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Article Open Access

Mild hypothermia pretreatment protects against liver ischemia reperfusion injury via the PI3K/AKT/FOXO3a pathway

  • Authors:
    • Qi Xiao
    • Qifa Ye
    • Wei Wang
    • Jiansheng Xiao
    • Biqi Fu
    • Zhiping Xia
    • Xingjian Zhang
    • Zhongzhong Liu
    • Xianpeng Zeng
  • View Affiliations / Copyright

    Affiliations: Department of Transplant Surgery, The Third Xiangya Hospital of Central South University, Central South University, Changsha, Hunan 410013, P.R. China, Department of Transplant Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Department of Rheumatology and Immunology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Hubei Key Laboratory of Medical Technology on Transplantation, Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Wuhan, Hubei 430071, P.R. China
    Copyright: © Xiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 7520-7526
    |
    Published online on: September 18, 2017
       https://doi.org/10.3892/mmr.2017.7501
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Abstract

Mild hypothermia is known to protect against ischemia and reperfusion (IR) injury. The exact mechanisms of the protection are not fully understood. Forkhead box O3 (FOXO3a) has been defined as a critical mediator in cellular processes, including oxidative stress, apoptosis, inflammation, cell death and DNA repair; however, the protection function in mild hypothermia has not been reported previously. The current study was designed to investigate the function of phosphoinositide 3‑kinase (PI3K)/protein kinase B (AKT)/FOXO3a pathway in pretreatment with mild hypothermia during IR injury. Additionally, PI3K/AKT/FOXO3a signaling was inhibited using Ly294002 and the effect on the protective function of mild hypothermia pretreatment was evaluated. Furthermore, the apoptotic and inflammatory response induced by the IR injury was evaluated. Liver IR injury induced a significant increase in the level of apoptosis and inflammatory responses. However, pretreatment with mild hypothermia increased phospho (p)‑AKT and p‑FOXO3a following IR injury, and significantly reduced apoptosis and inflammatory cytokines release. However, inhibiting p‑AKT and p‑FOXO3a using Ly294002 suppressed the liver protection produced by mild hypothermia. In conclusion, these findings indicated that mild hypothermia pretreatment exhibited liver protective effects against IR injury associated with suppressing inflammatory cytokine release and apoptosis via the PI3K/AKT/FOXO3a pathway.
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1 

Selzner N, Rudiger H, Graf R and Clavien PA: Protective strategies against ischemic injury of the liver. Gastroenterology. 125:917–936. 2003. View Article : Google Scholar : PubMed/NCBI

2 

Eltzschig HK and Eckle T: Ischemia and reperfusion-from mechanism to translation. Nat Med. 17:1391–1401. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Duarte S, Hamada T, Kuriyama N, Busuttil RW and Coito AJ: TIMP-1 deficiency leads to lethal partial hepatic ischemia and reperfusion injury. Hepatology. 56:1074–1085. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Jaeschke H and Woolbright BL: Current strategies to minimize hepatic ischemia-reperfusion injury by tageting reactive oxygen species. Transplant Rev (Orlando). 26:103–114. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Bigelow WG, Callaghan JC and Hopps JA: General hypothermia for experimental intracardiac surgery. Ann Surg. 132:531–537. 1950. View Article : Google Scholar : PubMed/NCBI

6 

Miao YF, Wu H, Yang SF, Dai J, Qiu YM, Tao ZY and Zhang XH: 5′-adenosine monophosphate-induced hypothermia attenuates brain ischemia/reperfusion injury in a rat model by inhibiting the inflammatory response. Mediators Inflamm. 2015:5207452015. View Article : Google Scholar : PubMed/NCBI

7 

Kida K, Shirozu K, Yu B, Mandeville JB, Bloch KD and Ichinose F: Beneficial effects of nitric oxide on outcomes after cardiac arrest and cardiopulmonary resuscitation in hypothermia-treated mice. Anesthesiology. 120:880–889. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Behrends M, Hirose R, Serkova NJ, Coatney JL, Bedolli M, Yardi J, Park YH and Niemann CU: Mild hypothermia reduces the inflammatory response and hepatic ischemia/reperfusion injury in rats. Liver Int. 26:734–741. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Niemann CU, Choi S, Behrends M, Hirose R, Noh J, Coatney JL, Roberts JP, Serkova NJ and Maher JJ: Mild hypothermia protects obese rats from fulminant hepatic necrosis induced by ischemia-reperfusion. Surgery. 140:404–412. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Zhang R, Zhang L, Manaenko A, Ye Z, Liu W and Sun X: Helium preconditioning protects mouse liver against ischemia and reperfusion injury through the PI3K/Akt pathway. J Hepatol. 61:1048–1055. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Suo L, Kang K, Wang X, Cao Y, Zhao H, Sun X, Tong L and Zhang F: Carvacrol alleviates ischemia reperfusion injury by regulating the PI3K-Akt pathway in rats. PLoS One. 9:e1040432014. View Article : Google Scholar : PubMed/NCBI

12 

Uranga RM, Katz S and Salvador GA: Enhanced phosphatidylinositol 3-kinase (PI3K)/Akt signaling has pleiotropic targets in hippocampal neurons exposed to iron-induced oxidative stress. J Biol Chem. 288:19773–19784. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J and Greenberg ME: AKT promotes cells survival by phosphorylating and inhibiting a forkhead transcription factor. Cell. 96:857–868. 1999. View Article : Google Scholar : PubMed/NCBI

14 

Lin K, Dorman JB, Rodan A and Kenyon C: daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science. 278:1319–1322. 1997. View Article : Google Scholar : PubMed/NCBI

15 

Furuyama T, Nakazawa T, Nakano I and Mori N: Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues. Biochem J. 349:629–634. 2000. View Article : Google Scholar : PubMed/NCBI

16 

Essers MA, de Vries-Smits LM, Barker N, Polderman PE, Burgering BM and Korswagen HC: Functional interaction between beta-catenin and FOXO in oxidative stress signaling. Science. 308:1181–1184. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Tzivion G, Dobson M and Ramakrishnan G: FoxO transcription factors; Regulation by AKT and 14-3-3 proteins. Biochim Biophys Acta. 1813:1938–1945. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Fischer AH, Jacobson KA, Rose J and Zeller R: Hematoxylin and eosin staining of tissue and cell sections. CSH Protoc. 2008:pdb.prot49862008.PubMed/NCBI

19 

Suzuki S, Toledo-Pereyra LH, Rodriguez FJ and Cejalvo D: Neutriphil infiltration as an important factor in liver ishcemia and reperfusion injury. Modulating effects of FK506 and cyclosporine. Transplantation. 55:1265–1272. 1993. View Article : Google Scholar : PubMed/NCBI

20 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Tang Y, Liu X, Zhao J, Tan X, Liu B, Zhang G, Sun L, Han D, Chen H and Wang M: Hypothermia-induced ischemic tolerance is associated with Drp1 inhibition in cerebral ischemia-reperfusion injury of mice. Brain Res. 1646:73–83. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Niemann CU, Xu F, Choi S, Behrends M, Park Y, Hirose R and Maher JJ: Short passive cooling protects rats during hepatectomy by inducing heat shock proteins and limiting the induction of pro-inflammatory cytokines. J Surg Res. 158:43–52. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Niemann CU, Feiner J, Swain S, Bunting S, Friedman M, Crutchfield M, Broglio K, Hirose R, Roberts JP and Malinoski D: Therapeutic hypothermia in deceased organ donors and kidney-graft function. New Engl J Med. 373:405–414. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Bernard SA, Gray TW, Buist MD, Jones BM, Silvester W, Gutteridge G and Smith K: Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. New Engl J Med. 346:557–563. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Ma J, Ding Y, Fang X, Wang R and Sun Z: Protein kinase C-θ inhibits inducible regulatory T cell differentiation via an AKT-Foxo1/3a-dependent pathway. J Immunol. 188:5337–5347. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Pei YH, Chen J, Xie L, Cai XM, Yang RH, Wang X and Gong JB: Hydroxytyrosol protects against myocardial ischemia/reperfusion injury through a PI3K/Akt-dependent mechanism. Mediators Inflamm. 2016:12321032016. View Article : Google Scholar : PubMed/NCBI

27 

Chen L, Wei X, Hou Y, Liu X, Li S, Sun B, Liu X and Liu H: Tetramethylpyrazine analogue CXC195 protects against cerebral ischemia/reperfusion-induced apoptosis through PI3K/Akt/GSK3β pathway in rats. Neurochem Int. 66:27–32. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Huang C, Gu H, Zhang W, Herrmann JL and Wang M: Testosterone-down-regulated Akt pathway during cardiac ischemia/reperfusion: A mechanism involving BAD, Bcl-2 and FOXO3a. J Surg Res. 164:e1–e11. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Luedde T, Kaplowitz N and Schwabe RF: Cell death and cell death responses in liver disease: Mechanisms and clinical relevance. Gastroenterology. 147:765–783.e4. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Seiler F, Hellberg J, Lepper PM, Kamyschnikow A, Herr C, Bischoff M, Langer F, Schäfers HJ, Lammert F, Menger MD, et al: FOXO transcription factors regulate innate immune mechanisms in respiratory epithelial cells. J Immunol. 190:1603–1613. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Zhai Y, Busuttil RW and Kupiec-Weglinski JW: Liver ischemia and reperfusion injury: New insights into mechanisms of innate adaptive immune-mediated tissue inflammation. Am J Transplant. 11:1563–1569. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Li Q and Verma IM: NF-kappaB regulation in the immune system. Nat Rev Immunol. 2:725–734. 2002. View Article : Google Scholar : PubMed/NCBI

33 

Yang JC, Lin MW, Rau CS, Jeng SF, Lu TH, Wu YC, Chen YC, Tzeng SL, Wu CJ and Hsieh CH: Altered exosomal protein expression in the serum of NF-κB knockout mice following skeletal muscle ischemia-reperfusion injury. J Biomed Sci. 22:402015. View Article : Google Scholar : PubMed/NCBI

34 

Rao J, Qian X, Li G, Pan X, Zhang C, Zhang F, Zhai Y, Wang X and Lu L: ATF3-mediated NRF2/HO-1 signaling regulates TLR4 innate immune responses in mouse liver ischemia/reperfusion injury. Am J Transplant. 15:76–87. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Nurmi A, Lindsberg PJ, Koistinaho M, Zhang W, Juettler E, Karjalainen-Lindsberg ML, Weih F, Frank N, Schwaninger M and Koistinaho J: Nuclear factor-kappaB contributes to infarction after permanent focal ischemia. Stroke. 35:987–991. 2004. View Article : Google Scholar : PubMed/NCBI

36 

Su D, Coudriet GM, Kim D Hyun, Lu Y, Perdomo G, Qu S, Slusher S, Tse HM, Piganelli J, Giannoukakis N, et al: FoxO1 links insulin resistance to proinflammatory cytokine IL-1beta production in macrophages. Diabetes. 58:2624–2633. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xiao Q, Ye Q, Wang W, Xiao J, Fu B, Xia Z, Zhang X, Liu Z and Zeng X: Mild hypothermia pretreatment protects against liver ischemia reperfusion injury via the PI3K/AKT/FOXO3a pathway. Mol Med Rep 16: 7520-7526, 2017.
APA
Xiao, Q., Ye, Q., Wang, W., Xiao, J., Fu, B., Xia, Z. ... Zeng, X. (2017). Mild hypothermia pretreatment protects against liver ischemia reperfusion injury via the PI3K/AKT/FOXO3a pathway. Molecular Medicine Reports, 16, 7520-7526. https://doi.org/10.3892/mmr.2017.7501
MLA
Xiao, Q., Ye, Q., Wang, W., Xiao, J., Fu, B., Xia, Z., Zhang, X., Liu, Z., Zeng, X."Mild hypothermia pretreatment protects against liver ischemia reperfusion injury via the PI3K/AKT/FOXO3a pathway". Molecular Medicine Reports 16.5 (2017): 7520-7526.
Chicago
Xiao, Q., Ye, Q., Wang, W., Xiao, J., Fu, B., Xia, Z., Zhang, X., Liu, Z., Zeng, X."Mild hypothermia pretreatment protects against liver ischemia reperfusion injury via the PI3K/AKT/FOXO3a pathway". Molecular Medicine Reports 16, no. 5 (2017): 7520-7526. https://doi.org/10.3892/mmr.2017.7501
Copy and paste a formatted citation
x
Spandidos Publications style
Xiao Q, Ye Q, Wang W, Xiao J, Fu B, Xia Z, Zhang X, Liu Z and Zeng X: Mild hypothermia pretreatment protects against liver ischemia reperfusion injury via the PI3K/AKT/FOXO3a pathway. Mol Med Rep 16: 7520-7526, 2017.
APA
Xiao, Q., Ye, Q., Wang, W., Xiao, J., Fu, B., Xia, Z. ... Zeng, X. (2017). Mild hypothermia pretreatment protects against liver ischemia reperfusion injury via the PI3K/AKT/FOXO3a pathway. Molecular Medicine Reports, 16, 7520-7526. https://doi.org/10.3892/mmr.2017.7501
MLA
Xiao, Q., Ye, Q., Wang, W., Xiao, J., Fu, B., Xia, Z., Zhang, X., Liu, Z., Zeng, X."Mild hypothermia pretreatment protects against liver ischemia reperfusion injury via the PI3K/AKT/FOXO3a pathway". Molecular Medicine Reports 16.5 (2017): 7520-7526.
Chicago
Xiao, Q., Ye, Q., Wang, W., Xiao, J., Fu, B., Xia, Z., Zhang, X., Liu, Z., Zeng, X."Mild hypothermia pretreatment protects against liver ischemia reperfusion injury via the PI3K/AKT/FOXO3a pathway". Molecular Medicine Reports 16, no. 5 (2017): 7520-7526. https://doi.org/10.3892/mmr.2017.7501
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