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Article

Differential regulation by IFN‑γ on TNF‑α‑induced chemokine expression in synovial fibroblasts from temporomandibular joint

  • Authors:
    • Kouji Ohta
    • Takako Naruse
    • Hiroki Kato
    • Yoko Ishida
    • Takayuki Nakagawa
    • Shigehiro Ono
    • Hideo Shigeishi
    • Masaaki Takechi
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, Division of Cervico‑Gnathostmatology, Programs for Applied Biomedicine, Graduate School of Biomedical Sciences, Hiroshima University, Minami, Hiroshima 734‑8553, Japan
  • Pages: 6850-6857
    |
    Published online on: September 7, 2017
       https://doi.org/10.3892/mmr.2017.7432
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Abstract

Tumor necrosis factor (TNF)‑α and interferon (IFN)‑γ, are inflammatory cytokines in the synovial fluid of patients with temporomandibular joint disorder (TMD). However, it remains unknown whether they participate in the regulation of various chemokine expression levels associated with TMD. The effects of TNF‑α and IFN‑γ on the expression of several different inflammatory chemokines, including interleukin (IL)‑8, C‑X‑C motif chemokine ligand (CXCL)1, C‑C motif chemokine ligand (CCL)20, CXCL9, CXCL10, and CXCL11 in synovial fibroblasts obtained from the temporomandibular joint (TMJ) were examined. The results demonstrated that TNF‑α increased the mRNA levels of all examined chemokines in synovial fibroblasts obtained from the TMJ. IFN‑γ treatment alone increased the mRNA expression levels of CXCR3 chemokines, including CXCL10, while they were significantly enhanced when administered in combination with TNF‑α compared with either treatment alone. However, the combination of IFN‑γ and TNF‑α resulted in lower mRNA expression levels of IL‑8 and CXCL1 as compared with those induced by TNF‑α alone. The nuclear factor‑κB inhibitor, Bay 11‑7082, decreased the TNF‑α‑mediated expression of IL‑8 and CXCL10 in the absence, and presence of IFN‑γ. In addition, the JAK2 inhibitor, AG490, decreased CXCL10 expression when administered with TNF‑α and IFN‑γ. Finally, the decrease in TNF‑α‑induced IL‑8 caused by IFN‑γ was recovered by AG490. The results of the present study suggest that TNF‑α and IFN‑γ function in a cooperative manner to regulate inflammatory chemokine expression in synovial fibroblasts, which may contribute to the pathological condition of the TMJ.
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1 

Dijkgraaf LC, de Bont LG, Boering G and Liem RS: Structure of the normal synovial membrane of the temporomandibular joint: A review of the literature. J Oral Maxillofac Surg. 54:332–338. 1996. View Article : Google Scholar : PubMed/NCBI

2 

Israel HA, Langevin CJ, Singer MD and Behrman DA: The relationship between temporomandibular joint synovitis and adhesions: pathogenic mechanisms and rheumatoidarthritis:aclinical, arthroscopic, histologic and immunohistochemical study. Int J Oral Maxillofac Surg. 26:10–16. 1997.PubMed/NCBI

3 

Israel HA, Diamond B, Saed-Nejad F and Ratcliffe A: Osteoarthritis and synovitis as major pa arthroscopic morphology. J Oral Maxillofac Surg. 56:1023–1027. 1998. View Article : Google Scholar : PubMed/NCBI

4 

Takahashi T, Kondoh T, Fukuda M, Yamazaki Y, Toyosaki T and Suzuki R: Proinflammatory cytokines detectable in synovial fluids from patients with temporomandibular disorders. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 85:135–141. 1998. View Article : Google Scholar : PubMed/NCBI

5 

Kaneyama K, Segami N, Nishimura M, Suzuki T and Sato J: Importance of proinflammatory cytokines in synovial fluid from 121 joints with temporomandibular disorders. Br J Oral Maxillofac Surg. 40:418–423. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Baud V and Karin M: Signal transduction by tumor necrosis factor and its relativs. Trends Cell Biol. 11:372–377. 2001. View Article : Google Scholar : PubMed/NCBI

7 

Puzas JE, Landeau JM, Tallents R, Albright J, Schwarz EM and Landesberg R: Degradative pathways in tissues of the temporomandibular joint. Use of in vitro and in vivo models to characterize matrix metalloproteinase and cytokine activity. Cells Tissues Organs. 169:248–256. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Ogura N, Tobe M, Sakamaki H, Nagura H, Abiko Y and Kondoh T: Tumor necrosis factor-alpha increases chemokine gene expression and production in synovial fibroblasts from human temporomandibular joint. J Oral Pathol Med. 34:357–363. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Akutsu M, Ogura N, Ito K, Kawashima M, Kishida T and Kondoh T: Effects of interleukin-1β and tumor necrosis factor-α on macrophage inflammatory protein-3α production in synovial fibroblast-like cells from human temporomandibular joints. J Oral Pathol Med. 42:491–498. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Rodig S, Kaplan D, Shankaran V, Old L and Schreiber RD: Signaling and signaling dysfunction through the interferon gamma receptor. Eur Cytokine Netw. 9 3 Suppl:S49–S53. 1998.

11 

Qin S, Rottman JB, Myers P, Kassam N, Weinblatt M, Loetscher M, Koch AE, Moser B and Mackay CR: The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions. J Clin Invest. 101:746–754. 1998. View Article : Google Scholar : PubMed/NCBI

12 

Matsumoto K, Honda K, Ohshima M, Yamaguchi Y, Nakajima I, Micke P and Otsuka K: Cytokine profile in synovial fluid from patients with internal derangement of the temporomandibular joint: A preliminary study. Dentomaxillofac Radiol. 35:432–441. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Lee EY, Lee ZH and Song YW: CXCL10 and autoimmune diseases. Autoimmun Rev. 8:379–383. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Alaaeddine N, DiBattista JA, Pelletier JP, Cloutier JM, Kiansa K, Dupuis M and Martel-Pelletier J: Osteoarthritic synovial fibroblasts possess an increased level of tumor necrosis factor-receptor 55 (TNF-R55) that mediates biological activation by TNF-alpha. J Rheumatol. 24:1985–1994. 1997.PubMed/NCBI

15 

Thanos D and Maniatis T: NF-kappa B: A lesson in family values. Cell. 80:529–532. 1995. View Article : Google Scholar : PubMed/NCBI

16 

Gough DJ, Messina NL, Hii L, Gould JA, Sabapathy K, Robertson AP, Trapani JA, Levy DE, Hertzog PJ, Clarke CJ and Johnstone RW: Functional crosstalk between type I and II interferon through the regulated expression of STAT1. PLoS Biol. 27:e10003612010. View Article : Google Scholar

17 

Suzuki T, Segami N, Nishimura M and Nojima T: Co-expression of interleukin-1beta and tumor necrosis factor alpha in synovial tissues and synovial fluids of temporomandibular joint with internal derangement: Comparison with histological grading of synovial inflammation. J Oral Pathol Med. 31:549–557. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Ke J, Long X, Liu Y, Zhang YF, Li J, Fang W and Meng QG: Role of NF-kappaB in TNF-alpha-induced COX-2 expression in synovial fibroblasts from human TMJ. J Dent Res. 86:363–367. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Patel DD, Zachariah JP and Whichard LP: CXCR3 and CCR5 ligands in rheumatoid arthritis synovium. Clin Immunol. 98:39–45. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Mohan K, Ding Z, Hanly J and Issekutz TB: IFN-gamma-inducible T cell a chemoattractant is a potent stimulator of normal human blood T lymphocyte transendothelial migration: Differential regulation by IFN-gamma and TNF-alpha. J Immunol. 168:6420–6428. 2002. View Article : Google Scholar : PubMed/NCBI

21 

Ueno A, Yamamura M, Iwahashi M, Okamoto A, Aita T, Ogawa N and Makino H: The production of CXCR3-agonistic chemokines by synovial fibroblasts from patients with rheumatoid arthritis. Rheumatol Int. 25:361–367. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Kuan WP, Tam LS, Wong CK, Ko FW, Li T, Zhu T and Li EK: CXCL 9 and CXCL 10 as sensitive markers of disease activity in patients with rheumatoid arthritis. J Rheumatol. 37:257–264. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Gynther GW, Holmlund AB, Reinholt FP and Lindblad S: Temporomandibular joint involvement in generalized osteoarthritis and rheumatoid arthritis: A clinical, arthroscopic, histologic, and immunohistochemical study. Int J Oral Maxillofac Surg. 26:10–16. 1997. View Article : Google Scholar : PubMed/NCBI

24 

Godiska R, Chantry D, Dietsch GN and Gray PW: Chemokine expression in murine experimental allergic encephalomyelitis. J Neuroimmunol. 58:167–176. 1995. View Article : Google Scholar : PubMed/NCBI

25 

Murphy PM: Neutrophil receptors for interleukin-8 and related CXC chemokines. Semin Hematol. 34:311–318. 1997.PubMed/NCBI

26 

Sukedai M, Tominaga K, Habu M, Matsukawa A, Nishihara T and Fukuda J: Involvement of tumor necrosis factor-alpha and interleukin-8 in antigen-induced arthritis of the rabbit temporomandibular joint. J Oral Pathol Med. 33:102–110. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Kohara H, Kitaura H, Fujimura Y, Yoshimatsu M, Morita Y, Eguchi T, Masuyama R and Yoshida N: IFN-γ directly inhibits TNF-α-induced osteoclastogenesis in vitro and in vivo and induces apoptosis mediated by Fas/Fas ligand interactions. Immunol Lett. 30:53–61. 2011. View Article : Google Scholar

28 

Meyer FA, Yaron I and Yaron M: Synergistic, additive, and antagonistic effects of interleukin-1beta, tumor necrosis factor-alpha and gamma-interferon on prostaglandin E, hyaluronic acid, and collagenase production by cultured synovial fibroblasts. Arthritis Rheum. 33:1518–1525. 1990. View Article : Google Scholar : PubMed/NCBI

29 

Kristensen KD, Alstergren P, Stoustrup P, Küseler A, Herlin T and Pedersen TK: Cytokines in healthy temporomandibular joint synovial fluid. J Oral Rehabil. 41:250–256. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Darnell JE Jr, Kerr IM and Stark GR: Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science. 264:1415–1421. 1994. View Article : Google Scholar : PubMed/NCBI

31 

Bromberg J and Darnell JE Jr: The role of STATs in transcriptional control and their impact on cellular function. Oncogene. 19:2468–2473. 2000. View Article : Google Scholar : PubMed/NCBI

32 

O'Shea JJ, Gadina M and Schreiber RD: Cytokine signaling in 2002: New surprises in the Jak/Stat pathway. Cell. 109 Suppl:S121–S131. 2002. View Article : Google Scholar : PubMed/NCBI

33 

Kasperkovitz PV, Verbeet NL, Smeets TJ, van Rietschoten JG, Kraan MC, van der Pouw Kraan TC, Tak PP and Verweij CL: Activation of the STAT1 pathway in rheumatoid arthritis. Ann Rheum Dis. 63:233–239. 2004. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ohta K, Naruse T, Kato H, Ishida Y, Nakagawa T, Ono S, Shigeishi H and Takechi M: Differential regulation by IFN‑γ on TNF‑α‑induced chemokine expression in synovial fibroblasts from temporomandibular joint. Mol Med Rep 16: 6850-6857, 2017.
APA
Ohta, K., Naruse, T., Kato, H., Ishida, Y., Nakagawa, T., Ono, S. ... Takechi, M. (2017). Differential regulation by IFN‑γ on TNF‑α‑induced chemokine expression in synovial fibroblasts from temporomandibular joint. Molecular Medicine Reports, 16, 6850-6857. https://doi.org/10.3892/mmr.2017.7432
MLA
Ohta, K., Naruse, T., Kato, H., Ishida, Y., Nakagawa, T., Ono, S., Shigeishi, H., Takechi, M."Differential regulation by IFN‑γ on TNF‑α‑induced chemokine expression in synovial fibroblasts from temporomandibular joint". Molecular Medicine Reports 16.5 (2017): 6850-6857.
Chicago
Ohta, K., Naruse, T., Kato, H., Ishida, Y., Nakagawa, T., Ono, S., Shigeishi, H., Takechi, M."Differential regulation by IFN‑γ on TNF‑α‑induced chemokine expression in synovial fibroblasts from temporomandibular joint". Molecular Medicine Reports 16, no. 5 (2017): 6850-6857. https://doi.org/10.3892/mmr.2017.7432
Copy and paste a formatted citation
x
Spandidos Publications style
Ohta K, Naruse T, Kato H, Ishida Y, Nakagawa T, Ono S, Shigeishi H and Takechi M: Differential regulation by IFN‑γ on TNF‑α‑induced chemokine expression in synovial fibroblasts from temporomandibular joint. Mol Med Rep 16: 6850-6857, 2017.
APA
Ohta, K., Naruse, T., Kato, H., Ishida, Y., Nakagawa, T., Ono, S. ... Takechi, M. (2017). Differential regulation by IFN‑γ on TNF‑α‑induced chemokine expression in synovial fibroblasts from temporomandibular joint. Molecular Medicine Reports, 16, 6850-6857. https://doi.org/10.3892/mmr.2017.7432
MLA
Ohta, K., Naruse, T., Kato, H., Ishida, Y., Nakagawa, T., Ono, S., Shigeishi, H., Takechi, M."Differential regulation by IFN‑γ on TNF‑α‑induced chemokine expression in synovial fibroblasts from temporomandibular joint". Molecular Medicine Reports 16.5 (2017): 6850-6857.
Chicago
Ohta, K., Naruse, T., Kato, H., Ishida, Y., Nakagawa, T., Ono, S., Shigeishi, H., Takechi, M."Differential regulation by IFN‑γ on TNF‑α‑induced chemokine expression in synovial fibroblasts from temporomandibular joint". Molecular Medicine Reports 16, no. 5 (2017): 6850-6857. https://doi.org/10.3892/mmr.2017.7432
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