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Gene expression profiles and protein‑protein interaction networks during tongue carcinogenesis in the tumor microenvironment

  • Authors:
    • Wei Sun
    • Zeting Qiu
    • Wenqi Huang
    • Minghui Cao
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Sun Yat‑sen Memorial Hospital, Sun Yat‑sen University, Guangzhou, Guangdong 510080, P.R. China
    Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 165-171
    |
    Published online on: October 20, 2017
       https://doi.org/10.3892/mmr.2017.7843
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Abstract

Oral tongue squamous cell carcinoma (OTSCC) has a high incidence and is associated with a high mortality rate. Studies regarding the potential molecular mechanism of OTSCC in the tumor microenvironment (TME) are required. The present study aimed to perform bioinformatic analysis to identify important nodes, clusters and functional pathways during tongue carcinogenesis in the TME. After downloading the gene expression data of GSE42780, differentially expressed genes (DEGs) among carcinoma, dysplastic and normal samples in epithelia and fibroblasts were identified using the affy and limma packages with R version 3.3. Subsequently, the Database for Annotation, Visualization and Integrated Discovery was employed to perform Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. Furthermore, a protein‑protein interaction (PPI) network was constructed by using the Search Tool for the Retrieval of Interacting Genes/Proteins and analyzed by Cytoscape software. In total, 85 DEGs were identified for tongue epithelia and 46 DEGs were identified for fibroblasts. Neutrophil chemotaxis and inflammatory response from GO, and cytokine‑cytokine receptor interaction from KEGG were enriched for epithelia and fibroblasts. The PPI network revealed that C‑X‑C motif chemokine ligand (Cxcl)1, Cxcl10, Cxcl13, Cxcl2 and pro‑platelet basic protein were a key cluster for epithelia, and interleukin (Il)1β, Il1 receptor 2, Il1a and Il1 receptor antagonist were a key cluster for fibroblasts. Therefore, the results indicate that fibroblasts and cytokines associated with an inflammatory immune response contributed substantially to tongue carcinogenesis in the TME, which is useful for the development of OTSCC targeted therapy. However, further investigation is required to elucidate the molecular and cellular mechanisms underlying the inflammatory immune network in the TME.
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1 

Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 127:2893–2917. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Blot WJ, Mclaughlin JK, Winn DM, Austin DF, Greenberg RS, Preston-Martin S, Bernstein L, Schoenberg JB, Stemhagen A and Fraumeni JF Jr: Smoking and drinking in relation to oral and pharyngeal cancer. Cancer Res. 48:3282–3287. 1988.PubMed/NCBI

3 

Siegel R, Naishadham D and Jemal A: Cancer statistics, 2013. CA Cancer J Clin. 63:11–30. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Castellsagué X, Alemany L, Quer M, Halec G, Quirós B, Tous S, Clavero O, Alòs L, Biegner T, Szafarowski T, et al: HPV involvement in head and neck cancers: Comprehensive assessment of biomarkers in 3680 patients. J Natl Cancer Inst. 108:djv4032016. View Article : Google Scholar : PubMed/NCBI

5 

Greene FL, Page DL, Fleming ID, Fritz A, Balch CM, Haller DG and Morrow M: American Joint Committee on Cancer: AJCC Cancer Staging Manual. 6th edition. Springer; New York, NY: pp. 157–164. 2002

6 

Rusthoven K, Ballonoff A, Raben D and Chen C: Poor prognosis in patients with stage I and II oral tongue squamous cell carcinoma. Cancer. 112:345–351. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Sessions DG, Lenox J, Spector GJ, Chao C and Chaudry OA: Analysis of treatment results for base of tongue cancer. Laryngoscope. 113:1252–1261. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Hanahan D and Coussens LM: Accessories to the crime: Functions of cells recruited to the tumor microenvironment. Cancer Cell. 21:309–322. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Quail DF and Joyce JA: Microenvironmental regulation of tumor progression and metastasis. Nat Med. 19:1423–1437. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Bullinger L, Döhner K, Bair E, Fröhling S, Schlenk RF, Tibshirani R, Döhner H and Pollack JR: Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia. N Engl J Med. 350:1605–1616. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Chung CH, Ely K, McGavran L, Varella-Garcia M, Parker J, Parker N, Jarrett C, Carter J, Murphy BA, Netterville J, et al: Increased epidermal growth factor receptor gene copy number is associated with poor prognosis in head and neck squamous cell carcinomas. J Clin Oncol. 24:4170–4176. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Chung CH, Parker JS, Karaca G, Wu J, Funkhouser WK, Moore D, Butterfoss D, Xiang D, Zanation A, Yin X, et al: Molecular classification of head and neck squamous cell carcinomas using patterns of gene expression. Cancer Cell. 5:489–500. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Wu T, Hong Y, Jia L, Wu J, Xia J, Wang J, Hu Q and Cheng B: Modulation of IL-1β reprogrammes the tumor microenvironment to interrupt oral carcinogenesis. Sci Rep. 6:202082016. View Article : Google Scholar : PubMed/NCBI

14 

Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al: Gene ontology: Tool for the unification of biology. the gene ontology consortium. Nat Genet. 25:25–29. 2000. View Article : Google Scholar : PubMed/NCBI

15 

Kanehisa M and Goto S: KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28:27–30. 2000. View Article : Google Scholar : PubMed/NCBI

16 

Dennis G Jr, Sherman BT, Hosack DA, Yang J, Gao W, Lane HC and Lempicki RA: DAVID: Database for annotation, visualization and integrated discovery. Genome Biol. 4:P32003. View Article : Google Scholar : PubMed/NCBI

17 

Krishnan NM, Dhas K, Nair J, Palve V, Bagwan J, Siddappa G, Suresh A, Kekatpure VD, Kuriakose MA and Panda B: A minimal DNA methylation signature in oral tongue squamous cell carcinoma links altered methylation with tumor attributes. Mol Cancer Res. 14:805–819. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Morita T, Uzawa N, Mogushi K, Sumino J, Michikawa C, Takahashi KI, Myo K, Izumo T and Harada K: Characterizing genetic transitions of copy number alterations and allelic imbalances in oral tongue carcinoma metastasis. Genes Chromosomes Cancer. 55:975–986. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Boldrup L, Coates PJ, Laurell G, Wilms T, Fahraeus R and Nylander K: Downregulation of miRNA-424: A sign of field cancerisation in clinically normal tongue adjacent to squamous cell carcinoma. Br J Cancer. 112:1760–1765. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Joyce JA and Pollard JW: Microenvironmental regulation of metastasis. Nat Rev Cancer. 9:239–252. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Polyak K, Haviv I and Campbell IG: Co-evolution of tumor cells and their microenvironment. Trends Genet. 25:30–38. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Lewis CE and Pollard JW: Distinct role of macrophages in different tumor microenvironments. Cancer Res. 66:605–612. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Kortylewski M, Xin H, Kujawski M, Lee H, Liu Y, Harris T, Drake C, Pardoll D and Yu H: Regulation of the IL-23 and IL-12 balance by Stat3 signaling in the tumor microenvironment. Cancer Cell. 15:114–123. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Sun W, Qiu Z, Huang W and Cao M: Gene expression profiles and protein‑protein interaction networks during tongue carcinogenesis in the tumor microenvironment. Mol Med Rep 17: 165-171, 2018.
APA
Sun, W., Qiu, Z., Huang, W., & Cao, M. (2018). Gene expression profiles and protein‑protein interaction networks during tongue carcinogenesis in the tumor microenvironment. Molecular Medicine Reports, 17, 165-171. https://doi.org/10.3892/mmr.2017.7843
MLA
Sun, W., Qiu, Z., Huang, W., Cao, M."Gene expression profiles and protein‑protein interaction networks during tongue carcinogenesis in the tumor microenvironment". Molecular Medicine Reports 17.1 (2018): 165-171.
Chicago
Sun, W., Qiu, Z., Huang, W., Cao, M."Gene expression profiles and protein‑protein interaction networks during tongue carcinogenesis in the tumor microenvironment". Molecular Medicine Reports 17, no. 1 (2018): 165-171. https://doi.org/10.3892/mmr.2017.7843
Copy and paste a formatted citation
x
Spandidos Publications style
Sun W, Qiu Z, Huang W and Cao M: Gene expression profiles and protein‑protein interaction networks during tongue carcinogenesis in the tumor microenvironment. Mol Med Rep 17: 165-171, 2018.
APA
Sun, W., Qiu, Z., Huang, W., & Cao, M. (2018). Gene expression profiles and protein‑protein interaction networks during tongue carcinogenesis in the tumor microenvironment. Molecular Medicine Reports, 17, 165-171. https://doi.org/10.3892/mmr.2017.7843
MLA
Sun, W., Qiu, Z., Huang, W., Cao, M."Gene expression profiles and protein‑protein interaction networks during tongue carcinogenesis in the tumor microenvironment". Molecular Medicine Reports 17.1 (2018): 165-171.
Chicago
Sun, W., Qiu, Z., Huang, W., Cao, M."Gene expression profiles and protein‑protein interaction networks during tongue carcinogenesis in the tumor microenvironment". Molecular Medicine Reports 17, no. 1 (2018): 165-171. https://doi.org/10.3892/mmr.2017.7843
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