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Cardiovascular risk assessment in osteoporotic patients using osteoprotegerin as a reliable predictive biochemical marker

  • Authors:
    • Carmen G. Barbu
    • Andreea L. Arsene
    • Suzana Florea
    • Alice Albu
    • Anca Sirbu
    • Sorina Martin
    • Alina C. Nicolae
    • George T.A. Burcea‑Dragomiroiu
    • Daniela E. Popa
    • Bruno S. Velescu
    • Ion B. Dumitrescu
    • Niculina Mitrea
    • Doina Draganescu
    • Dumitru Lupuliasa
    • Demetrios A. Spandidos
    • Aristides M. Tsatsakis
    • Cristina M. Dragoi
    • Simona Fica
  • View Affiliations / Copyright

    Affiliations: Elias Hospital, Department of Endocrinology, Faculty of Medicine, ‘Carol Davila’University of Medicine and Pharmacy, 011461 Bucharest, Romania, Department of General and Pharmaceutical Microbiology, Faculty of Pharmacy, ‘Carol Davila’ University of Medicine and Pharmacy, 020956 Bucharest, Romania, Department of Biochemistry, Faculty of Pharmacy, ‘Carol Davila’ University of Medicine and Pharmacy, 020956 Bucharest, Romania, Department of Drug Control, Faculty of Pharmacy, ‘Carol Davila’ University of Medicine and Pharmacy, 020956 Bucharest, Romania, Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, ‘Carol Davila’ University of Medicine and Pharmacy, 020956 Bucharest, Romania, Department of Pharmaceutical Physics and Informatics, Faculty of Pharmacy, ‘Carol Davila’ University of Medicine and Pharmacy, 020956 Bucharest, Romania, Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, ‘Carol Davila’ University of Medicine and Pharmacy, 020956 Bucharest, Romania, Laboratory of Clinical Virology, Medical School, University of Crete, Heraklion 71003, Crete, Greece, Laboratory of Toxicology, Medical School, University of Crete, Heraklion 71003, Crete, Greece
    Copyright: © Barbu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6059-6067
    |
    Published online on: August 28, 2017
       https://doi.org/10.3892/mmr.2017.7376
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Abstract

Osteoprotegerin (OPG), a member of the tumour necrosis factor receptor (TNFR) superfamily of proteins known to be involved in a large number of biological systems, plays a pivotal role in bone remodelling. In addition to the roles of OPG in bone metabolism, it has been reported to be associated with a high cardiovascular risk in patients with metabolic syndrome. In most cases, the exact functions of OPG remain to be established; however, the widespread expression of OPG suggests that this molecule may have multiple biological activities, mainly in the cardiometabolic environment. The aim of this study was to evaluate the value of OPG as a predictive marker for cardiovascular and metabolic risk in osteoporotic patients. The study group comprised patients with osteoporosis, in order to evaluate the association between OPG serum levels and cardiovascular pathology. Our results revealed significant correlations between classical biochemical bone and metabolic parameters, such as osteocalcin and parathyroid hormone with lipid and glucose biomarkers, sustaining the crosstalk between calcium and bone parameters and cardiovascular risk. The OPG serum level proved to have a significant and independent predictive value for metabolic syndrome (MetS) as a cardiovascular risk standard in osteoporotic patients. The OPG serum levels were increased in patients with MetS as a protective response against the atherosclerotic lesions. The serum levels of 25‑hydroxy vitamin D had significant and independent predictive value for cardiovascular and metabolic risk in our subjects, sustaining the active role of vitamin D beyond the area of bone metabolism.
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Copy and paste a formatted citation
Spandidos Publications style
Barbu CG, Arsene AL, Florea S, Albu A, Sirbu A, Martin S, Nicolae AC, Burcea‑Dragomiroiu GT, Popa DE, Velescu BS, Velescu BS, et al: Cardiovascular risk assessment in osteoporotic patients using osteoprotegerin as a reliable predictive biochemical marker. Mol Med Rep 16: 6059-6067, 2017.
APA
Barbu, C.G., Arsene, A.L., Florea, S., Albu, A., Sirbu, A., Martin, S. ... Fica, S. (2017). Cardiovascular risk assessment in osteoporotic patients using osteoprotegerin as a reliable predictive biochemical marker. Molecular Medicine Reports, 16, 6059-6067. https://doi.org/10.3892/mmr.2017.7376
MLA
Barbu, C. G., Arsene, A. L., Florea, S., Albu, A., Sirbu, A., Martin, S., Nicolae, A. C., Burcea‑Dragomiroiu, G. T., Popa, D. E., Velescu, B. S., Dumitrescu, I. B., Mitrea, N., Draganescu, D., Lupuliasa, D., Spandidos, D. A., Tsatsakis, A. M., Dragoi, C. M., Fica, S."Cardiovascular risk assessment in osteoporotic patients using osteoprotegerin as a reliable predictive biochemical marker". Molecular Medicine Reports 16.5 (2017): 6059-6067.
Chicago
Barbu, C. G., Arsene, A. L., Florea, S., Albu, A., Sirbu, A., Martin, S., Nicolae, A. C., Burcea‑Dragomiroiu, G. T., Popa, D. E., Velescu, B. S., Dumitrescu, I. B., Mitrea, N., Draganescu, D., Lupuliasa, D., Spandidos, D. A., Tsatsakis, A. M., Dragoi, C. M., Fica, S."Cardiovascular risk assessment in osteoporotic patients using osteoprotegerin as a reliable predictive biochemical marker". Molecular Medicine Reports 16, no. 5 (2017): 6059-6067. https://doi.org/10.3892/mmr.2017.7376
Copy and paste a formatted citation
x
Spandidos Publications style
Barbu CG, Arsene AL, Florea S, Albu A, Sirbu A, Martin S, Nicolae AC, Burcea‑Dragomiroiu GT, Popa DE, Velescu BS, Velescu BS, et al: Cardiovascular risk assessment in osteoporotic patients using osteoprotegerin as a reliable predictive biochemical marker. Mol Med Rep 16: 6059-6067, 2017.
APA
Barbu, C.G., Arsene, A.L., Florea, S., Albu, A., Sirbu, A., Martin, S. ... Fica, S. (2017). Cardiovascular risk assessment in osteoporotic patients using osteoprotegerin as a reliable predictive biochemical marker. Molecular Medicine Reports, 16, 6059-6067. https://doi.org/10.3892/mmr.2017.7376
MLA
Barbu, C. G., Arsene, A. L., Florea, S., Albu, A., Sirbu, A., Martin, S., Nicolae, A. C., Burcea‑Dragomiroiu, G. T., Popa, D. E., Velescu, B. S., Dumitrescu, I. B., Mitrea, N., Draganescu, D., Lupuliasa, D., Spandidos, D. A., Tsatsakis, A. M., Dragoi, C. M., Fica, S."Cardiovascular risk assessment in osteoporotic patients using osteoprotegerin as a reliable predictive biochemical marker". Molecular Medicine Reports 16.5 (2017): 6059-6067.
Chicago
Barbu, C. G., Arsene, A. L., Florea, S., Albu, A., Sirbu, A., Martin, S., Nicolae, A. C., Burcea‑Dragomiroiu, G. T., Popa, D. E., Velescu, B. S., Dumitrescu, I. B., Mitrea, N., Draganescu, D., Lupuliasa, D., Spandidos, D. A., Tsatsakis, A. M., Dragoi, C. M., Fica, S."Cardiovascular risk assessment in osteoporotic patients using osteoprotegerin as a reliable predictive biochemical marker". Molecular Medicine Reports 16, no. 5 (2017): 6059-6067. https://doi.org/10.3892/mmr.2017.7376
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