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Article Open Access

Adiponectin and its receptors are involved in hypertensive vascular injury

  • Authors:
    • Ruimin Guo
    • Min Han
    • Juan Song
    • Jun Liu
    • Yanni Sun
  • View Affiliations / Copyright

    Affiliations: Emergency Medicine, Putuo Hospital Affiliated to Shanghai Traditional Chinese Medicine University, Shanghai 200333, P.R. China
    Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 209-215
    |
    Published online on: October 25, 2017
       https://doi.org/10.3892/mmr.2017.7878
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Abstract

Adipocyte-derived adiponectin (APN) is involved in the protection against cardiovascular disease, but the endogenous APN and its receptor expression in the perivascular adipocytes and their role in hypertensive vascular injury remain unclear. The present study aimed to detect endogenous APN and its receptor expression and their protective effects against hypertensive vascular injury. APN was mainly expressed in the perivascular adipocytes, while its receptors AdipoR1 and AdipoR2 were ubiquitously expressed in the blood vessels. Angiotensin II (Ang II)‑induced hypertension resulted in a significant decrease of APN and AdipoR1 and AdipoR2 in the perivascular adipocytes and vascular cells. The migration assay used demonstrated that APN attenuated Ang II‑induced vascular smooth muscle cells migration and p38 phosphorylation Furthermore, the in vivo study demonstrated that APN receptor agonist AdipoRon attenuated Ang II‑induced hypertensive vascular hypertrophy and fibrosis. Taken together, the present study indicated that perivascular adipocytes‑derived APN attenuated hypertensive vascular injury possibly via its receptor‑mediated inhibition of p38 signaling pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Guo R, Han M, Song J, Liu J and Sun Y: Adiponectin and its receptors are involved in hypertensive vascular injury. Mol Med Rep 17: 209-215, 2018.
APA
Guo, R., Han, M., Song, J., Liu, J., & Sun, Y. (2018). Adiponectin and its receptors are involved in hypertensive vascular injury. Molecular Medicine Reports, 17, 209-215. https://doi.org/10.3892/mmr.2017.7878
MLA
Guo, R., Han, M., Song, J., Liu, J., Sun, Y."Adiponectin and its receptors are involved in hypertensive vascular injury". Molecular Medicine Reports 17.1 (2018): 209-215.
Chicago
Guo, R., Han, M., Song, J., Liu, J., Sun, Y."Adiponectin and its receptors are involved in hypertensive vascular injury". Molecular Medicine Reports 17, no. 1 (2018): 209-215. https://doi.org/10.3892/mmr.2017.7878
Copy and paste a formatted citation
x
Spandidos Publications style
Guo R, Han M, Song J, Liu J and Sun Y: Adiponectin and its receptors are involved in hypertensive vascular injury. Mol Med Rep 17: 209-215, 2018.
APA
Guo, R., Han, M., Song, J., Liu, J., & Sun, Y. (2018). Adiponectin and its receptors are involved in hypertensive vascular injury. Molecular Medicine Reports, 17, 209-215. https://doi.org/10.3892/mmr.2017.7878
MLA
Guo, R., Han, M., Song, J., Liu, J., Sun, Y."Adiponectin and its receptors are involved in hypertensive vascular injury". Molecular Medicine Reports 17.1 (2018): 209-215.
Chicago
Guo, R., Han, M., Song, J., Liu, J., Sun, Y."Adiponectin and its receptors are involved in hypertensive vascular injury". Molecular Medicine Reports 17, no. 1 (2018): 209-215. https://doi.org/10.3892/mmr.2017.7878
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