Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
November-2017 Volume 16 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2017 Volume 16 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Apolipoprotein A5 regulates intracellular triglyceride metabolism in adipocytes

  • Authors:
    • Xiao‑Yan Zheng
    • Bi‑Lian Yu
    • Yu‑Fei Xie
    • Shui‑Ping Zhao
    • Chen‑Lu Wu
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China
    Copyright: © Zheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6771-6779
    |
    Published online on: September 11, 2017
       https://doi.org/10.3892/mmr.2017.7461
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

It has previously been demonstrated that apolipoprotein A5 (apoA5) can be internalized by human adipocytes and significantly decreases intracellular triglyceride content. In the present study, endocytosis of apoA5 by adipocytes under different conditions, and the underlying mechanism by which apoA5 regulates cellular triglyceride storage, was investigated. The results revealed that the apoA5 protein was detected in human subcutaneous abdominal adipose tissues. In addition, the uptake of apoA5 was attenuated in human obese adipose tissues and in cultured adipocytes with hypertrophy or insulin resistance. Low‑density lipoprotein receptor protein 1 (LRP1) knockdown in adipocytes resulted in a decrease in internalized apoA5 content, suggesting that LRP1 serves a role in apoA5 uptake. Treatment of adipocytes with apoA5 decreased the expression of the lipid droplet‑associated proteins such as cidec and perilipin. ApoA5‑treated adipocytes demonstrated an increase in lipolysis activity and expression of uncoupling protein 1, which is the molecular effector of thermogenesis in brown adipocytes. These results suggested that decreased triglyceride accumulation in adipocytes induced by apoA5 may be associated with enhanced lipolysis and energy expenditure, which may result from reduced expression of cidec and perilipin. In conclusion, the present study demonstrated a novel role of apoA5 in regulating the intracellular triglyceride metabolism of adipocytes. The results of the present study suggested that apoA5 may serve as a potential therapeutic target for the treatment of obesity and its related disorders.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

View References

1 

Wong K and Ryan RO: Characterization of apolipoprotein A-V structure and mode of plasma triacylglycerol regulation. Curr Opin Lipidol. 18:319–324. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Horvatovich K, Bokor S, Baráth A, Maász A, Kisfali P, Járomi L, Polgár N, Tóth D, Répásy J, Endreffy E, et al: Haplotype analysis of the apolipoprotein A5 gene in obese pediatric patients. Int J Pediatr Obes. 6:e318–e325. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Niculescu LS, Fruchart-Najib J, Fruchart JC and Sima A: Apolipoprotein A-V gene polymorphisms in subjects with metabolic syndrome. Clin Chem Lab Med. 45:1133–1139. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Zheng XY, Zhao SP and Yan H: The role of apolipoprotein A5 in obesity and the metabolic syndrome. Biol Rev Camb Philos Soc. 88:490–498. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Huang XS, Zhao SP, Hu M, Bai L, Zhang Q and Zhao W: Decreased apolipoprotein A5 is implicated in insulin resistance-related hypertriglyceridemia in obesity. Atherosclerosis. 210:563–568. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Zhao SP, Hu S, Li J, Hu M, Liu Q, Wu LJ and Zhang T: Association of human serum apolipoprotein A5 with lipid profiles affected by gender. Clin Chim Acta. 376:68–71. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Corella D, Lai CQ, Demissie S, Cupples LA, Manning AK, Tucker KL and Ordovas JM: APOA5 gene variation modulates the effects of dietary fat intake on body mass index and obesity risk in the Framingham Heart Study. J Mol Med (Berl). 85:119–128. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Martin S, Nicaud V, Humphries SE and Talmud PJ; EARS group, : Contribution of APOA5 gene variants to plasma triglyceride determination and to the response to both fat and glucose tolerance challenges. Biochim Biophys Acta. 1637:217–225. 2003. View Article : Google Scholar : PubMed/NCBI

9 

Shu X, Chan J, Ryan RO and Forte TM: Apolipoprotein A-V association with intracellular lipid droplets. J Lipid Res. 48:1445–1450. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Shu X, Nelbach L, Ryan RO and Forte TM: Apolipoprotein A-V associates with intrahepatic lipid droplets and influences triglyceride accumulation. Biochim Biophys Acta. 1801:605–608. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Ress C, Moschen AR, Sausgruber N, Tschoner A, Graziadei I, Weiss H, Schgoer W, Ebenbichler CF, Konrad RJ, Patsch JR, et al: The role of apolipoprotein A5 in non-alcoholic fatty liver disease. Gut. 60:985–991. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Zheng XY, Zhao SP, Yu BL, Wu CL and Liu L: Apolipoprotein A5 internalized by human adipocytes modulates cellular triglyceride content. Biol Chem. 393:161–167. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Nilsson SK, Christensen S, Raarup MK, Ryan RO, Nielsen MS and Olivecrona G: Endocytosis of apolipoprotein A-V by members of the low density lipoprotein receptor and the VPS10p domain receptor families. J Biol Chem. 283:25920–25927. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Farese RV Jr and Walther TC: Lipid droplets finally get a little R-E-S-P-E-C-T. Cell. 139:855–860. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Wolins NE, Brasaemle DL and Bickel PE: A proposed model of fat packaging by exchangeable lipid droplet proteins. FEBS Lett. 580:5484–5491. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Brasaemle DL: Thematic review series: Adipocyte biology. The perilipin family of structural lipid droplet proteins: Stabilization of lipid droplets and control of lipolysis. J Lipid Res. 48:2547–2559. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Souza SC, Muliro KV, Liscum L, Lien P, Yamamoto MT, Schaffer JE, Dallal GE, Wang X, Kraemer FB, Obin M and Greenberg AS: Modulation of hormone-sensitive lipase and protein kinase A-mediated lipolysis by perilipin A in an adenoviral reconstituted system. J Biol Chem. 277:8267–8272. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Tansey JT, Sztalryd C, Gruia-Gray J, Roush DL, Zee JV, Gavrilova O, Reitman ML, Deng CX, Li C, Kimmel AR and Londos C: Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity. Proc Natl Acad Sci USA. 98:6494–6499. 2001; View Article : Google Scholar : PubMed/NCBI

19 

Martinez-Botas J, Anderson JB, Tessier D, Lapillonne A, Chang BH, Quast MJ, Gorenstein D, Chen KH and Chan L: Absence of perilipin results in leanness and reverses obesity in Lepr(db/db) mice. Nat Genet. 26:474–479. 2000. View Article : Google Scholar : PubMed/NCBI

20 

Keller P, Petrie JT, De Rose P, Gerin I, Wright WS, Chiang SH, Nielsen AR, Fischer CP, Pedersen BK and MacDougald OA: Fat-specific protein 27 regulates storage of triacylglycerol. J Biol Chem. 283:14355–14365. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Puri V, Konda S, Ranjit S, Aouadi M, Chawla A, Chouinard M, Chakladar A and Czech MP: Fat-specific protein 27, a novel lipid droplet protein that enhances triglyceride storage. J Biol Chem. 282:34213–34218. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Nishino N, Tamori Y, Tateya S, Kawaguchi T, Shibakusa T, Mizunoya W, Inoue K, Kitazawa R, Kitazawa S, Matsuki Y, et al: FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets. J Clin Invest. 118:2808–2821. 2008.PubMed/NCBI

23 

Toh SY, Gong J, Du G, Li JZ, Yang S, Ye J, Yao H, Zhang Y, Xue B, Li Q, et al: Up-regulation of mitochondrial activity and acquirement of brown adipose tissue-like property in the white adipose tissue of fsp27 deficient mice. PLoS One. 3:e28902008. View Article : Google Scholar : PubMed/NCBI

24 

Matsusue K: A physiological role for fat specific protein 27/cell death-inducing DFF45-like effector C in adipose and liver. Biol Pharm Bull. 33:346–350. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Inohara N, Koseki T, Chen S, Wu X and Núñez G: CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor. EMBO J. 17:2526–2533. 1998. View Article : Google Scholar : PubMed/NCBI

26 

Magnusson B, Gummesson A, Glad CA, Goedecke JH, Jernås M, Lystig TC, Carlsson B, Fagerberg B, Carlsson LM and Svensson PA: Cell death-inducing DFF45-like effector C is reduced by caloric restriction and regulates adipocyte lipid metabolism. Metabolism. 57:1307–1313. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Beckstead JA, Oda MN, Martin DD, Forte TM, Bielicki JK, Berger T, Luty R, Kay CM and Ryan RO: Structure-function studies of human apolipoprotein A-V: A regulator of plasma lipid homeostasis. Biochemistry. 42:9416–9423. 2003. View Article : Google Scholar : PubMed/NCBI

28 

Gauthier B, Robb M and McPherson R: Cholesteryl ester transfer protein gene expression during differentiation of human preadipocytes to adipocytes in primary culture. Atherosclerosis. 142:301–307. 1999. View Article : Google Scholar : PubMed/NCBI

29 

Prawitt J, Niemeier A, Kassem M, Beisiegel U and Heeren J: Characterization of lipid metabolism in insulin-sensitive adipocytes differentiated from immortalized human mesenchymal stem cells. Exp Cell Res. 314:814–824. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Suganami T, Nishida J and Ogawa Y: A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: Role of free fatty acids and tumor necrosis factor alpha. Arterioscler Thromb Vasc Biol. 25:2062–2068. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Suganami T, Tanimoto-Koyama K, Nishida J, Itoh M, Yuan X, Mizuarai S, Kotani H, Yamaoka S, Miyake K, Aoe S, et al: Role of the Toll-like receptor 4/NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages. Arterioscler Thromb Vasc Biol. 27:84–91. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

33 

Samad F, Pandey M, Bell PA and Loskutoff DJ: Insulin continues to induce plasminogen activator inhibitor 1 gene expression in insulin-resistant mice and adipocytes. Mol Med. 6:680–692. 2000.PubMed/NCBI

34 

Rousset S, Alves-Guerra MC, Mozo J, Miroux B, Cassard-Doulcier AM, Bouillaud F and Ricquier D: The biology of mitochondrial uncoupling proteins. Diabetes. 53 Suppl 1:S130–S135. 2004. View Article : Google Scholar : PubMed/NCBI

35 

Cederberg A, Grønning LM, Ahrén B, Taskén K, Carlsson P and Enerbäck S: FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance. Cell. 106:563–573. 2001. View Article : Google Scholar : PubMed/NCBI

36 

Masson O, Chavey C, Dray C, Meulle A, Daviaud D, Quilliot D, Muller C, Valet P and Liaudet-Coopman E: LRP1 receptor controls adipogenesis and is up-regulated in human and mouse obese adipose tissue. PLoS One. 4:e74222009. View Article : Google Scholar : PubMed/NCBI

37 

de Ferranti S and Mozaffarian D: The perfect storm: Obesity, adipocyte dysfunction, and metabolic consequences. Clin Chem. 54:945–955. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Ko KW, Avramoglu RK, McLeod RS, Vukmirica J and Yao Z: The insulin-stimulated cell surface presentation of low density lipoprotein receptor-related protein in 3T3-L1 adipocytes is sensitive to phosphatidylinositide 3-kinase inhibition. Biochemistry. 40:752–759. 2001. View Article : Google Scholar : PubMed/NCBI

39 

Corvera S, Graver DF and Smith RM: Insulin increases the cell surface concentration of alpha 2-macroglobulin receptors in 3T3-L1 adipocytes. Altered transit of the receptor among intracellular endocytic compartments. J Biol Chem. 264:10133–10138. 1989.PubMed/NCBI

40 

Sawada T, Miyoshi H, Shimada K, Suzuki A, Okamatsu-Ogura Y, Perfield JW II, Kondo T, Nagai S, Shimizu C, Yoshioka N, et al: Perilipin overexpression in white adipose tissue induces a brown fat-like phenotype. PLoS One. 5:e140062010. View Article : Google Scholar : PubMed/NCBI

41 

Busiello RA, Savarese S and Lombardi A: Mitochondrial uncoupling proteins and energy metabolism. Front Physiol. 6:362015. View Article : Google Scholar : PubMed/NCBI

42 

Nicholls DG and Locke RM: Thermogenic mechanisms in brown fat. Physiol Rev. 64:1–64. 1984.PubMed/NCBI

43 

Kopecky J, Clarke G, Enerbäck S, Spiegelman B and Kozak LP: Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity. J Clin Invest. 96:2914–2923. 1995. View Article : Google Scholar : PubMed/NCBI

44 

Tiraby C, Tavernier G, Lefort C, Larrouy D, Bouillaud F, Ricquier D and Langin D: Acquirement of brown fat cell features by human white adipocytes. J Biol Chem. 278:33370–33376. 2003. View Article : Google Scholar : PubMed/NCBI

45 

Si Y, Palani S, Jayaraman A and Lee K: Effects of forced uncoupling protein 1 expression in 3T3-L1 cells on mitochondrial function and lipid metabolism. J Lipid Res. 48:826–836. 2007. View Article : Google Scholar : PubMed/NCBI

46 

Oberkofler H, Dallinger G, Liu YM, Hell E, Krempler F and Patsch W: Uncoupling protein gene: Quantification of expression levels in adipose tissues of obese and non-obese humans. J Lipid Res. 38:2125–2133. 1997.PubMed/NCBI

47 

Yang X, Enerbäck S and Smith U: Reduced expression of FOXC2 and brown adipogenic genes in human subjects with insulin resistance. Obes Res. 11:1182–1191. 2003. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zheng XY, Yu BL, Xie YF, Zhao SP and Wu CL: Apolipoprotein A5 regulates intracellular triglyceride metabolism in adipocytes. Mol Med Rep 16: 6771-6779, 2017.
APA
Zheng, X., Yu, B., Xie, Y., Zhao, S., & Wu, C. (2017). Apolipoprotein A5 regulates intracellular triglyceride metabolism in adipocytes. Molecular Medicine Reports, 16, 6771-6779. https://doi.org/10.3892/mmr.2017.7461
MLA
Zheng, X., Yu, B., Xie, Y., Zhao, S., Wu, C."Apolipoprotein A5 regulates intracellular triglyceride metabolism in adipocytes". Molecular Medicine Reports 16.5 (2017): 6771-6779.
Chicago
Zheng, X., Yu, B., Xie, Y., Zhao, S., Wu, C."Apolipoprotein A5 regulates intracellular triglyceride metabolism in adipocytes". Molecular Medicine Reports 16, no. 5 (2017): 6771-6779. https://doi.org/10.3892/mmr.2017.7461
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng XY, Yu BL, Xie YF, Zhao SP and Wu CL: Apolipoprotein A5 regulates intracellular triglyceride metabolism in adipocytes. Mol Med Rep 16: 6771-6779, 2017.
APA
Zheng, X., Yu, B., Xie, Y., Zhao, S., & Wu, C. (2017). Apolipoprotein A5 regulates intracellular triglyceride metabolism in adipocytes. Molecular Medicine Reports, 16, 6771-6779. https://doi.org/10.3892/mmr.2017.7461
MLA
Zheng, X., Yu, B., Xie, Y., Zhao, S., Wu, C."Apolipoprotein A5 regulates intracellular triglyceride metabolism in adipocytes". Molecular Medicine Reports 16.5 (2017): 6771-6779.
Chicago
Zheng, X., Yu, B., Xie, Y., Zhao, S., Wu, C."Apolipoprotein A5 regulates intracellular triglyceride metabolism in adipocytes". Molecular Medicine Reports 16, no. 5 (2017): 6771-6779. https://doi.org/10.3892/mmr.2017.7461
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team