|
1
|
Arredondo M and Núñez MT: Iron and copper
metabolism. Mol Aspects Med. 26:313–327. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Doom JR and Georgieff MK: Striking while
the iron is hot: Understanding the biological and
neurodevelopmental effects of iron deficiency to optimize
intervention in early childhood. Curr Pediatr Rep. 2:291–298. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Bardou-Jacquet E, de Tayrac M, Mosser J
and Deugnier Y: GNPAT variant associated with severe iron overload
in HFE hemochromatosis. Hepatology. 62:1917–1918. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Krause A, Neitz S, Mägert HJ, Schulz A,
Forssmann WG, Schulz-Knappe P and Adermann K: LEAP-1, a novel
highly disulfide-bonded human peptide, exhibits antimicrobial
activity. FEBS Lett. 480:147–150. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Park CH, Valore EV, Waring AJ and Ganz T:
Hepcidin, a urinary antimicrobial peptide synthesized in the liver.
J Biol Chem. 276:7806–7810. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Bekri S, Gual P, Anty R, Luciani N, Dahman
M, Ramesh B, Iannelli A, Staccini-Myx A, Casanova D, Ben Amor I, et
al: Increased adipose tissue expression of hepcidin in severe
obesity is independent from diabetes and NASH. Gastroenterology.
131:788–796. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Aigner E, Felder TK, Oberkofler H, Hahne
P, Auer S, Soyal S, Stadlmayr A, Schwenoha K, Pirich C, Hengster P,
et al: Glucose acts as a regulator of serum iron by increasing
serum hepcidin concentrations. J Nutr Biochem. 24:112–117. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Theurl I, Theurl M, Seifert M, Mair S,
Nairz M, Rumpold H, Zoller H, Bellmann-Weiler R, Niederegger H,
Talasz H and Weiss G: Autocrine formation of hepcidin induces iron
retention in human monocytes. Blood. 111:2392–2399. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Zhang X and Rovin BH: Hepcidin expression
by human monocytes in response to adhesion and pro-inflammatory
cytokines. Biochim Biophys Acta. 1800:1262–1267. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Nguyen NB, Callaghan KD, Ghio AJ, Haile DJ
and Yang F: Hepcidin expression and iron transport in alveolar
macrophages. Am J Physiol Lung Cell Mol Physiol. 291:L417–L425.
2006. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Nemeth E, Tuttle MS, Powelson J, Vaughn
MB, Donovan A, Ward DM, Ganz T and Kaplan J: Hepcidin regulates
cellular iron efflux by binding to ferroportin and inducing its
internalization. Science. 306:2090–2093. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Jiang F, Sun ZZ, Tang YT, Xu C and Jiao
XY: Hepcidin expression and iron parameters change in Type 2
diabetic patients. Diabetes Res Clin Pract. 93:43–48. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Babitt JL, Huang FW, Wrighting DM, Xia Y,
Sidis Y, Samad TA, Campagna JA, Chung RT, Schneyer AL, Woolf CJ, et
al: Bone morphogenetic protein signaling by hemojuvelin regulates
hepcidin expression. Nat Genet. 38:531–539. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Wrighting DM and Andrews NC: Interleukin-6
induces hepcidin expression through STAT3. Blood. 108:3204–3209.
2006. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Meynard D, Kautz L, Darnaud V,
Canonne-Hergaux F, Coppin H and Roth MP: Lack of the bone
morphogenetic protein BMP6 induces massive iron overload. Nat
Genet. 41:478–481. 2009. View
Article : Google Scholar : PubMed/NCBI
|
|
16
|
Steinbicker AU, Bartnikas TB, Lohmeyer LK,
Leyton P, Mayeur C, Kao SM, Pappas AE, Peterson RT, Bloch DB, Yu
PB, et al: Perturbation of hepcidin expression by BMP type I
receptor deletion induces iron overload in mice. Blood.
118:4224–4230. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Wang RH, Li C, Xu X, Zheng Y, Xiao C,
Zerfas P, Cooperman S, Eckhaus M, Rouault T, Mishra L and Deng CX:
A role of SMAD4 in iron metabolism through the positive regulation
of hepcidin expression. Cell Metab. 2:399–409. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Babitt JL, Huang FW, Xia Y, Sidis Y,
Andrews NC and Lin HY: Modulation of bone morphogenetic protein
signaling in vivo regulates systemic iron balance. J Clin Invest.
117:1933–1939. 2007. View
Article : Google Scholar : PubMed/NCBI
|
|
19
|
Nemeth E, Rivera S, Gabayan V, Keller C,
Taudorf S, Pedersen BK and Ganz T: IL-6 mediates hypoferremia of
inflammation by inducing the synthesis of the iron regulatory
hormone hepcidin. J Clin Invest. 113:1271–1276. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Fleming RE: Iron and inflammation:
Cross-talk between pathways regulating hepcidin. J Mol Med (Berl).
86:491–494. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Al-Hakeim HK, Al-Khakani MM and Al-Kindi
MA: Correlation of hepcidin level with insulin resistance and
endocrine glands function in major thalassemia. Adv Clin Exp Med.
24:69–78. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Andrews M, Soto N and Arredondo-Olguin M:
Association between ferritin and hepcidin levels and inflammatory
status in patients with type 2 diabetes mellitus and obesity.
Nutrition. 31:51–57. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Guzmán Andrews M and Olguín Arredondo M:
Association between ferritin, high sensitivity C-reactive protein
(hsCRP) and relative abundance of Hepcidin mRNA with the risk of
type 2 diabetes in obese subjects. Nutr Hosp. 30:577–584.
2014.PubMed/NCBI
|
|
24
|
Dongiovanni P, Ruscica M, Rametta R,
Recalcati S, Steffani L, Gatti S, Girelli D, Cairo G, Magni P,
Fargion S and Valenti L: Dietary iron overload induces visceral
adipose tissue insulin resistance. Am J Pathol. 182:2254–2263.
2013. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Dubern B, Girardet JP and Tounian P:
Insulin resistance and ferritin as major determinants of abnormal
serum aminotransferase in severely obese children. Int J Pediatr
Obes. 1:77–82. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Aigner E, Hinz C, Steiner K, Rossmann B,
Pfleger J, Hohla F, Steger B, Stadlmayr A, Patsch W and Datz C:
Iron stores, liver transaminase levels and metabolic risk in
healthy teenagers. Eur J Clin Invest. 40:155–163. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Barisani D, Pelucchi S, Mariani R,
Galimberti S, Trombini P, Fumagalli D, Meneveri R, Nemeth E, Ganz T
and Piperno A: Hepcidin and iron-related gene expression in
subjects with dysmetabolic hepatic iron overload. J Hepatol.
49:123–133. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Aigner E, Theurl I, Theurl M, Lederer D,
Haufe H, Dietze O, Strasser M, Datz C and Weiss G: Pathways
underlying iron accumulation in human nonalcoholic fatty liver
disease. Am J Clin Nutr. 87:1374–1383. 2008.PubMed/NCBI
|
|
29
|
Demircioğlu F, Görünmez G, Dağıstan E,
Göksügür SB, Bekdaş M, Tosun M, Kızıldağ B and Kısmet E: Serum
hepcidin levels and iron metabolism in obese children with and
without fatty liver: Case-control study. Eur J Pediatr.
173:947–951. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Weinberg ED: Iron loading: A risk factor
for osteoporosis. Biometals. 19:633–635. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Weinberg ED: Role of iron in osteoporosis.
Pediatr Endocrinol Rev. 6 Suppl 1:S81–S85. 2008.
|
|
32
|
Matsushima S, Hoshimoto M, Torii M, Ozaki
K and Narama I: Iron lactate-induced osteopenia in male
Sprague-Dawley rats. Toxicol Pathol. 29:623–629. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Guggenbuhl P, Deugnier Y, Boisdet JF,
Rolland Y, Perdriger A, Pawlotsky Y and Chalès G: Bone mineral
density in men with genetic hemochromatosis and HFE gene mutation.
Osteoporos Int. 16:1809–1814. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Mahachoklertwattana P, Sirikulchayanonta
V, Chuansumrit A, Karnsombat P, Choubtum L, Sriphrapradang A,
Domrongkitchaiporn S, Sirisriro R and Rajatanavin R: Bone
histomorphometry in children and adolescents with beta-thalassemia
disease: Iron-associated focal osteomalacia. J Clin Endocrinol
Metab. 88:3966–3972. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Isomura H, Fujie K, Shibata K, Inoue N,
Iizuka T, Takebe G, Takahashi K, Nishihira J, Izumi H and Sakamoto
W: Bone metabolism and oxidative stress in postmenopausal rats with
iron overload. Toxicology. 197:93–100. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Huang XI: Treatment of osteoporosis in
peri- and post-menopausal women with hepcidin. US Patent
20100204122 A1. Filed Feb 11, 2010; issued April 7, 2015.
|
|
37
|
Guo Y, Tang CY, Man XF, Tang HN, Tang J,
Wang F, Zhou CL, Tan SW, Feng YZ and Zhou HD: Insulin receptor
substrate-1 time-dependently regulates bone formation by
controlling collagen Iα2 expression via miR-342. FASEB J.
30:4214–4226. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Park S, Kanayama K, Kaur K, Tseng HC,
Banankhah S, Quje DT, Sayre JW, Jewett A and Nishimura I:
Osteonecrosis of the jaw developed in mice: Disease variants
regulated by γδ T cells in oral mucosal barrier immunity. J Biol
Chem. 290:17349–17366. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Ramanathan G, Olynyk JK and Ferrari P:
Diagnosing and preventing iron overload. Hemodial Int. 21 Suppl
1:S58–S67. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Ratcliffe LE, Thomas W, Glen J, Padhi S,
Pordes BA, Wonderling D, Connell R, Stephens S, Mikhail AI, Fogarty
DG, et al: Diagnosis and management of iron deficiency in CKD: A
summary of the NICE guideline recommendations and their rationale.
Am J Kidney Dis. 67:548–558. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Dallalio G, Law E and Means RT Jr:
Hepcidin inhibits in vitro erythroid colony formation at reduced
erythropoietin concentrations. Blood. 107:2702–2704. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Nemeth E, Valore EV, Territo M, Schiller
G, Lichtenstein A and Ganz T: Hepcidin, a putative mediator of
anemia of inflammation, is a type II acute-phase protein. Blood.
101:2461–2463. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Lee P, Peng H, Gelbart T, Wang L and
Beutler E: Regulation of hepcidin transcription by interleukin-1
and interleukin-6. Proc Natl Acad Sci USA. 102:1906–1910. 2005.
View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Bogdan AR, Miyazawa M, Hashimoto K and
Tsuji Y: Regulators of iron homeostasis: New players in metabolism,
cell death, and disease. Trends Biochem Sci. 41:274–286. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Tsay J, Yang Z, Ross FP,
Cunningham-Rundles S, Lin H, Coleman R, Mayer-Kuckuk P, Doty SB,
Grady RW, Giardina PJ, et al: Bone loss caused by iron overload in
a murine model: Importance of oxidative stress. Blood.
116:2582–2589. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Chen L, Zhu Z, Peng X, Wang Y, Wang Y,
Chen M, Wang Q and Jin J: Hepatic magnetic resonance imaging with
T2* mapping of ovariectomized rats: Correlation between iron
overload and postmenopausal osteoporosis. Eur Radiol. 24:1715–1724.
2014. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Zhao GY, Di DH, Wang B, Huang X and Xu YJ:
Effects of mouse hepcidin 1 treatment on osteoclast differentiation
and intracellular iron concentration. Inflammation. 38:718–727.
2015. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Rossi F, Perrotta S, Bellini G, Luongo L,
Tortora C, Siniscalco D, Francese M, Torella M, Nobili B, Di Marzo
V and Maione S: Iron overload causes osteoporosis in thalassemia
major patients through interaction with transient receptor
potential vanilloid type 1 (TRPV1) channels. Haematologica.
99:1876–1884. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Yamasaki K and Hagiwara H: Excess iron
inhibits osteoblast metabolism. Toxicol Lett. 191:211–215. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Messer JG, Kilbarger AK, Erikson KM and
Kipp DE: Iron overload alters iron-regulatory genes and proteins,
down-regulates osteoblastic phenotype, and is associated with
apoptosis in fetal rat calvaria cultures. Bone. 45:972–979. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Messer JG, Cooney PT and Kipp DE: Iron
chelator deferoxamine alters iron-regulatory genes and proteins and
suppresses osteoblast phenotype in fetal rat calvaria cells. Bone.
46:1408–1415. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
He YF, Ma Y, Gao C, Zhao GY, Zhang LL, Li
GF, Pan YZ, Li K and Xu YJ: Iron overload inhibits osteoblast
biological activity through oxidative stress. Biol Trace Elem Res.
152:292–296. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Li GF, Xu YJ, He YF, Du BC, Zhang P, Zhao
DY, Yu C, Qin CH and Li K: Effect of hepcidin on intracellular
calcium in human osteoblasts. Mol Cell Biochem. 366:169–174. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Shen GS, Yang Q, Jian JL, Zhao GY, Liu LL,
Wang X, Zhang W, Huang X and Xu YJ: Hepcidin1 knockout mice display
defects in bone microarchitecture and changes of bone formation
markers. Calcif Tissue Int. 94:632–639. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Kautz L, Besson-Fournier C, Meynard D,
Latour C, Roth MP and Coppin H: Iron overload induces BMP6
expression in the liver but not in the duodenum. Haematologica.
96:199–203. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Chang JS, Li YL, Lu CH, Owaga E, Chen WY
and Chiou HY: Interleukin-10 as a potential regulator of hepcidin
homeostasis in overweight and obese children: A cross-sectional
study in Taiwan. Nutrition. 30:1165–1170. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Barbosa MC, Dos Santos TE, de Souza GF, de
Assis LC, Freitas MV and Gonçalves RP: Impact of iron overload on
interleukin-10 levels, biochemical parameters and oxidative stress
in patients with sickle cell anemia. Rev Bras Hematol Hemoter.
35:29–34. 2013. View Article : Google Scholar : PubMed/NCBI
|
