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Article

MicroRNA‑20a promotes inflammation via the nuclear factor‑κB signaling pathway in pediatric pneumonia

  • Authors:
    • Zhihong Liu
    • Haiying Yu
    • Qiuye Guo
  • View Affiliations / Copyright

    Affiliations: Department of Emergency, Jinan Maternity and Child Care Hospital, Jinan, Shandong 250001, P.R. China, Department of Pediatrics, Weifang People's Hospital, Weifang, Shandong 261000, P.R. China, Department of Respiratory Medicine, Hanzhong Central Hospital, Hanzhong, Shaanxi 723000, P.R. China
  • Pages: 612-617
    |
    Published online on: October 26, 2017
       https://doi.org/10.3892/mmr.2017.7899
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Abstract

Pneumonia is a common respiratory disease worldwide, which is preventable and treatable; however, it is recognized as a leading cause of mortality in children. The present study aimed to investigate the role and mechanism of microRNA (miR)‑20a in inflammation in pediatric pneumonia. Clinical serum samples were collected from children with pneumonia and healthy children. Initially, the serum expression levels of miR‑20a were detected by reverse transcription‑quantitative polymerase chain reaction. Subsequently, A549 cells were randomly divided into four groups: Control group; lipopolysaccharide (LPS; 1 µg/ml) group; LPS + miR‑20a group; and LPS + miR‑20a + pyrrolidine dithiocarbamate (PDTC; 100 mmol/l) group. The concentrations of interleukin‑6 (IL‑6), tumor necrosis factor (TNF)‑α and C‑reactive protein (CRP) in clinical serum samples and A549 cells were determined by ELISA. In addition, the protein expression levels of inhibitor of nuclear factor (NF)‑κB α (IκBα) and phosphorylated (p)‑NF‑κB were measured by western blotting. The results demonstrated that miR‑20a was upregulated in children with pneumonia and in lung cells with LPS‑induced inflammatory injury (P<0.01). In addition, compared with the LPS group, cells in the LPS + miR‑20a group exhibited increased expression levels of IL‑6, TNF‑α and CRP (P<0.05). Overexpression of miR‑20a also resulted in upregulation of the expression levels of IκBα and p‑NF‑κB compared with in the LPS group (P<0.05). Furthermore, treatment with the NF‑κB inhibitor PDTC inhibited the expression of inflammatory factors compared with in the LPS + miR‑20a group (P<0.05). In conclusion, the present study indicated that miR‑20a is upregulated in pediatric pneumonia, and overexpression of miR‑20a may promote inflammation through activation of the NF‑κB signaling pathway.
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1 

He C, Kang L, Miao L, Li Q, Liang J, Li X, Wang Y and Zhu J: Pneumonia mortality among children under 5 in China from 1996 to 2013: An analysis from national surveillance system. PLoS One. 10:e01336202015. View Article : Google Scholar : PubMed/NCBI

2 

Wardlaw T, Salama P, Johansson EW and Mason E: Pneumonia: The leading killer of children. Lancet. 368:1048–1050. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Liu L, Johnson HL, Cousens S, Perin J, Scott S, Lawn JE, Rudan I, Campbell H, Cibulskis R, Li M, et al: Global, regional, and national causes of child mortality: An updated systematic analysis for 2010 with time trends since 2000. Lancet. 379:2151–2161. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Bhutta ZA, Das JK, Walker N, Rizvi A, Campbell H, Rudan I and Black RE: Lancet Diarrhoea and Pneumonia Interventions Study Group: Interventions to address deaths from childhood pneumonia and diarrhoea equitably: What works and at what cost? Lancet. 381:1417–1429. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Leyenaar JK, Lagu T, Shieh MS, Pekow PS and Lindenauer PK: Management and outcomes of pneumonia among children with complex chronic conditions. Pediatr Infect Dis J. 33:907–911. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Plioplys AV and Kasnicka I: Nebulized tobramycin: Prevention of pneumonias in patients with severe cerebral palsy. J Pediatr Rehabil Med. 4:155–158. 2011.PubMed/NCBI

7 

Loddenkemper T, Syed TU, Ramgopal S, Gulati D, Thanaviratananich S, Kothare SV, Alshekhlee A and Koubeissi MZ: Risk factors associated with death in in-hospital pediatric convulsive status epilepticus. PLoS One. 7:e474742012. View Article : Google Scholar : PubMed/NCBI

8 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Kloosterman WP and Plasterk RH: The diverse functions of microRNAs in animal development and disease. Dev Cell. 11:441–450. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Jovanovic M and Hengartner MO: miRNAs and apoptosis: RNAs to die for. Oncogene. 25:6176–6187. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Michael MZ, O'Connor SM, van Holst Pellekaan NG, Young GP and James RJ: Reduced accumulation of specific microRNAs in colorectal neoplasia. Mol Cancer Res. 1:882–891. 2003.PubMed/NCBI

12 

Calin GA, Liu CG, Sevignani C, Ferracin M, Felli N, Dumitru CD, Shimizu M, Cimmino A, Zupo S, Dono M, et al: MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias. Proc Natl Acad Sci USA. 101:11755–11760. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Iorio MV, Ferracin M, Liu CG, Veronese A, Spizzo R, Sabbioni S, Magri E, Pedriali M, Fabbri M, Campiglio M, et al: MicroRNA gene expression deregulation in human breast cancer. Cancer Res. 65:7065–7070. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Murakami Y, Yasuda T, Saigo K, Urashima T, Toyoda H, Okanoue T and Shimotohno K: Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues. Oncogene. 25:2537–2545. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Yanaihara N, Caplen N, Bowman E, Seike M, Kumamoto K, Yi M, Stephens RM, Okamoto A, Yokota J, Tanaka T, et al: Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell. 9:189–198. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Khoshgoo N, Kholdebarin R, Iwasiow BM and Keijzer R: MicroRNAs and lung development. Pediatr Pulmonol. 48:317–323. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Booton R and Lindsay MA: Emerging role of MicroRNAs and long noncoding RNAs in respiratory disease. Chest. 146:193–204. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Omran A, Jagoo M, Ashhab MU, He F, Kong H, Peng J and Yin F: MicroRNAs expression changes in acute Streptococcus pneumoniae meningitis. Translational Neurosci. 5:131–136. 2014. View Article : Google Scholar

19 

Hayashita Y, Osada H, Tatematsu Y, Yamada H, Yanagisawa K, Tomida S, Yatabe Y, Kawahara K, Sekido Y and Takahashi T: A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation. Cancer Res. 65:9628–9632. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Qi W, Li H, Cai XH, Gu JQ, Meng J, Xie HQ, Zhang JL, Chen J, Jin XG, Tang Q, et al: Lipoxin A4 activates alveolar epithelial sodium channel gamma via the microRNA-21/PTEN/AKT pathway in lipopolysaccharide-induced inflammatory lung injury. Lab Invest. 95:1258–1268. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Romacho T, Azcutia V, Vazquez-Bella M, Matesanz N, Cercas E, Nevado J, Carraro R, Rodríguez-Mañas L, Sánchez-Ferrer CF and Peiró C: Extracellular PBEF/NAMPT/visfatin activates pro-inflammatory signalling in human vascular smooth muscle cells through nicotinamide phosphoribosyltransferase activity. Diabetologia. 52:2455–2463. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Plank M, Maltby S, Mattes J and Foster P: Targeting translational control as a novel way to treat inflammatory disease: The emerging role of microRNAs. Clin Exp Allergy. 43:981–999. 2013. View Article : Google Scholar : PubMed/NCBI

24 

O'Connell RM, Rao DS and Baltimore D: microRNA regulation of inflammatory responses. Annu Rev Immunol. 30:295–312. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Bazzoni F, Rossato M, Fabbri M, Gaudiosi D, Mirolo M, Mori L, Tamassia N, Mantovani A, Cassatella MA and Locati M: Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals. Proc Natl Acad Sci USA. 106:5282–5287. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Sheedy FJ, Palsson-McDermott E, Hennessy EJ, Martin C, O'Leary JJ, Ruan Q, Johnson DS, Chen Y and O'Neill LA: Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21. Nat Immunol. 11:141–147. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Tili E, Michaille JJ, Cimino A, Costinean S, Dumitru CD, Adair B, Fabbri M, Alder H, Liu CG, Calin GA and Croce CM: Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock. J Immunol. 179:5082–5089. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Tang B, Xiao B, Liu Z, Li N, Zhu ED, Li BS, Xie QH, Zhuang Y, Zou QM and Mao XH: Identification of MyD88 as a novel target of miR-155, involved in negative regulation of Helicobacter pylori-induced inflammation. FEBS Lett. 584:1481–1486. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Taganov KD, Boldin MP, Chang KJ and Baltimore D: NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci USA. 103:12481–12486. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Liu G, Friggeri A, Yang Y, Park YJ, Tsuruta Y and Abraham E: miR-147, a microRNA that is induced upon Toll-like receptor stimulation, regulates murine macrophage inflammatory responses. Proc Natl Acad Sci USA. 106:15819–15824. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Olive V, Jiang I and He L: mir-17-92, a cluster of miRNAs in the midst of the cancer network. Int J Biochem Cell Biol. 42:1348–1354. 2010. View Article : Google Scholar : PubMed/NCBI

32 

O'Donnell KA, Wentzel EA, Zeller KI, Dang CV and Mendell JT: c-Myc-regulated microRNAs modulate E2F1 expression. Nature. 435:839–843. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Pickering MT, Stadler BM and Kowalik TF: miR-17 and miR-20a temper an E2F1-induced G1 checkpoint to regulate cell cycle progression. Oncogene. 28:140–145. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Fan X, Liu Y, Jiang J, Ma Z, Wu H, Liu T, Liu M, Li X and Tang H: miR-20a promotes proliferation and invasion by targeting APP in human ovarian cancer cells. Acta Biochim Biophys Sin (Shanghai). 42:318–324. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Philippe L, Alsaleh G, Pichot A, Ostermann E, Zuber G, Frisch B, Sibilia J, Pfeffer S, Bahram S, Wachsmann D and Georgel P: MiR-20a regulates ASK1 expression and TLR4-dependent cytokine release in rheumatoid fibroblast-like synoviocytes. Ann Rheum Dis. 72:1071–1079. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Zhu D, Pan C, Li L, Bian Z, Lv Z, Shi L, Zhang J, Li D, Gu H, Zhang CY, et al: MicroRNA-17/20a/106a modulate macrophage inflammatory responses through targeting signal-regulatory protein α. J Allergy Clin Immunol. 132:426–436. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Han Z, Boyle DL, Manning AM and Firestein GS: AP-1 and NF-kB regulation in rheumatoid arthritis and murine collagen-induced arthritis. Autoimmunity. 28:197–208. 1998. View Article : Google Scholar : PubMed/NCBI

38 

Sakurai H, Hisada Y, Ueno M, Sugiura M, Kawashima K and Sugita T: Activation of transcription factor NF-κappa B in experimental glomerulonephritis in rats. Biochim Biophys Acta. 1316:132–138. 1996. View Article : Google Scholar : PubMed/NCBI

39 

van Den Brink GR, ten Kate FJ, Ponsioen CY, Rive MM, Tytgat GN, van Deventer SJ and Peppelenbosch MP: Expression and activation of NF-κappa B in the antrum of the human stomach. J Immunol. 164:3353–3359. 2000. View Article : Google Scholar : PubMed/NCBI

40 

Hart LA, Krishnan VL, Adcock IM, Barnes PJ and Chung KF: Activation and localization of transcription factor, nuclear factor-κappaB, in asthma. Am J Respir Crit Care Med. 158:1585–1592. 1998. View Article : Google Scholar : PubMed/NCBI

41 

Ma X, Buscaglia Becker LE, Barker JR and Li Y: MicroRNAs in NF-κB signaling. J Mol Cell Biol. 3:159–166. 2011. View Article : Google Scholar : PubMed/NCBI

42 

Bhaumik D, Scott GK, Schokrpur S, Patil CK, Orjalo AV, Rodier F, Lithgow GJ and Campisi J: MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8. Aging (Albany NY). 1:402–401. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu Z, Yu H and Guo Q: MicroRNA‑20a promotes inflammation via the nuclear factor‑κB signaling pathway in pediatric pneumonia. Mol Med Rep 17: 612-617, 2018.
APA
Liu, Z., Yu, H., & Guo, Q. (2018). MicroRNA‑20a promotes inflammation via the nuclear factor‑κB signaling pathway in pediatric pneumonia. Molecular Medicine Reports, 17, 612-617. https://doi.org/10.3892/mmr.2017.7899
MLA
Liu, Z., Yu, H., Guo, Q."MicroRNA‑20a promotes inflammation via the nuclear factor‑κB signaling pathway in pediatric pneumonia". Molecular Medicine Reports 17.1 (2018): 612-617.
Chicago
Liu, Z., Yu, H., Guo, Q."MicroRNA‑20a promotes inflammation via the nuclear factor‑κB signaling pathway in pediatric pneumonia". Molecular Medicine Reports 17, no. 1 (2018): 612-617. https://doi.org/10.3892/mmr.2017.7899
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Z, Yu H and Guo Q: MicroRNA‑20a promotes inflammation via the nuclear factor‑κB signaling pathway in pediatric pneumonia. Mol Med Rep 17: 612-617, 2018.
APA
Liu, Z., Yu, H., & Guo, Q. (2018). MicroRNA‑20a promotes inflammation via the nuclear factor‑κB signaling pathway in pediatric pneumonia. Molecular Medicine Reports, 17, 612-617. https://doi.org/10.3892/mmr.2017.7899
MLA
Liu, Z., Yu, H., Guo, Q."MicroRNA‑20a promotes inflammation via the nuclear factor‑κB signaling pathway in pediatric pneumonia". Molecular Medicine Reports 17.1 (2018): 612-617.
Chicago
Liu, Z., Yu, H., Guo, Q."MicroRNA‑20a promotes inflammation via the nuclear factor‑κB signaling pathway in pediatric pneumonia". Molecular Medicine Reports 17, no. 1 (2018): 612-617. https://doi.org/10.3892/mmr.2017.7899
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