mitochondrial function and reducing neuronal apoptosis. The present study aimed to investigate the neuroprotective effects of NBP in a lipopolysaccharide (LPS)‑induced mouse model of Parkinson's disease (PD). The behavior of mice was assessed using the rotarod test and open‑field test, the amount of tyrosine hydroxylase in the substantia nigra pars compacta was evaluated by immunohistochemistry, and the levels of phosphorylated c‑Jun N‑terminal kinase (JNK), mitogen‑activated protein kinase 14 (p38) and extracellular signal‑regulated kinase 1 were determined by western blotting. It was demonstrated that the LPS‑induced behavioral deficits were significantly improved. LPS‑induced dopaminergic neurodegeneration was relieved following treatment with NBP, as determined from tyrosine hydroxylase‑positive cells. Phosphorylation of JNK and p38 was significantly inhibited following treatment with NBP. Therefore in the present study, a role for NBP has been established in the treatment of a PD murine model, laying the experimental basis for the treatment of PD with this agent.
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November-2017
Volume 16 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Jiang MJ, Chen YH, Li L, Xu L, Liu H, Qu XL, Xu JJ, Ge BB and Qu HD: Protective effects of DL‑3‑n‑butylphthalide in the lipopolysaccharide‑induced mouse model of Parkinson's disease. Mol Med Rep 16: 6184-6189, 2017.
APA
Jiang, M., Chen, Y., Li, L., Xu, L., Liu, H., Qu, X. ... Qu, H. (2017). Protective effects of DL‑3‑n‑butylphthalide in the lipopolysaccharide‑induced mouse model of Parkinson's disease. Molecular Medicine Reports, 16, 6184-6189. https://doi.org/10.3892/mmr.2017.7352
MLA
Jiang, M., Chen, Y., Li, L., Xu, L., Liu, H., Qu, X., Xu, J., Ge, B., Qu, H."Protective effects of DL‑3‑n‑butylphthalide in the lipopolysaccharide‑induced mouse model of Parkinson's disease". Molecular Medicine Reports 16.5 (2017): 6184-6189.
Chicago
Jiang, M., Chen, Y., Li, L., Xu, L., Liu, H., Qu, X., Xu, J., Ge, B., Qu, H."Protective effects of DL‑3‑n‑butylphthalide in the lipopolysaccharide‑induced mouse model of Parkinson's disease". Molecular Medicine Reports 16, no. 5 (2017): 6184-6189. https://doi.org/10.3892/mmr.2017.7352