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Article

MicroRNA‑373 promotes tumorigenesis of renal cell carcinoma in vitro and in vivo

  • Authors:
    • Yanli Li
    • Da Zhang
    • Jiaxiang Wang
  • View Affiliations / Copyright

    Affiliations: Department of Pediatric Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
  • Pages: 7048-7055
    |
    Published online on: September 8, 2017
       https://doi.org/10.3892/mmr.2017.7443
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Abstract

Renal cell carcinoma (RCC) is the most common type of malignancy in the kidney parenchyma. MicroRNAs (miRNAs) are small non‑coding RNAs that serve a role in various biological processes associated with human cancer. The present study aimed to explore the potential role of miRNA (miR)‑373 in the tumorigenesis of RCC. The effects of miR‑373 on the proliferation and apoptosis of RCC cells were determined using MTT, colony formation and flow cytometry assays in vitro. The results demonstrated that miR‑373 was significantly upregulated in RCC tissues and cell lines. Knockdown of miR‑373 expression reduced cell proliferation and promoted cell apoptosis in 786‑O and ACHN cell lines. Furthermore, an in vivo tumorigenicity assay revealed that knockdown of miR‑373 expression reduced tumor growth in nude mice. Taken together, these data indicate that miR‑373 may promote tumorigenesis in RCC, suggesting that miR‑373 may act as a potential therapeutic target against RCC.
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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Zhang D and Wang J: MicroRNA‑373 promotes tumorigenesis of renal cell carcinoma in vitro and in vivo. Mol Med Rep 16: 7048-7055, 2017.
APA
Li, Y., Zhang, D., & Wang, J. (2017). MicroRNA‑373 promotes tumorigenesis of renal cell carcinoma in vitro and in vivo. Molecular Medicine Reports, 16, 7048-7055. https://doi.org/10.3892/mmr.2017.7443
MLA
Li, Y., Zhang, D., Wang, J."MicroRNA‑373 promotes tumorigenesis of renal cell carcinoma in vitro and in vivo". Molecular Medicine Reports 16.5 (2017): 7048-7055.
Chicago
Li, Y., Zhang, D., Wang, J."MicroRNA‑373 promotes tumorigenesis of renal cell carcinoma in vitro and in vivo". Molecular Medicine Reports 16, no. 5 (2017): 7048-7055. https://doi.org/10.3892/mmr.2017.7443
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Zhang D and Wang J: MicroRNA‑373 promotes tumorigenesis of renal cell carcinoma in vitro and in vivo. Mol Med Rep 16: 7048-7055, 2017.
APA
Li, Y., Zhang, D., & Wang, J. (2017). MicroRNA‑373 promotes tumorigenesis of renal cell carcinoma in vitro and in vivo. Molecular Medicine Reports, 16, 7048-7055. https://doi.org/10.3892/mmr.2017.7443
MLA
Li, Y., Zhang, D., Wang, J."MicroRNA‑373 promotes tumorigenesis of renal cell carcinoma in vitro and in vivo". Molecular Medicine Reports 16.5 (2017): 7048-7055.
Chicago
Li, Y., Zhang, D., Wang, J."MicroRNA‑373 promotes tumorigenesis of renal cell carcinoma in vitro and in vivo". Molecular Medicine Reports 16, no. 5 (2017): 7048-7055. https://doi.org/10.3892/mmr.2017.7443
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