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Review Open Access

Biological functions and role of CCN1/Cyr61 in embryogenesis and tumorigenesis in the female reproductive system (Review)

  • Authors:
    • Rui Yang
    • Ying Chen
    • Daozhen Chen
  • View Affiliations / Copyright

    Affiliations: Wuxi Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu 214002, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3-10
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    Published online on: October 26, 2017
       https://doi.org/10.3892/mmr.2017.7880
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Abstract

Abstract. Cysteine‑rich angiogenic inducer 61 (CCN1/Cyr61) is a prompt response transcription product activated by growth factors. As a member of the CCN family, it mediates cell survival, proliferation, differentiation, migration, adhesion and synthesis of the extracellular matrix by binding directly to the integrins and heparin sulfate proteoglycans or activating multiple signaling transduction pathways. It has previously been demonstrated that CCN1/Cyr61 exhibits an important role in the female reproductive system during embryogenesis and tumorigenesis. However, the functions of CCN1/Cyr61 in the female reproductive system have not been systematically investigated, therefore, the primary aim of the present review is to introduce the role and function of CCN1/Cyr61 in the female reproductive system. The current review presents the molecular structure and biological function of CCN1/Cyr61 and provides detailed data on its expression pattern and contribution to the female reproductive system, including the role in embryogenesis and tumorigenesis.
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Copy and paste a formatted citation
Spandidos Publications style
Yang R, Chen Y and Chen D: Biological functions and role of CCN1/Cyr61 in embryogenesis and tumorigenesis in the female reproductive system (Review). Mol Med Rep 17: 3-10, 2018.
APA
Yang, R., Chen, Y., & Chen, D. (2018). Biological functions and role of CCN1/Cyr61 in embryogenesis and tumorigenesis in the female reproductive system (Review). Molecular Medicine Reports, 17, 3-10. https://doi.org/10.3892/mmr.2017.7880
MLA
Yang, R., Chen, Y., Chen, D."Biological functions and role of CCN1/Cyr61 in embryogenesis and tumorigenesis in the female reproductive system (Review)". Molecular Medicine Reports 17.1 (2018): 3-10.
Chicago
Yang, R., Chen, Y., Chen, D."Biological functions and role of CCN1/Cyr61 in embryogenesis and tumorigenesis in the female reproductive system (Review)". Molecular Medicine Reports 17, no. 1 (2018): 3-10. https://doi.org/10.3892/mmr.2017.7880
Copy and paste a formatted citation
x
Spandidos Publications style
Yang R, Chen Y and Chen D: Biological functions and role of CCN1/Cyr61 in embryogenesis and tumorigenesis in the female reproductive system (Review). Mol Med Rep 17: 3-10, 2018.
APA
Yang, R., Chen, Y., & Chen, D. (2018). Biological functions and role of CCN1/Cyr61 in embryogenesis and tumorigenesis in the female reproductive system (Review). Molecular Medicine Reports, 17, 3-10. https://doi.org/10.3892/mmr.2017.7880
MLA
Yang, R., Chen, Y., Chen, D."Biological functions and role of CCN1/Cyr61 in embryogenesis and tumorigenesis in the female reproductive system (Review)". Molecular Medicine Reports 17.1 (2018): 3-10.
Chicago
Yang, R., Chen, Y., Chen, D."Biological functions and role of CCN1/Cyr61 in embryogenesis and tumorigenesis in the female reproductive system (Review)". Molecular Medicine Reports 17, no. 1 (2018): 3-10. https://doi.org/10.3892/mmr.2017.7880
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