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Human umbilical cord mesenchymal stem cells alleviate interstitial fibrosis and cardiac dysfunction in a dilated cardiomyopathy rat model by inhibiting TNF‑α and TGF‑β1/ERK1/2 signaling pathways

  • Authors:
    • Changyi Zhang
    • Guichi Zhou
    • Yezeng Chen
    • Sizheng Liu
    • Fen Chen
    • Lichun Xie
    • Wei Wang
    • Yonggang Zhang
    • Tianyou Wang
    • Xiulan Lai
    • Lian Ma
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, P.R. China, Department of Pediatrics, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, P.R. China, Department of Pediatrics, Maternal and Child Health Care Hospital of Pingshan District, Shenzhen, Guangdong 518000, P.R. China, Department of Pediatrics, Beijing Children's Hospital, Capital Medical Hospital, Beijing 100032, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 71-78
    |
    Published online on: October 26, 2017
       https://doi.org/10.3892/mmr.2017.7882
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Abstract

Dilated cardiomyopathy (DCM) is a disease of the heart characterized by pathological remodeling, including patchy interstitial fibrosis and degeneration of cardiomyocytes. In the present study, the beneficial role of human umbilical cord‑derived mesenchymal stem cells (HuMSCs) derived from Wharton's jelly was evaluated in the myosin‑induced rat model of DCM. Male Lewis rats (aged 8‑weeks) were injected with porcine myosin to induce DCM. Cultured HuMSCs (1x106 cells/rat) were intravenously injected 28 days after myosin injection and the effects on myocardial fibrosis and the underlying signaling pathways were investigated and compared with vehicle‑injected and negative control rats. Myosin injections in rats (vehicle group and experimental group) for 28 days led to severe fibrosis and significant deterioration of cardiac function indicative of DCM. HuMSC treatment reduced fibrosis as determined by Masson's staining of collagen deposits, as well as quantification of molecular markers of myocardial fibrosis such as collagen I/III, profibrotic factors transforming growth factor‑β1 (TGF‑β1), tumor necrosis factor‑α (TNF‑α), and connective tissue growth factor (CTGF). HuMSC treatment restored cardiac function as observed using echocardiography. In addition, western blot analysis indicated that HuMSC injections in DCM rats inhibited the expression of TNF‑α, extracellular‑signal regulated kinase 1/2 (ERK1/2) and TGF‑β1, which is a master switch for inducing myocardial fibrosis. These findings suggested that HuMSC injections attenuated myocardial fibrosis and dysfunction in a rat model of DCM, likely by inhibiting TNF‑α and the TGF‑β1/ERK1/2 fibrosis pathways. Therefore, HuMSC treatment may represent a potential therapeutic method for treatment of DCM.
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View References

1 

Krejci J, Mlejnek D, Sochorova D and Nemec P: Inflammatory Cardiomyopathy: A current view on the pathophysiology, diagnosis, and treatment. Biomed Res Int. 2016:40876322016. View Article : Google Scholar : PubMed/NCBI

2 

Lauer B, Schannwell M, Kühl U, Strauer BE and Schultheiss HP: Antimyosin autoantibodies are associated with deterioration of systolic and diastolic left ventricular function in patients with chronic myocarditis. J Am Coll Cardiol. 35:11–18. 2000. View Article : Google Scholar : PubMed/NCBI

3 

Binah O: Pharmacologic modulation of the immune interaction between cytotoxic lymphocytes and ventricular myocytes. J Cardiovasc Pharmacol. 38:298–316. 2001. View Article : Google Scholar : PubMed/NCBI

4 

Kodama M, Matsumoto Y, Fujiwara M, Masani F, Izumi T and Shibata A: A novel experimental model of giant cell myocarditis induced in rats by immunization with cardiac myosin fraction. Clin Immunol Immunopathol. 57:250–262. 1990. View Article : Google Scholar : PubMed/NCBI

5 

Spezzacatene A, Sinagra G, Merlo M, Barbati G, Graw SL, Brun F, Slavov D, Di Lenarda A, Salcedo EE, Towbin JA, et al: Arrhythmogenic phenotype in dilated cardiomyopathy: Natural history and predictors of life-threatening arrhythmias. J Am Heart Assoc. 4:e0021492015. View Article : Google Scholar : PubMed/NCBI

6 

Williams AR and Hare JM: Mesenchymal stem cells: Biology, pathophysiology, translational findings, and therapeutic implications for cardiac disease. Circ Res. 109:923–940. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Sanganalmath SK and Bolli R: Cell therapy for heart failure: A comprehensive overview of experimental and clinical studies, current challenges, and future directions. Circ Res. 113:810–834. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Kelkar AA, Butler J, Schelbert EB, Greene SJ, Quyyumi AA, Bonow RO, Cohen I, Gheorghiade M, Lipinski MJ, Sun W, et al: Mechanisms contributing to the progression of ischemic and nonischemic dilated cardiomyopathy: Possible modulating effects of paracrine activities of stem cells. J Am Coll Cardiol. 66:2038–2047. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Mancini Kizilay O, Shum-Tim D, Stochaj U, Correa JA and Colmegna I: Age, atherosclerosis and type 2 diabetes reduce human mesenchymal stromal cell-mediated T-cell suppression. Stem Cell Res Ther. 6:1402015. View Article : Google Scholar : PubMed/NCBI

10 

Hare JM, Fishman JE, Gerstenblith G, Zambrano JP, Suncion VY, Tracy M, Ghersin E, Johnston PV, Brinker JA, et al: Comparison of allogeneic vs. autologous bone marrow-derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy: The POSEIDON randomized trial. Jama. 308:2369–2379. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Karantalis V and Hare JM: Use of mesenchymal stem cells for therapy of cardiac disease. Circ Res. 116:1413–1430. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Golpanian S, Wolf A, Hatzistergos KE and Hare JM: Rebuilding the damaged heart: Mesenchymal stem cells, cell-based therapy, and engineered heart tissue. Physiol Rev. 96:1127–1168. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Wang HS, Hung SC, Peng ST, Huang CC, Wei HM, Guo YJ, Fu YS, Lai MC and Chen CC: Mesenchymal stem cells in the Wharton's jelly of the human umbilical cord. Stem Cells. 22:1330–1337. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Cho PS, Messina DJ, Hirsh EL, Chi N, Goldman SN, Lo DP, Harris IR, Popma SH, Sachs DH and Huang CA: Immunogenicity of umbilical cord tissue derived cells. Blood. 111:430–438. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Batsali AK, Kastrinaki MC, Papadaki HA and Pontikoglou C: Mesenchymal stem cells derived from Wharton's Jelly of the umbilical cord: Biological properties and emerging clinical applications. Curr Stem Cell Res Ther. 8:144–155. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Sun L, Wang D, Liang J, Zhang H, Feng X, Wang H, Hua B, Liu B, Ye S, Hu X, et al: Umbilical cord mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus. Arthritis Rheum. 62:2467–2475. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Wang L, Wang L, Cong X, Liu G, Zhou J, Bai B, Li Y, Bai W, Li M, Ji H, et al: Human umbilical cord mesenchymal stem cell therapy for patients with active rheumatoid arthritis: Safety and efficacy. Stem Cells Dev. 22:3192–3202. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Wang H, Qiu X, Ni P, Qiu X, Lin X, Wu W, Xie L, Lin L, Min J, Lai X, et al: Immunological characteristics of human umbilical cord mesenchymal stem cells and the therapeutic effects of their transplantion on hyperglycemia in diabetic rats. Int J Mol Med. 33:263–270. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Can A, Ulus AT, Cinar O, Celikkan Topal F, Simsek E, Akyol M, Canpolat U, Erturk M, Kara F and Ilhan O: Human umbilical cord mesenchymal stromal cell transplantation in myocardial ischemia (HUC-HEART Trial). A study protocol of a Phase 1/2, controlled and randomized trial in combination with coronary artery bypass grafting. Stem Cell Rev. 11:752–760. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Liu CB, Huang H, Sun P, Ma SZ, Liu AH, Xue J, Fu JH, Liang YQ, Liu B, Wu DY, et al: Human umbilical cord-derived mesenchymal stromal cells improve left ventricular function, perfusion, and remodeling in a porcine model of chronic myocardial ischemia. Stem Cells Transl Med. 5:1004–1013. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Cheng M, Wu G, Song Y, Wang L, Tu L, Zhang L and Zhang C: Celastrol-induced suppression of the MiR-21/ERK signalling pathway attenuates cardiac fibrosis and dysfunction. Cell Physiol Biochem. 38:1928–1938. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Wu H, Li GN, Xie J, Li R, Chen QH, Chen JZ, Wei ZH, Kang LN and Xu B: Resveratrol ameliorates myocardial fibrosis by inhibiting ROS/ERK/TGF-β/periostin pathway in STZ-induced diabetic mice. BMC Cardiovasc Disord. 16:52016. View Article : Google Scholar : PubMed/NCBI

23 

Soetikno V, Sari FR, Sukumaran V, Lakshmanan AP, Mito S, Harima M, Thandavarayan RA, Suzuki K, Nagata M, Takagi R and Watanabe K: Curcumin prevents diabetic cardiomyopathy in streptozotocin-induced diabetic Rats: Possible involvement of PKC-MAPK signaling pathway. Eur J Pharm Sci. 47:604–614. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Wang HW, Lin LM, He HY, You F, Li WZ, Huang TH, Ma GX and Ma L: Human umbilical cord mesenchymal stem cells derived from Wharton's jelly differentiate into insulin-producing cells in vitro. Chinese Med J (Engl). 124:1534–1539. 2011.

25 

Zhang C, Zhou G, Cai C, Li J, Chen F, Xie L, Wang W, Zhang Y, Lai X and Ma L: Human umbilical cord mesenchymal stem cells alleviate acute myocarditis by modulating endoplasmic reticulum stress and extracellular signal regulated 1/2-mediated apoptosis. Mol Med Rep. 15:3515–3520. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Dec GW and Fuster V: Idiopathic dilated cardiomyopathy. N Engl J Med. 331:1564–1575. 1994. View Article : Google Scholar : PubMed/NCBI

28 

Kania G, Blyszczuk P and Eriksson U: Mechanisms of cardiac fibrosis in inflammatory heart disease. Trends Cardiovasc Med. 19:247–252. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Eckhouse SR and Spinale FG: Changes in the myocardial interstitium and contribution to the progression of heart failure. Heart Fail Clin. 8:7–20. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Broberg CS and Burchill LJ: Myocardial factor revisited: The importance of myocardial fibrosis in adults with congenital heart disease. Int J Cardiol. 189:204–210. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Rosin NL, Falkenham A, Sopel MJ, Lee TD and Legare JF: Regulation and role of connective tissue growth factor in AngII-induced myocardial fibrosis. Am J Pathol. 182:714–726. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Dobaczewski M, Chen W and Frangogiannis NG: Transforming growth factor (TGF)-β signaling in cardiac remodeling. J Mol Cell Cardiol. 51:600–606. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Rosenkranz S, Flesch M, Amann K, Haeuseler C, Kilter H, Seeland U, Schlüter KD and Böhm M: Alterations of beta-adrenergic signaling and cardiac hypertrophy in transgenic mice overexpressing TGF-beta(1). Am J Physiol Heart Circ Physiol. 283:H1253–H1262. 2002. View Article : Google Scholar : PubMed/NCBI

34 

Sukumaran V, Watanabe K, Veeraveedu PT, Thandavarayan RA, Gurusamy N, Ma M, Yamaguchi K, Suzuki K, Kodama M and Aizawa Y: Telmisartan, an angiotensin-II receptor blocker ameliorates cardiac remodeling in rats with dilated cardiomyopathy. Hypertension Res. 33:695–702. 2010. View Article : Google Scholar

35 

Yu CM, Tipoe GL, Lai Wing-Hon K and Lau CP: Effects of combination of angiotensin-converting enzyme inhibitor and angiotensin receptor antagonist on inflammatory cellular infiltration and myocardial interstitial fibrosis after acute myocardial infarction. J Am Coll Cardiol. 38:1207–1215. 2001. View Article : Google Scholar : PubMed/NCBI

36 

Moodley Y, Atienza D, Manuelpillai U, Samuel CS, Tchongue J, Ilancheran S, Boyd R and Trounson A: Human umbilical cord mesenchymal stem cells reduce fibrosis of bleomycin-induced lung injury. Am J Pathol. 175:303–313. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Massague J: Integration of Smad and MAPK pathways: A link and a linker revisited. Genes Dev. 17:2993–2997. 2003. View Article : Google Scholar : PubMed/NCBI

38 

Guo X and Wang XF: Signaling cross-talk between TGF-beta/BMP and other pathways. Cell research. 19:71–88. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Huby AC, Turdi S, James J, Towbin JA and Purevjav E: FasL expression in cardiomyocytes activates the ERK1/2 pathway, leading to dilated cardiomyopathy and advanced heart failure. Clin Sci (Lond). 130:289–299. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Liu Y, Zhu H, Su Z, Sun C, Yin J, Yuan H, Sandoghchian S, Jiao Z, Wang S and Xu H: IL-17 contributes to cardiac fibrosis following experimental autoimmune myocarditis by a PKCβ/Erk1/2/NF-kappaB-dependent signaling pathway. Int Immunol. 24:605–612. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Sriramula S, Haque M, Majid DS and Francis J: Involvement of tumor necrosis factor-alpha in angiotensin II-mediated effects on salt appetite, hypertension, and cardiac hypertrophy. Hypertension. 51:1345–1351. 2008. View Article : Google Scholar : PubMed/NCBI

42 

Sun M, Chen M, Dawood F, Zurawska U, Li JY, Parker T, Kassiri Z, Kirshenbaum LA, Arnold M, Khokha R and Liu PP: Tumor necrosis factor-alpha mediates cardiac remodeling and ventricular dysfunction after pressure overload state. Circulation. 115:1398–1407. 2007. View Article : Google Scholar : PubMed/NCBI

43 

Sivasubramanian N, Coker ML, Kurrelmeyer KM, MacLellan WR, DeMayo FJ, Spinale FG and Mann DL: Left ventricular remodeling in transgenic mice with cardiac restricted overexpression of tumor necrosis factor. Circulation. 104:826–831. 2001. View Article : Google Scholar : PubMed/NCBI

44 

Westermann D, Van Linthout S, Dhayat S, Dhayat N, Schmidt A, Noutsias M, Song XY, Spillmann F, Riad A, Schultheiss HP and Tschöpe C: Tumor necrosis factor-alpha antagonism protects from myocardial inflammation and fibrosis in experimental diabetic cardiomyopathy. Basic Res Cardiol. 102:500–507. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang C, Zhou G, Chen Y, Liu S, Chen F, Xie L, Wang W, Zhang Y, Wang T, Lai X, Lai X, et al: Human umbilical cord mesenchymal stem cells alleviate interstitial fibrosis and cardiac dysfunction in a dilated cardiomyopathy rat model by inhibiting TNF‑α and TGF‑β1/ERK1/2 signaling pathways. Mol Med Rep 17: 71-78, 2018.
APA
Zhang, C., Zhou, G., Chen, Y., Liu, S., Chen, F., Xie, L. ... Ma, L. (2018). Human umbilical cord mesenchymal stem cells alleviate interstitial fibrosis and cardiac dysfunction in a dilated cardiomyopathy rat model by inhibiting TNF‑α and TGF‑β1/ERK1/2 signaling pathways. Molecular Medicine Reports, 17, 71-78. https://doi.org/10.3892/mmr.2017.7882
MLA
Zhang, C., Zhou, G., Chen, Y., Liu, S., Chen, F., Xie, L., Wang, W., Zhang, Y., Wang, T., Lai, X., Ma, L."Human umbilical cord mesenchymal stem cells alleviate interstitial fibrosis and cardiac dysfunction in a dilated cardiomyopathy rat model by inhibiting TNF‑α and TGF‑β1/ERK1/2 signaling pathways". Molecular Medicine Reports 17.1 (2018): 71-78.
Chicago
Zhang, C., Zhou, G., Chen, Y., Liu, S., Chen, F., Xie, L., Wang, W., Zhang, Y., Wang, T., Lai, X., Ma, L."Human umbilical cord mesenchymal stem cells alleviate interstitial fibrosis and cardiac dysfunction in a dilated cardiomyopathy rat model by inhibiting TNF‑α and TGF‑β1/ERK1/2 signaling pathways". Molecular Medicine Reports 17, no. 1 (2018): 71-78. https://doi.org/10.3892/mmr.2017.7882
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang C, Zhou G, Chen Y, Liu S, Chen F, Xie L, Wang W, Zhang Y, Wang T, Lai X, Lai X, et al: Human umbilical cord mesenchymal stem cells alleviate interstitial fibrosis and cardiac dysfunction in a dilated cardiomyopathy rat model by inhibiting TNF‑α and TGF‑β1/ERK1/2 signaling pathways. Mol Med Rep 17: 71-78, 2018.
APA
Zhang, C., Zhou, G., Chen, Y., Liu, S., Chen, F., Xie, L. ... Ma, L. (2018). Human umbilical cord mesenchymal stem cells alleviate interstitial fibrosis and cardiac dysfunction in a dilated cardiomyopathy rat model by inhibiting TNF‑α and TGF‑β1/ERK1/2 signaling pathways. Molecular Medicine Reports, 17, 71-78. https://doi.org/10.3892/mmr.2017.7882
MLA
Zhang, C., Zhou, G., Chen, Y., Liu, S., Chen, F., Xie, L., Wang, W., Zhang, Y., Wang, T., Lai, X., Ma, L."Human umbilical cord mesenchymal stem cells alleviate interstitial fibrosis and cardiac dysfunction in a dilated cardiomyopathy rat model by inhibiting TNF‑α and TGF‑β1/ERK1/2 signaling pathways". Molecular Medicine Reports 17.1 (2018): 71-78.
Chicago
Zhang, C., Zhou, G., Chen, Y., Liu, S., Chen, F., Xie, L., Wang, W., Zhang, Y., Wang, T., Lai, X., Ma, L."Human umbilical cord mesenchymal stem cells alleviate interstitial fibrosis and cardiac dysfunction in a dilated cardiomyopathy rat model by inhibiting TNF‑α and TGF‑β1/ERK1/2 signaling pathways". Molecular Medicine Reports 17, no. 1 (2018): 71-78. https://doi.org/10.3892/mmr.2017.7882
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