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Article

Aspirin ameliorates cerebral infarction through regulation of TLR4/NF‑κB‑mediated endoplasmic reticulum stress in mouse model

  • Authors:
    • Xin Wang
    • Bin Shen
    • Dezhou Sun
    • Xiangyu Cui
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Dezhou People's Hospital, Dezhou, Shandong 420065, P.R. China
  • Pages: 479-487
    |
    Published online on: October 25, 2017
       https://doi.org/10.3892/mmr.2017.7879
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Abstract

Cerebral infarction is a cerebrovascular disease caused by local brain ischemic necrosis or softening, which is associated with diabetes, obesity, hypertension and rheumatic heart arrhythmia. Previous studies have indicated that aspirin is a potential oral anticoagulant in the treatment of cerebral ischemic stroke. However, the potential mechanism mediated by aspirin in cerebral infarction therapy is not well understood. The present study analyzed the therapeutic effects of aspirin on cerebral infarction and investigated the underlying molecular mechanism of aspirin‑ameliorated benefits for thrombolysis. The results demonstrated that aspirin inhibited inflammation and apoptosis of cerebrovascular endothelial cells in a mouse model of cerebral infarction. Aspirin treatment suppressed toll‑like receptor (TLR)4 and nuclear factor (NF)‑κB expression in cerebrovascular endothelial cells. Endoplasmic reticulum (ER) stress was suppressed by aspirin treatment through the downregulation of protein kinase R‑like endoplasmic reticulum kinase, eukaryotic translation initiation factor 2 subunit 1 and C/EBP homologous protein expression levels in cerebrovascular endothelial cells. It was identified that knockdown of TLR4 inhibited aspirin‑mediated downregulation of NF‑κB signaling pathway and ER stress in cerebrovascular endothelial cells. Expression levels of adenosine diphosphate plasminogen activator inhibitors, von Willebrand factor and thromboxane were downregulated in cerebrovascular endothelial cells and in serum in experimental mice. The results demonstrated that aspirin was beneficial forthrombolysis by decreasing thrombin‑activatable fibrinolysis inhibitor and plasminogen activator inhibitor‑1 expression in a mouse model of cerebral infarction. These results suggested that aspirin may improve cerebral infarction by downregulating TLR4/NF‑κB‑mediated ER stress in a mouse model.
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Copy and paste a formatted citation
Spandidos Publications style
Wang X, Shen B, Sun D and Cui X: Aspirin ameliorates cerebral infarction through regulation of TLR4/NF‑κB‑mediated endoplasmic reticulum stress in mouse model. Mol Med Rep 17: 479-487, 2018.
APA
Wang, X., Shen, B., Sun, D., & Cui, X. (2018). Aspirin ameliorates cerebral infarction through regulation of TLR4/NF‑κB‑mediated endoplasmic reticulum stress in mouse model. Molecular Medicine Reports, 17, 479-487. https://doi.org/10.3892/mmr.2017.7879
MLA
Wang, X., Shen, B., Sun, D., Cui, X."Aspirin ameliorates cerebral infarction through regulation of TLR4/NF‑κB‑mediated endoplasmic reticulum stress in mouse model". Molecular Medicine Reports 17.1 (2018): 479-487.
Chicago
Wang, X., Shen, B., Sun, D., Cui, X."Aspirin ameliorates cerebral infarction through regulation of TLR4/NF‑κB‑mediated endoplasmic reticulum stress in mouse model". Molecular Medicine Reports 17, no. 1 (2018): 479-487. https://doi.org/10.3892/mmr.2017.7879
Copy and paste a formatted citation
x
Spandidos Publications style
Wang X, Shen B, Sun D and Cui X: Aspirin ameliorates cerebral infarction through regulation of TLR4/NF‑κB‑mediated endoplasmic reticulum stress in mouse model. Mol Med Rep 17: 479-487, 2018.
APA
Wang, X., Shen, B., Sun, D., & Cui, X. (2018). Aspirin ameliorates cerebral infarction through regulation of TLR4/NF‑κB‑mediated endoplasmic reticulum stress in mouse model. Molecular Medicine Reports, 17, 479-487. https://doi.org/10.3892/mmr.2017.7879
MLA
Wang, X., Shen, B., Sun, D., Cui, X."Aspirin ameliorates cerebral infarction through regulation of TLR4/NF‑κB‑mediated endoplasmic reticulum stress in mouse model". Molecular Medicine Reports 17.1 (2018): 479-487.
Chicago
Wang, X., Shen, B., Sun, D., Cui, X."Aspirin ameliorates cerebral infarction through regulation of TLR4/NF‑κB‑mediated endoplasmic reticulum stress in mouse model". Molecular Medicine Reports 17, no. 1 (2018): 479-487. https://doi.org/10.3892/mmr.2017.7879
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