Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
November-2017 Volume 16 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2017 Volume 16 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model Expression of Concern in /10.3892/mmr.2025.13691

Expression of Concern in: /10.3892/mmr.2025.13691
Corrigendum in: /10.3892/mmr.2025.13729
  • Authors:
    • Zhong‑Hua Fu
    • Guang‑Hua Guo
    • Zhen‑Fang Xiong
    • Xincheng Liao
    • Ming‑Zhuo Liu
    • Jinhua Luo
  • View Affiliations / Copyright

    Affiliations: Department of Burns, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Department of Pathology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China
    Copyright: © Fu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 7375-7381
    |
    Published online on: September 20, 2017
       https://doi.org/10.3892/mmr.2017.7537
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to determine the effects of early anticoagulation treatment on severe burns complicated by inhalation injury in a rabbit model. Under anesthetization, an electrical burns instrument (100˚C) was used to scald the backs of rabbits for 15 sec, which established a 30% III severe burns model. Treatment of the rabbits with early anticoagulation effectively improved the severe burns complicated by inhalation injury‑induced lung injury, reduced PaO2, PaCO2 and SPO2 levels, suppressed the expression of tumor necrosis factor‑α, interleukin (IL)‑1β and IL‑6, and increased the activity of IL‑10. In addition, it was found that early anticoagulation treatment effectively suppressed the activities of caspase‑3 and caspase‑9, upregulated the protein expression of vascular endothelial growth factor (VEGF) and decreased the protein expression of protease‑activated receptor 1 (PAR1) in the severe burns model. It was concluded that early anticoagulation treatment affected the severe burns complicated by inhalation injury in a rabbit model through the upregulation of VEGF and downregulation of PAR1 signaling pathways. Thus, early anticoagulation is a potential therapeutic option for severe burns complicated by inhalation injury.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

View References

1 

Zhang Y, Cai B, Jiang H, Yan H, Yang H, Peng J, Wang W, Ma S, Wu X and Peng X: Use of 1H-nuclear magnetic resonance to screen a set of biomarkers for monitoring metabolic disturbances in severe burn patients. Crit Care. 18:R1592014. View Article : Google Scholar : PubMed/NCBI

2 

Jeschke MG, Gauglitz GG, Kulp GA, Finnerty CC, Williams FN, Kraft R, Suman OE, Mlcak RP and Herndon DN: Long-term persistance of the pathophysiologic response to severe burn injury. PLoS One. 6:e212452011. View Article : Google Scholar : PubMed/NCBI

3 

Gray P, Kirby J, Smith MT, Cabot PJ, Williams B, Doecke J and Cramond T: Pregabalin in severe burn injury pain: A double-blind, randomised placebo-controlled trial. Pain. 152:1279–1288. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Diaz EC, Herndon DN, Lee J, Porter C, Cotter M, Suman OE, Sidossis LS and Børsheim E: Predictors of muscle protein synthesis after severe pediatric burns. J Trauma Acute Care Surg. 78:816–822. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Mariano F, Tedeschi L, Morselli M, Stella M and Triolo G: Normal citratemia and metabolic tolerance of citrate anticoagulation for hemodiafiltration in severe septic shock burn patients. Intensive Care Med. 36:1735–1743. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Miller AC, Elamin EM and Suffredini AF: Inhaled anticoagulation regimens for the treatment of smoke inhalation-associated acute lung injury: A systematic review. Crit Care Med. 42:413–419. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Gille J, Sablotzki A, Malcharek M, Raff T, Mogk M and Parentin T: Regional citrate anticoagulation for continuous renal replacement therapy in severe burns-a retrospective analysis of a protocol-guided approach. Burns. 40:1593–1601. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Ono I, Ohura T, Azami K, Hoshi M and Hasegawa T: Anticoagulation therapy for renal insufficiency after burns. Burns Incl Therm Inj. 11:104–110. 1984. View Article : Google Scholar : PubMed/NCBI

9 

Sorg H, Hoffmann JO, Hoffmann JN and Vollmar B: Analysis of the influence of antithrombin on microvascular thrombosis: Anti-inflammation is crucial for anticoagulation. Intensive Care Med Exp. 3:582015. View Article : Google Scholar : PubMed/NCBI

10 

Mohebali J, Ibrahim AE, MacGillivray TE, Goverman J and Fagan SP: Mitral valve repair via right thoracotomy for multidrug resistant pseudomonal endocarditis in a burn patient: Case report and review of the literature. Burns. 41:e47–e50. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Pourafkari L, Ghaffari S, Khaki N, Hobika GH, Masnadi-Shirazi K and Nader ND: Predictors of hospital mortality and serious complications in patients admitted with excessive warfarin anticoagulation. Thromb Res. 137:79–84. 2016. View Article : Google Scholar : PubMed/NCBI

12 

van den Bergh WM, Lansink-Hartgring AO, van Duijn AL, Engström AE, Lahpor JR and Slooter AJ: Thromboembolic stroke in patients with a HeartMate-II left ventricular assist device-the role of anticoagulation. J Cardiothorac Surg. 10:1282015. View Article : Google Scholar : PubMed/NCBI

13 

Moeinipour A, Zarifian A, Andalibi MS Sheikh, Shamloo AS, Ahmadabadi A, Amouzeshi A and Hoseinikhah H: The best anticoagulation therapy in multiple-trauma patients with mechanical heart valves: Evaluation of latest guidelines and studies. Heart Surg Forum. 18:E271–E274. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Maybauer MO, Maybauer DM, Fraser JF, Westphal M, Szabó C, Cox RA, Hawkins HK, Traber LD and Traber DL: Combined recombinant human activated protein C and ceftazidime prevent the onset of acute respiratory distress syndrome in severe sepsis. Shock. 37:170–176. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Schleich AR, Schweiger H, Becsey A and Cruse CW: Survival after severe intrathoracic electrical injury. Burns. 36:e61–e64. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Levy JH, Sniecinski RM, Welsby IJ and Levi M: Antithrombin: Anti-inflammatory properties and clinical applications. Thromb Haemost. 115:712–728. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Ruan Q, Zhao C, Ye Z, Ruan J, Xie Q and Xie W: Effect and possible mechanism of monocyte-derived VEGF on monocyte-endothelial cellular adhesion after electrical burns. Burns. 41:825–832. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Kim YR and Hong SH: Association between the polymorphisms of the vascular endothelial growth factor gene and metabolic syndrome. Biomed Rep. 3:319–326. 2015.PubMed/NCBI

19 

Azhar A, Singh P, Rashid Q, Naseem A, Khan MS and Jairajpuri MA: Antiangiogenic function of antithrombin is dependent on its conformational variation: Implication for other serpins. Protein Pept Lett. 20:403–411. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Gurbel PA, Bliden KP, Turner SE, Tantry US, Gesheff MG, Barr TP, Covic L and Kuliopulos A: Cell-penetrating pepducin therapy targeting PAR1 in subjects with coronary artery disease. Arterioscler Thromb Vasc Biol. 36:189–197. 2016.PubMed/NCBI

21 

Simmons S, Lee RV, Möller T and Weinstein JR: Thrombin induces release of proinflammatory chemokines interleukin-8 and interferon-γ-induced protein-10 from cultured human fetal astrocytes. Neuroreport. 24:36–40. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Tantivejkul K, Loberg RD, Mawocha SC, Day LL, John LS, Pienta BA, Rubin MA and Pienta KJ: PAR1-mediated NFkappaB activation promotes survival of prostate cancer cells through a Bcl-xL-dependent mechanism. J Cell Biochem. 96:641–652. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Hashemzadeh M, Arreguin JM, Roberts T and Movahed MR: A novel inhibitor of protease-activated receptor 1: A review of chemical structure and mode of action. Rev Cardiovasc Med. 16:68–73. 2015.PubMed/NCBI

24 

Austin KM, Covic L and Kuliopulos A: Matrix metalloproteases and PAR1 activation. Blood. 121:431–439. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Balzarotti M, Fontana F, Marras C, Boiardi A, Croci D, Ciusani E and Salmaggi A: In vitro study of low molecular weight heparin effect on cell growth and cell invasion in primary cell cultures of high-grade gliomas. Oncol Res. 16:245–250. 2006.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Fu ZH, Guo GH, Xiong ZF, Liao X, Liu MZ and Luo J: Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model Expression of Concern in /10.3892/mmr.2025.13691 Corrigendum in /10.3892/mmr.2025.13729. Mol Med Rep 16: 7375-7381, 2017.
APA
Fu, Z., Guo, G., Xiong, Z., Liao, X., Liu, M., & Luo, J. (2017). Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model Expression of Concern in /10.3892/mmr.2025.13691 Corrigendum in /10.3892/mmr.2025.13729. Molecular Medicine Reports, 16, 7375-7381. https://doi.org/10.3892/mmr.2017.7537
MLA
Fu, Z., Guo, G., Xiong, Z., Liao, X., Liu, M., Luo, J."Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model Expression of Concern in /10.3892/mmr.2025.13691 Corrigendum in /10.3892/mmr.2025.13729". Molecular Medicine Reports 16.5 (2017): 7375-7381.
Chicago
Fu, Z., Guo, G., Xiong, Z., Liao, X., Liu, M., Luo, J."Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model Expression of Concern in /10.3892/mmr.2025.13691 Corrigendum in /10.3892/mmr.2025.13729". Molecular Medicine Reports 16, no. 5 (2017): 7375-7381. https://doi.org/10.3892/mmr.2017.7537
Copy and paste a formatted citation
x
Spandidos Publications style
Fu ZH, Guo GH, Xiong ZF, Liao X, Liu MZ and Luo J: Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model Expression of Concern in /10.3892/mmr.2025.13691 Corrigendum in /10.3892/mmr.2025.13729. Mol Med Rep 16: 7375-7381, 2017.
APA
Fu, Z., Guo, G., Xiong, Z., Liao, X., Liu, M., & Luo, J. (2017). Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model Expression of Concern in /10.3892/mmr.2025.13691 Corrigendum in /10.3892/mmr.2025.13729. Molecular Medicine Reports, 16, 7375-7381. https://doi.org/10.3892/mmr.2017.7537
MLA
Fu, Z., Guo, G., Xiong, Z., Liao, X., Liu, M., Luo, J."Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model Expression of Concern in /10.3892/mmr.2025.13691 Corrigendum in /10.3892/mmr.2025.13729". Molecular Medicine Reports 16.5 (2017): 7375-7381.
Chicago
Fu, Z., Guo, G., Xiong, Z., Liao, X., Liu, M., Luo, J."Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model Expression of Concern in /10.3892/mmr.2025.13691 Corrigendum in /10.3892/mmr.2025.13729". Molecular Medicine Reports 16, no. 5 (2017): 7375-7381. https://doi.org/10.3892/mmr.2017.7537
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team