Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
November-2017 Volume 16 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2017 Volume 16 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Whole Wiskott‑Aldrich syndrome protein gene deletion identified by high throughput sequencing

  • Authors:
    • Xiangling He
    • Runying Zou
    • Bing Zhang
    • Yalan You
    • Yang Yang
    • Xin Tian
  • View Affiliations / Copyright

    Affiliations: Department of Hematology and Oncology of Children's Medical Center, Hunan Provincial People's Hospital/The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan 410005, P.R. China
    Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6526-6531
    |
    Published online on: August 31, 2017
       https://doi.org/10.3892/mmr.2017.7416
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Wiskott‑Aldrich syndrome (WAS) is a rare X‑linked recessive immunodeficiency disorder, characterized by thrombocytopenia, small platelets, eczema and recurrent infections associated with increased risk of autoimmunity and malignancy disorders. Mutations in the WAS protein (WASP) gene are responsible for WAS. To date, WASP mutations, including missense/nonsense, splicing, small deletions, small insertions, gross deletions, and gross insertions have been identified in patients with WAS. In addition, WASP‑interacting proteins are suspected in patients with clinical features of WAS, in whom the WASP gene sequence and mRNA levels are normal. The present study aimed to investigate the application of next generation sequencing in definitive diagnosis and clinical therapy for WAS. A 5 month‑old child with WAS who displayed symptoms of thrombocytopenia was examined. Whole exome sequence analysis of genomic DNA showed that the coverage and depth of WASP were extremely low. Quantitative polymerase chain reaction indicated total WASP gene deletion in the proband. In conclusion, high throughput sequencing is useful for the verification of WAS on the genetic profile, and has implications for family planning guidance and establishment of clinical programs.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Lemahieu V, Gastier JM and Francke U: Novel mutations in the Wiskott-Aldrich syndrome protein gene and their effects on transcriptional, translational and clinical phenotypes. Hum Mutat. 14:54–66. 1999. View Article : Google Scholar : PubMed/NCBI

2 

Aldrich RA, Steinberg AG and Campbell DC: Pedigree demonstrating a sex-linked recessive condition characterized by draining ears, eczematoid dermatitis and bloody diarrhea. Pediatrics. 13:133–139. 1954.PubMed/NCBI

3 

Derry JM, Ochs HD and Francke U: Isolation of a novel gene mutated in Wiskott-Aldrich syndrome. Cell. 78:635–644. 1994. View Article : Google Scholar : PubMed/NCBI

4 

Ochs HD and Thrasher AJ: The Wiskott-Aldrich syndrome. J Allergy Clin Immunol. 117:725–739. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Blundell MP, Worth A, Bouma G and Thrasher AJ: The Wiskott-Aldrich syndrome: The actin cytoskeleton and immune cell function. Dis Markers. 29:157–175. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Westerberg LS, Dahlberg C, Baptista M, Moran CJ, Detre C, Keszei M, Eston MA, Alt FW, Terhorst C, Notarangelo LD and Snapper SB: Wiskott-Aldrich syndrome protein (WASP) and N-WASP are critical for peripheral B-cell development and function. Blood. 119:3966–3974. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Adriani M, Aoki J, Horai R, Thornton AM, Konno A, Kirby M, Anderson SM, Siegel RM, Candotti F and Schwartzberg PL: Impaired in vitro regulatory T cell function associated with Wiskott-Aldrich syndrome. Clin Immunol. 124:41–48. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Wada T, Schurman SH, Garabedian EK, Yachie A and Candotti F: Analysis of T-cell repertoire diversity in Wiskott-Aldrich syndrome. Blood. 106:3895–3897. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Maillard MH, Cotta-de-Almeida V, Takeshima F, Nguyen DD, Michetti P, Nagler C, Bhan AK and Snapper SB: The Wiskott-Aldrich syndrome protein is required for the function of CD4(+) CD25(+) Foxp3(+) regulatory T cells. J Exp Med. 204:381–391. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Yarar D, To W, Abo A and Welch MD: The Wiskott-Aldrich syndrome protein directs actin-based motility by stimulating actin nucleation with the Arp2/3 complex. Curr Biol. 9:555–558. 1999. View Article : Google Scholar : PubMed/NCBI

11 

Davis BR and Candotti F: Revertant somatic mosaicism in the Wiskott-Aldrich syndrome. Immunol Res. 44:127–131. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Ochs HD: Mutations of the Wiskott-Aldrich syndrome protein affect protein expression and dictate the clinical phenotypes. Immunol Res. 44:84–88. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Luthi JN, Gandhi MJ and Drachman JG: X-linked thrombocytopenia caused by a mutation in the Wiskott-Aldrich syndrome (WAS) gene that disrupts interaction with the WAS protein (WASP)-interacting protein (WIP). Exp Hematol. 31:150–158. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Bender M, Stritt S, Nurden P, van Eeuwijk JM, Zieger B, Kentouche K, Schulze H, Morbach H, Stegner D, Heinze KG, et al: Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect. Nat Commun. 5:47462014. View Article : Google Scholar : PubMed/NCBI

15 

Sasahara Y: WASP-WIP complex in the molecular pathogenesis of Wiskott-Aldrich syndrome. Pediatr Int. 58:4–7. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Lanzi G, Moratto D, Vairo D, Masneri S, Delmonte O, Paganini T, Parolini S, Tabellini G, Mazza C, Savoldi G, et al: A novel primary human immunodeficiency due to deficiency in the WASP-interacting protein WIP. J Exp Med. 209:29–34. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Fried S, Matalon O, Noy E and Barda-Saad M: WIP: More than a WASp-interacting protein. J Leukoc Biol. 96:713–727. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Ramesh N, Massaad MJ, Kumar L, Koduru S, Sasahara Y, Anton I, Bhasin M, Libermann T and Geha R: Binding of the WASP/N-WASP-interacting protein WIP to actin regulates focal adhesion assembly and adhesion. Mol Cell Biol. 34:2600–2610. 2014. View Article : Google Scholar : PubMed/NCBI

19 

St-Jean M, Izard T and Sygusch J: A hydrophobic pocket in the active site of glycolytic aldolase mediates interactions with Wiskott-Aldrich syndrome protein. J Biol Chem. 282:14309–14315. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Ti SC, Jurgenson CT, Nolen BJ and Pollard TD: Structural and biochemical characterization of two binding sites for nucleation-promoting factor WASp-VCA on Arp2/3 complex. Proc Natl Acad Sci USA. 108:E463–E471. 2011; View Article : Google Scholar : PubMed/NCBI

21 

Jurgenson CT and Pollard TD: Crystals of the Arp2/3 complex in two new space groups with structural information about actin-related protein 2 and potential WASP binding sites. Acta Crystallogr F Struct Biol Commun. 71:1161–1168. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Wada T, Itoh M, Maeba H, Toma T, Niida Y, Saikawa Y and Yachie A: Intermittent X-linked thrombocytopenia with a novel WAS gene mutation. Pediatr Blood Cancer. 61:746–748. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Takimoto T, Takada H, Ishimura M, Kirino M, Hata K, Ohara O, Morio T and Hara T: Wiskott-Aldrich syndrome in a girl caused by heterozygous WASP mutation and extremely skewed X-chromosome inactivation: A novel association with maternal uniparental isodisomy 6. Neonatology. 107:185–190. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Szklarczyk D, Franceschini A, Wyder S, Forslund K, Heller D, Huerta-Cepas J, Simonovic M, Roth A, Santos A, Tsafou KP, et al: STRING v10: Protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res. 43(Database Issue): D447–D452. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Li H and Durbin R: Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics. 25:1754–1760. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Wassner AJ, Cohen LE, Hechter E and Dauber A: Isolated central hypothyroidism in young siblings as a manifestation of PROP1 deficiency: Clinical impact of whole exome sequencing. Horm Res Paediatr. 79:379–386. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Thrasher AJ: New insights into the biology of Wiskott-Aldrich syndrome (WAS). Hematology Am Soc Hematol Educ Program. 1–138. 2009.

29 

Jin Y, Mazza C, Christie JR, Giliani S, Fiorini M, Mella P, Gandellini F, Stewart DM, Zhu Q, Nelson DL, et al: Mutations of the Wiskott-Aldrich syndrome protein (WASP): Hotspots, effect on transcription and translation, and phenotype/genotype correlation. Blood. 104:4010–4019. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Ancliff PJ, Blundell MP, Cory GO, Calle Y, Worth A, Kempski H, Burns S, Jones GE, Sinclair J, Kinnon C, et al: Two novel activating mutations in the Wiskott-Aldrich syndrome protein result in congenital neutropenia. Blood. 108:2182–2189. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Peng F, Nong G, Jiang M, Liu X, Liu H and Li Y: Clinical features, genotype and phenotype analysis and literature review of Wiskott-Aldrich syndrome. J Applied Clin Pediatr. 29:675–679. 2014.

32 

Catucci M, Castiello MC, Pala F, Bosticardo M and Villa A: Autoimmunity in wiskott-Aldrich syndrome: An unsolved enigma. Front Immunol. 3:2092012. View Article : Google Scholar : PubMed/NCBI

33 

Imai K, Morio T, Zhu Y, Jin Y, Itoh S, Kajiwara M, Yata J, Mizutani S, Ochs HD and Nonoyama S: Clinical course of patients with WASP gene mutations. Blood. 103:456–464. 2004. View Article : Google Scholar : PubMed/NCBI

34 

Zhao Q, Jiang L, Yu J, Xiao J and Zhao X: Genotype and phenotype correlation of Wiskott-Aldrich syndrome: A report based on 24 Chinese patients. J Third Mil Med Univ. 33:1404–1407. 2011.

35 

Welch MD, DePace AH, Verma S, Iwamatsu A and Mitchison TJ: The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. J Cell Biol. 138:375–384. 1997. View Article : Google Scholar : PubMed/NCBI

36 

Wu M, Katta A, Gadde MK, Liu H, Kakarla SK, Fannin J, Paturi S, Arvapalli RK, Rice KM, Wang Y and Blough ER: Aging-associated dysfunction of Akt/protein kinase B: S-nitrosylation and acetaminophen intervention. PLoS One. 4:e64302009. View Article : Google Scholar : PubMed/NCBI

37 

Weed SA, Karginov AV, Schafer DA, Weaver AM, Kinley AW, Cooper JA and Parsons JT: Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex. J Cell Biol. 151:29–40. 2000. View Article : Google Scholar : PubMed/NCBI

38 

Di Ciano C, Nie Z, Szászi K, Lewis A, Uruno T, Zhan X, Rotstein OD, Mak A and Kapus A: Osmotic stress-induced remodeling of the cortical cytoskeleton. Am J Physiol Cell Physiol. 283:C850–C865. 2002. View Article : Google Scholar : PubMed/NCBI

39 

Latreille M, Laberge MK, Bourret G, Yamani L and Larose L: Deletion of Nck1 attenuates hepatic ER stress signaling and improves glucose tolerance and insulin signaling in liver of obese mice. Am J Physiol Endocrinol Metab. 300:E423–E434. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Qadir MI, Parveen A and Ali M: Cdc42: Role in cancer management. Chem Biol Drug Des. 86:432–439. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Boztug K, Schmidt M, Schwarzer A, Banerjee PP, Díez IA, Dewey RA, Böhm M, Nowrouzi A, Ball CR, Glimm H, et al: Stem-cell gene therapy for the Wiskott-Aldrich syndrome. N Engl J Med. 363:1918–1927. 2010. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
He X, Zou R, Zhang B, You Y, Yang Y and Tian X: Whole Wiskott‑Aldrich syndrome protein gene deletion identified by high throughput sequencing. Mol Med Rep 16: 6526-6531, 2017.
APA
He, X., Zou, R., Zhang, B., You, Y., Yang, Y., & Tian, X. (2017). Whole Wiskott‑Aldrich syndrome protein gene deletion identified by high throughput sequencing. Molecular Medicine Reports, 16, 6526-6531. https://doi.org/10.3892/mmr.2017.7416
MLA
He, X., Zou, R., Zhang, B., You, Y., Yang, Y., Tian, X."Whole Wiskott‑Aldrich syndrome protein gene deletion identified by high throughput sequencing". Molecular Medicine Reports 16.5 (2017): 6526-6531.
Chicago
He, X., Zou, R., Zhang, B., You, Y., Yang, Y., Tian, X."Whole Wiskott‑Aldrich syndrome protein gene deletion identified by high throughput sequencing". Molecular Medicine Reports 16, no. 5 (2017): 6526-6531. https://doi.org/10.3892/mmr.2017.7416
Copy and paste a formatted citation
x
Spandidos Publications style
He X, Zou R, Zhang B, You Y, Yang Y and Tian X: Whole Wiskott‑Aldrich syndrome protein gene deletion identified by high throughput sequencing. Mol Med Rep 16: 6526-6531, 2017.
APA
He, X., Zou, R., Zhang, B., You, Y., Yang, Y., & Tian, X. (2017). Whole Wiskott‑Aldrich syndrome protein gene deletion identified by high throughput sequencing. Molecular Medicine Reports, 16, 6526-6531. https://doi.org/10.3892/mmr.2017.7416
MLA
He, X., Zou, R., Zhang, B., You, Y., Yang, Y., Tian, X."Whole Wiskott‑Aldrich syndrome protein gene deletion identified by high throughput sequencing". Molecular Medicine Reports 16.5 (2017): 6526-6531.
Chicago
He, X., Zou, R., Zhang, B., You, Y., Yang, Y., Tian, X."Whole Wiskott‑Aldrich syndrome protein gene deletion identified by high throughput sequencing". Molecular Medicine Reports 16, no. 5 (2017): 6526-6531. https://doi.org/10.3892/mmr.2017.7416
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team