Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
November-2017 Volume 16 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2017 Volume 16 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Endocrine therapy inhibits proliferation and migration, promotes apoptosis and suppresses survivin protein expression in colorectal cancer cells

  • Authors:
    • Qing‑Jian Ou
    • Xiao‑Jun Wu
    • Jian‑Hong Peng
    • Rong‑Xin Zhang
    • Zhen‑Hai Lu
    • Wu Jiang
    • Lin Zhang
    • Zhi‑Zhong Pan
    • De‑Sen Wan
    • Yu‑Jing Fang
  • View Affiliations / Copyright

    Affiliations: Department of Colorectal Surgery, Sun Yat‑sen University Cancer Centre, State Key Laboratory of Oncology in South China, Collaborative Innovation Centre for Cancer Medicine, Guangzhou, Guangdong 510060, P.R. China, Department of Clinical Laboratory, Sun Yat‑sen University Cancer Centre, State Key Laboratory of Oncology in South China, Collaborative Innovation Centre for Cancer Medicine, Guangzhou, Guangdong 510060, P.R. China
    Copyright: © Ou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5769-5778
    |
    Published online on: August 28, 2017
       https://doi.org/10.3892/mmr.2017.7375
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The majority of colorectal cancers (CRCs) are hormone‑dependent. Thus, endocrine therapy has become an attractive strategy to treat CRC. The aim of the present study was to investigate the inhibitory effect of combined tamoxifen (TAM) plus β‑estradiol (E2) treatment on human DLD‑1 CRC cells. The human DLD‑1 CRC cell line was treated with different concentrations of TAM, β‑estradiol, or a combination of these two agents. Cell viability was assessed using an MTT assay, while apoptosis was detected using flow cytometry analysis. Alterations in the RNA and protein levels of the apoptosis‑associated factors cyclin D1 and survivin were measured in the treated DLD‑1 cells using semi‑quantitative polymerase chain reaction (sqPCR) and western blot analyses. Alterations in cellular migration ability were monitored using a Transwell migration assay. Treatment with TAM, β‑estradiol and TAM plus β‑estradiol inhibited DLD‑1 cell viability. The flow cytometry results revealed that these drugs promoted cell apoptosis, and the Transwell migration assay results indicated that the reduction in cell migration was greater in the TAM+E2 treatment group when compared with each treatment alone. sqPCR and western blot analysis results demonstrated that TAM, E2 and a combination of the two affected survivin expression based on the drug concentration and the treatment duration; however, they demonstrated no significant effect on cyclin D1 expression. In conclusion, treatment of DLD‑1 cells with TAM, β‑estradiol, or a combination of these two drugs, inhibited cell viability and migration, promoted cell apoptosis, and reduced the mRNA and protein expression levels of survivin in a dose‑ and time‑dependent manner. These results provide novel experimental basis for hormonal adjuvant therapy for the treatment of CRC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Pan F, Bao YH, Huang RY, Li J and Zhang Z: Epidemiological study on the incidence of large intestine cancer in Wenzhou city from 2001 to 2005. Zhonghua Zhongliu Fangzhi Zazhi. 14:1286–1287. 2007.(In Chinese).

2 

Chen WQ, Zheng RS, Zhang SW, Li N, Zhao P, Li GL, Wu LY and He J: Report of incidence and mortality in China cancer registries, 2008. Chin J Cancer Res. 24:171–180. 2012. View Article : Google Scholar : PubMed/NCBI

3 

László L: Predictive and prognostric factors in the complex treatment of patients with colorectal cancer. Magy Onkol. 54:383–394. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Meyerhardt JA and Mayer RJ: Systemic therapy for colorectal cancer. N Engl J Med. 352:476–487. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Zhang J, Xu J, Zhang RX, Zhang Y, Ou QJ, Li JQ, Jiang ZZ, Wu XJ, Fang YJ and Zheng L: CD169 identifies an activated CD8(+) T cell subset in regional lymph nodes that predicts favorable prognosis in colorectal cancer patients. Oncoimmunology. 5:e11776902016. View Article : Google Scholar : PubMed/NCBI

6 

Jensen EV, Block GE, Smith S, Kyser K and DeSombre ER: Estrogen receptors and breast cancer response to adrenalectomy. Natl Cancer Inst Monogr. 34:55–70. 1971.PubMed/NCBI

7 

Jordan VC, Gapstur S and Morrow M: Selective estrogen receptor modulation and reduction in risk of breast cancer, osteoporosis, and coronary heart disease. J Natl Cancer Inst. 93:1449–1457. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Couse JF, Lindzey J, Grandien K, Gustafsson JA and Korach KS: Tissue distribution and quantitative analysis of estrogen receptor-alpha (ERalpha) and estrogen receptor-beta (ERbeta) messenger ribonucleic acid in the wild-type and ERalpha-knockout mouse. Endocrinology. 138:4613–4621. 1997. View Article : Google Scholar : PubMed/NCBI

9 

Paech K, Webb P, Kuiper GG, Nilsson S, Gustafsson J, Kushner PJ and Scanlan TS: Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites. Science. 277:1508–1510. 1997. View Article : Google Scholar : PubMed/NCBI

10 

Enmark E, Pelto-Huikko M, Grandien K, Lagercrantz S, Lagercrantz J, Fried G, Nordenskjöld M and Gustafsson JA: Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern. J Clin Endocrinol Metab. 82:4258–4265. 1997. View Article : Google Scholar : PubMed/NCBI

11 

Campbell-Thompson M, Lynch IJ and Bhardwaj B: Expression of estrogen receptor (ER) subtypes and ERbeta isoforms in colon cancer. Cancer Res. 61:632–640. 2001.PubMed/NCBI

12 

Takeyama J, Suzuki T, Inoue S, Kaneko C, Nagura H, Harada N and Sasano H: Expression and cellular localization of estrogen receptors alpha and beta in the human fetus. J Clin Endocrinol Metab. 86:2258–2262. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Singh S and Langman MJ: Oestrogen and colonic epithelial cell growth. Gut. 37:737–739. 1995. View Article : Google Scholar : PubMed/NCBI

14 

Grodstein F, Newcomb PA and Stampfer MJ: Postmenopausal hormone therapy and the risk of colorectal cancer: A review and meta-analysis. Am J Med. 106:574–582. 1999. View Article : Google Scholar : PubMed/NCBI

15 

Fiorelli G, Picariello L, Martineti V, Tonelli F and Brandi ML: Functional estrogen receptor beta in colon cancer cells. Biochem Biophys Res Commun. 261:521–527. 1999. View Article : Google Scholar : PubMed/NCBI

16 

Arai N, Ström A, Rafter JJ and Gustafsson JA: Estrogen receptor beta mRNA in colon cancer cells: Growth effects of estrogen and genistein. Biochem Biophys Res Commun. 270:425–431. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Smith CL, Nawaz Z and O'Malley BW: Coactivator and corepressor regulation of the agonist/antagonist activity of the mixed antiestrogen, 4-hydroxytamoxifen. Mol Endocrinol. 11:657–666. 1997. View Article : Google Scholar : PubMed/NCBI

18 

Shao R, Feng Y, Zou S, Weijdegård B, Wu G, Brännström M and Billig H: The role of estrogen in the pathophysiology of tubal ectopic pregnancy. Am J Transl Res. 4:269–278. 2012.PubMed/NCBI

19 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2016. CA Cancer J Clin. 66:7–30. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Chute CG, Willett WC, Colditz GA, Stampfer MJ, Rosner B and Speizer FE: A prospective study of reproductive history and exogenous estrogens on the risk of colorectal cancer in women. Epidemiology. 2:201–207. 1991. View Article : Google Scholar : PubMed/NCBI

22 

Calle EE, Miracle-McMahill HL, Thun MJ and Heath CW Jr: Estrogen replacement therapy and risk of fatal colon cancer in a prospective cohort of postmenopausal women. J Natl Cancer Inst. 87:517–523. 1995. View Article : Google Scholar : PubMed/NCBI

23 

English MA, Kane KF, Cruickshank N, Langman MJ, Stewart PM and Hewison M: Loss of estrogen inactivation in colonic cancer. J Clin Endocrinol Metab. 84:2080–2085. 1999. View Article : Google Scholar : PubMed/NCBI

24 

Oduwole OO, Isomaa VV, Nokelainen PA, Stenbäck F and Vihko PT: Downregulation of estrogen-metabolizing 17 beta-hydroxysteroid dehydrogenase type 2 expression correlates inversely with Ki67 proliferation marker in colon-cancer development. Int J Cancer. 97:1–6. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Neuhouser ML, Aragaki AK, Prentice RL, Manson JE, Chlebowski R, Carty CL, Ochs-Balcom HM, Thomson CA, Caan BJ, Tinker LF, et al: Overweight, obesity, and postmenopausal invasive breast cancer risk: A secondary analysis of the women's health initiative randomized clinical trials. JAMA Oncol. 1:611–621. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Chlebowski RT, Wactawski-Wende J, Ritenbaugh C, Hubbell FA, Ascensao J, Rodabough RJ, Rosenberg CA, Taylor VM, Harris R, Chen C, et al: Estrogen plus progestin and colorectal cancer in postmenopausal women. N Engl J Med. 350:991–1004. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, Jackson RD, Beresford SA, Howard BV, Johnson KC, et al: Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the women's health initiative randomized controlled trial. JAMA. 288:321–333. 2002. View Article : Google Scholar : PubMed/NCBI

28 

Paruthiyil S, Parmar H, Kerekatte V, Cunha GR, Firestone GL and Leitman DC: Estrogen receptor beta inhibits human breast cancer cell proliferation and tumor formation by causing a G2 cell cycle arrest. Cancer Res. 64:423–428. 2004. View Article : Google Scholar : PubMed/NCBI

29 

Li YH, Wang C, Meng K, Chen LB and Zhou XJ: Influence of survivin and caspase-3 on cell apoptosis and prognosis in gastric carcinoma. World J Gastroenterol. 10:1984–1988. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Hendrickse CW, Jones CE, Donovan IA, Neoptolemos JP and Baker PR: Oestrogen and progesterone receptors in colorectal cancer and human colonic cancer cell lines. Br J Surg. 80:636–640. 1993. View Article : Google Scholar : PubMed/NCBI

31 

Fox EM, Davis RJ and Shupnik MA: ERbeta in breast cancer-onlooker, passive player, or active protector? Steroids. 73:1039–1051. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Miller WR, Anderson TJ, Dixon JM and Saunders PT: Oestrogen receptor beta and neoadjuvant therapy with tamoxifen: Prediction of response and effects of treatment. Br J Cancer. 94:1333–1338. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Rivera-Guevara C and Camacho J: Tamoxifen and its new derivatives in cancer research. Recent Pat Anticancer Drug Discov. 6:237–245. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Garrido JM, Manuela E, Garrido PJ, Oliveira-Brett AM and Borges F: An electrochemical outlook on tamoxifen biotransformation: Current and future prospects. Curr Drug Metab. 12:372–382. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Krishnan K, Campbell S, Abdel-Rahman F, Whaley S and Stone WL: Cancer chemoprevention drug targets. Curr Drug Targets. 4:45–54. 2003. View Article : Google Scholar : PubMed/NCBI

36 

Hou YF, Yuan ST, Li HC, Wu J, Lu JS, Liu G, Lu LJ, Shen ZZ, Ding J and Shao ZM: ERbeta exerts multiple stimulative effects on human breast carcinoma cells. Oncogene. 23:5799–5806. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Onozato W, Yamashita K, Yamashita K, Kuba T, Katoh H, Nakamura T, Sato T, Ihara A, Okayasu I and Watanabe M: Genetic alterations of K-ras may reflect prognosis in stage III colon cancer patients below 60 years of age. J Surg Oncol. 103:25–33. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Sharrard RM, Royds JA, Rogers S and Shorthouse AJ: Patterns of methylation of the c-myc gene in human colorectal cancer progression. Br J Cancer. 65:667–672. 1992. View Article : Google Scholar : PubMed/NCBI

39 

Sun N, Meng Q and Tian A: Expressions of the anti-apoptotic genes Bag-1 and Bcl-2 in colon cancer and their relationship. Am J Surg. 200:341–345. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Roger L, Jullien L, Gire V and Roux P: Gain of oncogenic function of p53 mutants regulates E-cadherin expression uncoupled from cell invasion in colon cancer cells. J Cell Sci. 123:1295–1305. 2010. View Article : Google Scholar : PubMed/NCBI

41 

Wang XH, Fu ZX, Zhao Y, Shen W, Wu X and Wang C: Survivin: An overexpression protein with notable cellular localization and multiple roles in colon cancer. Chinese-German J Clin Oncol. 9:519–523. 2010. View Article : Google Scholar

42 

Garg H, Suri P, Gupta JC, Talwar GP and Dubey S: Survivin: A unique target for tumor therapy. Cancer Cell Int. 16:492016. View Article : Google Scholar : PubMed/NCBI

43 

Scantlebury JB, Luo J, Thorstad WL, El-Mofty SK and Lewis JS Jr: Cyclin D1-a prognostic marker in oropharyngeal squamous cell carcinoma that is tightly associated with high-risk human papillomavirus status. Hum Pathol. 44:1672–1680. 2013. View Article : Google Scholar : PubMed/NCBI

44 

El-Hafez AA, El Aaty Shawky A and Hasan B: Cyclin D1 overexpression associates with favourable prognostic factors in invasive breast carcinoma. Cancer Biomark. 12:149–154. 2012. View Article : Google Scholar : PubMed/NCBI

45 

Zhang GJ, Kimijima I, Onda M, Kanno M, Sato H, Watanabe T, Tsuchiya A, Abe R and Takenoshita S: Tamoxifen-induced apoptosis in breast cancer cells relates to down-regulation of bcl-2, but not bax and bcl-X(L), without alteration of p53 protein levels. Clin Cancer Res. 5:2971–2977. 1999.PubMed/NCBI

46 

Lin LJ, Zheng CQ, Jin Y, Ma Y, Jiang WG and Ma T: Expression of survivin protein in human colorectal carcinogenesis. World J Gastroenterol. 9:974–977. 2003. View Article : Google Scholar : PubMed/NCBI

47 

Fang YJ, Lu ZH, Wang GQ, Pan ZZ, Zhou ZW, Yun JP, Zhang MF and Wan DS: Elevated expressions of MMP7, TROP2, and survivin are associated with survival, disease recurrence, and liver metastasis of colon cancer. Int J Colorectal Dis. 24:875–884. 2009. View Article : Google Scholar : PubMed/NCBI

48 

He Q, Liang CH and Lippard SJ: Steroid hormones induce HMG1 overexpression and sensitize breast cancer cells to cisplatin and carboplatin. Proc Natl Acad Sci USA. 97:5768–5772. 2000; View Article : Google Scholar : PubMed/NCBI

49 

Hwang TS, Han HS, Hong YC, Lee HJ and Paik NS: Prognostic value of combined analysis of cyclin D1 and estrogen receptor status in breast cancer patients. Pathol Int. 53:74–80. 2003. View Article : Google Scholar : PubMed/NCBI

50 

Kdroxenidou L, Ohlson LC and Porsch-Hällström I: Long-term 17 a1pha-ethinyl estradiol treatment decreses cyclin E and cdlc2 expression, reduces cdk2 kinase activity and inhibits S phase entry in regenerating rat liver. J Hepatol. 43:478–484. 2005. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ou QJ, Wu XJ, Peng JH, Zhang RX, Lu ZH, Jiang W, Zhang L, Pan ZZ, Wan DS, Fang YJ, Fang YJ, et al: Endocrine therapy inhibits proliferation and migration, promotes apoptosis and suppresses survivin protein expression in colorectal cancer cells. Mol Med Rep 16: 5769-5778, 2017.
APA
Ou, Q., Wu, X., Peng, J., Zhang, R., Lu, Z., Jiang, W. ... Fang, Y. (2017). Endocrine therapy inhibits proliferation and migration, promotes apoptosis and suppresses survivin protein expression in colorectal cancer cells. Molecular Medicine Reports, 16, 5769-5778. https://doi.org/10.3892/mmr.2017.7375
MLA
Ou, Q., Wu, X., Peng, J., Zhang, R., Lu, Z., Jiang, W., Zhang, L., Pan, Z., Wan, D., Fang, Y."Endocrine therapy inhibits proliferation and migration, promotes apoptosis and suppresses survivin protein expression in colorectal cancer cells". Molecular Medicine Reports 16.5 (2017): 5769-5778.
Chicago
Ou, Q., Wu, X., Peng, J., Zhang, R., Lu, Z., Jiang, W., Zhang, L., Pan, Z., Wan, D., Fang, Y."Endocrine therapy inhibits proliferation and migration, promotes apoptosis and suppresses survivin protein expression in colorectal cancer cells". Molecular Medicine Reports 16, no. 5 (2017): 5769-5778. https://doi.org/10.3892/mmr.2017.7375
Copy and paste a formatted citation
x
Spandidos Publications style
Ou QJ, Wu XJ, Peng JH, Zhang RX, Lu ZH, Jiang W, Zhang L, Pan ZZ, Wan DS, Fang YJ, Fang YJ, et al: Endocrine therapy inhibits proliferation and migration, promotes apoptosis and suppresses survivin protein expression in colorectal cancer cells. Mol Med Rep 16: 5769-5778, 2017.
APA
Ou, Q., Wu, X., Peng, J., Zhang, R., Lu, Z., Jiang, W. ... Fang, Y. (2017). Endocrine therapy inhibits proliferation and migration, promotes apoptosis and suppresses survivin protein expression in colorectal cancer cells. Molecular Medicine Reports, 16, 5769-5778. https://doi.org/10.3892/mmr.2017.7375
MLA
Ou, Q., Wu, X., Peng, J., Zhang, R., Lu, Z., Jiang, W., Zhang, L., Pan, Z., Wan, D., Fang, Y."Endocrine therapy inhibits proliferation and migration, promotes apoptosis and suppresses survivin protein expression in colorectal cancer cells". Molecular Medicine Reports 16.5 (2017): 5769-5778.
Chicago
Ou, Q., Wu, X., Peng, J., Zhang, R., Lu, Z., Jiang, W., Zhang, L., Pan, Z., Wan, D., Fang, Y."Endocrine therapy inhibits proliferation and migration, promotes apoptosis and suppresses survivin protein expression in colorectal cancer cells". Molecular Medicine Reports 16, no. 5 (2017): 5769-5778. https://doi.org/10.3892/mmr.2017.7375
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team