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Article

GMZ-1 is a podophyllotoxin derivative that suppresses growth and induces apoptosis in adriamycin-resistant K562/A02 cells through modulation of MDR1 expression

  • Authors:
    • Bo Cao
    • Shuwang Yang
    • Wuwei Li
    • Hong Chen
    • Yaze Chen
    • Yongfeng Liu
    • Bin Liu
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacognosy, Logistics University of Chinese People's Armed Police Forces, Tianjin 300309, P.R. China, Department of Pharmacology, School of Basic Medicine, Tianjin Medical University, Tianjin 300070, P.R. China, Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, Tianjin 300162, P.R. China
  • Pages: 474-478
    |
    Published online on: October 25, 2017
       https://doi.org/10.3892/mmr.2017.7862
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Abstract

The incidence of multidrug resistance (MDR) during cancer chemotherapy is a major challenge for treatment. With the aim of identifying drugs that are capable of targeting treatment‑resistant cancer cells, the present study evaluated the efficacy of GMZ‑1 in cancer chemotherapy using K562/A02, an MDR leukemia cell line. Cell viability and apoptosis were measured by MTT assay and flow cytometry/Giemsa staining, respectively. The expression levels of the MDR protein 1 (MDR1) gene transcript and protein in K562/A02 cells were determined by reverse transcription‑quantitative polymerase chain reaction and western blot analyses, respectively. GMZ‑1 suppressed the viability of various human cancer cell lines and induced apoptosis in the K562/A02 cell line in a time‑ and concentration‑dependent manner. GMZ‑1 toxicity may be associated with a decrease in MDR gene expression. These findings demonstrated that GMZ‑1 may have efficacy as a potential antitumor drug to overcome leukemia cell resistance to apoptosis induced by chemotherapy.
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1 

Yang CZ, Luan FJ, Xiong DS, Liu BR, Xu YF and Gu KS: Multidrug resistance in leukemic cell line K562/A02 induced by doxorubicin. Zhongguo Yao Li Xue Bao. 16:333–337. 1995.PubMed/NCBI

2 

Hackl H, Astanina K and Wieser R: Molecular and genetic alterations associated with therapy resistance and relapse of acute myeloid leukemia. J Hematol Oncol. 10:512017. View Article : Google Scholar : PubMed/NCBI

3 

Dalton WS: Mechanisms of drug resistance in hematologic malignancies. Semin Hematol. 34 4 Suppl 5:S3–S8. 1997.

4 

Young AM, Allen CE and Audus KL: Efflux transporters of the human placenta. Adv Drug Deliv Rev. 55:125–132. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Lee SY, Rhee YH, Jeong SJ, Lee HJ, Lee HJ, Jung MH and Kim SH, Lee EO, Ahn KS, Ahn KS and Kim SH: Hydrocinchonine, cinchonine, and quinidine potentiate paclitaxel-induced cytotoxicity and apoptosis via multidrug resistance reversal in MES-SA/DX5 uterine sarcoma cells. Environ Toxicol. 26:424–431. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Dönmez Y, Akhmetova L, Iseri ÖD, Kars MD and Gündüz U: Effect of MDR modulators verapamil and promethazine on gene expression levels of MDR1 and MRP1 in doxorubicin-resistant MCF-7 cells. Cancer Chemother Pharmacol. 67:823–828. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Wibowo M, Levrier C, Sadowski MC, Nelson CC, Wang Q, Holst J, Healy PC, Hofmann A and Davis RA: Bioactive dihydro-β-agarofuran sesquiterpenoids from the Australian rainforest plant Maytenus bilocularis. J Nat Prod. 79:1445–1453. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Pajeva I and Wiese M: Molecular modeling of phenothiazines and related drugs as multidrug resistance modifiers: A comparative molecular field analysis study. J Med Chem. 41:1815–1826. 1998. View Article : Google Scholar : PubMed/NCBI

9 

Schondörf T, Kurbacher CM, Göhring UJ, Benz C, Becker M, Sartorius J, Kolhagen H, Mallman P and Neumann R: Induction of MDR1-gene expression by antineoplastic agents in ovarian cancer cell lines. Anticancer Res. 22:2199–2203. 2002.PubMed/NCBI

10 

Gottesman MM: Mechanisms of cancer drug resistance. Annu Rev Med. 53:615–627. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Anuchapreeda S, Leechanachai P, Smith MM, Ambudkar SV and Limtrakul PN: Modulation of P-glycoprotein expression and function by curcumin in multidrug-resistant human KB cells. Biochem Pharmacol. 64:573–582. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Yu ST, Chen TM, Tseng SY and Chen YH: Tryptanthrin inhibits MDR1 and reverses doxorubicin resistance in breast cancer cells. Biochem Biophys Res Commun. 358:79–84. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Mutoh K, Tsukahara S, Mitsuhashi J, Katayama K and Sugimoto Y: Estrogen-mediated post transcriptional down-regulation of P-glycoprotein in MDR1-transduced human breast cancer cells. Cancer Sci. 97:1198–1204. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Zhou YG, Li KY and Li HD: Effect of the novel antipsychotic drug perospirone on P-glycoprotein function and expression in Caco-2 cells. Eur J Clin Pharmacol. 64:697–703. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Baldwin EL and Osheroff N: Etoposide, topoisomerase II and cancer. Curr Med Chem Anticancer Agents. 5:363–372. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Hande KR: Etoposide: Four decades of development of a topoisomerase II inhibitor. Eur J Cancer. 34:1514–1521. 1998. View Article : Google Scholar : PubMed/NCBI

17 

Kobayashi K and Ratain MJ: Pharmacodynamics and long-term toxicity of etoposide. Cancer Chemother Pharmacol. 34 Suppl:S64–S68. 1994. View Article : Google Scholar : PubMed/NCBI

18 

Smith MA, Rubinstein L, Anderson JR, Arthur D, Catalano PJ, Freidlin B, Heyn R, Khayat A, Krailo M, Land VJ, et al: Secondary leukemia or myelodysplastic syndrome after treatment with epipodophyllotoxins. J Clin Oncol. 17:569–577. 1999. View Article : Google Scholar : PubMed/NCBI

19 

Choudhury RC, Palo AK and Sahu P: Cytogenetic risk assessment of etoposide from mouse bone marrow. J Appl Toxicol. 24:115–122. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Attia SM, Al-Anteet AA, Al-Rasheed NM, Alhaider AA and Al-Harbi MM: Protection of mouse bone marrow from etoposide-induced genomic damage by dexrazoxane. Cancer Chemother Pharmacol. 64:837–845. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Kapiszewska M, Cierniak A, Papiez MA, Pietrzycka A, Stepniewski M and Lomnicki A: Prolonged quercetin administration diminishes the etoposide-induced DNA damage in bone marrow cells of rats. Drug Chem Toxicol. 30:67–81. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Enomoto R, Koshiba C, Suzuki C and Lee E: Wogonin potentiates the antitumor action of etoposide and ameliorates its adverse effects. Cancer Chemother Pharmacol. 67:1063–1072. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Cao B, Yang S, Li W, Chen H, Chen Y, Liu Y and Liu B: GMZ-1 is a podophyllotoxin derivative that suppresses growth and induces apoptosis in adriamycin-resistant K562/A02 cells through modulation of MDR1 expression. Mol Med Rep 17: 474-478, 2018.
APA
Cao, B., Yang, S., Li, W., Chen, H., Chen, Y., Liu, Y., & Liu, B. (2018). GMZ-1 is a podophyllotoxin derivative that suppresses growth and induces apoptosis in adriamycin-resistant K562/A02 cells through modulation of MDR1 expression. Molecular Medicine Reports, 17, 474-478. https://doi.org/10.3892/mmr.2017.7862
MLA
Cao, B., Yang, S., Li, W., Chen, H., Chen, Y., Liu, Y., Liu, B."GMZ-1 is a podophyllotoxin derivative that suppresses growth and induces apoptosis in adriamycin-resistant K562/A02 cells through modulation of MDR1 expression". Molecular Medicine Reports 17.1 (2018): 474-478.
Chicago
Cao, B., Yang, S., Li, W., Chen, H., Chen, Y., Liu, Y., Liu, B."GMZ-1 is a podophyllotoxin derivative that suppresses growth and induces apoptosis in adriamycin-resistant K562/A02 cells through modulation of MDR1 expression". Molecular Medicine Reports 17, no. 1 (2018): 474-478. https://doi.org/10.3892/mmr.2017.7862
Copy and paste a formatted citation
x
Spandidos Publications style
Cao B, Yang S, Li W, Chen H, Chen Y, Liu Y and Liu B: GMZ-1 is a podophyllotoxin derivative that suppresses growth and induces apoptosis in adriamycin-resistant K562/A02 cells through modulation of MDR1 expression. Mol Med Rep 17: 474-478, 2018.
APA
Cao, B., Yang, S., Li, W., Chen, H., Chen, Y., Liu, Y., & Liu, B. (2018). GMZ-1 is a podophyllotoxin derivative that suppresses growth and induces apoptosis in adriamycin-resistant K562/A02 cells through modulation of MDR1 expression. Molecular Medicine Reports, 17, 474-478. https://doi.org/10.3892/mmr.2017.7862
MLA
Cao, B., Yang, S., Li, W., Chen, H., Chen, Y., Liu, Y., Liu, B."GMZ-1 is a podophyllotoxin derivative that suppresses growth and induces apoptosis in adriamycin-resistant K562/A02 cells through modulation of MDR1 expression". Molecular Medicine Reports 17.1 (2018): 474-478.
Chicago
Cao, B., Yang, S., Li, W., Chen, H., Chen, Y., Liu, Y., Liu, B."GMZ-1 is a podophyllotoxin derivative that suppresses growth and induces apoptosis in adriamycin-resistant K562/A02 cells through modulation of MDR1 expression". Molecular Medicine Reports 17, no. 1 (2018): 474-478. https://doi.org/10.3892/mmr.2017.7862
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