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Effect of silencing the T‑Box transcription factor TBX2 in prostate cancer PC3 and LNCaP cells

  • Authors:
    • Wen‑Liang Du
    • Qian Fang
    • Yue Chen
    • Jing‑Wei Teng
    • Yong‑Shuang Xiao
    • Ping Xie
    • Bo Jin
    • Jun‑Qi Wang
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R. China
    Copyright: © Du et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6050-6058
    |
    Published online on: August 24, 2017
       https://doi.org/10.3892/mmr.2017.7361
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Abstract

T‑Box (TBX)‑2 is a member of the T‑box gene family, which is aberrantly expressed in numerous types of malignant tumors, and has previously been demonstrated to be conducive to tumor progression by acting as a transcription factor. However, specific information regarding the expression and function of TBX2 in prostate cancer cells remains to be elucidated. The present study demonstrated that silencing of TBX2 by TBX2 small interfering RNA inhibited cell proliferation and promoted cell senescence. It was demonstrated that knockdown of TBX2 inhibited cell metastatic abilities by upregulating E‑cadherin and downregulating N‑cadherin, Vimentin and fibronectin. In addition, the expression of TBX2 in prostate cancer tissues and tumor adjacent tissues was detected by immunohistochemistry. The results indicated that the expression rates of TBX2 were significantly increased in the cancerous tissues, compared with the healthy tumor adjacent tissue, and TBX2 increased staining was associated with the clinical stage and pathological grade. The findings of the present study therefore suggest that TBX2 expression is markedly increased in prostate cancer and TBX2 may act as a potential beneficial therapeutic target for the future treatment of prostate cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Du WL, Fang Q, Chen Y, Teng JW, Xiao YS, Xie P, Jin B and Wang JQ: Effect of silencing the T‑Box transcription factor TBX2 in prostate cancer PC3 and LNCaP cells. Mol Med Rep 16: 6050-6058, 2017.
APA
Du, W., Fang, Q., Chen, Y., Teng, J., Xiao, Y., Xie, P. ... Wang, J. (2017). Effect of silencing the T‑Box transcription factor TBX2 in prostate cancer PC3 and LNCaP cells. Molecular Medicine Reports, 16, 6050-6058. https://doi.org/10.3892/mmr.2017.7361
MLA
Du, W., Fang, Q., Chen, Y., Teng, J., Xiao, Y., Xie, P., Jin, B., Wang, J."Effect of silencing the T‑Box transcription factor TBX2 in prostate cancer PC3 and LNCaP cells". Molecular Medicine Reports 16.5 (2017): 6050-6058.
Chicago
Du, W., Fang, Q., Chen, Y., Teng, J., Xiao, Y., Xie, P., Jin, B., Wang, J."Effect of silencing the T‑Box transcription factor TBX2 in prostate cancer PC3 and LNCaP cells". Molecular Medicine Reports 16, no. 5 (2017): 6050-6058. https://doi.org/10.3892/mmr.2017.7361
Copy and paste a formatted citation
x
Spandidos Publications style
Du WL, Fang Q, Chen Y, Teng JW, Xiao YS, Xie P, Jin B and Wang JQ: Effect of silencing the T‑Box transcription factor TBX2 in prostate cancer PC3 and LNCaP cells. Mol Med Rep 16: 6050-6058, 2017.
APA
Du, W., Fang, Q., Chen, Y., Teng, J., Xiao, Y., Xie, P. ... Wang, J. (2017). Effect of silencing the T‑Box transcription factor TBX2 in prostate cancer PC3 and LNCaP cells. Molecular Medicine Reports, 16, 6050-6058. https://doi.org/10.3892/mmr.2017.7361
MLA
Du, W., Fang, Q., Chen, Y., Teng, J., Xiao, Y., Xie, P., Jin, B., Wang, J."Effect of silencing the T‑Box transcription factor TBX2 in prostate cancer PC3 and LNCaP cells". Molecular Medicine Reports 16.5 (2017): 6050-6058.
Chicago
Du, W., Fang, Q., Chen, Y., Teng, J., Xiao, Y., Xie, P., Jin, B., Wang, J."Effect of silencing the T‑Box transcription factor TBX2 in prostate cancer PC3 and LNCaP cells". Molecular Medicine Reports 16, no. 5 (2017): 6050-6058. https://doi.org/10.3892/mmr.2017.7361
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