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Review Open Access

Role of hypoxia‑mediated cellular prion protein functional change in stem cells and potential application in angiogenesis (Review)

  • Authors:
    • Seung Pil Yun
    • Yong‑Seok Han
    • Jun Hee Lee
    • Yeo Min Yoon
    • Chul Won Yun
    • Peter Rhee
    • Sang Hun Lee
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA, Department of Biochemistry, Medical Science Research Institute, Soonchunhyang University College of Medicine, Cheonan, South Chungcheong 31151, Republic of Korea, Department of Pharmacology and Toxicology, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294, USA
    Copyright: © Yun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5747-5751
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    Published online on: August 29, 2017
       https://doi.org/10.3892/mmr.2017.7387
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Abstract

Cellular prion protein (PrPC) can replace other pivotal molecules due to its interaction with several partners in performing a variety of important biological functions that may differ between embryonic and mature stem cells. Recent studies have revealed major advances in elucidating the putative role of PrPC in the regulation of stem cells and its application in stem cell therapy. What is special about PrPC is that its expression may be regulated by hypoxia‑inducible factor (HIF)‑1α, which is the transcriptional factor of cellular response to hypoxia. Hypoxic conditions have been known to drive cellular responses that can enhance cell survival, differentiation and angiogenesis through adaptive processes. Our group recently reported hypoxia‑enhanced vascular repair of endothelial colony‑forming cells on ischemic injury. Hypoxia‑induced AKT/signal transducer and activator of transcription 3 phosphorylation eventually increases neovasculogenesis. In stem cell biology, hypoxia promotes the expression of growth factors. According to other studies, aspects of tissue regeneration and cell function are influenced by hypoxia, which serves an essential role in stem cell HIF‑1α signaling. All these data suggest the possibility that hypoxia‑mediated PrPC serves an important role in angiogenesis. Therefore, the present review summarizes the characteristics of PrPC, which is produced by HIF‑1α in hypoxia, as it relates to angiogenesis.
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Spandidos Publications style
Yun SP, Han YS, Lee JH, Yoon YM, Yun CW, Rhee P and Lee SH: Role of hypoxia‑mediated cellular prion protein functional change in stem cells and potential application in angiogenesis (Review). Mol Med Rep 16: 5747-5751, 2017.
APA
Yun, S.P., Han, Y., Lee, J.H., Yoon, Y.M., Yun, C.W., Rhee, P., & Lee, S.H. (2017). Role of hypoxia‑mediated cellular prion protein functional change in stem cells and potential application in angiogenesis (Review). Molecular Medicine Reports, 16, 5747-5751. https://doi.org/10.3892/mmr.2017.7387
MLA
Yun, S. P., Han, Y., Lee, J. H., Yoon, Y. M., Yun, C. W., Rhee, P., Lee, S. H."Role of hypoxia‑mediated cellular prion protein functional change in stem cells and potential application in angiogenesis (Review)". Molecular Medicine Reports 16.5 (2017): 5747-5751.
Chicago
Yun, S. P., Han, Y., Lee, J. H., Yoon, Y. M., Yun, C. W., Rhee, P., Lee, S. H."Role of hypoxia‑mediated cellular prion protein functional change in stem cells and potential application in angiogenesis (Review)". Molecular Medicine Reports 16, no. 5 (2017): 5747-5751. https://doi.org/10.3892/mmr.2017.7387
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Spandidos Publications style
Yun SP, Han YS, Lee JH, Yoon YM, Yun CW, Rhee P and Lee SH: Role of hypoxia‑mediated cellular prion protein functional change in stem cells and potential application in angiogenesis (Review). Mol Med Rep 16: 5747-5751, 2017.
APA
Yun, S.P., Han, Y., Lee, J.H., Yoon, Y.M., Yun, C.W., Rhee, P., & Lee, S.H. (2017). Role of hypoxia‑mediated cellular prion protein functional change in stem cells and potential application in angiogenesis (Review). Molecular Medicine Reports, 16, 5747-5751. https://doi.org/10.3892/mmr.2017.7387
MLA
Yun, S. P., Han, Y., Lee, J. H., Yoon, Y. M., Yun, C. W., Rhee, P., Lee, S. H."Role of hypoxia‑mediated cellular prion protein functional change in stem cells and potential application in angiogenesis (Review)". Molecular Medicine Reports 16.5 (2017): 5747-5751.
Chicago
Yun, S. P., Han, Y., Lee, J. H., Yoon, Y. M., Yun, C. W., Rhee, P., Lee, S. H."Role of hypoxia‑mediated cellular prion protein functional change in stem cells and potential application in angiogenesis (Review)". Molecular Medicine Reports 16, no. 5 (2017): 5747-5751. https://doi.org/10.3892/mmr.2017.7387
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