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Genomic profile of oral squamous cell carcinomas with an adjacent leukoplakia or with an erythroleukoplakia that evolved after the treatment of primary tumor: A report of two cases

  • Authors:
    • Ilda P. Ribeiro
    • Francisco Marques
    • Leonor Barroso
    • Joana Rodrigues
    • Francisco Caramelo
    • Joana B. Melo
    • Isabel M. Carreira
  • View Affiliations / Copyright

    Affiliations: Cytogenetics and Genomics Laboratory, Faculty of Medicine, University of Coimbra, 3000‑354 Coimbra, Portugal, Center of Investigation on Environment Genetics and Oncobiology, Faculty of Medicine, University of Coimbra, 3000‑354 Coimbra, Portugal, Maxillofacial Surgery Department, Coimbra Hospital and University Centre, EPE, 3000‑075 Coimbra, Portugal, Laboratory of Biostatistics and Medical Informatics, Faculty of Medicine, University of Coimbra, 3000‑354 Coimbra, Portugal
    Copyright: © Ribeiro et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6780-6786
    |
    Published online on: September 5, 2017
       https://doi.org/10.3892/mmr.2017.7428
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Abstract

Oral leukoplakia and erythroleukoplakia are common oral potentially malignant disorders diagnosed in the oral cavity. The specific outcome of these lesions remains to be elucidated, as their malignant transformation rate exhibits great variation. The ability to predict which of those potentially malignant lesions are likely to progress to cancer would be vital to guide their future clinical management. The present study reported two patients with tongue squamous cell carcinoma: Case study 1 was diagnosed with a simultaneous leukoplakia and case study 2 developed an erythroleukoplakia following the primary tumor treatment. Whole genome copy number alterations were analyzed using array comparative genomic hybridization. The present study determined more genomic imbalances in the tissues from leukoplakia and erythroleukoplakia compared with their respective tumors. The present study also identified in tumor and potentially malignant lesions common alterations of chromosomal regions and genes, including FBXL5, UGT2B15, UGT2B28, KANSL1, GSTT1 and DUSP22, being some of these typical aberrations described in oral cancer and others are linked to chemoradioresistance. Several putative genes associated with hallmarks of malignancy that may have an important role in predicting the progression of leukoplakia and erythroleukoplakia to squamous cell carcinoma, namely gains in BNIPL, MCL1, STAG2, CSPP1 and ZNRF3 genes were also identified.
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Copy and paste a formatted citation
Spandidos Publications style
Ribeiro IP, Marques F, Barroso L, Rodrigues J, Caramelo F, Melo JB and Carreira IM: Genomic profile of oral squamous cell carcinomas with an adjacent leukoplakia or with an erythroleukoplakia that evolved after the treatment of primary tumor: A report of two cases. Mol Med Rep 16: 6780-6786, 2017.
APA
Ribeiro, I.P., Marques, F., Barroso, L., Rodrigues, J., Caramelo, F., Melo, J.B., & Carreira, I.M. (2017). Genomic profile of oral squamous cell carcinomas with an adjacent leukoplakia or with an erythroleukoplakia that evolved after the treatment of primary tumor: A report of two cases. Molecular Medicine Reports, 16, 6780-6786. https://doi.org/10.3892/mmr.2017.7428
MLA
Ribeiro, I. P., Marques, F., Barroso, L., Rodrigues, J., Caramelo, F., Melo, J. B., Carreira, I. M."Genomic profile of oral squamous cell carcinomas with an adjacent leukoplakia or with an erythroleukoplakia that evolved after the treatment of primary tumor: A report of two cases". Molecular Medicine Reports 16.5 (2017): 6780-6786.
Chicago
Ribeiro, I. P., Marques, F., Barroso, L., Rodrigues, J., Caramelo, F., Melo, J. B., Carreira, I. M."Genomic profile of oral squamous cell carcinomas with an adjacent leukoplakia or with an erythroleukoplakia that evolved after the treatment of primary tumor: A report of two cases". Molecular Medicine Reports 16, no. 5 (2017): 6780-6786. https://doi.org/10.3892/mmr.2017.7428
Copy and paste a formatted citation
x
Spandidos Publications style
Ribeiro IP, Marques F, Barroso L, Rodrigues J, Caramelo F, Melo JB and Carreira IM: Genomic profile of oral squamous cell carcinomas with an adjacent leukoplakia or with an erythroleukoplakia that evolved after the treatment of primary tumor: A report of two cases. Mol Med Rep 16: 6780-6786, 2017.
APA
Ribeiro, I.P., Marques, F., Barroso, L., Rodrigues, J., Caramelo, F., Melo, J.B., & Carreira, I.M. (2017). Genomic profile of oral squamous cell carcinomas with an adjacent leukoplakia or with an erythroleukoplakia that evolved after the treatment of primary tumor: A report of two cases. Molecular Medicine Reports, 16, 6780-6786. https://doi.org/10.3892/mmr.2017.7428
MLA
Ribeiro, I. P., Marques, F., Barroso, L., Rodrigues, J., Caramelo, F., Melo, J. B., Carreira, I. M."Genomic profile of oral squamous cell carcinomas with an adjacent leukoplakia or with an erythroleukoplakia that evolved after the treatment of primary tumor: A report of two cases". Molecular Medicine Reports 16.5 (2017): 6780-6786.
Chicago
Ribeiro, I. P., Marques, F., Barroso, L., Rodrigues, J., Caramelo, F., Melo, J. B., Carreira, I. M."Genomic profile of oral squamous cell carcinomas with an adjacent leukoplakia or with an erythroleukoplakia that evolved after the treatment of primary tumor: A report of two cases". Molecular Medicine Reports 16, no. 5 (2017): 6780-6786. https://doi.org/10.3892/mmr.2017.7428
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