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Article

CXC chemokine‑7 inhibits growth and migration of oral tongue squamous cell carcinoma cells, mediated by the epithelial‑mesenchymal transition signaling pathway

  • Authors:
    • Tong‑Jun Liu
    • Jian‑Lian Guo
    • Xin Xu
  • View Affiliations / Copyright

    Affiliations: Department of Implantology, Shandong Provincial Key Laboratory of Oral Biomedicine, School of Stomatology, Shandong University, Jinan, Shandong 250012, P.R. China, Department of Ophthalmology, The Eighth People's Hospital of Jinan, Jinan, Shandong 250014, P.R. China
  • Pages: 6896-6903
    |
    Published online on: September 8, 2017
       https://doi.org/10.3892/mmr.2017.7441
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Abstract

Oral tongue squamous cell carcinoma (OTSCC) is the most common oral malignancy with different histopathological symptoms and etiology of tumorigenesis. Migration and invasion is the most important characteristics of OTSCC, and limits tumor therapy in clinics. The epithelial‑to‑mesenchymal transition (EMT) signaling pathway is an important process in the progress of tumor cell migration and invasion. Previous studies have indicated that C‑X‑C chemokine receptor‑7 (CXCR‑7) promotes the progression and metastasis of tumor cells, presenting a potential target molecule for cancer therapy. The present study investigated the inhibitory effects of C‑X‑C chemokine‑7 (CXC‑7) on human OTSCC cells both in vitro and in vivo. The results demonstrated that the Tca8113 human OTSCC cell line expressed higher levels of CXC‑7 mRNA compared with the hNOE human normal oral epithelial cell line. MTT assays indicated that CXC‑7 suppressed Tca8113 cell growth, and the cytotoxicity of CXC‑7 was indicated as the cell survival of the negative control group was significantly decreased compared with the blank control and hNOE cells. Migration and invasion assays revealed that CXC‑7 inhibited Tca8113 cell local expansion and distant metastasis. In addition, the results demonstrated that the extracellular signal‑regulated kinase (ERK)/protein kinase B (AKT) signaling pathway was inhibited after CXC‑7 treatment in Tca8113 cells. N‑cadherin, E‑Cadherin, Snail and Slug expression levels in the ERK/AKT signaling pathway were inhibited in Tca8113 cells after treatment with CXC‑7. It was demonstrated that important extracellular matrix proteins involved in cell migration, including Slug, collagen type I and Vimentin, were significantly downregulated by CXC‑7 treatment. In conclusion, CXC‑7 inhibited growth and migration in OTSCC cells, mediated by the EMT signaling pathway. This suggests that CXC‑7 serves an inhibitory role in OTSCC migration, implicating CXCR‑7 as a promising biomarker for chemokine receptor‑based drug development.
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View References

1 

Dik EA, Willems SM, Ipenburg NA, Rosenberg AJ, Van Cann EM and van Es RJ: Watchful waiting of the neck in early stage oral cancer is unfavourable for patients with occult nodal disease. Int J Oral Maxillofac Surg. 45:945–950. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Kolokythas A, Park S, Schlieve T, Pytynia K and Cox D: Squamous cell carcinoma of the oral tongue: Histopathological parameters associated with outcome. Int J Oral Maxillofac Surg. 44:1069–1074. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Bhartiya D, Kumar A, Singh H, Sharma A, Kaushik A, Kumari S and Mehrotra R: OrCanome: A comprehensive resource for oral cancer. Asian Pac J Cancer Prev. 17:1333–1336. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Wong WM, Parvathaneni U, Jewell PD, Martins RG, Futran ND, Laramore GE and Liao JJ: Squamous cell carcinoma of the oral tongue in a patient with Fanconi anemia treated with radiotherapy and concurrent cetuximab: A case report and review of the literature. Head Neck. 35:E292–298. 2013.PubMed/NCBI

5 

Amichetti M: Squamous cell carcinoma of the oral tongue in patients less than fifteen years of age. Report of a case and review of the literature. J Craniomaxillofac Surg. 17:75–77. 1989. View Article : Google Scholar : PubMed/NCBI

6 

Martínez C, Hernández M, Martínez B and Adorno D: Frequency of oral squamous cell carcinoma and oral epithelial dysplasia in oral and oropharyngeal mucosa in Chile. Rev Med Chil. 144:169–174. 2016.(In Spanish). View Article : Google Scholar : PubMed/NCBI

7 

Shrestha A, Marla V, Shrestha S and Agrawal D: Awareness of undergraduate dental and medical students towards oral cancer. J Cancer Educ. Mar 28–2016.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

8 

Matsumoto K, Sasaki T, Shioyama Y, Nakamura K, Atsumi K, Nonoshita T, Ooga S, Yoshitake T, Uehara S, Hirata H and Honda H: Treatment outcome of high-dose-rate interstitial radiation therapy for patients with stage I and II mobile tongue cancer. Jpn J Clin Oncol. 43:1012–1017. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Hirota K, Wakisaka N, Sawada-Kitamura S, Kondo S, Endo K, Tsuji A, Murono S and Yoshizaki T: Lymphangiogenesis in regional lymph nodes predicts nodal recurrence in pathological N0 squamous cell carcinoma of the tongue. Histopathology. 61:1065–1071. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Mehrotra R and Yadav S: Oral squamous cell carcinoma: Etiology, pathogenesis and prognostic value of genomic alterations. Indian J Cancer. 43:60–66. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Yates TJ, Knapp J, Gosalbez M, Lokeshwar SD, Gomez CS, Benitez A, Ekwenna OO, Young EE, Manoharan M and Lokeshwar VB: C-X-C chemokine receptor 7: A functionally associated molecular marker for bladder cancer. Cancer. 119:61–71. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Wang Y, Fu W, Zhang S, He X, Liu Z, Gao D and Xu T: CXCR-7 receptor promotes SDF-1α-induced migration of bone marrow mesenchymal stem cells in the transient cerebral ischemia/reperfusion rat hippocampus. Brain Res. 1575:78–86. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Wang J, Shiozawa Y, Wang J, Wang Y, Jung Y, Pienta KJ, Mehra R, Loberg R and Taichman RS: The role of CXCR7/RDC1 as a chemokine receptor for CXCL12/SDF-1 in prostate cancer. J Biol Chem. 283:4283–4294. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Tang T, Xia QJ, Qiao X and Xi M: Expression of C-X-C chemokine receptor type 7 in otorhinolaryngologic neoplasms. Singapore Med J. 57:157–160. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Ma Y, Liu H, Zhang H and Shao RG: The TGF-β signaling pathway induced EMT in breast cancer. Yao Xue Xue Bao. 50:385–392. 2015.(In Chinese). PubMed/NCBI

16 

Elsum IA, Martin C and Humbert PO: Scribble regulates an EMT polarity pathway through modulation of MAPK-ERK signaling to mediate junction formation. J Cell Sci. 126:3990–3999. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Gu K, Li MM, Shen J, Liu F, Cao JY, Jin S and Yu Y: Interleukin-17-induced EMT promotes lung cancer cell migration and invasion via NF-κB/ZEB1 signal pathway. Am J Cancer Res. 5:1169–1179. 2015.PubMed/NCBI

18 

David CJ, Huang YH, Chen M, Su J, Zou Y, Bardeesy N, Iacobuzio-Donahue CA and Massagué J: TGF-β tumor suppression through a lethal EMT. Cell. 164:1015–1030. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Attramadal CG, Kumar S, Boysen ME, Dhakal HP, Nesland JM and Bryne M: Tumor budding, EMT and cancer stem cells in T1-2/N0 oral squamous cell carcinomas. Anticancer Res. 35:6111–6120. 2015.PubMed/NCBI

20 

Li Y, Ma J, Qian X, Wu Q, Xia J, Miele L, Sarkar FH and Wang Z: Regulation of EMT by notch signaling pathway in tumor progression. Curr Cancer Drug Targets. 13:957–962. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Mitra A, Mishra L and Li S: EMT, CTCs and CSCs in tumor relapse and drug-resistance. Oncotarget. 6:10697–10711. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Sawicka D, Chojnacka-Puchta L, Zielinski M, Plucienniczak G, Plucienniczak A and Bednarczyk M: Flow cytometric analysis of apoptosis in cryoconserved chicken primordial germ cells. Cell Mol Biol Lett. 20:143–159. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Pouessel D, Neuzillet Y, Mertens LS, Van Der Heijden MS, de Jong J, Sanders J, Peters D, Leroy K, Manceau A and Maille P: Tumor heterogeneity of fibroblast growth factor receptor 3 (FGFR3) mutations in invasive bladder cancer: Implications for perioperative anti-FGFR3 treatment. Ann Oncol. 27:1311–1316. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Allegra M, Zaragkoulias A, Vorgia E, Ioannou M, Litos G, Beug H and Mavrothalassitis G: Semaphorin-7a reverses the ERF-induced inhibition of EMT in ras-dependent mouse mammary epithelial cells. Mol Biol Cell. 23:3873–3881. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Goepfert RP, Kezirian EJ and Wang SJ: Oral tongue squamous cell carcinoma in young women: A matched comparison-do outcomes justify treatment intensity? ISRN otolaryngol 2014. 5293952014.

27 

Fan KH, Lin CY, Kang CJ, Huang SF, Wang HM, Chen EY, Chen IH, Liao CT, Cheng AJ and Chang JT: Combined-modality treatment for advanced oral tongue squamous cell carcinoma. Int J Radiat Oncol Biol Phys. 67:453–461. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Lim YC, Lee JS, Koo BS, Kim SH, Kim YH and Choi EC: Treatment of contralateral N0 neck in early squamous cell carcinoma of the oral tongue: Elective neck dissection versus observation. Laryngoscope. 116:461–465. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Schiff BA, Roberts DB, El-Naggar A, Garden AS and Myers JN: Selective vs modified radical neck dissection and postoperative radiotherapy vs observation in the treatment of squamous cell carcinoma of the oral tongue. Arch Otolaryngol Head Neck Surg. 131:874–878. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Abu-Serriah M, Shah KA, Rajamanohara R, Fasanmade A, Graystone J, Gerry S and Bond S: Tumour depth of invasion of pT1 squamous cell carcinoma of the oral tongue and risk of pathologically detected neck metastases. Head Neck. Jun 3–2015.(Epub ahead of print). PubMed/NCBI

31 

Helal HH, Qi CE, Zhao YY, Yao CS and Li de C: The effects of combination of gefitinib and cisplatin on tongue squamous cell carcinoma cell lines. J Cancer Res Ther. 11:37–40. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Vandercappellen J, Van Damme J and Struyf S: The role of CXC chemokines and their receptors in cancer. Cancer Lett. 267:226–244. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Bernatoniene J, Zhang Q, Dogan S, Mitchell TJ, Paton JC and Finn A: Induction of CC and CXC chemokines in human antigen-presenting dendritic cells by the pneumococcal proteins pneumolysin and CbpA, and the role played by toll-like receptor 4, NF-kappaB, and mitogen-activated protein kinases. J Infect Dis. 198:1823–1833. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Maksym RB, Tarnowski M, Grymula K, Tarnowska J, Wysoczynski M, Liu R, Czerny B, Ratajczak J, Kucia M and Ratajczak MZ: The role of stromal-derived factor-1-CXCR7 axis in development and cancer. Eur J Pharmacol. 625:31–40. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Shakeel Uz Zaman, Adeel M and Suhail A: Squamous cell carcinoma of oral tongue in young patients-A 10 years tertiary care experience. J Pak Med Assoc. 66:155–158. 2016.PubMed/NCBI

36 

Zheng M, Jiang YP, Chen W, Li KD, Liu X, Gao SY, Feng H, Wang SS, Jiang J and Ma XR: Snail and Slug collaborate on EMT and tumor metastasis through miR-101-mediated EZH2 axis in oral tongue squamous cell carcinoma. Oncotarget. 6:6797–6810. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Ren ZH, Wu HJ, Zhang S, Wang K, Gong ZJ, He ZJ and Peng J: A new surgical strategy for treatment of tongue squamous cell carcinoma based on anatomic study with preliminary clinical evaluation. J Craniomaxillofac Surg. 43:1577–1582. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Keski-Säntti H, Atula T, Törnwall J, Koivunen P and Mäkitie A: Elective neck treatment versus observation in patients with T1/T2 N0 squamous cell carcinoma of oral tongue. Oral Oncol. 42:96–101. 2006. View Article : Google Scholar : PubMed/NCBI

39 

Umeda M, Komatsubara H, Ojima Y, Minamikawa T, Shibuya Y, Yokoo S, Ishii J and Komori T: A comparison of brachytherapy and surgery for the treatment of stage I–II squamous cell carcinoma of the tongue. Int J Oral Maxillofac Surg. 34:739–744. 2005. View Article : Google Scholar : PubMed/NCBI

40 

Wang Z, Li Y, Kong D and Sarkar FH: The role of Notch signaling pathway in epithelial-mesenchymal transition (EMT) during development and tumor aggressiveness. Curr Drug Targets. 11:745–751. 2010. View Article : Google Scholar : PubMed/NCBI

41 

de Ridder M, Verovski VN, van den Berge DL, Sermeus AB, Monsaert C, Wauters N and Storme GA: Lipid a radiosensitizes hypoxic EMT-6 tumor cells: Role of the NF-kappaB signaling pathway. Int J Radiat Oncol Biol Phys. 57:779–786. 2003. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu TJ, Guo JL and Xu X: CXC chemokine‑7 inhibits growth and migration of oral tongue squamous cell carcinoma cells, mediated by the epithelial‑mesenchymal transition signaling pathway. Mol Med Rep 16: 6896-6903, 2017.
APA
Liu, T., Guo, J., & Xu, X. (2017). CXC chemokine‑7 inhibits growth and migration of oral tongue squamous cell carcinoma cells, mediated by the epithelial‑mesenchymal transition signaling pathway. Molecular Medicine Reports, 16, 6896-6903. https://doi.org/10.3892/mmr.2017.7441
MLA
Liu, T., Guo, J., Xu, X."CXC chemokine‑7 inhibits growth and migration of oral tongue squamous cell carcinoma cells, mediated by the epithelial‑mesenchymal transition signaling pathway". Molecular Medicine Reports 16.5 (2017): 6896-6903.
Chicago
Liu, T., Guo, J., Xu, X."CXC chemokine‑7 inhibits growth and migration of oral tongue squamous cell carcinoma cells, mediated by the epithelial‑mesenchymal transition signaling pathway". Molecular Medicine Reports 16, no. 5 (2017): 6896-6903. https://doi.org/10.3892/mmr.2017.7441
Copy and paste a formatted citation
x
Spandidos Publications style
Liu TJ, Guo JL and Xu X: CXC chemokine‑7 inhibits growth and migration of oral tongue squamous cell carcinoma cells, mediated by the epithelial‑mesenchymal transition signaling pathway. Mol Med Rep 16: 6896-6903, 2017.
APA
Liu, T., Guo, J., & Xu, X. (2017). CXC chemokine‑7 inhibits growth and migration of oral tongue squamous cell carcinoma cells, mediated by the epithelial‑mesenchymal transition signaling pathway. Molecular Medicine Reports, 16, 6896-6903. https://doi.org/10.3892/mmr.2017.7441
MLA
Liu, T., Guo, J., Xu, X."CXC chemokine‑7 inhibits growth and migration of oral tongue squamous cell carcinoma cells, mediated by the epithelial‑mesenchymal transition signaling pathway". Molecular Medicine Reports 16.5 (2017): 6896-6903.
Chicago
Liu, T., Guo, J., Xu, X."CXC chemokine‑7 inhibits growth and migration of oral tongue squamous cell carcinoma cells, mediated by the epithelial‑mesenchymal transition signaling pathway". Molecular Medicine Reports 16, no. 5 (2017): 6896-6903. https://doi.org/10.3892/mmr.2017.7441
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