Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
January-2018 Volume 17 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2018 Volume 17 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Melatonin ameliorates myocardial apoptosis by suppressing endoplasmic reticulum stress in rats with long‑term diabetic cardiomyopathy

  • Authors:
    • Fang‑Yuan Xiong
    • Song‑Tao Tang
    • Huan Su
    • Hai‑Qin Tang
    • Pin Jiang
    • Qing Zhou
    • Yuan Wang
    • Hua‑Qing Zhu
  • View Affiliations / Copyright

    Affiliations: Laboratory of Molecular Biology, Department of Biochemistry, Anhui Medical University, Hefei, Anhui 230032, P.R. China, Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, P.R. China, Department of Geriatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, P.R. China
  • Pages: 374-381
    |
    Published online on: October 20, 2017
       https://doi.org/10.3892/mmr.2017.7841
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The effects of melatonin (MLT), which exerts cardioprotective effects against myocardial apoptosis, in long‑term diabetic cardiomyopathy are not currently well defined. The present study aimed to investigate how MLT protects the heart through modulating myocardial apoptosis in rats with type 2 diabetes mellitus (DM). In total, 36 rats were randomly divided into three groups, including control (n=12), DM (n=12) and DM + MLT (n=12) groups. The results demonstrated that, in DM rats, a significant increase was observed in the serum fasting blood glucose and lipid levels, in addition to insulin resistance and cardiac dysfunction, which were attenuated in DM rats treated with MLT. Additionally, cellular apoptosis in rats with DM was increased, and the expression of Bcl‑2 was downregulated, while levels of Bcl‑2‑associated X and caspase‑3 were upregulated, and these observations were reversed by MLT, as determined by TUNEL and western blot analysis, respectively. As increased endoplasmic reticulum (ER) stress induced by hyperglycemia is reported to be a factor for apoptosis, the present study also determined the expression of proteins associated with ER stress in cardiac tissues following MLT treatment by western blotting. The results further indicated that MLT decreased the expression of ER stress hallmarks, including CCAAT/enhancer‑binding protein homologous protein, glucose‑regulated protein 78, protein kinase RNA‑like endoplasmic reticulum kinase (PERK) and activating transcription factor 6α in cardiac tissues. In conclusion, the results of the present study indicate that MLT may protect heart by ameliorating cardiac ER stress‑induced apoptosis in diabetic cardiomyopathy.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Gregg EW, Li Y, Wang J, Burrows NR, Ali MK, Rolka D, Williams DE and Geiss L: Changes in diabetes-related complications in the United States, 1990–2010. N Engl J Med. 370:1514–1523. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Duckworth WC: Hyperglycemia and cardiovascular disease. Curr Atheroscler Rep. 3:383–391. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Cicek FA, Toy A, Tuncay E, Can B and Turan B: Beta-blocker timolol alleviates hyperglycemia-induced cardiac damage via inhibition of endoplasmic reticulum stress. J Bioenerg Biomembr. 46:377–387. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Zhang X, Ma X, Zhao M, Zhang B, Chi J, Liu W, Chen W, Fu Y, Liu Y and Yin X: H2 and H3 relaxin inhibit high glucose-induced apoptosis in neonatal rat ventricular myocytes. Biochimie. 108:59–67. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Li Z, Zhang T, Dai H, Liu G, Wang H, Sun Y, Zhang Y and Ge Z: Endoplasmic reticulum stress is involved in myocardial apoptosis of streptozocin-induced diabetic rats. J Endocrinol. 196:565–572. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Sari FR, Watanabe K, Widyantoro B, Thandavarayan RA, Harima M, Zhang S, Muslin AJ, Kodama M and Aizawa Y: Partial inactivation of cardiac 14-3-3 protein in vivo elicits endoplasmic reticulum stress (ERS) and activates ERS-initiated apoptosis in ERS-induced mice. Cell Physiol Biochem. 26:167–178. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Lakshmanan AP, Harima M, Suzuki K, Soetikno V, Nagata M, Nakamura T, Takahashi T, Sone H, Kawachi H and Watanabe K: The hyperglycemia stimulated myocardial endoplasmic reticulum (ER) stress contributes to diabetic cardiomyopathy in the transgenic non-obese type 2 diabetic rats: A differential role of unfolded protein response (UPR) signaling proteins. Int J Biochem Cell Biol. 45:438–447. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Cai L and Kang YJ: Cell death and diabetic cardiomyopathy. Cardiovasc Toxicol. 3:219–228. 2003. View Article : Google Scholar : PubMed/NCBI

9 

Gao Q, Wang XM, Ye HW, Yu Y, Kang PF, Wang HJ, Guan SD and Li ZH: Changes in the expression of cardiac mitofusin-2 in different stages of diabetes in rats. Mol Med Rep. 6:811–814. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Groenendyk J, Agellon LB and Michalak M: Coping with endoplasmic reticulum stress in the cardiovascular system. Annu Rev Physiol. 75:49–67. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Prins D and Michalak M: Endoplasmic reticulum proteins in cardiac development and dysfunction. Can J Physiol Pharmacol. 87:419–425. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Zhou H and Liu R: ER stress and hepatic lipid metabolism. Front Genet. 9:1122014.

13 

Senft D and Ronai ZA: UPR, autophagy, and mitochondria crosstalk underlies the ER stress response. Trends Biochem Sci. 40:141–148. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Zhang L, Lai E, Teodoro T and Volchuk A: GRP78, but not protein-disulfide isomerase, partially reverses hyperglycemia induced inhibition of insulin synthesis and secretion in pancreatic {beta}-cells. J Biol Chem. 284:5289–5298. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Kepp O, Semeraro M, Pedro Bravo-San JM, Bloy N, Buqué A, Huang X, Zhou H, Senovilla L, Kroemer G and Galluzzi L: eIF2α phosphorylation as a biomarker of immunogenic cell death. Semin Cancer Biol. 33:86–92. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Scull CM and Tabas I: Mechanisms of ER stress-induced apoptosis in atherosclerosis. Arterioscler Thromb Vasc Biol. 31:2792–2797. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Sano R and Reed JC: ER stress-induced cell death mechanisms. Biochim Biophys Acta. 1833:3460–3470. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Boyce M and Yuan J: Cellular response to endoplasmic reticulum stress: A matter of life or death. Cell Death Differ. 13:363–373. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Wu L, Cai B, Zheng S, Liu X, Cai H and Li H: Effect of emodin on endoplasmic reticulum stress in rats with severe acute pancreatitis. Inflammation. 36:1020–1029. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Araki E, Oyadomari S and Mori M: Endoplasmic reticulum stress and diabetes mellitus. Intern Med. 42:7–14. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Oyadomari S and Mori M: Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ. 11:381–389. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA and Yuan J: Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature. 403:98–103. 2000. View Article : Google Scholar : PubMed/NCBI

23 

Hill SM, Frasch T, Xiang S, Yuan L, Duplessis T and Mao L: Molecular mechanisms of melatonin anticancer effects. Integr Cancer Ther. 8:337–346. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Mauriz JL, Collado PS, Veneroso C, Reiter RJ and González-Gallego J: A review of the molecular aspects of melatonins anti-inflammatory actions: Recent insights and new perspectives. J Pineal Res. 54:1–14. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Galano A, Tan DX and Reiter RJ: Melatonin as a naturally against oxidative stress: A physiochemical examination. J Pineal Res. 51:1–16. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Yu L, Liang H, Dong X, Zhao G, Jin Z, Zhai M, Yang Y, Chen W, Liu J, Yi W, et al: Reduced silent information regulator 1 signaling exacerbates myocardial ischemia-reperfusion injury in type 2 diabetic rats and the protective effect of melatonin. J Pineal Res. 59:376–390. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Yang Y, Duan W, Jin Z, Yi W, Yan J, Zhang S, Wang N, Liang Z, Li Y, Chen W, et al: JAK2/STAT3 activation by melatonin attenuates the mitochondrial oxidative damage induced by myocardial ischemia/reperfusion injury. J Pineal Res. 55:275–286. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Amin AH, El-Missiry MA and Othman AL: Melatonin ameliorates metabolic risk factors, modulates apoptotic proteins, and protects the rat heart against diabetes-induced apoptosis. Eur J Pharmacol. 747:166–173. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Dominguez-Rodriguez A, Abreu-Gonzalez P and Reiter RJ: The potential usefulness of serum melatonin level to predict heart failure in patients with hypertensive cardiomyopathy. Int J Cardiol. 174:415–417. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Hadj Ayed Tka K, Mahfoudh Boussaid A, Zaouali MA, Kammoun R, Bejaoui M, Mazgar Ghoul S, Catafau Rosello J and Ben Abdennebi H: Melatonin modulates endoplasmic reticulum stress and Akt/GSK3-beta signaling pathway in a rat model of renal warm ischemia reperfusion. Anal Cell Pathol (Amst). 2015:6351722015.PubMed/NCBI

31 

Fernández A, Ordóñez R, Reiter RJ, González-Gallego J and Mauriz JL: Melatonin and endoplasmic reticulum stress: Relation to autophagy and apoptosis. J Pineal Res. 59:292–307. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Layland J, Cave AC, Warren C, Grieve DJ, Sparks E, Kentish JC, Solaro RJ and Shah AM: Protection against endotoxemia-induced contractile dysfunction in mice with cardiac-specific expression of slow skeletal troponin I. FASEB J. 19:1137–1139. 2005.PubMed/NCBI

33 

Ouyang C, You J and Xie Z: The interplay between autophagy and apoptosis in the diabetic heart. J Mol Cell Cardio. 71:71–80. 2014. View Article : Google Scholar

34 

Liu Q, Wang S and Cai L: Diabetic cardiomyopathy and its mechanisms: Role of oxidative stress and damage. J Diabetes Investig. 5:623–634. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Roos WP and Kaina B: DNA damage-induced cell death by apoptosis. Trends Mol Med. 12:440–450. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Wang JY: DNA damage and apoptosis. Cell Death Differ. 8:1047–1048. 2001. View Article : Google Scholar : PubMed/NCBI

37 

Tsujimoto Y: Role of Bcl-2 family proteins in apoptosis: Apoptosomes or mitochondria? Genes Cells. 3:697–707. 1998. View Article : Google Scholar : PubMed/NCBI

38 

Acikel M, Buyukokuroglu ME, Aksoy H, Erdogan F and Erol MK: Protective effects of melatonin against myocardial injury induced by isoproterenol in rats. J Pineal Res. 35:75–79. 2003. View Article : Google Scholar : PubMed/NCBI

39 

Sheu JJ, Chang LT, Chiang CH, Sun CK, Chang NK, Youssef AA, Wu CJ, Lee FY and Yip HK: Impact of diabetes on cardiomyocyte apoptosis and connexin43 gap junction integrity: Role of pharmacological modulation. Int Heart J. 48:233–245. 2007. View Article : Google Scholar : PubMed/NCBI

40 

Ghosh S, Pulinilkunnil T, Yuen G, Kewalramani G, An D, Qi D, Abrahani A and Rodrigues B: Cardiomyocyte apoptosis induced by short-term diabetes requires mitochondrial GSH depletion. Am J Physiol Heart Circ Physiol. 289:H768–H776. 2005. View Article : Google Scholar : PubMed/NCBI

41 

Li Z, Zhang T, Dai H, Liu G, Wang H, Sun Y, Zhang Y and Ge Z: Involvement of endoplasmic reticulum stress in myocardial apoptosis of streptozocin-induced diabetic rats. J Clin Biochem Nutr. 41:58–67. 2007. View Article : Google Scholar : PubMed/NCBI

42 

Sovolyova N, Healy S, Samali A and Logue SE: Stressed to death-mechanisms of ER stress-induced cell death. Biol Chem. 395:1–13. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Di Sano F, Ferraro E, Tufi R, Achsel T, Piacentini M and Cecconi F: Endoplasmic reticulum stress induces apoptosis by an apoptosome-dependent but Caspase 12-independent mechanism. J Biol Chem. 281:2693–2700. 2006. View Article : Google Scholar : PubMed/NCBI

44 

Szegezdi E, Logue SE, Gorman AM and Samali A: Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep. 7:880–885. 2006. View Article : Google Scholar : PubMed/NCBI

45 

Xu MF, Ho S, Qian ZM and Tang PL: Melatonin protects against cardiac toxicity of doxorubicin in rat. J Pineal Res. 31:301–307. 2001. View Article : Google Scholar : PubMed/NCBI

46 

Erşahin M, Sehirli O, Toklu HZ, Süleymanoglu S, Emekli-Alturfan E, Yarat A, Tatlidede E, Yeğen BC and Sener G: Melatonin improves cardiovascular function and ameliorates renal, cardiac and cerebral damage in rats with renovascular hypertension. J Pineal Res. 47:97–106. 2009. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xiong FY, Tang ST, Su H, Tang HQ, Jiang P, Zhou Q, Wang Y and Zhu HQ: Melatonin ameliorates myocardial apoptosis by suppressing endoplasmic reticulum stress in rats with long‑term diabetic cardiomyopathy. Mol Med Rep 17: 374-381, 2018.
APA
Xiong, F., Tang, S., Su, H., Tang, H., Jiang, P., Zhou, Q. ... Zhu, H. (2018). Melatonin ameliorates myocardial apoptosis by suppressing endoplasmic reticulum stress in rats with long‑term diabetic cardiomyopathy. Molecular Medicine Reports, 17, 374-381. https://doi.org/10.3892/mmr.2017.7841
MLA
Xiong, F., Tang, S., Su, H., Tang, H., Jiang, P., Zhou, Q., Wang, Y., Zhu, H."Melatonin ameliorates myocardial apoptosis by suppressing endoplasmic reticulum stress in rats with long‑term diabetic cardiomyopathy". Molecular Medicine Reports 17.1 (2018): 374-381.
Chicago
Xiong, F., Tang, S., Su, H., Tang, H., Jiang, P., Zhou, Q., Wang, Y., Zhu, H."Melatonin ameliorates myocardial apoptosis by suppressing endoplasmic reticulum stress in rats with long‑term diabetic cardiomyopathy". Molecular Medicine Reports 17, no. 1 (2018): 374-381. https://doi.org/10.3892/mmr.2017.7841
Copy and paste a formatted citation
x
Spandidos Publications style
Xiong FY, Tang ST, Su H, Tang HQ, Jiang P, Zhou Q, Wang Y and Zhu HQ: Melatonin ameliorates myocardial apoptosis by suppressing endoplasmic reticulum stress in rats with long‑term diabetic cardiomyopathy. Mol Med Rep 17: 374-381, 2018.
APA
Xiong, F., Tang, S., Su, H., Tang, H., Jiang, P., Zhou, Q. ... Zhu, H. (2018). Melatonin ameliorates myocardial apoptosis by suppressing endoplasmic reticulum stress in rats with long‑term diabetic cardiomyopathy. Molecular Medicine Reports, 17, 374-381. https://doi.org/10.3892/mmr.2017.7841
MLA
Xiong, F., Tang, S., Su, H., Tang, H., Jiang, P., Zhou, Q., Wang, Y., Zhu, H."Melatonin ameliorates myocardial apoptosis by suppressing endoplasmic reticulum stress in rats with long‑term diabetic cardiomyopathy". Molecular Medicine Reports 17.1 (2018): 374-381.
Chicago
Xiong, F., Tang, S., Su, H., Tang, H., Jiang, P., Zhou, Q., Wang, Y., Zhu, H."Melatonin ameliorates myocardial apoptosis by suppressing endoplasmic reticulum stress in rats with long‑term diabetic cardiomyopathy". Molecular Medicine Reports 17, no. 1 (2018): 374-381. https://doi.org/10.3892/mmr.2017.7841
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team