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Article Open Access

Paeonol exerts potential activities to inhibit the growth, migration and invasion of human gastric cancer BGC823 cells via downregulating MMP‑2 and MMP‑9

  • Authors:
    • Zhong‑Kuan Lyu
    • Chang‑Ling Li
    • Yan Jin
    • Yu‑Zhao Liu
    • Xi Zhang
    • Fang Zhang
    • Lu‑Ning Ning
    • Er‑Shun Liang
    • Min Ma
    • Wei Gao
    • Ming‑Xiang Zhang
    • De‑Shan Liu
  • View Affiliations / Copyright

    Affiliations: Department of Traditional Chinese Medicine, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, P.R. China, Shandong University School of Medicine, Jinan, Shandong 250012, P.R. China, Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China
    Copyright: © Lyu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 7513-7519
    |
    Published online on: September 21, 2017
       https://doi.org/10.3892/mmr.2017.7576
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Abstract

Paeonol (Pae) is an herbal extract that has attracted extensive attention for its anti‑cancer effects demonstrated by a number of studies, which have predominantly demonstrated inhibition of cell proliferation and induction of apoptosis. The influence of Pae on cancer cell metastasis has been less widely reported. The present study aimed to investigate the under‑reported effects of Pae on the growth, invasion and migration of poorly differentiated BGC823 gastric cancer cells with strong invasive and metastatic abilities. The anti‑proliferative and pro‑apoptotic effects of Pae on BGC823 cells were verified by Cell Counting kit‑8 and Annexin V‑fluorescein isothiocyanate/propidium iodide assays. Cell scratch‑wound healing and Transwell methods were applied, and it was demonstrated that Pae could exert inhibitory activities on the invasion and migration of BGC823 cells. Furthermore, it was indicated by western blot analysis that Pae could downregulate the protein expression levels of matrix metalloproteinase (MMP)‑2 and ‑9 in a concentration‑dependent manner, which may support a novel potential mechanism accounting for its anti‑cancer effects on gastric cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Lyu ZK, Li CL, Jin Y, Liu YZ, Zhang X, Zhang F, Ning LN, Liang ES, Ma M, Gao W, Gao W, et al: Paeonol exerts potential activities to inhibit the growth, migration and invasion of human gastric cancer BGC823 cells via downregulating MMP‑2 and MMP‑9. Mol Med Rep 16: 7513-7519, 2017.
APA
Lyu, Z., Li, C., Jin, Y., Liu, Y., Zhang, X., Zhang, F. ... Liu, D. (2017). Paeonol exerts potential activities to inhibit the growth, migration and invasion of human gastric cancer BGC823 cells via downregulating MMP‑2 and MMP‑9. Molecular Medicine Reports, 16, 7513-7519. https://doi.org/10.3892/mmr.2017.7576
MLA
Lyu, Z., Li, C., Jin, Y., Liu, Y., Zhang, X., Zhang, F., Ning, L., Liang, E., Ma, M., Gao, W., Zhang, M., Liu, D."Paeonol exerts potential activities to inhibit the growth, migration and invasion of human gastric cancer BGC823 cells via downregulating MMP‑2 and MMP‑9". Molecular Medicine Reports 16.5 (2017): 7513-7519.
Chicago
Lyu, Z., Li, C., Jin, Y., Liu, Y., Zhang, X., Zhang, F., Ning, L., Liang, E., Ma, M., Gao, W., Zhang, M., Liu, D."Paeonol exerts potential activities to inhibit the growth, migration and invasion of human gastric cancer BGC823 cells via downregulating MMP‑2 and MMP‑9". Molecular Medicine Reports 16, no. 5 (2017): 7513-7519. https://doi.org/10.3892/mmr.2017.7576
Copy and paste a formatted citation
x
Spandidos Publications style
Lyu ZK, Li CL, Jin Y, Liu YZ, Zhang X, Zhang F, Ning LN, Liang ES, Ma M, Gao W, Gao W, et al: Paeonol exerts potential activities to inhibit the growth, migration and invasion of human gastric cancer BGC823 cells via downregulating MMP‑2 and MMP‑9. Mol Med Rep 16: 7513-7519, 2017.
APA
Lyu, Z., Li, C., Jin, Y., Liu, Y., Zhang, X., Zhang, F. ... Liu, D. (2017). Paeonol exerts potential activities to inhibit the growth, migration and invasion of human gastric cancer BGC823 cells via downregulating MMP‑2 and MMP‑9. Molecular Medicine Reports, 16, 7513-7519. https://doi.org/10.3892/mmr.2017.7576
MLA
Lyu, Z., Li, C., Jin, Y., Liu, Y., Zhang, X., Zhang, F., Ning, L., Liang, E., Ma, M., Gao, W., Zhang, M., Liu, D."Paeonol exerts potential activities to inhibit the growth, migration and invasion of human gastric cancer BGC823 cells via downregulating MMP‑2 and MMP‑9". Molecular Medicine Reports 16.5 (2017): 7513-7519.
Chicago
Lyu, Z., Li, C., Jin, Y., Liu, Y., Zhang, X., Zhang, F., Ning, L., Liang, E., Ma, M., Gao, W., Zhang, M., Liu, D."Paeonol exerts potential activities to inhibit the growth, migration and invasion of human gastric cancer BGC823 cells via downregulating MMP‑2 and MMP‑9". Molecular Medicine Reports 16, no. 5 (2017): 7513-7519. https://doi.org/10.3892/mmr.2017.7576
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