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Article

Anticancer effect of quinacrine on diffuse large B‑cell lymphoma via inhibition of MSI2‑NUMB signaling pathway

Corrigendum in: /10.3892/mmr.2020.11813
  • Authors:
    • Shujun Yang
    • Lixia Sheng
    • Kaihong Xu
    • Yi Wang
    • Huiling Zhu
    • Ping Zhang
    • Qitian Mu
    • Guifang Ouyang
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Ningbo First Hospital, Ningbo, Zhejiang 315010, P.R. China
  • Pages: 522-530
    |
    Published online on: October 26, 2017
       https://doi.org/10.3892/mmr.2017.7892
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Abstract

Diffuse large B‑cell lymphoma (DLBCL) is the most common subtype of non‑Hodgkin's lymphoma. Despite improvements in the clinical outcomes of DLBCL, ~30% of patients will develop relapse/refractory disease. Therefore, novel therapeutic drugs have been investigated to improve disease outcomes. Previous studies have revealed the anticancer effects of quinacrine (QC) on tumor cells in vitro, although its role in human DLBCL is yet to be identified. The present study sought to examine the cytotoxic effect of QC on DLBCL cells. QC induced G0/G1 cell cycle arrest and apoptosis in the DLBCL cell lines SU‑DHL‑8 and OCI‑LY01, in a dose‑dependent manner, in addition to the downregulation of cyclin‑dependent kinase 4/6 and the upregulation of cleaved poly‑ADP ribose polymerase 1. Upon exposure to QC, RNA‑binding protein Musashi homolog 2 inactivation and activation of protein numb homolog were observed. In addition, QC was able to inhibit the expression of Myc proto‑oncogene protein. The results of the present study indicated that QC may be a potential anti‑DLBCL drug.
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Copy and paste a formatted citation
Spandidos Publications style
Yang S, Sheng L, Xu K, Wang Y, Zhu H, Zhang P, Mu Q and Ouyang G: Anticancer effect of quinacrine on diffuse large B‑cell lymphoma via inhibition of MSI2‑NUMB signaling pathway Corrigendum in /10.3892/mmr.2020.11813. Mol Med Rep 17: 522-530, 2018.
APA
Yang, S., Sheng, L., Xu, K., Wang, Y., Zhu, H., Zhang, P. ... Ouyang, G. (2018). Anticancer effect of quinacrine on diffuse large B‑cell lymphoma via inhibition of MSI2‑NUMB signaling pathway Corrigendum in /10.3892/mmr.2020.11813. Molecular Medicine Reports, 17, 522-530. https://doi.org/10.3892/mmr.2017.7892
MLA
Yang, S., Sheng, L., Xu, K., Wang, Y., Zhu, H., Zhang, P., Mu, Q., Ouyang, G."Anticancer effect of quinacrine on diffuse large B‑cell lymphoma via inhibition of MSI2‑NUMB signaling pathway Corrigendum in /10.3892/mmr.2020.11813". Molecular Medicine Reports 17.1 (2018): 522-530.
Chicago
Yang, S., Sheng, L., Xu, K., Wang, Y., Zhu, H., Zhang, P., Mu, Q., Ouyang, G."Anticancer effect of quinacrine on diffuse large B‑cell lymphoma via inhibition of MSI2‑NUMB signaling pathway Corrigendum in /10.3892/mmr.2020.11813". Molecular Medicine Reports 17, no. 1 (2018): 522-530. https://doi.org/10.3892/mmr.2017.7892
Copy and paste a formatted citation
x
Spandidos Publications style
Yang S, Sheng L, Xu K, Wang Y, Zhu H, Zhang P, Mu Q and Ouyang G: Anticancer effect of quinacrine on diffuse large B‑cell lymphoma via inhibition of MSI2‑NUMB signaling pathway Corrigendum in /10.3892/mmr.2020.11813. Mol Med Rep 17: 522-530, 2018.
APA
Yang, S., Sheng, L., Xu, K., Wang, Y., Zhu, H., Zhang, P. ... Ouyang, G. (2018). Anticancer effect of quinacrine on diffuse large B‑cell lymphoma via inhibition of MSI2‑NUMB signaling pathway Corrigendum in /10.3892/mmr.2020.11813. Molecular Medicine Reports, 17, 522-530. https://doi.org/10.3892/mmr.2017.7892
MLA
Yang, S., Sheng, L., Xu, K., Wang, Y., Zhu, H., Zhang, P., Mu, Q., Ouyang, G."Anticancer effect of quinacrine on diffuse large B‑cell lymphoma via inhibition of MSI2‑NUMB signaling pathway Corrigendum in /10.3892/mmr.2020.11813". Molecular Medicine Reports 17.1 (2018): 522-530.
Chicago
Yang, S., Sheng, L., Xu, K., Wang, Y., Zhu, H., Zhang, P., Mu, Q., Ouyang, G."Anticancer effect of quinacrine on diffuse large B‑cell lymphoma via inhibition of MSI2‑NUMB signaling pathway Corrigendum in /10.3892/mmr.2020.11813". Molecular Medicine Reports 17, no. 1 (2018): 522-530. https://doi.org/10.3892/mmr.2017.7892
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