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Article

Effect of continuous positive airway pressure therapy on inflammatory cytokines and atherosclerosis in patients with obstructive sleep apnea syndrome

  • Authors:
    • Fa Jin
    • Jiannan Liu
    • Xiuwei Zhang
    • Wei Cai
    • Yuqiong Zhang
    • Wei Zhang
    • Jian Yang
    • Gan Lu
    • Xilong Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Respiration, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, Jiangsu 211100, P.R. China, Department of Respiratory, Jiangsu Province Official Hospital, Nanjing, Jiangsu 211100, P.R. China, Department of Cardiology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, Jiangsu 211100, P.R. China, Department of Respiratory, Jiangsu Province Hospital, Nanjing, Jiangsu 210029, P.R. China
  • Pages: 6334-6339
    |
    Published online on: August 30, 2017
       https://doi.org/10.3892/mmr.2017.7399
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Abstract

Obstructive sleep apnea syndrome (OSAS) is known to be a risk factor for atherosclerosis (AS), derived from a series of chronic inflammatory reactions caused by hypoxia. However, the association between chronic inflammation and high blood pressure caused by hypoxia remains to be fully elucidated. The aim of the present study was to investigate the effect of continuous positive airway pressure (CPAP) therapy on inflammatory cytokines and AS. A total of 100 patients with OSAS and 50 healthy control subjects were enrolled. Fresh venous blood samples were collected prior to and following a 3‑months period of CPAP treatment. The inflammatory factors, interleukin (IL)‑18 and tumor necrosis factor (TNF)‑α, C‑reactive protein (CRP), intercellular cell adhesion molecule 1 (ICAM‑1), vascular cell adhesion molecule 1 (VCAM‑1), E‑selectin and P‑selectin, were detected using standard enzyme‑linked immunosorbent assay kits. Intima‑media thickness (IMT), brachial‑ankle pulse wave velocity (Ba‑PWV), apnea‑hypopnea index (AHI) and transcutaneous oxygen saturation (SpO2) were also detected to compare differences prior to and following treatment. The results showed that, compared with the pre‑treatment data, the expression levels of IL‑8, TNF‑α, CRP, ICAM‑1, VCAM‑1, E‑selectin and P‑selectin were significantly decreased following treatment (P<0.05). The AHI, IMT, blood pressure and Ba‑PWV values were significantly decreased (P<0.05), and the SpO2 was increased (P<0.05). Taken together, by comparing the pre‑ and post‑intervention data, it was confirmed that inflammatory factors were involved in the process of AS in patients with OSAS. Following CPAP treatment, blood pressure and primary indicators in the patients improved.
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Copy and paste a formatted citation
Spandidos Publications style
Jin F, Liu J, Zhang X, Cai W, Zhang Y, Zhang W, Yang J, Lu G and Zhang X: Effect of continuous positive airway pressure therapy on inflammatory cytokines and atherosclerosis in patients with obstructive sleep apnea syndrome. Mol Med Rep 16: 6334-6339, 2017.
APA
Jin, F., Liu, J., Zhang, X., Cai, W., Zhang, Y., Zhang, W. ... Zhang, X. (2017). Effect of continuous positive airway pressure therapy on inflammatory cytokines and atherosclerosis in patients with obstructive sleep apnea syndrome. Molecular Medicine Reports, 16, 6334-6339. https://doi.org/10.3892/mmr.2017.7399
MLA
Jin, F., Liu, J., Zhang, X., Cai, W., Zhang, Y., Zhang, W., Yang, J., Lu, G., Zhang, X."Effect of continuous positive airway pressure therapy on inflammatory cytokines and atherosclerosis in patients with obstructive sleep apnea syndrome". Molecular Medicine Reports 16.5 (2017): 6334-6339.
Chicago
Jin, F., Liu, J., Zhang, X., Cai, W., Zhang, Y., Zhang, W., Yang, J., Lu, G., Zhang, X."Effect of continuous positive airway pressure therapy on inflammatory cytokines and atherosclerosis in patients with obstructive sleep apnea syndrome". Molecular Medicine Reports 16, no. 5 (2017): 6334-6339. https://doi.org/10.3892/mmr.2017.7399
Copy and paste a formatted citation
x
Spandidos Publications style
Jin F, Liu J, Zhang X, Cai W, Zhang Y, Zhang W, Yang J, Lu G and Zhang X: Effect of continuous positive airway pressure therapy on inflammatory cytokines and atherosclerosis in patients with obstructive sleep apnea syndrome. Mol Med Rep 16: 6334-6339, 2017.
APA
Jin, F., Liu, J., Zhang, X., Cai, W., Zhang, Y., Zhang, W. ... Zhang, X. (2017). Effect of continuous positive airway pressure therapy on inflammatory cytokines and atherosclerosis in patients with obstructive sleep apnea syndrome. Molecular Medicine Reports, 16, 6334-6339. https://doi.org/10.3892/mmr.2017.7399
MLA
Jin, F., Liu, J., Zhang, X., Cai, W., Zhang, Y., Zhang, W., Yang, J., Lu, G., Zhang, X."Effect of continuous positive airway pressure therapy on inflammatory cytokines and atherosclerosis in patients with obstructive sleep apnea syndrome". Molecular Medicine Reports 16.5 (2017): 6334-6339.
Chicago
Jin, F., Liu, J., Zhang, X., Cai, W., Zhang, Y., Zhang, W., Yang, J., Lu, G., Zhang, X."Effect of continuous positive airway pressure therapy on inflammatory cytokines and atherosclerosis in patients with obstructive sleep apnea syndrome". Molecular Medicine Reports 16, no. 5 (2017): 6334-6339. https://doi.org/10.3892/mmr.2017.7399
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