Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
November-2017 Volume 16 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2017 Volume 16 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Profiling of differentially expressed genes in adipose tissues of multiple symmetric lipomatosis

  • Authors:
    • Ke Chen
    • Linghao Wang
    • Wenjun Yang
    • Changfa Wang
    • Gui Hu
    • Zhaohui Mo
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P.R. China, Department of General Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6570-6579
    |
    Published online on: September 7, 2017
       https://doi.org/10.3892/mmr.2017.7437
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Multiple symmetric lipomatosis (MSL) is a rare disorder characterized by aberrant multiple and symmetric subcutaneous adipose tissue accumulation in the face, neck, shoulders, back, chest and abdomen, severely affecting the quality of life of patients. At present, precise MSL etiology and pathogenesis remain to be elucidated. The present study first utilized a digital gene expression technique with a next‑generation sequencing platform to profile differentially expressed genes in three cases of MSL vs. normal control tissue. cDNA libraries from these tissue specimens were constructed and DNA sequenced for identification of differentially expressed genes, which underwent bioinformatic analysis using the Gene Ontology (GO) enrichment, Kyoto Encyclopedia of Genes and Genomes (KEGG) and protein‑protein interaction (PPI) network analyses. As a result, a total of 859 differentially expressed genes were identified, including 308 upregulated genes (C19orf80, Apelin, C21orf33, FAM166B and HSD11B2 were mostly upregulated 6.984‑, 4.670‑, 4.412‑, 3.693‑ and 3.561‑fold, respectively) and 551 downregulated genes [FosB proto‑oncogene, AP‑1 transcription factor subunit (FOSB), selectin (SEL) E, RAR related orphan receptor (ROR) B, salt inducible kinase (SIK)1 and epidermal growth factor‑like protein (EGFL)6 were mostly downregulated ‑9.845, ‑8.243, ‑8.123, ‑7.702 and ‑7.664 fold, respectively). The GO functional enrichment analysis demonstrated these differentially expressed genes were predominantly involved in biological processes and cellular components, while the KEGG pathway enrichment analysis demonstrated that ribosome, non‑alcoholic fatty liver disease, human T‑lymphotropic virus type 1 (HTLV‑I) infection and Alzheimer's disease pathways were altered in MSL. The PPI network data demonstrated ubiquitin C (UBC), translocator protein (TSPO), Jun Proto‑Oncogene, AP‑1 Transcription Factor (JUN) and FOS were among these differentially expressed genes that participated in regulation of adipocyte differentiation, although no previous study has linked them to MSL. In conclusion, the present study profiled differentially expressed genes in MSL and identified gene pathways that may be associated with MSL development and progression.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Brodie BC: Lecture XIV: On Fatty or Adipose TumorsLectures Illustrative of Various Subjects In Pathology and Surgery. Longman, Brown, Green and Longmans; London: pp. 275–282. 1846

2 

Nisi G and Sisti A: Images in clinical medicine. Madelung's disease. N Engl J Med. 374:5722016. View Article : Google Scholar : PubMed/NCBI

3 

Rendina D, De Filippo G, Nazzaro A and Strazzullo P: Impaired gonadal function in a woman with multiple symmetric lipomatosis. Minerva Endocrinol. 38:211–215. 2013.PubMed/NCBI

4 

Palacios E, Neitzschman HR and Nguyen J: Madelung disease: Multiple symmetric lipomatosis. Ear Nose Throat J. 93:94–96. 2014.PubMed/NCBI

5 

Esteban J, úlvez L, Perelló Aragonés S and Bargalló X Aguilar: Sleep apnea-hypopnea syndrome and multiple symmetrical lipomatosis. Arch Bronconeumol. 49:86–87. 2013.(In English, Spanish). View Article : Google Scholar : PubMed/NCBI

6 

Ardeleanu V, Chicos S, Georgescu C and Tutunaru D: Multiple benign symmetric lipomatosis-a differential diagnosis of obesity. Chirurgia (Bucur). 108:580–583. 2013.PubMed/NCBI

7 

Yeh NC, Yang CY, Chou CW, Yen FC, Lee SY and Tien KJ: Madelung's disease. J Clin Endocrinol Metab. 97:3012–3013. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Tadisina KK, Mlynek KS, Hwang LK, Riazi H, Papay FA and Zins JE: Syndromic lipomatosis of the head and neck: A review of the literature. Aesthetic Plast Surg. 39:440–448. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Haap M, Siewecke C, Thamer C, Machann J, Schick F, Häring HU, Szeimies RM and Stumvoll M: Multiple symmetric lipomatosis: A paradigm of metabolically innocent obesity? Diabetes Care. 27:794–795. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Chen K, Xie Y, Hu P, Zhao S and Mo Z: Multiple Symmetric Lipomatosis: Substantial subcutaneous adipose tissue accumulation did not induce glucose and lipid metabolism dysfunction. Ann Nutr Metab. 57:68–73. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Cojocaru DC, Cozma CD and Postolache P: Markers of insulin resistance in a case of Launois-Bensaude syndrome. Rev Med Chir Soc Med Nat Iasi. 117:404–408. 2013.PubMed/NCBI

12 

Brea-García B, Cameselle-Teijeiro J, Couto-González I, Taboada-Suárez A and González-Álvarez E: Madelung's disease: Comorbidities, fatty mass distribution and response to treatment of 22 patients. Aesthetic Plast Surg. 37:409–416. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Heike Z, Gudrun UM, Frank RD, Vetter H and Walger P: Multiple benign symmetric lipomatosis-a differential diagnosis of obesity: Is there a rationale for fibrate treatment? Obes Surg. 18:240–242. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Verhelle NA, Nizet JL, van den Hof B, Guelinckx P and Heymans O: Liposuction in benign symmetric lipomatosis: Sense or senseless? Aesthetic Plast Surg. 27:319–321. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Enzi G, Busetto L, Sergi G, Coin A, Inelmen EM, Vindigni V, Bassetto F and Cinti S: Multiple symmetric lipomatosis: A rare disease and its possible links to brown adipose tissue. Nutr Metab Cardiovasc Dis. 25:347–353. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Ballester S, ánchez R, Mira MÁ Navarro, Marco C Pujol and Estrada R Botella: Symmetric benign lipomatosis: Madelung syndrome. Med Clin (Barc). 141:366–367. 2013.(In Spanish). View Article : Google Scholar : PubMed/NCBI

17 

Kobayashi J, Nagao M, Miyamoto K and Matsubara S: MERRF syndrome presenting with multiple symmetric lipomatosis in a Japanese patient. Intern Med. 49:479–482. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Schoffer K and Grant I: Multiple lipomas, alcoholism, and neuropathy: Madelung's disease or MERRF? Muscle Nerve. 33:142–146. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Nisoli E, Regianini L, Briscini L, Bulbarelli A, Busetto L, Coin A, Enzi G and Carruba MO: Multiple symmetric lipomatosis may be the consequence of defective noradrenergic modulation of proliferation and differentiation of brown fat cells. J Pathol. 198:378–387. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Plummer C, Spring PJ, Marotta R, Chin J, Taylor G, Sharpe D, Athanasou NA, Thyagarajan D and Berkovic SF: Multiple symmetrical lipomatosis-a mitochondrial disorder of brown fat. Mitochondrion. 13:269–276. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Prantl L, Schreml J, Gehmert S, Klein S, Bai X, Zeitler K, Schreml S, Alt E, Gehmert S and Felthaus O: Transcription profile in sporadic multiple symmetric lipomatosis reveals differential expression at the level of adipose tissue-derived stem cells. Plast Reconstr Surg. 137:1181–1190. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Chen K, He H, Xie Y, Zhao L, Zhao S, Wan X, Yang W and Mo Z: miR-125a-3p and miR-483-5p promote adipogenesis via suppressing the RhoA/ROCK1/ERK1/2 pathway in multiple symmetric lipomatosis. Sci Rep. 5:119092015. View Article : Google Scholar : PubMed/NCBI

23 

Wang L, Feng Z, Wang X, Wang X and Zhang X: DEGseq: An Rpackage for identifying differentially expressed genes from RNA-seq data. Bioinformatics. 26:136–138. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Benjamini Y and Hochberg Y: Controlling the false discovery rate: A practical and powerful approach to multipletesting. J R Statist Soc. 57:289–300. 1995.

25 

Mao X, Cai T, Olyarchuk JG and Wei L: Automated genome annotation and pathway identification using the KEGG Orthology (KO) as a controlled vocabulary. Bioinformatics. 21:3787–3793. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Kanehisa M, Araki M, Goto S, Hattori M, Hirakawa M, Itoh M, Katayama T, Kawashima S, Okuda S, Tokimatsu T and Yamanishi Y: KEGG for linking genomes to life and the environment. Nucleic Acids Res. 36(Database Issue): D480–D484. 2008.PubMed/NCBI

27 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Harsch IA, Bergmann T, Koebnick C, Wiedmann R, Ruderich F, Hahn EG and Konturek PC: Adiponectin, resistin and subclinical inflammation-the metabolic burden in Launois Bensaude Syndrome, a rare form of obesity. J Physiol Pharmacol. 58 Suppl 1:S65–S76. 2007.

29 

Ouchi N: Adipocytokines in cardiovascular and metabolic diseases. J Atheroscler Thromb. 23:645–654. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Matsuzawa Y: Therapy insight: Adipocytokines in metabolic syndrome and related cardiovascular disease. Nat Clin Pract Cardiovasc Med. 3:35–42. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Ryu KY, Maehr R, Gilchrist CA, Long MA, Bouley DM, Mueller B, Ploegh HL and Kopito RR: The mouse polyubiquitin gene UbC is essential for fetal liver development, cell-cycle progression and stress tolerance. EMBO J. 26:2693–2706. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Dikic I, Wakatsuki S and Walters KJ: Ubiquitin-binding domains-from structures to functions. Nat Rev Mol Cell Biol. 10:659–671. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Ciechanover A: Intracellular protein degradation: From a vague idea through the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting. Neurodegener Dis. 10:7–22. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Wójcik C, Lohe K, Kuang C, Xiao Y, Jouni Z and Poels E: Modulation of adipocyte differentiation by omega-3 polyunsaturated fatty acids involves the ubiquitin-proteasome system. J Cell Mol Med. 18:590–599. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Santoro A, Raso G Mattace, Taliani S, Da Pozzo E, Simorini F, Costa B, Martini C, Laneri S, Sacchi A, Cosimelli B, et al: TSPO-ligands prevent oxidative damage and inflammatory response in C6 glioma cells by neurosteroid synthesis. Eur J Pharm Sci. 88:124–131. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Wyatt SK, Manning HC, Bai M, Ehtesham M, Mapara KY, Thompson RC and Bornhop DJ: Preclinical molecular imaging of the translocator protein (TSPO) in a metastases model based on breast cancer xenografts propagated in the murine brain. Curr Mol Med. 12:458–466. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Repalli J: Translocator protein (TSPO) role in aging and Alzheimer's disease. Curr Aging Sci. 7:168–175. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Cumming P and Borghammer P: Molecular imaging and the neuropathologies of Parkinson's disease. Curr Top Behav Neurosci. 11:117–148. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Qi X, Xu J, Wang F and Xiao J: Translocator protein (18 kDa): A promising therapeutic target and diagnostic tool for cardiovascular diseases. Oxid Med Cell Longev. 2012:1629342012. View Article : Google Scholar : PubMed/NCBI

40 

Li F, Liu J, Liu N, Kuhn LA, Garavito RM and Ferguson-Miller S: Protein 18 kDa (TSPO): An Old protein with new functions? Biochemistry. 55:2821–2831. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Dimitrova-Shumkovska J, Veenman L, Ristoski T, Leschiner S and Gavish M: Chronic high fat, high cholesterol supplementation decreases 18 kDa translocator protein binding capacity in association with increased oxidative stress in rat liver and aorta. Food Chem Toxicol. 48:910–921. 2010. View Article : Google Scholar : PubMed/NCBI

42 

Lecanu L, Yao ZX, McCourty A, Sidahmed el-K, Orellana ME, Burnier MN and Papadopoulos V: Control of hypercholesterolemia and atherosclerosis using the cholesterol recognition/interaction amino acid sequence of the translocator protein TSPO. Steroids. 78:137–146. 2013. View Article : Google Scholar : PubMed/NCBI

43 

Wagner EF and Eferl R: Fos/AP-1 proteins in bone and the immune system. Immunol Rev. 208:126–140. 2005. View Article : Google Scholar : PubMed/NCBI

44 

Kveiborg M, Sabatakos G, Chiusaroli R, Wu M, Philbrick WM, Horne WC and Baron R: DeltaFosB induces osteosclerosis and decreases adipogenesis by two independent cell-autonomous mechanisms. Mol Cell Biol. 24:2820–2830. 2004. View Article : Google Scholar : PubMed/NCBI

45 

Luther J, Driessler F, Megges M, Hess A, Herbort B, Mandic V, Zaiss MM, Reichardt A, Zech C, Tuckermann JP, et al: Elevated Fra-1 expression causes severe lipodystrophy. J Cell Sci. 124:1465–1476. 2011. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Chen K, Wang L, Yang W, Wang C, Hu G and Mo Z: Profiling of differentially expressed genes in adipose tissues of multiple symmetric lipomatosis. Mol Med Rep 16: 6570-6579, 2017.
APA
Chen, K., Wang, L., Yang, W., Wang, C., Hu, G., & Mo, Z. (2017). Profiling of differentially expressed genes in adipose tissues of multiple symmetric lipomatosis. Molecular Medicine Reports, 16, 6570-6579. https://doi.org/10.3892/mmr.2017.7437
MLA
Chen, K., Wang, L., Yang, W., Wang, C., Hu, G., Mo, Z."Profiling of differentially expressed genes in adipose tissues of multiple symmetric lipomatosis". Molecular Medicine Reports 16.5 (2017): 6570-6579.
Chicago
Chen, K., Wang, L., Yang, W., Wang, C., Hu, G., Mo, Z."Profiling of differentially expressed genes in adipose tissues of multiple symmetric lipomatosis". Molecular Medicine Reports 16, no. 5 (2017): 6570-6579. https://doi.org/10.3892/mmr.2017.7437
Copy and paste a formatted citation
x
Spandidos Publications style
Chen K, Wang L, Yang W, Wang C, Hu G and Mo Z: Profiling of differentially expressed genes in adipose tissues of multiple symmetric lipomatosis. Mol Med Rep 16: 6570-6579, 2017.
APA
Chen, K., Wang, L., Yang, W., Wang, C., Hu, G., & Mo, Z. (2017). Profiling of differentially expressed genes in adipose tissues of multiple symmetric lipomatosis. Molecular Medicine Reports, 16, 6570-6579. https://doi.org/10.3892/mmr.2017.7437
MLA
Chen, K., Wang, L., Yang, W., Wang, C., Hu, G., Mo, Z."Profiling of differentially expressed genes in adipose tissues of multiple symmetric lipomatosis". Molecular Medicine Reports 16.5 (2017): 6570-6579.
Chicago
Chen, K., Wang, L., Yang, W., Wang, C., Hu, G., Mo, Z."Profiling of differentially expressed genes in adipose tissues of multiple symmetric lipomatosis". Molecular Medicine Reports 16, no. 5 (2017): 6570-6579. https://doi.org/10.3892/mmr.2017.7437
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team