Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
November-2017 Volume 16 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2017 Volume 16 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Protective role of berberine and Coptischinensis extract on T2MD rats and associated islet Rin‑5f cells

  • Authors:
    • Yu‑Yu Jiang
    • Han‑Ming Cui
    • Jia‑Long Wang
    • Hui Liu
    • Meng‑Meng Dang
    • Qiu‑Yan Zhang
    • Fang Yang
    • Jian‑Tao Kou
    • Xiao‑Lin Tong
  • View Affiliations / Copyright

    Affiliations: The Management of Chronic Disease and Rehabilitation Department, Wuxi Medical School, Jiangnan University, Wuxi, Jiangsu 214122, P.R. China, Department of Chinese Traditional Medicine Research and Development Center, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, P.R. China, Department of Traditional Chinese Medicine, College of Pharmacy, Shaanxi University of Traditional Chinese Medicine, Xianyang, Shaanxi 712046, P.R. China, Department of Agriculture and Life Sciences, Ankang University, Ankang, Shaanxi 725000, P.R. China, Department of Orthopedics, Hebei Wen'an Hospital, Langfang, Hebei 065800, P.R. China, Department of Endocrinology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, P.R. China
  • Pages: 6981-6991
    |
    Published online on: September 12, 2017
       https://doi.org/10.3892/mmr.2017.7467
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to compare the different effects of berberine (Ber) and Coptischinensis extract (CCE) on a rat model of type 2 diabetes mellitus (T2DM), and the islet Rin‑5f cell line was used to examine the differences between Ber and CCE and the underlying mechanisms. CCE was extracted and purified prior to analysis. Male Sprague‑Dawley rats were provided with a high‑fat diet to induce insulin resistance prior to injecting with streptozotocinto establish the T2DM model, the T2DM rats were treated with Ber and CCE, and blood samples and pancreatic tissues were obtained and compared to examine T2DM metabolic syndromes among the groups of rats, which included healthy rats, model rats, and model rats treated with Ber and CCE at different doses between 0 and 8 weeks. The protective effects of Ber and CCE on the Rin‑5f islet cell line were also evaluated. The effects on Rin‑5f cell proliferation and cell cycle, glucose‑stimulated insulin release test (GSIS), the anti‑apoptotic effects caused by fat induction, and protein expression levels of poly ADP‑ribose polymerase (PARP‑1) were evaluated. The results showed that the content of the prepared CCE was 96.07% for five alkaloids. When it was used for treatment of the T2DM rats, compared with Ber, metformin and rosiglitazone, the fasting blood glucose, glucosylated serum protein (GSP) and glucose infusion rate indicesin the fasting rats were ameliorated, compared with those in the T2MD rats, with no significant differences between treatment with Ber or CCE and metformin or rosiglitazone. The indices of mean optical density and fasting β‑cell function index (FBCI) were different following treatment with Ber and CCE, compared with those in the model rats, which may have stimulated the pancreatic secretion of insulin. When Ber and CCE were used to examine the protective effects on Rin‑5F cells, it was found that the Rin‑5f cell GSIS, cell cycle, lipotoxic islet cell proliferation and protein expression of PARP‑1 were altered and improved, which may have protected pancreatic islet β‑cells by improving islet β‑cell proliferation and the protein expression of PARP‑1. CCE and Ber exerted similar effects when used for the treatment of T2MD rats, and may have stimulated the pancreatic secretion of insulin through the protective effect on islet β‑cells via improving islet β‑cell proliferation and the protein expression of PARP‑1.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

Figure 10

View References

1 

Mao T, Yan Q, Zhou F and Shen YZ: Isolation and identification of berberine from cell cultures of Coptis chinensis. Chin J Biotechnol. 13:193–199. 1997.PubMed/NCBI

2 

Ríos JL, Francini F and Schinella GR: Natural products for the treatment of Type 2 diabetes mellitus. Planta Med. 81:975–994. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Sun SF, Zhao TT, Zhang HJ, Huang XR, Zhang WK, Zhang L, Yan MH, Dong X, Wang H, Wen YM, et al: Renoprotective effect of berberine on type 2 diabetic nephropathy in rats. Clin Exp Pharmacol Physiol. 42:662–670. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Di Pierro F, Bellone I, Rapacioli G and Putignano P: Clinical role of a fixed combination of standardized Berberis aristata and Silybum marianum extracts in diabetic and hypercholesterolemic patients intolerant to statins. Diabetes Metab Syndr Obes. 8:89–96. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Chang W, Chen L and Hatch GM: Berberine as a therapy for type 2 diabetes and its complications: From mechanism of action to clinical studies. Biochem Cell Biol. 93:479–486. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Lan J, Zhao Y, Dong F, Yan Z, Zheng W, Fan J and Sun G: Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension. J Ethnopharmacol. 161:69–81. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Dong Y, Chen YT, Yang YX, Zhou XJ, Dai SJ, Tong JF, Shou D and Li C: Metabolomics study of type 2 diabetes mellitus and the antidiabetic effect of berberine in zucker diabetic fatty rats using Uplc-ESI-Hdms. Phytother Res. 30:823–828. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Yi Q, He XE, Luo KF, Zhang GS, Liu YH, Xue Q, Hou N, Chen WL and Luo JD: Protection of long-term treatment with huang-lian-jie-du-tang on vascular endothelium in rats with type 2 diabetes mellitus. Curr Ther Res Clin Exp. 73:174–185. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Li CB, Li XX, Chen YG, Gao HQ, Bu PL, Zhang Y and Ji XP: Huang-lian-jie-du-tang protects rats from cardiac damages induced by metabolic disorder by improving inflammation-mediated insulin resistance. PLoS One. 8:e675302013. View Article : Google Scholar : PubMed/NCBI

10 

Wu JS, Shi R, Lu X, Ma YM and Cheng NN: Combination of active components of Xiexin decoction ameliorates renal fibrosis through the inhibition of NF-κB and TGF-β1/Smad pathways in db/db diabetic mice. PLoS One. 10:e01226612015. View Article : Google Scholar : PubMed/NCBI

11 

Yang Z, Wang L, Zhang F and Li Z: Evaluating the antidiabetic effects of Chinese herbal medicine: Xiao-Ke-An in 3T3-L1 cells and KKAy mice using both conventional and holistic omics approaches. BMC Complement Altern Med. 15:2722015. View Article : Google Scholar : PubMed/NCBI

12 

Chang YX, Ge AH, Donnapee S, Li J, Bai Y, Liu J, He J, Yang X, Song LJ, Zhang BL and Gao XM: The multi-targets integrated fingerprinting for screening anti-diabetic compounds from a Chinese medicine Jinqi Jiangtang Tablet. J Ethnopharmacol. 164:210–222. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Zarei A, Changizi-Ashtiyani S, Taheri S and Ramezani M: A quick overview on some aspects of endocrinological and therapeutic effects of Berberis vulgaris L. Avicenna J Phytomed. 5:485–497. 2015.PubMed/NCBI

14 

Pang B, Zhao LH, Zhou Q, Zhao TY, Wang H, Gu CJ and Tong XL: Application of berberine on treating type 2 diabetes mellitus. Int J Endocrinol. 2015:9057492015. View Article : Google Scholar : PubMed/NCBI

15 

Pang B, Yu XT, Zhou Q, Zhao TY, Wang H, Gu CJ and Tong XL: Effect of rhizoma coptidis (Huang Lian) on treating diabetes mellitus. Evid Based Complement Alternat Med. 2015:9214162015. View Article : Google Scholar : PubMed/NCBI

16 

Li F, Zhao YB, Wang DK, Zou X, Fang K and Wang KF: Berberine relieves insulin resistance via the cholinergic anti-inflammatory pathway in HepG2 cells. J Huazhong Univ Sci Technolog Med Sci. 36:1–69. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Geng FH, Li GH, Zhang X, Zhang P, Dong MQ, Zhao ZJ, Zhang Y, Dong L and Gao F: Berberine improves mesenteric artery insulin sensitivity through up-regulating insulin receptor-mediated signaling in diabetic rats. Br J Pharmacol. 173:1569–1579. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Lu L, Zhijian H, Lei L, Wenchuan C and Zhimin Z: Berberine in combination with insulin has additive effects on titanium implants osseointegration in diabetes mellitus rats. Evid Based Complement Alternat Med. 2015:8242592015. View Article : Google Scholar : PubMed/NCBI

19 

Yu Y, Hao G, Zhang Q, Hua W, Wang M, Zhou W, Zong S, Huang M and Wen X: Berberine induces GLP-1 secretion through activation of bitter taste receptor pathways. Biochem Pharmacol. 97:173–177. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Zhou J, Du X, Long M, Zhang Z, Zhou S, Zhou J and Qian G: Neuroprotective effect of berberine is mediated by MAPK signaling pathway in experimental diabetic neuropathy in rats. Eur J Pharmacol. 774:87–94. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Tang LQ, Ni WJ, Cai M, Ding HH, Liu S and Zhang ST: The renoprotective effects of berberine and its potential impact on the expression of β-arrestins and ICAM-1/VCAM-1 in streptozocin induced-diabetic nephropathy rats. J Diabetes. November 3–2015.(Epub ahead of print).

22 

Friedemann T, Schumacher U, Tao Y, Leung AK and Schröder S: Neuroprotective activity of coptisine from coptis Chinensis (Franch). Evid Based Complement Alternat Med. 2015:8273082015. View Article : Google Scholar : PubMed/NCBI

23 

Zhang X, Zhao Y, Xu J, Xue Z, Zhang M, Pang X, Zhang X and Zhao L: Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats. Sci Rep. 5:144052015. View Article : Google Scholar : PubMed/NCBI

24 

Xie W, Gu D, Li J, Cui K and Zhang Y: Effects and action mechanisms of berberine and Rhizoma coptidis on gut microbes and obesity in high-fat diet-fed C57BL/6J mice. PLoS One. 6:e245202011. View Article : Google Scholar : PubMed/NCBI

25 

Wu X, Li Y, Wang Q, Li W and Feng Y: Effects of berberine and pomegranate seed oil on plasma phospholipid metabolites associated with risks of type 2 diabetes mellitus by U-HPLC/Q-TOF-MS. J Chromatogr B Analyt Technol Biomed Life Sci. 1007:110–120. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Chang W, Li K, Guan F, Yao F, Yu Y, Zhang M, Hatch GM and Chen L: Berberine pretreatment confers cardioprotection against ischemia-reperfusion injury in a rat model of type 2 diabetes. J Cardiovasc Pharmacol Ther. 21:486–494. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Dai P, Wang J, Lin L, Zhang Y and Wang Z: Renoprotective effects of berberine as adjuvant therapy for hypertensive patients with type 2 diabetes mellitus: Evaluation via biochemical markers and color Doppler ultrasonography. Exp Ther Med. 10:869–876. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Chang W, Zhang M, Meng Z, Yu Y, Yao F, Hatch GM and Chen L: Berberine treatment prevents cardiac dysfunction and remodeling through activation of 5′-adenosine monophosphate-activated protein kinase in type 2 diabetic rats and in palmitate-induced hypertrophic H9c2 cells. Eur J Pharmacol. 769:55–63. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Jiang SJ, Dong H, Li JB, Xu LJ, Zou X, Wang KF, Lu FE and Yi P: Berberine inhibits hepatic gluconeogenesis via the LKB1-AMPK-TORC2 signaling pathway in streptozotocin-induced diabetic rats. World J Gastroenterol. 21:7777–7785. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Jhong CH, Riyaphan J, Lin SH, Chia YC and Weng CF: Screening alpha-glucosidase and alpha-amylase inhibitors from natural compounds by molecular docking in silico. Biofactors. 41:242–251. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Chang W, Chen L and Hatch GM: Berberine treatment attenuates the palmitate-mediated inhibition of glucose uptake and consumption through increased 1,2,3-triacyl-sn-glycerol synthesis and accumulation in H9c2 cardiomyocytes. Biochim Biophys Acta. 1864:352–362. 2016. View Article : Google Scholar

32 

Pirillo A and Catapano AL: Berberine, a plant alkaloid with lipid- and glucose-lowering properties: From in vitro evidence to clinical studies. Atherosclerosis. 243:449–461. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Xue M, Zhang L, Yang MX, Zhang W, Li XM, Ou ZM, Li ZP, Liu SH, Li XJ and Yang SY: Berberine-loaded solid lipid nanoparticles are concentrated in the liver and ameliorate hepatosteatosis in db/db mice. Int J Nanomedicine. 10:5049–5057. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Zhang Y, Chang X, Song X, Chen C, Chen H, Lu Z, Gao X and Lu D: Berberine reverses abnormal expression of L-type pyruvate kinase by DNA demethylation and histone acetylation in the livers of the non-alcoholic fatty disease rat. Int J Clin Exp Med. 8:7535–7543. 2015.PubMed/NCBI

35 

Zhang J, Tang H, Deng R, Wang N, Zhang Y, Wang Y, Liu Y, Li F, Wang X and Zhou L: Berberine suppresses adipocyte differentiation via decreasing Creb transcriptional activity. PLoS One. 10:e01256672015. View Article : Google Scholar : PubMed/NCBI

36 

Wang Z, Wu J, Zhou Q, Wang Y and Chen T: Berberine nanosuspension enhances hypoglycemic efficacy on streptozotocin induced diabetic C57BL/6 mice. Evid Based Complement Alternat Med 2015. 2397492015.

37 

Liu C, Wang Z, Song Y, Wu D, Zheng X, Li P, Jin J, Xu N and Li L: Effects of berberine on amelioration of hyperglycemia and oxidative stress in high glucose and high fat diet-induced diabetic hamsters in vivo. Biomed Res Int. 2015:3138082015.PubMed/NCBI

38 

Cui E, Zhi X, Chen Y, Gao Y, Fan Y, Zhang W, Ma W, Hou W, Guo C and Song X: Coptis chinensis and myrobalan (Terminalia chebula) can synergistically inhibit inflammatory response in vitro and in vivo. Evid Based Complement Alternat Med. 2014:5101572014. View Article : Google Scholar : PubMed/NCBI

39 

Wang O, Cai K, Pang S, Wang T, Qi D, Zhu Q, Ni Z and Le Y: Mechanisms of glucose-induced expression of pancreatic-derived factor in pancreatic beta-cells. Endocrinology. 149:672–680. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Gastaldelli A, Ferrannini E, Miyazaki Y, Matsuda M, Mari A and DeFronzo RA: Thiazolidinediones improve beta-cell function in type 2 diabetic patients. Am J Physiol Endocrinol Metab. 292:E871–E883. 2007. View Article : Google Scholar : PubMed/NCBI

41 

Guardado-Mendoza R, Davalli AM, Chavez AO, Hubbard GB, Dick EJ, Majluf-Cruz A, Tene-Perez CE, Goldschmidt L, Hart J, Perego C, et al: Pancreatic islet amyloidosis, beta-cell apoptosis, and alpha-cell proliferation are determinants of islet remodeling in type-2 diabetic baboons. Proc Natl Acad Sci USA. 106:13992–13997. 2009; View Article : Google Scholar : PubMed/NCBI

42 

Andreone T, Meares GP, Hughes KJ, Hansen PA and Corbett JA: Cytokine-mediated β-cell damage in PARP-1-deficient islets. Am J Physiol Endocrinol Metab. 303:E172–E179. 2012. View Article : Google Scholar : PubMed/NCBI

43 

Radzi SF Muhd, Rückert C, Sam SS, Teoh BT, Jee PF, Phoon WH, Abubakar S and Zandi K: Detection of Langat virus by TaqMan real-time one-step qRT-PCR method. Sci Rep. 5:140072015. View Article : Google Scholar : PubMed/NCBI

44 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Jiang YY, Cui HM, Wang JL, Liu H, Dang MM, Zhang QY, Yang F, Kou JT and Tong XL: Protective role of berberine and Coptischinensis extract on T2MD rats and associated islet Rin‑5f cells. Mol Med Rep 16: 6981-6991, 2017.
APA
Jiang, Y., Cui, H., Wang, J., Liu, H., Dang, M., Zhang, Q. ... Tong, X. (2017). Protective role of berberine and Coptischinensis extract on T2MD rats and associated islet Rin‑5f cells. Molecular Medicine Reports, 16, 6981-6991. https://doi.org/10.3892/mmr.2017.7467
MLA
Jiang, Y., Cui, H., Wang, J., Liu, H., Dang, M., Zhang, Q., Yang, F., Kou, J., Tong, X."Protective role of berberine and Coptischinensis extract on T2MD rats and associated islet Rin‑5f cells". Molecular Medicine Reports 16.5 (2017): 6981-6991.
Chicago
Jiang, Y., Cui, H., Wang, J., Liu, H., Dang, M., Zhang, Q., Yang, F., Kou, J., Tong, X."Protective role of berberine and Coptischinensis extract on T2MD rats and associated islet Rin‑5f cells". Molecular Medicine Reports 16, no. 5 (2017): 6981-6991. https://doi.org/10.3892/mmr.2017.7467
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang YY, Cui HM, Wang JL, Liu H, Dang MM, Zhang QY, Yang F, Kou JT and Tong XL: Protective role of berberine and Coptischinensis extract on T2MD rats and associated islet Rin‑5f cells. Mol Med Rep 16: 6981-6991, 2017.
APA
Jiang, Y., Cui, H., Wang, J., Liu, H., Dang, M., Zhang, Q. ... Tong, X. (2017). Protective role of berberine and Coptischinensis extract on T2MD rats and associated islet Rin‑5f cells. Molecular Medicine Reports, 16, 6981-6991. https://doi.org/10.3892/mmr.2017.7467
MLA
Jiang, Y., Cui, H., Wang, J., Liu, H., Dang, M., Zhang, Q., Yang, F., Kou, J., Tong, X."Protective role of berberine and Coptischinensis extract on T2MD rats and associated islet Rin‑5f cells". Molecular Medicine Reports 16.5 (2017): 6981-6991.
Chicago
Jiang, Y., Cui, H., Wang, J., Liu, H., Dang, M., Zhang, Q., Yang, F., Kou, J., Tong, X."Protective role of berberine and Coptischinensis extract on T2MD rats and associated islet Rin‑5f cells". Molecular Medicine Reports 16, no. 5 (2017): 6981-6991. https://doi.org/10.3892/mmr.2017.7467
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team